DE2217044C2 - Optisch aktive Prostaglandinderivate und deren racemische Gemische sowie Verfahren zu ihrer Herstellung - Google Patents

Optisch aktive Prostaglandinderivate und deren racemische Gemische sowie Verfahren zu ihrer Herstellung

Info

Publication number
DE2217044C2
DE2217044C2 DE2217044A DE2217044A DE2217044C2 DE 2217044 C2 DE2217044 C2 DE 2217044C2 DE 2217044 A DE2217044 A DE 2217044A DE 2217044 A DE2217044 A DE 2217044A DE 2217044 C2 DE2217044 C2 DE 2217044C2
Authority
DE
Germany
Prior art keywords
optically active
compound
compounds
formula
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2217044A
Other languages
German (de)
English (en)
Other versions
DE2217044A1 (de
Inventor
Barney John Portage Mich. Magerlein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of DE2217044A1 publication Critical patent/DE2217044A1/de
Application granted granted Critical
Publication of DE2217044C2 publication Critical patent/DE2217044C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
DE2217044A 1971-04-12 1972-04-08 Optisch aktive Prostaglandinderivate und deren racemische Gemische sowie Verfahren zu ihrer Herstellung Expired DE2217044C2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13334271A 1971-04-12 1971-04-12
US05/555,780 US4212811A (en) 1971-04-12 1975-03-06 Bicyclic lactone intermediates

Publications (2)

Publication Number Publication Date
DE2217044A1 DE2217044A1 (de) 1972-10-26
DE2217044C2 true DE2217044C2 (de) 1985-07-11

Family

ID=26831285

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2217044A Expired DE2217044C2 (de) 1971-04-12 1972-04-08 Optisch aktive Prostaglandinderivate und deren racemische Gemische sowie Verfahren zu ihrer Herstellung

Country Status (10)

Country Link
US (1) US4212811A (en, 2012)
JP (2) JPS5069063A (en, 2012)
BE (1) BE781979A (en, 2012)
CA (1) CA984387A (en, 2012)
CH (2) CH573384A5 (en, 2012)
DE (1) DE2217044C2 (en, 2012)
FR (1) FR2132859B1 (en, 2012)
GB (2) GB1392991A (en, 2012)
NL (1) NL163507C (en, 2012)
SE (3) SE401364B (en, 2012)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1060007A (en) * 1975-02-18 1979-08-07 Gilbert A. Youngdale 2a,2b-dihomo-16,16-dimethyl-prostaglandin analogs

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS503362B1 (en, 2012) * 1970-06-10 1975-02-04
US3778450A (en) * 1971-03-23 1973-12-11 Upjohn Co Certain bicyclic lactones
US3901923A (en) * 1971-03-23 1975-08-26 Upjohn Co Acylated bicyclic lactones

Also Published As

Publication number Publication date
SE418289B (sv) 1981-05-18
CH573384A5 (en, 2012) 1976-03-15
GB1392991A (en) 1975-05-07
GB1392992A (en) 1975-05-07
BE781979A (fr) 1972-10-12
JPS5069063A (en, 2012) 1975-06-09
JPS5069050A (en, 2012) 1975-06-09
US4212811A (en) 1980-07-15
SE7506373L (sv) 1975-06-04
NL163507C (nl) 1980-09-15
NL7204869A (en, 2012) 1972-10-16
FR2132859B1 (en, 2012) 1976-04-16
CH573887A5 (en, 2012) 1976-03-31
SE7700095L (sv) 1977-01-05
JPS562063B2 (en, 2012) 1981-01-17
SE401364B (sv) 1978-05-02
FR2132859A1 (en, 2012) 1972-11-24
CA984387A (en) 1976-02-24
DE2217044A1 (de) 1972-10-26
NL163507B (nl) 1980-04-15
SE401365B (sv) 1978-05-02

Similar Documents

Publication Publication Date Title
DE2355731C3 (de) Derivate von w -nor-Prostaglandinen- E2IUId -F2 a , Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Zusammensetzungen Pfizer Ine, New York, N.Y. (YStA.)
DE2242239C2 (de) 2-Descarboxy-2- (tetrazol-5-yl) prostaglandine der A-, E- oder F-Reihe
DE2437388A1 (de) Prostansaeurederivate
DE2627910A1 (de) 16-phenoxy- und 16-substituierte phenoxyprostatriensaeurederivate und verfahren zu ihrer herstellung
DE2355540C2 (de) 16-Phenoxy-ω-tetranorprostaglandinderivate
DE2154309C3 (de) 17-Phenyl-18,19,20-trinor-PGE↓2↓ und - PGF↓2↓ α und dieselben enthaltende Arzneimittel
DE2223365C3 (de) Prostansäurederivate, Verfahren zu ihrer Herstellung, solche Derivate enthaltende pharmazeutische und veterinäre Zusammensetzungen sowie Zwischenprodukte zur Herstellung dieser Derivate
DE2317019A1 (de) Neue 4,5-didehydro-prostaglandine
CH618968A5 (en, 2012)
DE2234709C2 (de) Prostanoesäurederivate und Verfahren zu deren Herstellung
DE2626888A1 (de) 11-desoxy-16-aryloxy-omega-tetranorprostaglandine
DE2638827A1 (de) Neue 11-deoxy-prostaglandine e, f tief alpha und f tief beta
DE2721534A1 (de) Omega-nor-aromatische-13,14-dehydro-prostaglandine, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische und veterinaermittel
DE2217044C2 (de) Optisch aktive Prostaglandinderivate und deren racemische Gemische sowie Verfahren zu ihrer Herstellung
DE2611788A1 (de) Fluorprostaglandine, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische mittel
DE2555210A1 (de) Neue analoga natuerlich vorkommender prostaglandine
DE2355042A1 (de) Neue prostaglandinanaloge und verfahren zu deren herstellung
DE2814711A1 (de) Neue prostaglandin-analoge
CH640847A5 (en) Process for preparing analogues of 5,6-dihydroprostacyclin
DE2716075A1 (de) Neue zwischenprodukte und verfahren zur herstellung von thromboxan-analoga
DE2825855C3 (de) 15-substituierte-ι-Pentanorprostaglandin-derivate
DE2640692C3 (de) Optisch aktive 5- (2-Carboxythiophen5-yl)-16phenoxy- a -tetranor- w tetranor-prostaglandine
DE2715921A1 (de) Neue zwischenprodukte und verfahren zur herstellung von thromboxan b tief 2
DE2709347A1 (de) Erythro-15,16-dioxyprostensaeuren und -ester sowie verfahren zu ihrer herstellung
DE2513371C2 (de) 9,11,15-Trihydroxy-13-thia-5-prostensäure-Derivate und diese enthaltende pharmazeutische Zubereitungen

Legal Events

Date Code Title Description
OD Request for examination
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee