DE2406930A1 - Neue heterocyclische verbindungen und verfahren zu ihrer herstellung - Google Patents

Neue heterocyclische verbindungen und verfahren zu ihrer herstellung

Info

Publication number
DE2406930A1
DE2406930A1 DE19742406930 DE2406930A DE2406930A1 DE 2406930 A1 DE2406930 A1 DE 2406930A1 DE 19742406930 DE19742406930 DE 19742406930 DE 2406930 A DE2406930 A DE 2406930A DE 2406930 A1 DE2406930 A1 DE 2406930A1
Authority
DE
Germany
Prior art keywords
lower alkyl
carbon atoms
formula
alkoxy
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19742406930
Other languages
German (de)
English (en)
Inventor
Joerg Dr Frei
Knut A Dr Jaeggi
Franz Dr Ostermayer
Herbert Dr Schroeter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH244473A external-priority patent/CH584209A5/de
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of DE2406930A1 publication Critical patent/DE2406930A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19742406930 1973-02-20 1974-02-14 Neue heterocyclische verbindungen und verfahren zu ihrer herstellung Ceased DE2406930A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH244473A CH584209A5 (en) 1973-02-20 1973-02-20 3-amino-2-hydroxypropoxy substd. diazines and pyridines - with beta-adrenergic blocking or stimulating activity
FI193/74A FI60391C (fi) 1973-02-20 1974-01-23 Analogifoerfarande foer framstaellning av beta-reseptor-aktiva 1-heterocyklyloxi-3-amino-2-propanolfoereningar

Publications (1)

Publication Number Publication Date
DE2406930A1 true DE2406930A1 (de) 1974-08-22

Family

ID=25690464

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19742406930 Ceased DE2406930A1 (de) 1973-02-20 1974-02-14 Neue heterocyclische verbindungen und verfahren zu ihrer herstellung

Country Status (15)

Country Link
AR (6) AR206801A1 (xx)
AT (1) AT335455B (xx)
BE (1) BE811274A (xx)
CA (1) CA1027131A (xx)
CS (1) CS203970B2 (xx)
DD (1) DD110041A5 (xx)
DE (1) DE2406930A1 (xx)
DK (1) DK143501C (xx)
ES (2) ES446081A1 (xx)
FR (1) FR2218101B1 (xx)
GB (1) GB1465946A (xx)
IE (1) IE38839B1 (xx)
IL (1) IL44202A (xx)
LU (1) LU69415A1 (xx)
SE (1) SE420834B (xx)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5186473A (xx) * 1974-12-16 1976-07-29 Merck & Co Inc
JPS5283759A (en) * 1976-01-01 1977-07-12 Merck & Co Inc Substituted pyridines
DE2726796A1 (de) * 1976-06-15 1977-12-29 Merck & Co Inc Neue substituierte pyridine, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
US4091104A (en) * 1976-06-15 1978-05-23 Merck & Co., Inc. Substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines, their preparation and use
US4092419A (en) * 1976-06-15 1978-05-30 Merck & Co., Inc. Substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines, their preparation and use
DE2820938A1 (de) * 1977-05-16 1978-11-23 Merck & Co Inc Neue imidazoazine und imidazodiazine
EP0018016A1 (de) * 1979-04-23 1980-10-29 I. S. F. Società per Azioni 3-(3'-Amino-2'-hydroxy-n-prop-1'-oxy)-6-isopropylidenhydrazinopyridazine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
EP0027990A1 (de) * 1979-10-26 1981-05-06 Schering Aktiengesellschaft Substituierte Pyridine, Verfahren zu ihrer Herstellung und ihre Verwendung
US4753673A (en) * 1977-07-22 1988-06-28 The Dow Chemical Company Trifluoromethyl pyridinyloxyphenoxy and pyridinylthiophenoxy propanoic acids and propanols and derivatives thereof and methods of herbicidal use
JP2008507491A (ja) * 2004-07-23 2008-03-13 バイエル・クロツプサイエンス・エス・アー 殺真菌剤としての３−ピリジニルエチルベンズアミド誘導体

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4195090A (en) * 1973-02-20 1980-03-25 Ciba-Geigy Corporation 2-(3-Amino-2-hydroxy-propoxy)pyridine derivatives and pharmaceutical compositions therewith
DE2711655A1 (de) * 1977-03-17 1978-09-21 Basf Ag Pyridinyl-aminoalkylaether
US4279913A (en) * 1978-01-04 1981-07-21 Merck & Co., Inc. Polysubstituted-2-(3-loweralkylamino-2-R1 O-propoxy)pyridines
US4144343A (en) * 1978-01-04 1979-03-13 Merck & Co., Inc. Heterocycle substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines
JPS54106476A (en) * 1978-01-04 1979-08-21 Merck & Co Inc Multiisubstituted 22*33lower alkylaminoo22 r100propoxy*pyridine
US4208416A (en) * 1978-06-27 1980-06-17 Merck & Co., Inc. N-Aralkyl containing cyanopyridines
DK267779A (da) * 1978-06-27 1979-12-28 Merck & Co Inc Fr&mgangsmaade til fremstilling af n-aralkylamino-propoxycyanopyridiner
US4210653A (en) * 1978-06-27 1980-07-01 Merck & Co., Inc. Pyridyloxypropanolamines
US4393212A (en) * 1979-01-29 1983-07-12 Merck & Co., Inc. Certain nicotinic acid esters and corresponding nicotinonitriles
US4294969A (en) * 1979-01-29 1981-10-13 Merck & Co., Inc. Process for producing 2-bromo-3,5-disubstituted pyridines
DD150456A5 (de) * 1979-03-01 1981-09-02 Ciba Geigy Ag Verfahren zur herstellung von derivaten des 3-amino-1,2-propandiols
US4281005A (en) 1979-03-05 1981-07-28 Merck & Co., Inc. Novel 2-pyridylimidazole compounds
IL62602A (en) * 1980-05-19 1984-06-29 Labaz Sanofi Nv Pyridoxine derivatives,their preparation and pharmaceutical compositions containing them
FR2502618A1 (fr) * 1981-03-25 1982-10-01 Synthelabo Derives de pyridine, leur preparation et leur application en therapeutique
US4517188A (en) * 1983-05-09 1985-05-14 Mead Johnson & Company 1-Pyrimidinyloxy-3-hetaryl-alkylamino-2-propanols
US4598149A (en) * 1984-03-02 1986-07-01 Merck & Co., Inc. 3-amino-2-hydroxypropyl of pyrimidin-4-one useful as antihypertensive, cardioprotective, antiarrythmic, and antianginal agents
US6465467B1 (en) 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
US7361671B2 (en) * 2001-11-15 2008-04-22 The Institute For Pharmaceutical Discovery, Inc. Substituted heteroarylalkanoic acids
BR0311970A (pt) 2002-06-19 2005-03-29 Biovitrum Ab Novos compostos, seu uso e preparação
MXPA05005661A (es) * 2002-11-27 2005-11-23 Artesian Therapeutics Inc Compuestos con actividad antagonista o antagonista parcial mixta inhibidora de fosfodiesterasa y beta-adrenergica para el tratamiento de insuficiencia cardiaca.
US20110183980A1 (en) * 2009-09-21 2011-07-28 Conn P Jeffrey O-benzyl nicotinamide analogs as mglur5 positive allosteric modulators

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1001631A (en) * 1972-05-05 1976-12-14 Merck Sharp And Dohme (I.A.) Corp. 2-(3-substituted amino-2-hydroxy-propoxy)-3-substituted pyrazines and method for preparation

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5186473A (xx) * 1974-12-16 1976-07-29 Merck & Co Inc
US4000282A (en) * 1974-12-16 1976-12-28 Merck & Co., Inc. 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines
JPS5283759A (en) * 1976-01-01 1977-07-12 Merck & Co Inc Substituted pyridines
DE2726796A1 (de) * 1976-06-15 1977-12-29 Merck & Co Inc Neue substituierte pyridine, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
US4091104A (en) * 1976-06-15 1978-05-23 Merck & Co., Inc. Substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines, their preparation and use
US4092419A (en) * 1976-06-15 1978-05-30 Merck & Co., Inc. Substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines, their preparation and use
DE2820938A1 (de) * 1977-05-16 1978-11-23 Merck & Co Inc Neue imidazoazine und imidazodiazine
US4753673A (en) * 1977-07-22 1988-06-28 The Dow Chemical Company Trifluoromethyl pyridinyloxyphenoxy and pyridinylthiophenoxy propanoic acids and propanols and derivatives thereof and methods of herbicidal use
EP0018016A1 (de) * 1979-04-23 1980-10-29 I. S. F. Società per Azioni 3-(3'-Amino-2'-hydroxy-n-prop-1'-oxy)-6-isopropylidenhydrazinopyridazine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
EP0027990A1 (de) * 1979-10-26 1981-05-06 Schering Aktiengesellschaft Substituierte Pyridine, Verfahren zu ihrer Herstellung und ihre Verwendung
JP2008507491A (ja) * 2004-07-23 2008-03-13 バイエル・クロツプサイエンス・エス・アー 殺真菌剤としての３−ピリジニルエチルベンズアミド誘導体

Also Published As

Publication number Publication date
IL44202A0 (en) 1974-06-30
CS203970B2 (en) 1981-03-31
AR203878A1 (es) 1975-10-31
IL44202A (en) 1978-10-31
IE38839L (en) 1974-08-20
ATA133074A (de) 1976-07-15
AR214612A1 (es) 1979-07-13
AR206801A1 (es) 1976-08-23
LU69415A1 (xx) 1975-12-09
AR208397A1 (es) 1976-12-27
IE38839B1 (en) 1978-06-07
DD110041A5 (xx) 1974-12-05
AR207133A1 (es) 1976-09-15
SE420834B (sv) 1981-11-02
GB1465946A (en) 1977-03-02
DK143501C (da) 1982-02-22
BE811274A (fr) 1974-08-19
DK143501B (da) 1981-08-31
AR208043A1 (es) 1976-11-22
AT335455B (de) 1977-03-10
FR2218101B1 (xx) 1977-07-15
FR2218101A1 (xx) 1974-09-13
ES446081A1 (es) 1977-06-16
CA1027131A (en) 1978-02-28
ES446083A1 (es) 1977-09-16

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