GB1443680A - Manufacture of hydroxylated chloesterol derivatives - Google Patents

Manufacture of hydroxylated chloesterol derivatives

Info

Publication number
GB1443680A
GB1443680A GB4872274A GB4872274A GB1443680A GB 1443680 A GB1443680 A GB 1443680A GB 4872274 A GB4872274 A GB 4872274A GB 4872274 A GB4872274 A GB 4872274A GB 1443680 A GB1443680 A GB 1443680A
Authority
GB
United Kingdom
Prior art keywords
hydroxy
cholestan
cholestane
dihydroxy
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4872274A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1443680A publication Critical patent/GB1443680A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
GB4872274A 1973-11-12 1974-11-11 Manufacture of hydroxylated chloesterol derivatives Expired GB1443680A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US415186A US3887545A (en) 1973-11-12 1973-11-12 Synthesis of 1{60 -hydroxylated cholesterol derivatives

Publications (1)

Publication Number Publication Date
GB1443680A true GB1443680A (en) 1976-07-21

Family

ID=23644712

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4872274A Expired GB1443680A (en) 1973-11-12 1974-11-11 Manufacture of hydroxylated chloesterol derivatives

Country Status (9)

Country Link
US (1) US3887545A (enExample)
JP (1) JPS5438098B2 (enExample)
AT (1) AT342793B (enExample)
BE (1) BE821983A (enExample)
CH (1) CH599247A5 (enExample)
DE (1) DE2453648C3 (enExample)
FR (1) FR2250764B1 (enExample)
GB (1) GB1443680A (enExample)
NL (1) NL7414675A (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993675A (en) * 1975-02-24 1976-11-23 Hoffmann-La Roche Inc. Process for the preparation of 1α,25-dihydroxycholecalciferol
US4264512A (en) * 1975-09-29 1981-04-28 The Regents Of The University Of California 3-Deoxy-1α-hydroxy- and 3-deoxy-1α,25-dihydroxycholecalciferol and processes for the preparation thereof
JPS603045B2 (ja) * 1976-04-19 1985-01-25 中外製薬株式会社 １α―ヒドロキシビタミンＤ類軟カプセルの製造方法
US4098801A (en) * 1977-01-26 1978-07-04 Hoffmann-La Roche Inc. Synthesis of 1α-hydroxylated derivatives of cholesterol
US4260549A (en) * 1979-05-21 1981-04-07 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
LU80545A1 (de) * 1978-11-17 1980-06-05 Hoffmann La Roche Verfahren zur herstellung von 1a,3s-dihydroxy->5-steroiden
US4217279A (en) * 1978-12-18 1980-08-12 Kaiser Emil T Synthesis of steroids
US5952317A (en) * 1995-09-21 1999-09-14 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
US5976784A (en) * 1996-09-20 1999-11-02 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
EP0946584B1 (en) 1996-12-20 2003-04-23 Novo Nordisk A/S Meiosis regulating compounds
JP2002543216A (ja) * 1999-04-30 2002-12-17 アーチ ディベロップメント コーポレイション ステロイド誘導体
WO2002062302A2 (en) * 2001-02-08 2002-08-15 The University Of Chicago Steroidal derivatives
US20070197484A1 (en) * 2001-05-03 2007-08-23 Ching Song Method of treating disorder related to high cholesterol concentration
US7078396B2 (en) * 2001-05-03 2006-07-18 Arch Development Corporation Method of treating disorder related to high cholesterol concentration
AU2003228485A1 (en) * 2002-04-12 2003-10-27 The University Of Chicago Farnesoid x-activated receptor agonists
JP2006503819A (ja) * 2002-08-29 2006-02-02 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 骨形成を増進するための作用剤および方法
US9532994B2 (en) * 2003-08-29 2017-01-03 The Regents Of The University Of California Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins
US20070032464A1 (en) * 2004-10-08 2007-02-08 Shutsung Liao Methods of treating cancers
EP1877663B1 (de) * 2005-04-23 2009-01-28 ixetic MAC GmbH Axialkolbenmaschine
US20090220562A1 (en) * 2005-09-02 2009-09-03 Farhad Parhami Osteogenic and anti-adipogenic oxysterols
AU2007217366A1 (en) * 2006-02-27 2007-08-30 The Regents Of The University Of California Oxysterol compounds and the hedgehog pathway
WO2008011071A2 (en) * 2006-07-19 2008-01-24 The Regents Of The University Of California Interactions of hedgehog and liver x receptor signaling pathways
AU2007339325A1 (en) 2006-12-19 2008-07-10 The Regents Of The University Of California Inhibition of PPAR gamma expression by specific osteogenic oxysterols
WO2008115469A2 (en) * 2007-03-16 2008-09-25 The Regents Of The University Of California Role of hedgehog signaling in atherosclerosis and cardiovascular disease
US9526737B2 (en) * 2007-12-03 2016-12-27 The Regents Of The University Of California Oxysterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and Wnt signaling
JP2013500986A (ja) * 2009-07-29 2013-01-10 ザ・ユニバーシティ・オブ・シカゴ 肝臓ｘ受容体アゴニスト
CA2872751A1 (en) 2012-05-07 2013-11-14 The Regents Of The University Of California Oxysterol analogue oxy133 induces osteogenesis and hedgehog signaling and inhibits adipogenesis
JP2016517888A (ja) 2013-05-02 2016-06-20 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 骨選択的骨形成のオキシステロール骨標的薬剤
CN114315947B (zh) * 2021-11-17 2023-10-03 王涛 一种由22-甾醇作为原料合成胆固醇和25-羟基胆固醇的新方法
CN116514891B (zh) * 2022-01-28 2025-08-05 珂阑(上海)医药科技有限公司 甾类化合物、其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3080937A (en) * 1960-11-07 1963-03-12 Garbell Res Foundation Combined acoustic wall and exhaust gas deflector in operation of jet engines
US3741996A (en) * 1971-12-02 1973-06-26 Wisconsin Alumni Res Found 1{60 -hydroxycholecalciferol

Also Published As

Publication number Publication date
JPS5077360A (enExample) 1975-06-24
BE821983A (fr) 1975-05-09
CH599247A5 (enExample) 1978-05-31
FR2250764B1 (enExample) 1979-08-03
DE2453648C3 (de) 1981-08-06
NL7414675A (nl) 1975-05-14
DE2453648A1 (de) 1975-05-15
US3887545A (en) 1975-06-03
JPS5438098B2 (enExample) 1979-11-19
DE2453648B2 (de) 1980-06-26
ATA899274A (de) 1977-08-15
FR2250764A1 (enExample) 1975-06-06
AT342793B (de) 1978-04-25

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee