DE2453648C3 - Verfahren zur Herstellung von 1α-Hydroxycholesterinen sowie 1α,2α-Epoxy-6β sulfonyloxyderivate des 5α-Cholestan-3-ons als Zwischenprodukte - Google Patents

Verfahren zur Herstellung von 1α-Hydroxycholesterinen sowie 1α,2α-Epoxy-6β sulfonyloxyderivate des 5α-Cholestan-3-ons als Zwischenprodukte

Info

Publication number
DE2453648C3
DE2453648C3 DE2453648A DE2453648A DE2453648C3 DE 2453648 C3 DE2453648 C3 DE 2453648C3 DE 2453648 A DE2453648 A DE 2453648A DE 2453648 A DE2453648 A DE 2453648A DE 2453648 C3 DE2453648 C3 DE 2453648C3
Authority
DE
Germany
Prior art keywords
cholestan
epoxy
hydroxy
solution
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2453648A
Other languages
German (de)
English (en)
Other versions
DE2453648B2 (de
DE2453648A1 (de
Inventor
Thomas Albert Pompton Plains N.J. Narwid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE2453648A1 publication Critical patent/DE2453648A1/de
Publication of DE2453648B2 publication Critical patent/DE2453648B2/de
Application granted granted Critical
Publication of DE2453648C3 publication Critical patent/DE2453648C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
DE2453648A 1973-11-12 1974-11-12 Verfahren zur Herstellung von 1α-Hydroxycholesterinen sowie 1α,2α-Epoxy-6β sulfonyloxyderivate des 5α-Cholestan-3-ons als Zwischenprodukte Expired DE2453648C3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US415186A US3887545A (en) 1973-11-12 1973-11-12 Synthesis of 1{60 -hydroxylated cholesterol derivatives

Publications (3)

Publication Number Publication Date
DE2453648A1 DE2453648A1 (de) 1975-05-15
DE2453648B2 DE2453648B2 (de) 1980-06-26
DE2453648C3 true DE2453648C3 (de) 1981-08-06

Family

ID=23644712

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2453648A Expired DE2453648C3 (de) 1973-11-12 1974-11-12 Verfahren zur Herstellung von 1α-Hydroxycholesterinen sowie 1α,2α-Epoxy-6β sulfonyloxyderivate des 5α-Cholestan-3-ons als Zwischenprodukte

Country Status (9)

