DE2240052C3 - Verfahren zur Herstellung von Zitronensäure durch submerse Gärung - Google Patents
Verfahren zur Herstellung von Zitronensäure durch submerse GärungInfo
- Publication number
- DE2240052C3 DE2240052C3 DE2240052A DE2240052A DE2240052C3 DE 2240052 C3 DE2240052 C3 DE 2240052C3 DE 2240052 A DE2240052 A DE 2240052A DE 2240052 A DE2240052 A DE 2240052A DE 2240052 C3 DE2240052 C3 DE 2240052C3
- Authority
- DE
- Germany
- Prior art keywords
- addition
- citric acid
- fermentation
- hours
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 title claims description 35
- 238000000855 fermentation Methods 0.000 title claims description 23
- 230000004151 fermentation Effects 0.000 title claims description 23
- 238000000034 method Methods 0.000 title claims description 14
- 238000004519 manufacturing process Methods 0.000 title claims description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 36
- 238000007792 addition Methods 0.000 claims description 16
- 235000011121 sodium hydroxide Nutrition 0.000 claims description 12
- 238000011081 inoculation Methods 0.000 claims description 10
- 235000014633 carbohydrates Nutrition 0.000 claims description 5
- 150000001720 carbohydrates Chemical class 0.000 claims description 5
- 230000033228 biological regulation Effects 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 241000228212 Aspergillus Species 0.000 claims description 2
- 238000005342 ion exchange Methods 0.000 claims description 2
- 239000000243 solution Substances 0.000 description 12
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 5
- 239000003112 inhibitor Substances 0.000 description 5
- 235000015097 nutrients Nutrition 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- 241000228245 Aspergillus niger Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- VQFAIAKCILWQPZ-UHFFFAOYSA-N bromoacetone Chemical compound CC(=O)CBr VQFAIAKCILWQPZ-UHFFFAOYSA-N 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 241000272814 Anser sp. Species 0.000 description 1
- 102000004317 Lyases Human genes 0.000 description 1
- 108090000856 Lyases Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/48—Tricarboxylic acids, e.g. citric acid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/913—Aspergillus
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT721971A AT307346B (de) | 1971-08-18 | 1971-08-18 | Verfahren zur Herstellung von Zitronensäure durch submerse Gärung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2240052A1 DE2240052A1 (de) | 1973-02-22 |
| DE2240052B2 DE2240052B2 (de) | 1979-03-22 |
| DE2240052C3 true DE2240052C3 (de) | 1979-12-06 |
Family
ID=3593883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2240052A Expired DE2240052C3 (de) | 1971-08-18 | 1972-08-16 | Verfahren zur Herstellung von Zitronensäure durch submerse Gärung |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US3886041A (OSRAM) |
| JP (1) | JPS4828688A (OSRAM) |
| AT (1) | AT307346B (OSRAM) |
| AU (1) | AU467172B2 (OSRAM) |
| BE (1) | BE787594A (OSRAM) |
| BR (1) | BR7205665D0 (OSRAM) |
| CA (1) | CA978121A (OSRAM) |
| CH (1) | CH566393A5 (OSRAM) |
| DE (1) | DE2240052C3 (OSRAM) |
| FR (1) | FR2149549B1 (OSRAM) |
| GB (1) | GB1392942A (OSRAM) |
| IT (1) | IT1008529B (OSRAM) |
| NL (1) | NL7211219A (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT392799B (de) * | 1989-10-25 | 1991-06-10 | Jungbunzlauer Ag | Verfahren zur fermentativen herstellung von zitronensaeure aus kohlehydraten |
| US5532148A (en) * | 1995-08-30 | 1996-07-02 | Ntec, Inc. | Process for producing of citric acid and monovalent citrate salts |
| WO1997010350A1 (en) * | 1995-09-11 | 1997-03-20 | Likospol S.R.O. | Process, apparatus and microorganism strain for the manufacture of citric acid |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3335067A (en) * | 1965-05-25 | 1967-08-08 | Miles Lab | Process for producing citric acid |
| JPS496117B1 (OSRAM) * | 1969-01-22 | 1974-02-12 |
-
1971
- 1971-08-18 AT AT721971A patent/AT307346B/de not_active IP Right Cessation
-
1972
- 1972-08-15 CH CH1204172A patent/CH566393A5/xx not_active IP Right Cessation
- 1972-08-15 GB GB3799472A patent/GB1392942A/en not_active Expired
- 1972-08-15 CA CA149,793A patent/CA978121A/en not_active Expired
- 1972-08-16 BE BE787594A patent/BE787594A/xx not_active IP Right Cessation
- 1972-08-16 AU AU45617/72A patent/AU467172B2/en not_active Expired
- 1972-08-16 DE DE2240052A patent/DE2240052C3/de not_active Expired
- 1972-08-17 NL NL7211219A patent/NL7211219A/xx unknown
- 1972-08-17 US US281368A patent/US3886041A/en not_active Expired - Lifetime
- 1972-08-18 IT IT52236/72A patent/IT1008529B/it active
- 1972-08-18 JP JP47082699A patent/JPS4828688A/ja active Pending
- 1972-08-18 BR BR005665/72A patent/BR7205665D0/pt unknown
- 1972-08-18 FR FR7229586A patent/FR2149549B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CA978121A (en) | 1975-11-18 |
| FR2149549B1 (OSRAM) | 1975-06-13 |
| JPS4828688A (OSRAM) | 1973-04-16 |
| FR2149549A1 (OSRAM) | 1973-03-30 |
| BE787594A (fr) | 1972-12-18 |
| DE2240052B2 (de) | 1979-03-22 |
| IT1008529B (it) | 1976-11-30 |
| NL7211219A (OSRAM) | 1973-02-20 |
| CH566393A5 (OSRAM) | 1975-09-15 |
| US3886041A (en) | 1975-05-27 |
| AU467172B2 (en) | 1975-11-20 |
| DE2240052A1 (de) | 1973-02-22 |
| AT307346B (de) | 1973-05-25 |
| GB1392942A (en) | 1975-05-07 |
| AU4561772A (en) | 1974-02-21 |
| BR7205665D0 (pt) | 1973-08-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) |