ES441863A1 - D-homo steroids - Google Patents
D-homo steroidsInfo
- Publication number
- ES441863A1 ES441863A1 ES441863A ES441863A ES441863A1 ES 441863 A1 ES441863 A1 ES 441863A1 ES 441863 A ES441863 A ES 441863A ES 441863 A ES441863 A ES 441863A ES 441863 A1 ES441863 A1 ES 441863A1
- Authority
- ES
- Spain
- Prior art keywords
- homosteroids
- beta
- alpha
- acyl
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
D-Homosteroids of the formula < IMAGE > in which R<3> is (H,H) or ( alpha -H, beta -O-acyl), R<13> is lower alkyl, R<17a beta > is H or acyl, R<17a alpha > is ethynyl, 1-propynyl, vinyl, chloroethynyl, butadienyl or propadienyl, and the dotted line in the A ring indicates an additional C-C bond in the 4,5 or 5(10) position. These D-homosteroids have hormonal activity and can be prepared in a manner known per se starting from the 17-keto-D-homosteroids corresponding to the D-homosteroids of the formula I, on the one hand by reaction of these 17-ketosteroids with an organometallic compound supplying a radical R<17a alpha > or, on the other hand, by following this reaction by acylation of the resulting 17a beta -hydroxy-D-homosteroid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1398974A CH606113A5 (en) | 1974-10-18 | 1974-10-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES441863A1 true ES441863A1 (en) | 1977-04-01 |
Family
ID=4397020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES441863A Expired ES441863A1 (en) | 1974-10-18 | 1975-10-17 | D-homo steroids |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS5165750A (en) |
| AT (1) | AT348697B (en) |
| BE (1) | BE834597A (en) |
| CA (1) | CA1052768A (en) |
| CH (2) | CH606113A5 (en) |
| DD (1) | DD123331A5 (en) |
| DE (1) | DE2546613A1 (en) |
| DK (1) | DK137088B (en) |
| ES (1) | ES441863A1 (en) |
| FI (1) | FI53974C (en) |
| FR (1) | FR2287902A1 (en) |
| GB (1) | GB1477567A (en) |
| HK (1) | HK40580A (en) |
| HU (1) | HU174009B (en) |
| IE (1) | IE42024B1 (en) |
| IL (1) | IL48239A (en) |
| KE (1) | KE3062A (en) |
| LU (1) | LU73595A1 (en) |
| MY (1) | MY8100137A (en) |
| NL (1) | NL7512221A (en) |
| NO (2) | NO142349C (en) |
| NZ (1) | NZ178880A (en) |
| PH (1) | PH13491A (en) |
| PL (1) | PL100429B1 (en) |
| SE (1) | SE7511640L (en) |
| SU (1) | SU602121A3 (en) |
| ZA (1) | ZA756243B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL51468A (en) * | 1976-02-23 | 1981-01-30 | Sparamedica Ag | 17 -hydroxy- -d-homosteroid derivatives,their preparation and pharmaceutical compositions containing them |
| US4788218A (en) * | 1984-05-21 | 1988-11-29 | Sri International | 17 a β-hydroxy-7 α-methyl-d-homo-19-norandrost-4,16-diene-3-one and the 17-esters thereof: methods of preparation and uses |
| JPS61502186A (en) * | 1984-05-21 | 1986-10-02 | エス・ア−ル・アイ・インタ−ナシヨナル | 17αβ-Hydroxy-7α-methyl-D-homo-19-norandrost-4,16-dien-3-one and its 17-ester, and its preparation and use |
-
1974
- 1974-10-18 CH CH1398974A patent/CH606113A5/xx not_active IP Right Cessation
-
1975
- 1975-10-01 ZA ZA00756243A patent/ZA756243B/en unknown
- 1975-10-03 IL IL48239A patent/IL48239A/en unknown
- 1975-10-07 FI FI752797A patent/FI53974C/en not_active IP Right Cessation
- 1975-10-15 FR FR7531502A patent/FR2287902A1/en active Granted
- 1975-10-15 NZ NZ178880A patent/NZ178880A/en unknown
- 1975-10-15 CA CA237,710A patent/CA1052768A/en not_active Expired
- 1975-10-16 SU SU752180252A patent/SU602121A3/en active
- 1975-10-16 JP JP50123871A patent/JPS5165750A/en active Pending
- 1975-10-16 SE SE7511640A patent/SE7511640L/en not_active Application Discontinuation
- 1975-10-16 LU LU73595A patent/LU73595A1/xx unknown
- 1975-10-16 DD DD188897A patent/DD123331A5/xx unknown
- 1975-10-16 PH PH17667A patent/PH13491A/en unknown
- 1975-10-17 NL NL7512221A patent/NL7512221A/en not_active Application Discontinuation
- 1975-10-17 PL PL1975184060A patent/PL100429B1/en unknown
- 1975-10-17 GB GB4263775A patent/GB1477567A/en not_active Expired
- 1975-10-17 BE BE161009A patent/BE834597A/en unknown
- 1975-10-17 ES ES441863A patent/ES441863A1/en not_active Expired
- 1975-10-17 HU HU75HO1848A patent/HU174009B/en unknown
- 1975-10-17 AT AT793775A patent/AT348697B/en not_active IP Right Cessation
- 1975-10-17 NO NO753505A patent/NO142349C/en unknown
- 1975-10-17 IE IE2264/75A patent/IE42024B1/en unknown
- 1975-10-17 DK DK469975AA patent/DK137088B/en unknown
- 1975-10-17 DE DE19752546613 patent/DE2546613A1/en not_active Withdrawn
-
1977
- 1977-11-10 CH CH1371977A patent/CH618446A5/en not_active IP Right Cessation
-
1979
- 1979-06-25 NO NO792125A patent/NO143503C/en unknown
-
1980
- 1980-07-07 KE KE3062A patent/KE3062A/en unknown
- 1980-08-07 HK HK405/80A patent/HK40580A/en unknown
-
1981
- 1981-12-30 MY MY137/81A patent/MY8100137A/en unknown
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