Country Link
US (1) US3887545A (enExample)
JP (1) JPS5438098B2 (enExample)
AT (1) AT342793B (enExample)
BE (1) BE821983A (enExample)
CH (1) CH599247A5 (enExample)
DE (1) DE2453648C3 (enExample)
FR (1) FR2250764B1 (enExample)
GB (1) GB1443680A (enExample)
NL (1) NL7414675A (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993675A (en) * 1975-02-24 1976-11-23 Hoffmann-La Roche Inc. Process for the preparation of 1α,25-dihydroxycholecalciferol
US4264512A (en) * 1975-09-29 1981-04-28 The Regents Of The University Of California 3-Deoxy-1α-hydroxy- and 3-deoxy-1α,25-dihydroxycholecalciferol and processes for the preparation thereof
JPS603045B2 (ja) * 1976-04-19 1985-01-25 中外製薬株式会社 １α―ヒドロキシビタミンＤ類軟カプセルの製造方法
US4098801A (en) * 1977-01-26 1978-07-04 Hoffmann-La Roche Inc. Synthesis of 1α-hydroxylated derivatives of cholesterol
US4260549A (en) * 1979-05-21 1981-04-07 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
LU80545A1 (de) * 1978-11-17 1980-06-05 Hoffmann La Roche Verfahren zur herstellung von 1a,3s-dihydroxy->5-steroiden
US4217279A (en) * 1978-12-18 1980-08-12 Kaiser Emil T Synthesis of steroids
US5952317A (en) * 1995-09-21 1999-09-14 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
US5976784A (en) * 1996-09-20 1999-11-02 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
KR20000069616A (ko) 1996-12-20 2000-11-25 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 감수분열 조절화합물
WO2000066611A1 (en) * 1999-04-30 2000-11-09 Arch Development Corporation Steroid derivatives
CA2438221A1 (en) * 2001-02-08 2002-08-15 The University Of Chicago Steroidal derivatives
US7078396B2 (en) * 2001-05-03 2006-07-18 Arch Development Corporation Method of treating disorder related to high cholesterol concentration
US20070197484A1 (en) * 2001-05-03 2007-08-23 Ching Song Method of treating disorder related to high cholesterol concentration
CA2482195A1 (en) * 2002-04-12 2003-10-23 The University Of Chicago Farnesoid x-activated receptor agonists
US7897588B2 (en) * 2002-08-29 2011-03-01 The Regents Of The University Of California Agents and methods for enhancing bone formation
WO2005020928A2 (en) * 2003-08-29 2005-03-10 The Regents Of The University Of California Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins
US20070032464A1 (en) * 2004-10-08 2007-02-08 Shutsung Liao Methods of treating cancers
CN101163882B (zh) * 2005-04-23 2011-08-10 艾克塞蒂克马克有限公司 轴向活塞机及其制造方法
JP2009512422A (ja) * 2005-09-02 2009-03-26 ザ リージェンツ オブ ザ ユニヴァーシティー オブ カリフォルニア 骨形成及び抗脂肪細胞形成オキシステロール類
CA2643732C (en) * 2006-02-27 2012-08-21 The Regents Of The University Of California Oxysterol compounds and the hedgehog pathway
US20100048944A1 (en) * 2006-07-19 2010-02-25 Farhad Parhami Interactions of hedgehog and liver x receptor signaling pathways
AU2007339325A1 (en) 2006-12-19 2008-07-10 The Regents Of The University Of California Inhibition of PPAR gamma expression by specific osteogenic oxysterols
WO2008115469A2 (en) * 2007-03-16 2008-09-25 The Regents Of The University Of California Role of hedgehog signaling in atherosclerosis and cardiovascular disease
AU2008331808B2 (en) * 2007-03-16 2014-08-21 The Regents Of The University Of California Oxysterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and Wnt signaling
EP2459581A4 (en) * 2009-07-29 2012-12-26 Univ Chicago LIVER X-RECEPTOR AGONISTS
KR20150013232A (ko) 2012-05-07 2015-02-04 더 리전트 오브 더 유니버시티 오브 캘리포니아 골형성 및 헤지호그 신호전달을 유도하고 지방생성을 억제하는 옥시스테롤 유사체 oxy133
CN105263500A (zh) 2013-05-02 2016-01-20 加利福尼亚大学董事会 骨选择性成骨性氧固醇-骨靶向剂
CN114315947B (zh) * 2021-11-17 2023-10-03 王涛 一种由22-甾醇作为原料合成胆固醇和25-羟基胆固醇的新方法
WO2023143398A1 (zh) * 2022-01-28 2023-08-03 珂阑(上海)医药科技有限公司 甾类化合物、其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3080937A (en) * 1960-11-07 1963-03-12 Garbell Res Foundation Combined acoustic wall and exhaust gas deflector in operation of jet engines
US3741996A (en) * 1971-12-02 1973-06-26 Wisconsin Alumni Res Found 1{60 -hydroxycholecalciferol

Also Published As

Publication number Publication date
AT342793B (de) 1978-04-25
NL7414675A (nl) 1975-05-14
FR2250764B1 (enExample) 1979-08-03
US3887545A (en) 1975-06-03
CH599247A5 (enExample) 1978-05-31
ATA899274A (de) 1977-08-15
DE2453648B2 (de) 1980-06-26
FR2250764A1 (enExample) 1975-06-06
JPS5077360A (enExample) 1975-06-24
GB1443680A (en) 1976-07-21
BE821983A (fr) 1975-05-09
DE2453648A1 (de) 1975-05-15
JPS5438098B2 (enExample) 1979-11-19

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Legal Events

Date Code Title Description
OD Request for examination
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee