DE2260530A1 - Verfahren zur herstellung allergenhaltiger extrakte und praeparate - Google Patents
Verfahren zur herstellung allergenhaltiger extrakte und praeparateInfo
- Publication number
- DE2260530A1 DE2260530A1 DE2260530A DE2260530A DE2260530A1 DE 2260530 A1 DE2260530 A1 DE 2260530A1 DE 2260530 A DE2260530 A DE 2260530A DE 2260530 A DE2260530 A DE 2260530A DE 2260530 A1 DE2260530 A1 DE 2260530A1
- Authority
- DE
- Germany
- Prior art keywords
- extraction
- preparations
- ultrasound
- extracts
- allergen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000284 extract Substances 0.000 title claims description 22
- 230000002009 allergenic effect Effects 0.000 title claims description 16
- 238000002360 preparation method Methods 0.000 title claims description 14
- 238000004519 manufacturing process Methods 0.000 title claims description 12
- 238000000034 method Methods 0.000 title claims description 12
- 238000000605 extraction Methods 0.000 claims description 30
- 239000013566 allergen Substances 0.000 claims description 18
- 238000002604 ultrasonography Methods 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 15
- 238000000527 sonication Methods 0.000 claims description 8
- 238000009210 therapy by ultrasound Methods 0.000 claims description 5
- 239000000243 solution Substances 0.000 description 16
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 12
- 238000001816 cooling Methods 0.000 description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000003405 delayed action preparation Substances 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 4
- 208000024780 Urticaria Diseases 0.000 description 4
- 241000256856 Vespidae Species 0.000 description 4
- 229960004784 allergens Drugs 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 241000735552 Erythroxylum Species 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 230000007815 allergy Effects 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 235000008957 cocaer Nutrition 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 238000000586 desensitisation Methods 0.000 description 3
- 239000000428 dust Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000005457 ice water Substances 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 229940074608 allergen extract Drugs 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 235000011114 ammonium hydroxide Nutrition 0.000 description 2
- 239000006286 aqueous extract Substances 0.000 description 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- OENLEHTYJXMVBG-UHFFFAOYSA-N pyridine;hydrate Chemical compound [OH-].C1=CC=[NH+]C=C1 OENLEHTYJXMVBG-UHFFFAOYSA-N 0.000 description 2
- 230000002787 reinforcement Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- 230000002568 urticarial effect Effects 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000002156 adsorbate Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 229940037003 alum Drugs 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical group [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 229940111121 antirheumatic drug quinolines Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000001364 causal effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000012154 double-distilled water Substances 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical compound [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000011085 pressure filtration Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 230000001235 sensitizing effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000012859 sterile filling Methods 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000010414 supernatant solution Substances 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0261—Solvent extraction of solids comprising vibrating mechanisms, e.g. mechanical, acoustical
- B01D11/0265—Applying ultrasound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
- A61K39/36—Allergens from pollen
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
- B01J19/10—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing sonic or ultrasonic vibrations
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Acoustics & Sound (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mechanical Engineering (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2260530A DE2260530A1 (de) | 1972-12-11 | 1972-12-11 | Verfahren zur herstellung allergenhaltiger extrakte und praeparate |
ZA738357*A ZA738357B (en) | 1972-12-11 | 1973-10-29 | Process for the production of allergenic extracts and preparations |
