GB1477567A - D-homo steroids - Google Patents

D-homo steroids

Info

Publication number
GB1477567A
GB1477567A GB4263775A GB4263775A GB1477567A GB 1477567 A GB1477567 A GB 1477567A GB 4263775 A GB4263775 A GB 4263775A GB 4263775 A GB4263775 A GB 4263775A GB 1477567 A GB1477567 A GB 1477567A
Authority
GB
United Kingdom
Prior art keywords
homosteroids
beta
alpha
acyl
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4263775A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1477567A publication Critical patent/GB1477567A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

D-Homosteroids of the formula <IMAGE> in which R<3> is (H,H) or ( alpha -H, beta -O-acyl), R<13> is lower alkyl, R<17a beta > is H or acyl, R<17a alpha > is ethynyl, 1-propynyl, vinyl, chloroethynyl, butadienyl or propadienyl, and the dotted line in the A ring indicates an additional C-C bond in the 4,5 or 5(10) position. These D-homosteroids have hormonal activity and can be prepared in a manner known per se starting from the 17-keto-D-homosteroids corresponding to the D-homosteroids of the formula I, on the one hand by reaction of these 17-ketosteroids with an organometallic compound supplying a radical R<17a alpha > or, on the other hand, by following this reaction by acylation of the resulting 17a beta -hydroxy-D-homosteroid.
GB4263775A 1974-10-18 1975-10-17 D-homo steroids Expired GB1477567A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1398974A CH606113A5 (en) 1974-10-18 1974-10-18

Publications (1)

Publication Number Publication Date
GB1477567A true GB1477567A (en) 1977-06-22

Family

ID=4397020

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4263775A Expired GB1477567A (en) 1974-10-18 1975-10-17 D-homo steroids

Country Status (27)

Country Link
JP (1) JPS5165750A (en)
AT (1) AT348697B (en)
BE (1) BE834597A (en)
CA (1) CA1052768A (en)
CH (2) CH606113A5 (en)
DD (1) DD123331A5 (en)
DE (1) DE2546613A1 (en)
DK (1) DK137088B (en)
ES (1) ES441863A1 (en)
FI (1) FI53974C (en)
FR (1) FR2287902A1 (en)
GB (1) GB1477567A (en)
HK (1) HK40580A (en)
HU (1) HU174009B (en)
IE (1) IE42024B1 (en)
IL (1) IL48239A (en)
KE (1) KE3062A (en)
LU (1) LU73595A1 (en)
MY (1) MY8100137A (en)
NL (1) NL7512221A (en)
NO (2) NO142349C (en)
NZ (1) NZ178880A (en)
PH (1) PH13491A (en)
PL (1) PL100429B1 (en)
SE (1) SE7511640L (en)
SU (1) SU602121A3 (en)
ZA (1) ZA756243B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL51468A (en) * 1976-02-23 1981-01-30 Sparamedica Ag 17 -hydroxy- -d-homosteroid derivatives,their preparation and pharmaceutical compositions containing them
US4788218A (en) * 1984-05-21 1988-11-29 Sri International 17 a β-hydroxy-7 α-methyl-d-homo-19-norandrost-4,16-diene-3-one and the 17-esters thereof: methods of preparation and uses
JPS61502186A (en) * 1984-05-21 1986-10-02 エス・ア−ル・アイ・インタ−ナシヨナル 17αβ-Hydroxy-7α-methyl-D-homo-19-norandrost-4,16-dien-3-one and its 17-ester, and its preparation and use

Also Published As

Publication number Publication date
SU602121A3 (en) 1978-04-05
NO142349C (en) 1980-08-06
NO143503C (en) 1981-02-25
AU8567175A (en) 1977-04-21
DD123331A5 (en) 1976-12-12
DK137088C (en) 1978-06-19
IE42024L (en) 1976-04-18
SE7511640L (en) 1976-04-20
NO792125L (en) 1976-04-21
CA1052768A (en) 1979-04-17
CH606113A5 (en) 1978-10-13
FI53974C (en) 1978-09-11
HU174009B (en) 1979-10-28
PL100429B1 (en) 1978-10-31
DK137088B (en) 1978-01-16
DE2546613A1 (en) 1976-04-22
NO753505L (en) 1976-04-21
MY8100137A (en) 1981-12-31
KE3062A (en) 1980-07-25
NZ178880A (en) 1978-06-20
BE834597A (en) 1976-04-20
HK40580A (en) 1980-08-15
IE42024B1 (en) 1980-05-21
JPS5165750A (en) 1976-06-07
NL7512221A (en) 1976-04-21
AT348697B (en) 1979-02-26
NO143503B (en) 1980-11-17
FR2287902B1 (en) 1980-05-30
ES441863A1 (en) 1977-04-01
FI752797A (en) 1976-04-19
LU73595A1 (en) 1977-05-24
ATA793775A (en) 1978-07-15
CH618446A5 (en) 1980-07-31
IL48239A (en) 1979-01-31
FI53974B (en) 1978-05-31
FR2287902A1 (en) 1976-05-14
IL48239A0 (en) 1975-12-31
NO142349B (en) 1980-04-28
ZA756243B (en) 1976-09-29
PH13491A (en) 1980-05-21
DK469975A (en) 1976-04-19

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee