JPS5551099A - Preparation of estrone - Google Patents

Preparation of estrone

Info

Publication number
JPS5551099A
JPS5551099A JP12547878A JP12547878A JPS5551099A JP S5551099 A JPS5551099 A JP S5551099A JP 12547878 A JP12547878 A JP 12547878A JP 12547878 A JP12547878 A JP 12547878A JP S5551099 A JPS5551099 A JP S5551099A
Authority
JP
Japan
Prior art keywords
formula
androsta
dione
acetal
diene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12547878A
Other languages
Japanese (ja)
Other versions
JPS6111238B2 (en
Inventor
Yoshimi Morita
Tadashi Shirasaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Priority to JP12547878A priority Critical patent/JPS5551099A/en
Publication of JPS5551099A publication Critical patent/JPS5551099A/en
Publication of JPS6111238B2 publication Critical patent/JPS6111238B2/ja
Granted legal-status Critical Current

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  • Steroid Compounds (AREA)

Abstract

PURPOSE: To obtain the title compound in high yield, by bringing an androsta- 1,4-diene-3,17-dione 17-acetal into contact with anions derived from Na and a polycyclic aromatic compound in a solvent, e.g. tetrahydrofuran.
CONSTITUTION: An androsta-1,4-diene-3,17-dione 17-acetal of formula I (R is 1W6C alkyl group) or formula II (R1 is 2W6C alkyl group) is brought into contact with a reaction mixture formed from Na and a polycyclic aromatic compound capable of acting as a precursor of radical anions in a mixed solvent of tetrahydrofuran and a polyether of formula III or IV (R2 and R3 are methyl or ethyl groups; n is an integer ≥2; m is an integer 4W6) to give an estrone.
USE: Important female hormone, a medicine for prostatomegaly and intermediate for other various steroid medicines.
COPYRIGHT: (C)1980,JPO&Japio
JP12547878A 1978-10-12 1978-10-12 Preparation of estrone Granted JPS5551099A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12547878A JPS5551099A (en) 1978-10-12 1978-10-12 Preparation of estrone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12547878A JPS5551099A (en) 1978-10-12 1978-10-12 Preparation of estrone

Publications (2)

Publication Number Publication Date
JPS5551099A true JPS5551099A (en) 1980-04-14
JPS6111238B2 JPS6111238B2 (en) 1986-04-01

Family

ID=14911076

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12547878A Granted JPS5551099A (en) 1978-10-12 1978-10-12 Preparation of estrone

Country Status (1)

Country Link
JP (1) JPS5551099A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984003094A1 (en) * 1983-02-02 1984-08-16 Mitsubishi Chem Ind Process for preparing estrone acetal
CN105001293A (en) * 2015-06-10 2015-10-28 浙江仙居君业药业有限公司 Preparation method of estrone

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0264126U (en) * 1988-11-02 1990-05-14

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984003094A1 (en) * 1983-02-02 1984-08-16 Mitsubishi Chem Ind Process for preparing estrone acetal
US4622181A (en) * 1983-02-02 1986-11-11 Mitsubishi Chemical Industries Ltd. Process for producing an estrone acetal
DE3490045C2 (en) * 1983-02-02 1992-10-01 Mitsubishi Kasei Corp., Tokio/Tokyo, Jp
CN105001293A (en) * 2015-06-10 2015-10-28 浙江仙居君业药业有限公司 Preparation method of estrone

Also Published As

Publication number Publication date
JPS6111238B2 (en) 1986-04-01

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