IL43545A IL43545A (en) | 1972-12-11 | 1973-11-01 | Process for the production of allergenic extracts and preparations |
DK646873A DK135214C (da) | 1972-12-11 | 1973-11-29 | Fremgangsmade til fremstilling af allergenholdige ekstrakter og preparater ved ekstraktion af allergifremkaldende materialer |
NL7316423A NL7316423A (ja) | 1972-12-11 | 1973-11-30 | |
GB5557873A GB1395830A (en) | 1972-12-11 | 1973-11-30 | Allergen-containing extracts and preparations |
CH1705873A CH587056A5 (ja) | 1972-12-11 | 1973-12-05 | |
BR9548/73A BR7309548D0 (pt) | 1972-12-11 | 1973-12-05 | Processo para a preparacao de extratos e composicoes contendo alergeno |
FR7343695A FR2209550B1 (ja) | 1972-12-11 | 1973-12-07 | |
CA187,830A CA1020459A (en) | 1972-12-11 | 1973-12-10 | Production of allergen-containing extracts and preparations |
ES421324A ES421324A1 (es) | 1972-12-11 | 1973-12-10 | Procedimiento para la obtencion de preparados y extractos alergenicos. |
BE138685A BE808426A (fr) | 1972-12-11 | 1973-12-10 | Procede de fabrication de preparations et d'extraits contenant des allergenes |
AU63416/73A AU486542B2 (en) | 1972-12-11 | 1973-12-10 | Process forthe production of allergenic extracts and preparations |
AT1034473A AT327387B (de) | 1972-12-11 | 1973-12-11 | Verfahren zur herstellung von allergenhaltigen praparaten und extrakten |
JP48137439A JPS4986531A (ja) | 1972-12-11 | 1973-12-11 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2260530A DE2260530A1 (de) | 1972-12-11 | 1972-12-11 | Verfahren zur herstellung allergenhaltiger extrakte und praeparate |
Publications (1)
Publication Number | Publication Date |
---|---|
DE2260530A1 true DE2260530A1 (de) | 1974-06-12 |
Family
ID=5864073
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2260530A Pending DE2260530A1 (de) | 1972-12-11 | 1972-12-11 | Verfahren zur herstellung allergenhaltiger extrakte und praeparate |
Country Status (14)
Country | Link |
---|---|
JP (1) | JPS4986531A (ja) |
AT (1) | AT327387B (ja) |
BE (1) | BE808426A (ja) |
BR (1) | BR7309548D0 (ja) |
CA (1) | CA1020459A (ja) |
CH (1) | CH587056A5 (ja) |
DE (1) | DE2260530A1 (ja) |
DK (1) | DK135214C (ja) |
ES (1) | ES421324A1 (ja) |
FR (1) | FR2209550B1 (ja) |
GB (1) | GB1395830A (ja) |
IL (1) | IL43545A (ja) |
NL (1) | NL7316423A (ja) |
ZA (1) | ZA738357B (ja) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07285875A (ja) * | 1994-04-19 | 1995-10-31 | Mineo Hayazaki | ノミアレルゲンの製造方法および該方法により製造されるノミアレルゲン |
CN115336730B (zh) * | 2022-08-16 | 2024-04-09 | 汇能生物科技(江苏)有限公司 | 一种脱敏克氏原螯虾调味基料的制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE813706C (de) * | 1948-10-02 | 1952-01-07 | Atlas Werke Ag | Verfahren zum Extrahieren von Stoffen, insbesondere fuer pharmazeutische Zwecke |
US3558066A (en) * | 1969-01-21 | 1971-01-26 | Howard Alliger | Ultrasonic extraction of viable antigens from gram positive bacteria |
-
1972
- 1972-12-11 DE DE2260530A patent/DE2260530A1/de active Pending
-
1973
- 1973-10-29 ZA ZA738357*A patent/ZA738357B/xx unknown
- 1973-11-01 IL IL43545A patent/IL43545A/en unknown
- 1973-11-29 DK DK646873A patent/DK135214C/da active
- 1973-11-30 NL NL7316423A patent/NL7316423A/xx not_active Application Discontinuation
- 1973-11-30 GB GB5557873A patent/GB1395830A/en not_active Expired
- 1973-12-05 BR BR9548/73A patent/BR7309548D0/pt unknown
- 1973-12-05 CH CH1705873A patent/CH587056A5/xx not_active IP Right Cessation
- 1973-12-07 FR FR7343695A patent/FR2209550B1/fr not_active Expired
- 1973-12-10 BE BE138685A patent/BE808426A/xx unknown
- 1973-12-10 ES ES421324A patent/ES421324A1/es not_active Expired
- 1973-12-10 CA CA187,830A patent/CA1020459A/en not_active Expired
- 1973-12-11 AT AT1034473A patent/AT327387B/de active
- 1973-12-11 JP JP48137439A patent/JPS4986531A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
NL7316423A (ja) | 1974-06-13 |
FR2209550B1 (ja) | 1976-12-03 |
IL43545A0 (en) | 1974-03-14 |
AU6341673A (en) | 1975-06-12 |
ATA1034473A (de) | 1975-04-15 |
DK135214B (da) | 1977-03-21 |
ZA738357B (en) | 1974-09-25 |
CA1020459A (en) | 1977-11-08 |
AT327387B (de) | 1976-01-26 |
DK135214C (da) | 1977-09-12 |
BE808426A (fr) | 1974-06-10 |
CH587056A5 (ja) | 1977-04-29 |
IL43545A (en) | 1976-08-31 |
JPS4986531A (ja) | 1974-08-19 |
FR2209550A1 (ja) | 1974-07-05 |
GB1395830A (en) | 1975-05-29 |
BR7309548D0 (pt) | 1974-09-24 |
ES421324A1 (es) | 1976-06-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
OHJ | Non-payment of the annual fee |