DE2010221A1 - - Google Patents
Info
- Publication number
- DE2010221A1 DE2010221A1 DE19702010221 DE2010221A DE2010221A1 DE 2010221 A1 DE2010221 A1 DE 2010221A1 DE 19702010221 DE19702010221 DE 19702010221 DE 2010221 A DE2010221 A DE 2010221A DE 2010221 A1 DE2010221 A1 DE 2010221A1
- Authority
- DE
- Germany
- Prior art keywords
- nitro
- hydroxy
- benzamide
- salicylamide
- formulas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960000581 salicylamide Drugs 0.000 claims description 17
- 150000002828 nitro derivatives Chemical class 0.000 claims description 12
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 10
- SKZKKFZAGNVIMN-UHFFFAOYSA-N Salicilamide Chemical compound NC(=O)C1=CC=CC=C1O SKZKKFZAGNVIMN-UHFFFAOYSA-N 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 8
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 230000000802 nitrating effect Effects 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- 238000006396 nitration reaction Methods 0.000 claims 1
- 238000001953 recrystallisation Methods 0.000 claims 1
- 238000009835 boiling Methods 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- FECMDSYYFNKSJZ-UHFFFAOYSA-N 2-hydroxy-3-nitrobenzamide Chemical compound NC(=O)C1=CC=CC([N+]([O-])=O)=C1O FECMDSYYFNKSJZ-UHFFFAOYSA-N 0.000 description 3
- SVIKHLOGVRDSGQ-UHFFFAOYSA-N 2-hydroxy-5-nitrobenzamide Chemical compound NC(=O)C1=CC([N+]([O-])=O)=CC=C1O SVIKHLOGVRDSGQ-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- XMVJITFPVVRMHC-UHFFFAOYSA-N roxarsone Chemical group OC1=CC=C([As](O)(O)=O)C=C1[N+]([O-])=O XMVJITFPVVRMHC-UHFFFAOYSA-N 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 1
- 206010003645 Atopy Diseases 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000000763 evoking effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- ZODDGFAZWTZOSI-UHFFFAOYSA-N nitric acid;sulfuric acid Chemical compound O[N+]([O-])=O.OS(O)(=O)=O ZODDGFAZWTZOSI-UHFFFAOYSA-N 0.000 description 1
- 235000019645 odor Nutrition 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR6906021A FR2035762A1 (en) | 1969-03-05 | 1969-03-05 | 3-and 5-nitro-salicylamides with analgesic - antiphlogistic and antifungal activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2010221A1 true DE2010221A1 (enrdf_load_stackoverflow) | 1970-09-17 |
Family
ID=9030099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19702010221 Pending DE2010221A1 (enrdf_load_stackoverflow) | 1969-03-05 | 1970-03-04 |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE746884A (enrdf_load_stackoverflow) |
| CH (1) | CH511804A (enrdf_load_stackoverflow) |
| DE (1) | DE2010221A1 (enrdf_load_stackoverflow) |
| ES (1) | ES377445A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2035762A1 (enrdf_load_stackoverflow) |
| NL (1) | NL7003193A (enrdf_load_stackoverflow) |
| OA (1) | OA03445A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7379920B2 (en) | 2001-12-04 | 2008-05-27 | Gary Leung | System and method for facilitating electronic financial transactions using a mobile telecommunication device |
-
1969
- 1969-03-05 FR FR6906021A patent/FR2035762A1/fr not_active Withdrawn
-
1970
- 1970-03-03 ES ES377445A patent/ES377445A1/es not_active Expired
- 1970-03-04 OA OA53866A patent/OA03445A/xx unknown
- 1970-03-04 DE DE19702010221 patent/DE2010221A1/de active Pending
- 1970-03-04 CH CH318470A patent/CH511804A/fr not_active IP Right Cessation
- 1970-03-05 BE BE746884D patent/BE746884A/xx unknown
- 1970-03-05 NL NL7003193A patent/NL7003193A/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7379920B2 (en) | 2001-12-04 | 2008-05-27 | Gary Leung | System and method for facilitating electronic financial transactions using a mobile telecommunication device |
Also Published As
| Publication number | Publication date |
|---|---|
| ES377445A1 (es) | 1972-07-01 |
| FR2035762A1 (en) | 1970-12-24 |
| BE746884A (fr) | 1970-08-17 |
| NL7003193A (enrdf_load_stackoverflow) | 1970-09-08 |
| OA03445A (fr) | 1971-03-30 |
| CH511804A (fr) | 1971-08-31 |
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