SE7511640L - NEW D-HOMOSTEROIDS - Google Patents

NEW D-HOMOSTEROIDS

Info

Publication number
SE7511640L
SE7511640L SE7511640A SE7511640A SE7511640L SE 7511640 L SE7511640 L SE 7511640L SE 7511640 A SE7511640 A SE 7511640A SE 7511640 A SE7511640 A SE 7511640A SE 7511640 L SE7511640 L SE 7511640L
Authority
SE
Sweden
Prior art keywords
homosteroids
beta
alpha
acyl
reaction
Prior art date
Application number
SE7511640A
Other languages
Unknown language ( )
Swedish (sv)
Inventor
A Furst
M Muller
J A W Gutzwiller
U Kerb
R Wiechert
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SE7511640L publication Critical patent/SE7511640L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

D-Homosteroids of the formula <IMAGE> in which R<3> is (H,H) or ( alpha -H, beta -O-acyl), R<13> is lower alkyl, R<17a beta > is H or acyl, R<17a alpha > is ethynyl, 1-propynyl, vinyl, chloroethynyl, butadienyl or propadienyl, and the dotted line in the A ring indicates an additional C-C bond in the 4,5 or 5(10) position. These D-homosteroids have hormonal activity and can be prepared in a manner known per se starting from the 17-keto-D-homosteroids corresponding to the D-homosteroids of the formula I, on the one hand by reaction of these 17-ketosteroids with an organometallic compound supplying a radical R<17a alpha > or, on the other hand, by following this reaction by acylation of the resulting 17a beta -hydroxy-D-homosteroid.
SE7511640A 1974-10-18 1975-10-16 NEW D-HOMOSTEROIDS SE7511640L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1398974A CH606113A5 (en) 1974-10-18 1974-10-18

Publications (1)

Publication Number Publication Date
SE7511640L true SE7511640L (en) 1976-04-20

Family

ID=4397020

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7511640A SE7511640L (en) 1974-10-18 1975-10-16 NEW D-HOMOSTEROIDS

Country Status (27)

Country Link
JP (1) JPS5165750A (en)
AT (1) AT348697B (en)
BE (1) BE834597A (en)
CA (1) CA1052768A (en)
CH (2) CH606113A5 (en)
DD (1) DD123331A5 (en)
DE (1) DE2546613A1 (en)
DK (1) DK137088B (en)
ES (1) ES441863A1 (en)
FI (1) FI53974C (en)
FR (1) FR2287902A1 (en)
GB (1) GB1477567A (en)
HK (1) HK40580A (en)
HU (1) HU174009B (en)
IE (1) IE42024B1 (en)
IL (1) IL48239A (en)
KE (1) KE3062A (en)
LU (1) LU73595A1 (en)
MY (1) MY8100137A (en)
NL (1) NL7512221A (en)
NO (2) NO142349C (en)
NZ (1) NZ178880A (en)
PH (1) PH13491A (en)
PL (1) PL100429B1 (en)
SE (1) SE7511640L (en)
SU (1) SU602121A3 (en)
ZA (1) ZA756243B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL51468A (en) * 1976-02-23 1981-01-30 Sparamedica Ag 17 -hydroxy- -d-homosteroid derivatives,their preparation and pharmaceutical compositions containing them
US4788218A (en) * 1984-05-21 1988-11-29 Sri International 17 a β-hydroxy-7 α-methyl-d-homo-19-norandrost-4,16-diene-3-one and the 17-esters thereof: methods of preparation and uses
JPS61502186A (en) * 1984-05-21 1986-10-02 エス・ア−ル・アイ・インタ−ナシヨナル 17αβ-Hydroxy-7α-methyl-D-homo-19-norandrost-4,16-dien-3-one and its 17-ester, and its preparation and use

