GB1308849A - Process for the preparation of 6alpha-methyl-19-nor-pregnenes - Google Patents

Process for the preparation of 6alpha-methyl-19-nor-pregnenes

Info

Publication number
GB1308849A
GB1308849A GB4669771A GB4669771A GB1308849A GB 1308849 A GB1308849 A GB 1308849A GB 4669771 A GB4669771 A GB 4669771A GB 4669771 A GB4669771 A GB 4669771A GB 1308849 A GB1308849 A GB 1308849A
Authority
GB
United Kingdom
Prior art keywords
methyl
ethylenedioxy
steroids
pregnenes
6alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4669771A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of GB1308849A publication Critical patent/GB1308849A/en
Expired legal-status Critical Current

Links

Landscapes

  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)

Abstract

1308849 6α - Methyl - 19 - nor - steroids CIBA-GEIGY AG 7 Oct 1971 [7 Oct 1970] 46697/71 Heading C2U 6α-Methyl-steroids of the formula (wherein R 1 is H or CH 3 and R 2 is an aliphatic hydrocarbon radical) are prepared by converting 6#-methyl steroids of the formula (wherein R 3 is -OH or -O.CO.R 2 ) or their mixtures with the 6α-epimers into #<SP>3,5</SP>-3-enol esters, the esterifying agent being derived from the acid R 2 .COOH when R 3 is OH, and then hydrolysing the enol esters with a base at a temperature at or below 30‹ C. 3,20 - Dioxo - 6# - methyl - 17α - hydroxy - #<SP>4</SP>- 19-nor-pregnene is prepared from 3#,5α,17α-trihydroxy - 6# - methyl - 20,20 - ethylenedioxy- 19 - nor-pregnano via 3 - oxo - 5α,17α - dihydroxy - 6# - methyl - 20,20 - ethylenedioxy - 19- nor - pregnane and 3 - oxo - 6# - methyl - 17α- hydroxy-20,20-ethylenedioxy-#<SP>4</SP>-19-nor-pregnene.
GB4669771A 1970-10-07 1971-10-07 Process for the preparation of 6alpha-methyl-19-nor-pregnenes Expired GB1308849A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1486570A CH538462A (en) 1970-10-07 1970-10-07 A new process for the production of 6a-methyl-19-nor-pregnenen

Publications (1)

Publication Number Publication Date
GB1308849A true GB1308849A (en) 1973-03-07

Family

ID=4404422

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4669771A Expired GB1308849A (en) 1970-10-07 1971-10-07 Process for the preparation of 6alpha-methyl-19-nor-pregnenes

Country Status (10)

Country Link
AT (1) AT310960B (en)
AU (1) AU455685B2 (en)
BE (1) BE773550A (en)
CA (1) CA953708A (en)
CH (1) CH538462A (en)
DE (1) DE2148261A1 (en)
DK (1) DK127977B (en)
FR (1) FR2111097A5 (en)
GB (1) GB1308849A (en)
ZA (1) ZA716504B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008151746A2 (en) * 2007-06-12 2008-12-18 Bayer Schering Pharma Aktiengesellschaft 17β-CYANO-19-NOR-ANDROST-4-ENE DERIVATIVE, USE THEREOF AND MEDICAMENTS CONTAINING SAID DERIVATIVE
CN106810585A (en) * 2016-12-03 2017-06-09 丽江映华生物药业有限公司 The synthetic method of the diketone of 6 α methyl, 17 α acetoxyl groups, 19 norpregna, 4 alkene 3,20

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795884A (en) * 1991-07-18 1998-08-18 Laboratoire Theramex Sa 3-keto-nor-pregnenes substituted in the 6-position and treatment of menopause
EP0785211A1 (en) * 1996-01-22 1997-07-23 Laboratoire Theramex New substituted 19-nor-pregnane derivatives
EP0785212A1 (en) * 1996-01-22 1997-07-23 Laboratoire Theramex New 19-nor-pregnene derivatives

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008151746A2 (en) * 2007-06-12 2008-12-18 Bayer Schering Pharma Aktiengesellschaft 17β-CYANO-19-NOR-ANDROST-4-ENE DERIVATIVE, USE THEREOF AND MEDICAMENTS CONTAINING SAID DERIVATIVE
WO2008151746A3 (en) * 2007-06-12 2009-03-12 Bayer Schering Pharma Ag 17β-CYANO-19-NOR-ANDROST-4-ENE DERIVATIVE, USE THEREOF AND MEDICAMENTS CONTAINING SAID DERIVATIVE
US8207150B2 (en) 2007-06-12 2012-06-26 Bayer Pharma AG 17β-cyano-19-nor-androst-4-ene derivative, its use and medicaments comprising the derivative
CN106810585A (en) * 2016-12-03 2017-06-09 丽江映华生物药业有限公司 The synthetic method of the diketone of 6 α methyl, 17 α acetoxyl groups, 19 norpregna, 4 alkene 3,20

Also Published As

Publication number Publication date
AT310960B (en) 1973-10-25
DK127977B (en) 1974-02-11
AU3416371A (en) 1973-04-12
DE2148261A1 (en) 1972-04-13
FR2111097A5 (en) 1972-06-02
ZA716504B (en) 1972-06-28
CH538462A (en) 1973-06-30
BE773550A (en) 1972-04-06
CA953708A (en) 1974-08-27
AU455685B2 (en) 1974-11-21

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Legal Events

Date Code Title Description
PS Patent sealed
49S Specification amended (sect. 9/1949)
PLNP Patent lapsed through nonpayment of renewal fees