CH614217A5 - Process for the preparation of 1,3,5(10)-8alpha-oestratrienes - Google Patents
Process for the preparation of 1,3,5(10)-8alpha-oestratrienesInfo
- Publication number
- CH614217A5 CH614217A5 CH1035978A CH1035978A CH614217A5 CH 614217 A5 CH614217 A5 CH 614217A5 CH 1035978 A CH1035978 A CH 1035978A CH 1035978 A CH1035978 A CH 1035978A CH 614217 A5 CH614217 A5 CH 614217A5
- Authority
- CH
- Switzerland
- Prior art keywords
- compounds
- hydroxy
- alpha
- keto
- oestratrienes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0074—Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
Abstract
1,3,5(10)-8 alpha -oestratrienes of the following formula <IMAGE> in which R<1> is acyl and R<2> is lower alkyl are prepared. These compounds are obtained by oxidising a corresponding 3-hydroxy-13-R<2>-8 alpha -oestra-1,3,5(10)-trien-17-one with lead tetraacylate and rearranging the reaction product in the presence of a strong acid. The corresponding 1,3-hydroxy compounds are likewise prepared from the 1,3-diacyl compounds and can be converted into the corresponding diethers. The reduction of 17-keto compounds I into corresponding 17ss-hydroxy compounds is also described. The conversion of the said 17-keto compounds into 17ss-hydroxy-17 alpha R<4> compounds by reacting the 17-keto compounds with an organometallic compound which supplies the radical R<4>, which is a saturated or unsaturated, optionally substituted hydrocarbon group, is also described. The said compounds display favourable oestrogenic dissociation and can be used for the treatment of manifestations of oestrogen deficiency.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2336431A DE2336431C2 (en) | 1973-07-13 | 1973-07-13 | 1.3-oxygenated 8-alpha-estratrienes, processes for their production and pharmaceuticals containing them |
| DE19742426777 DE2426777A1 (en) | 1974-05-31 | 1974-05-31 | 1,3-Oxygenated-8-alpha-oestratrienes for post-menopausal disorders - with vaginotropic, but low uterotrophic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH614217A5 true CH614217A5 (en) | 1979-11-15 |
Family
ID=25765510
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH964674A CH609064A5 (en) | 1973-07-13 | 1974-07-12 | Process for the preparation of dihydroxy-1,3,5(10)-8alpha-oestratrienes or their ethers or esters |
| CH1035978A CH614217A5 (en) | 1973-07-13 | 1974-07-12 | Process for the preparation of 1,3,5(10)-8alpha-oestratrienes |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH964674A CH609064A5 (en) | 1973-07-13 | 1974-07-12 | Process for the preparation of dihydroxy-1,3,5(10)-8alpha-oestratrienes or their ethers or esters |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS5821639B2 (en) |
| AT (1) | ATA575574A (en) |
| AU (1) | AU477010B2 (en) |
| CA (1) | CA1030951A (en) |
| CH (2) | CH609064A5 (en) |
| CS (2) | CS182260B2 (en) |
| DD (1) | DD114066A5 (en) |
| DK (1) | DK133051C (en) |
| ES (1) | ES428226A1 (en) |
| FI (1) | FI54131C (en) |
| FR (1) | FR2236505B1 (en) |
| GB (1) | GB1479934A (en) |
| HU (1) | HU169791B (en) |
| IE (1) | IE39872B1 (en) |
| IL (1) | IL45259A (en) |
| NO (1) | NO742546L (en) |
| SE (1) | SE7409151L (en) |
| SU (1) | SU626705A3 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020096485A1 (en) * | 2018-11-08 | 2020-05-14 | Шамиль Сионович ИЛЬЯСОВ | Treatment for breast cancer, including triple-negative breast cancer |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2551214C2 (en) * | 1975-11-12 | 1984-07-12 | Schering AG, 1000 Berlin und 4709 Bergkamen | Process for the preparation of 1,3-oxygenated 8α-estatrienes |
| JPS5862734U (en) * | 1981-10-22 | 1983-04-27 | 日工株式会社 | formwork support sabot |