Also Published As

Publication number Publication date
DK137088C (en) 1978-06-19
KE3062A (en) 1980-07-25
NO142349C (en) 1980-08-06
NO143503C (en) 1981-02-25
IL48239A0 (en) 1975-12-31
BE834597A (en) 1976-04-20
NO143503B (en) 1980-11-17
ES441863A1 (en) 1977-04-01
LU73595A1 (en) 1977-05-24
FI53974B (en) 1978-05-31
AT348697B (en) 1979-02-26
HK40580A (en) 1980-08-15
PL100429B1 (en) 1978-10-31
FR2287902A1 (en) 1976-05-14
FR2287902B1 (en) 1980-05-30
CH606113A5 (en) 1978-10-13
IE42024B1 (en) 1980-05-21
ZA756243B (en) 1976-09-29
MY8100137A (en) 1981-12-31
FI752797A (en) 1976-04-19
DD123331A5 (en) 1976-12-12
IE42024L (en) 1976-04-18
SU602121A3 (en) 1978-04-05
NO792125L (en) 1976-04-21
HU174009B (en) 1979-10-28
DE2546613A1 (en) 1976-04-22
ATA793775A (en) 1978-07-15
CA1052768A (en) 1979-04-17
JPS5165750A (en) 1976-06-07
NO142349B (en) 1980-04-28
DK469975A (en) 1976-04-19
DK137088B (en) 1978-01-16
FI53974C (en) 1978-09-11
CH618446A5 (en) 1980-07-31
AU8567175A (en) 1977-04-21
PH13491A (en) 1980-05-21
NZ178880A (en) 1978-06-20
NO753505L (en) 1976-04-21
IL48239A (en) 1979-01-31
NL7512221A (en) 1976-04-21
GB1477567A (en) 1977-06-22

Similar Documents

Publication Publication Date Title
GB1152226A (en) Novel Gona-1,3,5(10)-Trienes, processes for their preparation, and compositions incorporating them
SE7511640L (en) NEW D-HOMOSTEROIDS
ES367716A1 (en) Process for the preparation of a catalyst useful for the polymerization of olefins
SE416054B (en) PROCEDURE FOR THE PREPARATION OF NEW 11-SUBSTITUTED STEROIDS FROM THE OSTRANSERY.
ES417737A1 (en) Steroids of the pregnane series
GB1112840A (en) Steroids having pro-oestrogenic activity
ES421511A1 (en) Novel antiandrogenic compounds
ES364322A1 (en) Procedure for the obtaining of amino unsaturated steroids. (Machine-translation by Google Translate, not legally binding)
GB983125A (en) Preparation of 9(11)-dehydro spirostanes and 3-esters thereof
ES281669A1 (en) A procedure for preparing a steroid cetone (Machine-translation by Google Translate, not legally binding)
ES461325A1 (en) D-homosteroids
ES457731A1 (en) D-homosteroids
GB1089237A (en) Improvements in or relating to tetrahydrofuranyl ethers of 17ª‰-hydroxy-androstane compounds
SE7906721L (en) NEW D-HOMOSTEROIDS
GB981468A (en) Improvements in or relating to androstane derivatives and the production thereof
GB1047790A (en) Improvements in or relating to steroid compounds
GB1090066A (en) Preparation of 17-keto-androstane derivatives
ES469513A1 (en) Novel DELTA 4-pregnenes
ES375061A1 (en) Sulphamido-steroids and the preparation thereof
ES345997A1 (en) A procedure for the preparation of substitute steroids 17 alpha-dihalociclopropenil or 17 substitute alpha-dihalociclopropil. (Machine-translation by Google Translate, not legally binding)
SE7514513L (en) 15 ALFA, 16 ALFA-METHYLENE-4-OSTRENE-17BETA OLES FOR USE AS CONTRACTIVE AGENT
FR2088228A1 (en) Androgenic and myotropic steroids - 3-keto-17-(bicyclo-(2,2,2)-octane-1&#39;-methoxy carbonyloxy steroids
ES316281A1 (en) A procedure to prepare a 3-ceto delta 4 (5) -19-nor-10-iso steroids. (Machine-translation by Google Translate, not legally binding)
ES352066A1 (en) A procedure for the preparation of 17-alpha-propodien steroids. (Machine-translation by Google Translate, not legally binding)
ES301729A1 (en) Procedure for preparing steroid compounds. (Machine-translation by Google Translate, not legally binding)

Legal Events

Date Code Title Description
NAV Patent application has lapsed

Ref document number: 7511640-0

Format of ref document f/p: F