JPS5551099A - Preparation of estrone - Google Patents
Preparation of estroneInfo
- Publication number
- JPS5551099A JPS5551099A JP12547878A JP12547878A JPS5551099A JP S5551099 A JPS5551099 A JP S5551099A JP 12547878 A JP12547878 A JP 12547878A JP 12547878 A JP12547878 A JP 12547878A JP S5551099 A JPS5551099 A JP S5551099A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- androsta
- dione
- acetal
- diene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Steroid Compounds (AREA)
Abstract
PURPOSE: To obtain the title compound in high yield, by bringing an androsta- 1,4-diene-3,17-dione 17-acetal into contact with anions derived from Na and a polycyclic aromatic compound in a solvent, e.g. tetrahydrofuran.
CONSTITUTION: An androsta-1,4-diene-3,17-dione 17-acetal of formula I (R is 1W6C alkyl group) or formula II (R1 is 2W6C alkyl group) is brought into contact with a reaction mixture formed from Na and a polycyclic aromatic compound capable of acting as a precursor of radical anions in a mixed solvent of tetrahydrofuran and a polyether of formula III or IV (R2 and R3 are methyl or ethyl groups; n is an integer ≥2; m is an integer 4W6) to give an estrone.
USE: Important female hormone, a medicine for prostatomegaly and intermediate for other various steroid medicines.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12547878A JPS5551099A (en) | 1978-10-12 | 1978-10-12 | Preparation of estrone |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12547878A JPS5551099A (en) | 1978-10-12 | 1978-10-12 | Preparation of estrone |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5551099A true JPS5551099A (en) | 1980-04-14 |
JPS6111238B2 JPS6111238B2 (en) | 1986-04-01 |
Family
ID=14911076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12547878A Granted JPS5551099A (en) | 1978-10-12 | 1978-10-12 | Preparation of estrone |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5551099A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1984003094A1 (en) * | 1983-02-02 | 1984-08-16 | Mitsubishi Chem Ind | Process for preparing estrone acetal |
CN105001293A (en) * | 2015-06-10 | 2015-10-28 | 浙江仙居君业药业有限公司 | Preparation method of estrone |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0264126U (en) * | 1988-11-02 | 1990-05-14 |
-
1978
- 1978-10-12 JP JP12547878A patent/JPS5551099A/en active Granted
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1984003094A1 (en) * | 1983-02-02 | 1984-08-16 | Mitsubishi Chem Ind | Process for preparing estrone acetal |
US4622181A (en) * | 1983-02-02 | 1986-11-11 | Mitsubishi Chemical Industries Ltd. | Process for producing an estrone acetal |
DE3490045C2 (en) * | 1983-02-02 | 1992-10-01 | Mitsubishi Kasei Corp., Tokio/Tokyo, Jp | |
CN105001293A (en) * | 2015-06-10 | 2015-10-28 | 浙江仙居君业药业有限公司 | Preparation method of estrone |
Also Published As
Publication number | Publication date |
---|---|
JPS6111238B2 (en) | 1986-04-01 |
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