IE42024L - D-homo steroids - Google Patents

D-homo steroids

Info

Publication number
IE42024L
IE42024L IE752264A IE226475A IE42024L IE 42024 L IE42024 L IE 42024L IE 752264 A IE752264 A IE 752264A IE 226475 A IE226475 A IE 226475A IE 42024 L IE42024 L IE 42024L
Authority
IE
Ireland
Prior art keywords
homosteroids
beta
alpha
acyl
reaction
Prior art date
Application number
IE752264A
Other versions
IE42024B1 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IE42024L publication Critical patent/IE42024L/en
Publication of IE42024B1 publication Critical patent/IE42024B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

D-Homosteroids of the formula <IMAGE> in which R<3> is (H,H) or ( alpha -H, beta -O-acyl), R<13> is lower alkyl, R<17a beta > is H or acyl, R<17a alpha > is ethynyl, 1-propynyl, vinyl, chloroethynyl, butadienyl or propadienyl, and the dotted line in the A ring indicates an additional C-C bond in the 4,5 or 5(10) position. These D-homosteroids have hormonal activity and can be prepared in a manner known per se starting from the 17-keto-D-homosteroids corresponding to the D-homosteroids of the formula I, on the one hand by reaction of these 17-ketosteroids with an organometallic compound supplying a radical R<17a alpha > or, on the other hand, by following this reaction by acylation of the resulting 17a beta -hydroxy-D-homosteroid. [GB1477567A]
IE2264/75A 1974-10-18 1975-10-17 D-homo steroids IE42024B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1398974A CH606113A5 (en) 1974-10-18 1974-10-18

Publications (2)

Publication Number Publication Date
IE42024L true IE42024L (en) 1976-04-18
IE42024B1 IE42024B1 (en) 1980-05-21

Family

ID=4397020

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2264/75A IE42024B1 (en) 1974-10-18 1975-10-17 D-homo steroids

Country Status (27)

Country Link
JP (1) JPS5165750A (en)
AT (1) AT348697B (en)
BE (1) BE834597A (en)
CA (1) CA1052768A (en)
CH (2) CH606113A5 (en)
DD (1) DD123331A5 (en)
DE (1) DE2546613A1 (en)
DK (1) DK137088B (en)
ES (1) ES441863A1 (en)
FI (1) FI53974C (en)
FR (1) FR2287902A1 (en)
GB (1) GB1477567A (en)
HK (1) HK40580A (en)
HU (1) HU174009B (en)
IE (1) IE42024B1 (en)
IL (1) IL48239A (en)
KE (1) KE3062A (en)
LU (1) LU73595A1 (en)
MY (1) MY8100137A (en)
NL (1) NL7512221A (en)
NO (2) NO142349C (en)
NZ (1) NZ178880A (en)
PH (1) PH13491A (en)
PL (1) PL100429B1 (en)
SE (1) SE7511640L (en)
SU (1) SU602121A3 (en)
ZA (1) ZA756243B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL51468A (en) * 1976-02-23 1981-01-30 Sparamedica Ag 17 -hydroxy- -d-homosteroid derivatives,their preparation and pharmaceutical compositions containing them
EP0182808A1 (en) * 1984-05-21 1986-06-04 Sri International 17 a?$g(b)-HYDROXY-7$g(a)-METHYL-D-HOMO-19-NORANDROST-4,16-DIENE-3-ONE AND THE 17-ESTERS THEREOF: METHODS OF PREPARATION AND USES
US4788218A (en) * 1984-05-21 1988-11-29 Sri International 17 a β-hydroxy-7 α-methyl-d-homo-19-norandrost-4,16-diene-3-one and the 17-esters thereof: methods of preparation and uses

Also Published As

Publication number Publication date
NO753505L (en) 1976-04-21
HK40580A (en) 1980-08-15
BE834597A (en) 1976-04-20
CH606113A5 (en) 1978-10-13
DE2546613A1 (en) 1976-04-22
FR2287902A1 (en) 1976-05-14
MY8100137A (en) 1981-12-31
SU602121A3 (en) 1978-04-05
PH13491A (en) 1980-05-21
DD123331A5 (en) 1976-12-12
NO143503B (en) 1980-11-17
FI53974B (en) 1978-05-31
IL48239A (en) 1979-01-31
KE3062A (en) 1980-07-25
JPS5165750A (en) 1976-06-07
GB1477567A (en) 1977-06-22
DK137088C (en) 1978-06-19
SE7511640L (en) 1976-04-20
FR2287902B1 (en) 1980-05-30
NL7512221A (en) 1976-04-21
LU73595A1 (en) 1977-05-24
PL100429B1 (en) 1978-10-31
HU174009B (en) 1979-10-28
NO142349B (en) 1980-04-28
AU8567175A (en) 1977-04-21
ZA756243B (en) 1976-09-29
IL48239A0 (en) 1975-12-31
CA1052768A (en) 1979-04-17
ATA793775A (en) 1978-07-15
NO142349C (en) 1980-08-06
NZ178880A (en) 1978-06-20
NO143503C (en) 1981-02-25
FI53974C (en) 1978-09-11
DK469975A (en) 1976-04-19
DK137088B (en) 1978-01-16
NO792125L (en) 1976-04-21
FI752797A (en) 1976-04-19
CH618446A5 (en) 1980-07-31
ES441863A1 (en) 1977-04-01
IE42024B1 (en) 1980-05-21
AT348697B (en) 1979-02-26

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