DE2218221C3 - Verfahren zur Herstellung von 2,4-Diamino-5-(3,43-trimethoxybenzyO-pyrimidin - Google Patents

Verfahren zur Herstellung von 2,4-Diamino-5-(3,43-trimethoxybenzyO-pyrimidin

Info

Publication number
DE2218221C3
DE2218221C3 DE2218221A DE2218221A DE2218221C3 DE 2218221 C3 DE2218221 C3 DE 2218221C3 DE 2218221 A DE2218221 A DE 2218221A DE 2218221 A DE2218221 A DE 2218221A DE 2218221 C3 DE2218221 C3 DE 2218221C3
Authority
DE
Germany
Prior art keywords
diamino
pyrimidine
och
preparation
dimethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2218221A
Other languages
German (de)
English (en)
Other versions
DE2218221B2 (de
DE2218221A1 (de
Inventor
Barbara Chapel Hill N.C. Roth (V.St.A.)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of DE2218221A1 publication Critical patent/DE2218221A1/de
Publication of DE2218221B2 publication Critical patent/DE2218221B2/de
Application granted granted Critical
Publication of DE2218221C3 publication Critical patent/DE2218221C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10W—GENERIC PACKAGES, INTERCONNECTIONS, CONNECTORS OR OTHER CONSTRUCTIONAL DETAILS OF DEVICES COVERED BY CLASS H10
    • H10W72/00—Interconnections or connectors in packages
    • H10W72/30—Die-attach connectors
    • H10W72/381—Auxiliary members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
DE2218221A 1971-04-16 1972-04-14 Verfahren zur Herstellung von 2,4-Diamino-5-(3,43-trimethoxybenzyO-pyrimidin Expired DE2218221C3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB964071A GB1401612A (en) 1971-04-16 1971-04-16 2,4-diamino-5-benzylpyrimidines and preparations thereof

Publications (3)

Publication Number Publication Date
DE2218221A1 DE2218221A1 (de) 1972-11-02
DE2218221B2 DE2218221B2 (de) 1978-05-24
DE2218221C3 true DE2218221C3 (de) 1979-02-01

Family

ID=9875907

Family Applications (2)

Application Number Title Priority Date Filing Date
DE2218221A Expired DE2218221C3 (de) 1971-04-16 1972-04-14 Verfahren zur Herstellung von 2,4-Diamino-5-(3,43-trimethoxybenzyO-pyrimidin
DE2265413A Expired DE2265413C2 (de) 1971-04-16 1972-04-14 2,4-Diamino-5-(3,5-dimethoxy-4hydroxybenzyl)-6-methylthiopyrimidin

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE2265413A Expired DE2265413C2 (de) 1971-04-16 1972-04-14 2,4-Diamino-5-(3,5-dimethoxy-4hydroxybenzyl)-6-methylthiopyrimidin

Country Status (25)

Country Link
US (1) US3822264A (enExample)
JP (1) JPS5324433B1 (enExample)
AR (1) AR193078A1 (enExample)
AT (1) AT316560B (enExample)
AU (1) AU468410B2 (enExample)
BE (1) BE782154R (enExample)
CA (1) CA978954A (enExample)
CH (1) CH565159A5 (enExample)
CS (2) CS178140B2 (enExample)
DD (1) DD97653A6 (enExample)
DE (2) DE2218221C3 (enExample)
DK (1) DK132221C (enExample)
ES (1) ES401796A2 (enExample)
FI (1) FI57400C (enExample)
FR (1) FR2133753B2 (enExample)
GB (1) GB1401612A (enExample)
HU (1) HU165865B (enExample)
IE (1) IE36289B1 (enExample)
IL (1) IL39221A (enExample)
NL (1) NL163214C (enExample)
NO (1) NO136046C (enExample)
PL (1) PL75399B3 (enExample)
SE (2) SE405118B (enExample)
ZA (1) ZA722533B (enExample)
ZM (1) ZM7072A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515948A (en) * 1973-09-12 1985-05-07 Hoffmann-La Roche Inc. 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines
US4039543A (en) * 1974-12-24 1977-08-02 Hoffmann-La Roche Inc. Benzylpyrimidines
DE2720771C3 (de) * 1977-05-09 1979-11-29 Ludwig Heumann & Co Gmbh, 8500 Nuernberg 2,4-Diamino-5-(33-dimethoxy-4thioalkyl-benzyD-pyrimidine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE3250132C2 (de) * 1981-11-09 1997-01-16 Mallinckrodt Veterinary Inc Verfahren zur Herstellung von 2,4-Diamino-5-benzyl-pyrimidinen und neue Zwischenprodukte des Verfahrens
FR2516081B1 (fr) * 1981-11-09 1987-05-29 Wellcome Found Synthese de benzylpyrimidines et produits intermediaires pour cette synthese

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR94837E (fr) * 1966-02-19 1969-11-28 Wellcome Found Procédé de préparation de dérivés de la pyrimidine.

Also Published As

Publication number Publication date
AR193078A1 (es) 1973-03-30
HU165865B (enExample) 1974-11-28
SE7503993L (enExample) 1975-04-08
DK132221B (da) 1975-11-10
DD97653A6 (enExample) 1973-05-14
US3822264A (en) 1974-07-02
JPS5324433B1 (enExample) 1978-07-20
NL163214B (nl) 1980-03-17
CS178105B2 (enExample) 1977-08-31
FI57400C (fi) 1980-08-11
NO136046B (enExample) 1977-04-04
ES401796A2 (es) 1975-03-01
DE2218221B2 (de) 1978-05-24
AU4117772A (en) 1973-10-18
AT316560B (de) 1974-07-25
CA978954A (en) 1975-12-02
FR2133753B2 (enExample) 1975-10-10
DE2265413B1 (de) 1980-04-10
IL39221A (en) 1975-11-25
ZM7072A1 (en) 1974-03-21
DE2265413C2 (de) 1980-12-04
SE417097B (sv) 1981-02-23
DK132221C (da) 1976-04-20
NL7205046A (enExample) 1972-10-18
ZA722533B (en) 1973-11-28
NO136046C (no) 1977-07-13
CS178140B2 (enExample) 1977-08-31
IE36289B1 (en) 1976-09-29
IL39221A0 (en) 1972-06-28
IE36289L (en) 1972-10-16
BE782154R (fr) 1972-10-16
PL75399B3 (en) 1974-12-31
FR2133753A2 (enExample) 1972-12-01
GB1401612A (en) 1975-07-16
DE2218221A1 (de) 1972-11-02
NL163214C (nl) 1980-08-15
FI57400B (fi) 1980-04-30
SE405118B (sv) 1978-11-20
AU468410B2 (en) 1973-10-18
CH565159A5 (enExample) 1975-08-15

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Legal Events

Date Code Title Description
OI Miscellaneous see part 1
OI Miscellaneous see part 1
OI Miscellaneous see part 1
C3 Grant after two publication steps (3rd publication)
8328 Change in the person/name/address of the agent

Free format text: BERG, W., DIPL.-CHEM. DR.RER.NAT. STAPF, O., DIPL.-ING. SCHWABE, H., DIPL.-ING. SANDMAIR, K., DIPL.-CHEM. DR.JUR. DR.RER.NAT., PAT.-ANW., 8000 MUENCHEN

8328 Change in the person/name/address of the agent

Free format text: SCHWABE, H., DIPL.-ING. SANDMAIR, K., DIPL.-CHEM. DR.JUR. DR.RER.NAT., PAT.-ANW., 8000 MUENCHEN

8339 Ceased/non-payment of the annual fee