| JPS59146759A (en) * | 1984-01-06 | 1984-08-22 | 株式会社日立製作所 | Automatic screwing device |
| JPS60155376A (en) * | 1984-01-24 | 1985-08-15 | 松下電器産業株式会社 | Nut float detection apparatus |
| DE3710728A1 (en) * | 1987-03-31 | 1988-10-13 | Schering Ag | METHOD FOR PRODUCING 17 (ALPHA) -ETHINYL-17SS-HYDROXY-18-METHYL-4.15-ESTRADIEN-3-ON AND THE NEW INTERMEDIATE PRODUCTS FOR THIS METHOD |
| US6011024A (en) | 1991-08-28 | 2000-01-04 | Imperial College Of Science Technology & Medicine | Steroid sulphatase inhibitors |
| US6476011B1 (en) | 1991-08-28 | 2002-11-05 | Sterix Limited | Methods for introducing an estrogenic compound |
| US6903084B2 (en) | 1991-08-29 | 2005-06-07 | Sterix Limited | Steroid sulphatase inhibitors |
| US7335650B2 (en) | 2000-01-14 | 2008-02-26 | Sterix Limited | Composition |
| GB0020498D0 (en) | 2000-08-18 | 2000-10-11 | Sterix Ltd | Compound |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3436411A (en) * | 1967-12-28 | 1969-04-01 | American Home Prod | Process for cleaving an a-ring ether group in 13-alkylgona (and 8-isogona)-1,3,5(10)-trienes and delta-7-,delta-8(9)-,and delta-8(9),14(15)-dehydro derivatives thereof |
-
1974
- 1974-07-09 DK DK368074A patent/DK133051C/en not_active IP Right Cessation
- 1974-07-11 DD DD179870A patent/DD114066A5/xx unknown
- 1974-07-11 AU AU71123/74A patent/AU477010B2/en not_active Expired
- 1974-07-11 AT AT575574A patent/ATA575574A/en not_active Application Discontinuation
- 1974-07-11 IE IE1461/74A patent/IE39872B1/en unknown
- 1974-07-11 SE SE7409151A patent/SE7409151L/en unknown
- 1974-07-12 CA CA204,667A patent/CA1030951A/en not_active Expired
- 1974-07-12 CH CH964674A patent/CH609064A5/en not_active IP Right Cessation
- 1974-07-12 HU HU74@@E480A patent/HU169791B/en unknown
- 1974-07-12 CS CS7400004984A patent/CS182260B2/en unknown
- 1974-07-12 CH CH1035978A patent/CH614217A5/en not_active IP Right Cessation
- 1974-07-12 SU SU742043783A patent/SU626705A3/en active
- 1974-07-12 NO NO742546A patent/NO742546L/no unknown
- 1974-07-12 JP JP49080116A patent/JPS5821639B2/en not_active Expired
- 1974-07-12 FI FI2139/74A patent/FI54131C/en active
- 1974-07-12 ES ES428226A patent/ES428226A1/en not_active Expired
- 1974-07-12 CS CS7600001694A patent/CS182300B2/en unknown
- 1974-07-14 IL IL45259A patent/IL45259A/en unknown
- 1974-07-15 FR FR7424499A patent/FR2236505B1/fr not_active Expired
- 1974-07-15 GB GB31241/74A patent/GB1479934A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020096485A1 (en) * | 2018-11-08 | 2020-05-14 | Шамиль Сионович ИЛЬЯСОВ | Treatment for breast cancer, including triple-negative breast cancer |
Also Published As
| Publication number | Publication date |
|---|---|
| DK133051B (en) | 1976-03-15 |
| CA1030951A (en) | 1978-05-09 |
| SU626705A3 (en) | 1978-09-30 |
| IL45259A0 (en) | 1974-10-22 |
| JPS5032160A (en) | 1975-03-28 |
| DD114066A5 (en) | 1975-07-12 |
| AU7112374A (en) | 1976-01-15 |
| JPS5821639B2 (en) | 1983-05-02 |
| AU477010B2 (en) | 1976-10-14 |
| FR2236505B1 (en) | 1977-07-08 |
| IL45259A (en) | 1977-10-31 |
| GB1479934A (en) | 1977-07-13 |
| CS182300B2 (en) | 1978-04-28 |
| CS182260B2 (en) | 1978-04-28 |
| HU169791B (en) | 1977-01-28 |
| FI54131C (en) | 1978-10-10 |
| IE39872B1 (en) | 1979-01-17 |
| IE39872L (en) | 1975-01-13 |
| ATA575574A (en) | 1978-05-15 |
| CH609064A5 (en) | 1979-02-15 |
| DK133051C (en) | 1976-08-16 |
| FI54131B (en) | 1978-06-30 |
| NO742546L (en) | 1975-02-10 |
| FR2236505A1 (en) | 1975-02-07 |
| DK368074A (en) | 1975-03-17 |
| ES428226A1 (en) | 1976-07-16 |
| FI213974A (en) | 1975-01-14 |
| SE7409151L (en) | 1975-01-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |