DE2165401C3 - Inaktivierter Kombinationsimpfstoff zum Immunisieren von Geflügel gegen Infektion der Atmungsorgane - Google Patents
Inaktivierter Kombinationsimpfstoff zum Immunisieren von Geflügel gegen Infektion der AtmungsorganeInfo
- Publication number
- DE2165401C3 DE2165401C3 DE2165401A DE2165401A DE2165401C3 DE 2165401 C3 DE2165401 C3 DE 2165401C3 DE 2165401 A DE2165401 A DE 2165401A DE 2165401 A DE2165401 A DE 2165401A DE 2165401 C3 DE2165401 C3 DE 2165401C3
- Authority
- DE
- Germany
- Prior art keywords
- vaccine
- inactivated
- strain
- volume
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 208000015181 infectious disease Diseases 0.000 title claims description 35
- 229940001442 combination vaccine Drugs 0.000 title claims description 26
- 244000144977 poultry Species 0.000 title claims description 22
- 230000003053 immunization Effects 0.000 title claims description 6
- 210000002345 respiratory system Anatomy 0.000 title claims description 3
- 241000606767 Avibacterium paragallinarum Species 0.000 claims description 16
- 241000700605 Viruses Species 0.000 claims description 15
- 235000015097 nutrients Nutrition 0.000 claims description 12
- 241000711450 Infectious bronchitis virus Species 0.000 claims description 10
- 210000000056 organ Anatomy 0.000 claims description 4
- 229960005486 vaccine Drugs 0.000 description 50
- 239000000203 mixture Substances 0.000 description 24
- 230000002458 infectious effect Effects 0.000 description 21
- 235000013594 poultry meat Nutrition 0.000 description 20
- 210000002966 serum Anatomy 0.000 description 15
- 239000000499 gel Substances 0.000 description 14
- 241000287828 Gallus gallus Species 0.000 description 13
- 235000013330 chicken meat Nutrition 0.000 description 13
- 238000004519 manufacturing process Methods 0.000 description 13
- 229940024546 aluminum hydroxide gel Drugs 0.000 description 12
- SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 description 12
- 206010039083 rhinitis Diseases 0.000 description 12
- 239000000725 suspension Substances 0.000 description 12
- 210000004027 cell Anatomy 0.000 description 11
- 229940031551 inactivated vaccine Drugs 0.000 description 11
- 239000002609 medium Substances 0.000 description 11
- 239000006228 supernatant Substances 0.000 description 11
- 206010006451 bronchitis Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 239000008055 phosphate buffer solution Substances 0.000 description 8
- 239000002504 physiological saline solution Substances 0.000 description 8
- 208000010359 Newcastle Disease Diseases 0.000 description 7
- 239000002671 adjuvant Substances 0.000 description 7
- 239000001506 calcium phosphate Substances 0.000 description 7
- 229910000389 calcium phosphate Inorganic materials 0.000 description 7
- 235000011010 calcium phosphates Nutrition 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 229910052753 mercury Inorganic materials 0.000 description 7
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 6
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 6
- 230000001900 immune effect Effects 0.000 description 6
- 239000002244 precipitate Substances 0.000 description 6
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 5
- 238000002255 vaccination Methods 0.000 description 5
- 229930194936 Tylosin Natural products 0.000 description 4
- 239000004182 Tylosin Substances 0.000 description 4
- 210000000991 chicken egg Anatomy 0.000 description 4
- 235000013601 eggs Nutrition 0.000 description 4
- HXQVQGWHFRNKMS-UHFFFAOYSA-M ethylmercurithiosalicylic acid Chemical compound CC[Hg]SC1=CC=CC=C1C(O)=O HXQVQGWHFRNKMS-UHFFFAOYSA-M 0.000 description 4
- 229940005660 ethylmercurithiosalicylic acid Drugs 0.000 description 4
- 230000035931 haemagglutination Effects 0.000 description 4
- 238000002649 immunization Methods 0.000 description 4
- 229960000380 propiolactone Drugs 0.000 description 4
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 description 4
- 229960004059 tylosin Drugs 0.000 description 4
- 235000019375 tylosin Nutrition 0.000 description 4
- -1 / J-propiolactone Chemical compound 0.000 description 3
- 239000005711 Benzoic acid Substances 0.000 description 3
- 108010026389 Gramicidin Proteins 0.000 description 3
- 108010040201 Polymyxins Proteins 0.000 description 3
- 229960001950 benzethonium chloride Drugs 0.000 description 3
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 3
- 235000010233 benzoic acid Nutrition 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 229960004905 gramicidin Drugs 0.000 description 3
- ZWCXYZRRTRDGQE-SORVKSEFSA-N gramicidina Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC=O)C(C)C)CC(C)C)C(=O)NCCO)=CNC2=C1 ZWCXYZRRTRDGQE-SORVKSEFSA-N 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 230000000415 inactivating effect Effects 0.000 description 3
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 238000006386 neutralization reaction Methods 0.000 description 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 3
- 230000000241 respiratory effect Effects 0.000 description 3
- 229960004889 salicylic acid Drugs 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 159000000000 sodium salts Chemical class 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 241000272517 Anseriformes Species 0.000 description 2
- 241000271566 Aves Species 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241000606790 Haemophilus Species 0.000 description 2
- 241000286209 Phasianidae Species 0.000 description 2
- 229940037003 alum Drugs 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 239000004599 antimicrobial Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000006161 blood agar Substances 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
- 229910000397 disodium phosphate Inorganic materials 0.000 description 2
- 235000019800 disodium phosphate Nutrition 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000002941 microtiter virus yield reduction assay Methods 0.000 description 2
- 210000003928 nasal cavity Anatomy 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 208000023504 respiratory system disease Diseases 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000004448 titration Methods 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 241000272201 Columbiformes Species 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- 206010053759 Growth retardation Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 241000272458 Numididae Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 206010042682 Swelling face Diseases 0.000 description 1
- 230000010530 Virus Neutralization Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229940024545 aluminum hydroxide Drugs 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- LCQXXBOSCBRNNT-UHFFFAOYSA-K ammonium aluminium sulfate Chemical compound [NH4+].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O LCQXXBOSCBRNNT-UHFFFAOYSA-K 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 229960004365 benzoic acid Drugs 0.000 description 1
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 231100000001 growth retardation Toxicity 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 231100000668 minimum lethal dose Toxicity 0.000 description 1
- 208000010753 nasal discharge Diseases 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 235000012015 potatoes Nutrition 0.000 description 1
- 239000013630 prepared media Substances 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 206010041232 sneezing Diseases 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- 210000001325 yolk sac Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
- A61K39/17—Newcastle disease virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP45129817A JPS4823893B1 (enExample) | 1970-12-29 | 1970-12-29 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2165401A1 DE2165401A1 (de) | 1972-07-13 |
| DE2165401B2 DE2165401B2 (de) | 1979-03-15 |
| DE2165401C3 true DE2165401C3 (de) | 1979-10-31 |
Family
ID=15018943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2165401A Expired DE2165401C3 (de) | 1970-12-29 | 1971-12-29 | Inaktivierter Kombinationsimpfstoff zum Immunisieren von Geflügel gegen Infektion der Atmungsorgane |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS4823893B1 (enExample) |
| BE (1) | BE777498A (enExample) |
| DE (1) | DE2165401C3 (enExample) |
| DK (1) | DK135853B (enExample) |
| FI (1) | FI48480C (enExample) |
| FR (1) | FR2120078B1 (enExample) |
| GB (2) | GB1324618A (enExample) |
| NL (1) | NL7117873A (enExample) |
| SE (1) | SE398514B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT70556A (en) * | 1978-12-20 | 1980-01-01 | Gist Brocades Nv | Vaccines against diseases caused by reo-virus and process for the preparation of those vaccines |
| IL99097A0 (en) * | 1990-09-05 | 1992-07-15 | Akzo Nv | Haemophilus paragallinarum vaccine |
| CN115462444A (zh) * | 2022-08-29 | 2022-12-13 | 中国科学院深圳先进技术研究院 | 一种丁酸梭菌动物饲料及其应用 |
-
1970
- 1970-12-29 JP JP45129817A patent/JPS4823893B1/ja active Pending
-
1971
- 1971-12-23 GB GB6011171A patent/GB1324618A/en not_active Expired
- 1971-12-23 GB GB5928872A patent/GB1324619A/en not_active Expired
- 1971-12-23 FI FI713674A patent/FI48480C/fi active
- 1971-12-27 NL NL7117873A patent/NL7117873A/xx unknown
- 1971-12-28 SE SE7116725A patent/SE398514B/xx unknown
- 1971-12-28 FR FR7147074A patent/FR2120078B1/fr not_active Expired
- 1971-12-28 DK DK637271AA patent/DK135853B/da not_active IP Right Cessation
- 1971-12-29 DE DE2165401A patent/DE2165401C3/de not_active Expired
- 1971-12-29 BE BE777498A patent/BE777498A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SE398514B (sv) | 1977-12-27 |
| GB1324619A (en) | 1973-07-25 |
| FR2120078B1 (enExample) | 1975-06-13 |
| FR2120078A1 (enExample) | 1972-08-11 |
| DK135853B (da) | 1977-07-04 |
| DE2165401A1 (de) | 1972-07-13 |
| DK135853C (enExample) | 1978-01-02 |
| FI48480C (fi) | 1974-10-10 |
| BE777498A (fr) | 1972-04-17 |
| JPS4823893B1 (enExample) | 1973-07-17 |
| GB1324618A (en) | 1973-07-25 |
| NL7117873A (enExample) | 1972-07-03 |
| FI48480B (enExample) | 1974-07-01 |
| DE2165401B2 (de) | 1979-03-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60012042T2 (de) | Entepneumovirus und entsprechendes impfstoff | |
| DE2836507C2 (enExample) | ||
| US3876763A (en) | Infectious coryza infectious bronchitis and newcastle disease vaccines and production thereof | |
| DE2713371C2 (enExample) | ||
| EP2497480A1 (de) | Extrakte aus phototrophen Mikroorganismen als Adjuvans | |
| DE69216732T2 (de) | Impfstoff gegen den Geflügelanämieerreger | |
| DE2360118C3 (de) | Impfstoff gegen Ferkel-Colibacillose | |
| DD232822A5 (de) | Verfahren zur herstellung eines viruspraeparates gegen die mareksche gefluegelkrankheit | |
| DE2553998C2 (de) | Mumpsvaccin und Verfahren zu seiner Herstellung | |
| DE2165401C3 (de) | Inaktivierter Kombinationsimpfstoff zum Immunisieren von Geflügel gegen Infektion der Atmungsorgane | |
| DE3784397T2 (de) | Lebendvaccine fuer ansteckungskrankheiten von kueken. | |
| DE1198489B (de) | Verfahren zur Herstellung eines Impfstoffes gegen Panleucopenie | |
| DE2415353C2 (enExample) | ||
| DE2058645C2 (de) | Verfahren zur Herstellung eines stark abgeschwächten Newcastle-Disease-Virus-Lebendimpfstoffs | |
| CH423095A (de) | Verfahren zur Herstellung eines Tollwutimpfstoffes | |
| DE2050945C3 (de) | Züchten lebensfähiger Staphylococcus-Bakterien zur Erzeugung einer Antivirus-Substanz | |
| DE3878982T2 (de) | Abgeschwaechtes virus und impfstoffe davon zur verwendung gegen infektionen bei gefluegel, verursacht durch truthahn-rhinotracheitis-virus. | |
| DE2045160C3 (de) | Verfahren zur Herstellung einer Lebendvaccine gegen die infektiöse Bursitis der Hühner | |
| Motha et al. | Outbreak of atypical fowlpox in chickens with persistent reticuloendotheliosis viraemia | |
| DE2126957B2 (de) | Verfahren zur herstellung von impfstoffen gegen gaensehepatitis | |
| DE2225548A1 (de) | Intravenoes vertraegliche staupe- und hepatitisvaccine | |
| DE1179670B (de) | Verfahren zur Herstellung von Impfstoff gegen die Newcastle-Krankheit | |
| DE2936061C2 (de) | Impfstoff für Vögel gegen Viren, Bakterien, Einzeller, Nematoden, Trematoden und/oder Pilzinfektionen | |
| DE2914813C2 (de) | Lebend-Impfstoff gegen Theieriosis beim Rindvieh und Verfahren zu dessen Herstellung | |
| DE967241C (de) | Verfahren zum Trennen von lebendem Virus von virusfremden Eiweissstoffen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| 8339 | Ceased/non-payment of the annual fee |