DE2009341C3 - 3-Octadecyloxy-propanol-(l)-phosphorsäure-monocholinester und Verfahren zu dessen Herstellung - Google Patents

3-Octadecyloxy-propanol-(l)-phosphorsäure-monocholinester und Verfahren zu dessen Herstellung

Info

Publication number
DE2009341C3
DE2009341C3 DE2009341A DE2009341A DE2009341C3 DE 2009341 C3 DE2009341 C3 DE 2009341C3 DE 2009341 A DE2009341 A DE 2009341A DE 2009341 A DE2009341 A DE 2009341A DE 2009341 C3 DE2009341 C3 DE 2009341C3
Authority
DE
Germany
Prior art keywords
phosphoric acid
octadecyloxy
propanol
preparation
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2009341A
Other languages
German (de)
English (en)
Other versions
DE2009341A1 (de
DE2009341B2 (de
Inventor
Auf Nichtnennung Antrag
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority to DE2009341A priority Critical patent/DE2009341C3/de
Priority to YU343/71A priority patent/YU35144B/xx
Priority to BG016830A priority patent/BG17619A3/xx
Priority to RO65949A priority patent/RO58353A/ro
Priority to CS1230A priority patent/CS152390B2/cs
Priority to ES388446A priority patent/ES388446A1/es
Priority to US00118083A priority patent/US3708558A/en
Priority to CH279071A priority patent/CH542247A/de
Priority to NLAANVRAGE7102495,A priority patent/NL168518C/xx
Priority to JP962071A priority patent/JPS558995B1/ja
Priority to ZA711241A priority patent/ZA711241B/xx
Priority to IL36299A priority patent/IL36299A/en
Priority to AT168571A priority patent/AT299248B/de
Priority to NO727/71A priority patent/NO134057C/no
Priority to DK88571AA priority patent/DK129352B/da
Priority to BE763578A priority patent/BE763578A/xx
Priority to FR7106702A priority patent/FR2081545B1/fr
Priority to IE245/71A priority patent/IE34973B1/xx
Priority to SE02515/71A priority patent/SE369192B/xx
Priority to PL1971146518A priority patent/PL74270B1/pl
Priority to HUTO845A priority patent/HU162911B/hu
Priority to GB22746/71A priority patent/GB1280788A/en
Publication of DE2009341A1 publication Critical patent/DE2009341A1/de
Publication of DE2009341B2 publication Critical patent/DE2009341B2/de
Application granted granted Critical
Publication of DE2009341C3 publication Critical patent/DE2009341C3/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE2009341A 1970-02-27 1970-02-27 3-Octadecyloxy-propanol-(l)-phosphorsäure-monocholinester und Verfahren zu dessen Herstellung Expired DE2009341C3 (de)

Priority Applications (22)

Application Number Priority Date Filing Date Title
DE2009341A DE2009341C3 (de) 1970-02-27 1970-02-27 3-Octadecyloxy-propanol-(l)-phosphorsäure-monocholinester und Verfahren zu dessen Herstellung
YU343/71A YU35144B (en) 1970-02-27 1971-02-12 Process for preparing a monocholine ester of 3-octadecyloxy-propanol-(1)-phosphoric acid
BG016830A BG17619A3 (bg) 1970-02-27 1971-02-16 Метод за получаване на монохолии естер на 3- октадецилокси пропанол -/1/- фосфорна киселина
RO65949A RO58353A (OSRAM) 1970-02-27 1971-02-16
CS1230A CS152390B2 (OSRAM) 1970-02-27 1971-02-18
ES388446A ES388446A1 (es) 1970-02-27 1971-02-19 Procedimiento para la preparacion de ester monocolinico de acido 3-octadeciloxi-propanol-(1)-fosforico.
US00118083A US3708558A (en) 1970-02-27 1971-02-23 Monochlorine ester of 3-octadecyloxy-propanol-(1)-phosphoric acid
CH279071A CH542247A (de) 1970-02-27 1971-02-24 Verfahren zur Herstellung von 3-Octadecyloxy-propanol-(1)-phosphorsäure-monocholinester
JP962071A JPS558995B1 (OSRAM) 1970-02-27 1971-02-25
NLAANVRAGE7102495,A NL168518C (nl) 1970-02-27 1971-02-25 Werkwijze ter bereiding of vervaardiging van een farmaceutisch preparaat met immunologische activiteit, alsmede werkwijze ter bereiding van een 1.3-propaan-diol-3-fosforylethanolamine-derivaat, geschikt voor gebruik bij de voornoemde werkwijze.
PL1971146518A PL74270B1 (OSRAM) 1970-02-27 1971-02-26
AT168571A AT299248B (de) 1970-02-27 1971-02-26 Verfahren zur Herstellung des neuen 3-Octadecyloxy-propanol-(1)-phosphorsäure-monocholinesters
ZA711241A ZA711241B (en) 1970-02-27 1971-02-26 3-octadecyloxy-propanol-(1)-phosphoric acidmonocholine ester
DK88571AA DK129352B (da) 1970-02-27 1971-02-26 Analogifremgangsmåde til fremstilling af 3-octadecyloxy-propanol-(1)-phosphorsyre-monocholinester.
BE763578A BE763578A (fr) 1970-02-27 1971-02-26 3-octadecyloxy-propanol-(1)-phosphate de monocholine
FR7106702A FR2081545B1 (OSRAM) 1970-02-27 1971-02-26
IE245/71A IE34973B1 (en) 1970-02-27 1971-02-26 3-octadecyloxypropyl-2'-trimethylammonium-ethyl phosphate
SE02515/71A SE369192B (OSRAM) 1970-02-27 1971-02-26
IL36299A IL36299A (en) 1970-02-27 1971-02-26 3-octadecyloxypropyl-2'-(trimethylammonium)ethyl phosphate,its preparation and pharmaceutical compositions containing it
HUTO845A HU162911B (OSRAM) 1970-02-27 1971-02-26
NO727/71A NO134057C (OSRAM) 1970-02-27 1971-02-26
GB22746/71A GB1280788A (en) 1970-02-27 1971-04-19 3-octadecyloxypropyl-2'-trimethylammonium-ethyl phosphate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2009341A DE2009341C3 (de) 1970-02-27 1970-02-27 3-Octadecyloxy-propanol-(l)-phosphorsäure-monocholinester und Verfahren zu dessen Herstellung

Publications (3)

Publication Number Publication Date
DE2009341A1 DE2009341A1 (de) 1971-09-02
DE2009341B2 DE2009341B2 (de) 1978-10-19
DE2009341C3 true DE2009341C3 (de) 1979-06-21

Family

ID=5763597

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2009341A Expired DE2009341C3 (de) 1970-02-27 1970-02-27 3-Octadecyloxy-propanol-(l)-phosphorsäure-monocholinester und Verfahren zu dessen Herstellung

Country Status (22)

Country Link
US (1) US3708558A (OSRAM)
JP (1) JPS558995B1 (OSRAM)
AT (1) AT299248B (OSRAM)
BE (1) BE763578A (OSRAM)
BG (1) BG17619A3 (OSRAM)
CH (1) CH542247A (OSRAM)
CS (1) CS152390B2 (OSRAM)
DE (1) DE2009341C3 (OSRAM)
DK (1) DK129352B (OSRAM)
ES (1) ES388446A1 (OSRAM)
FR (1) FR2081545B1 (OSRAM)
GB (1) GB1280788A (OSRAM)
HU (1) HU162911B (OSRAM)
IE (1) IE34973B1 (OSRAM)
IL (1) IL36299A (OSRAM)
NL (1) NL168518C (OSRAM)
NO (1) NO134057C (OSRAM)
PL (1) PL74270B1 (OSRAM)
RO (1) RO58353A (OSRAM)
SE (1) SE369192B (OSRAM)
YU (1) YU35144B (OSRAM)
ZA (1) ZA711241B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0395849A1 (de) * 1989-03-04 1990-11-07 Roche Diagnostics GmbH /3-(C16-C18)alkansulfinyl- und sulfonyl-2-methoxymethyl-propyl/-(2-trimethylammonio-ethyl)phosphate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE792662A (fr) * 1971-12-13 1973-06-13 Hoechst Ag Composes du phosphore qui sont des ions mixtes
DE2345060C3 (de) * 1973-09-06 1982-04-22 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen 1,2-Dialkylketonglycerin-3-phosphatide und Verfahren zu deren Herstellung
DE2619686C2 (de) * 1976-05-04 1986-08-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Verwendung eines Lysolecithins zur Tumorbehandlung
GB2046092B (en) * 1979-03-05 1983-11-02 Toyama Chemical Co Ltd Pharmaceutical composition containing a lysophospholid and a phospholipid
CA1138773A (en) * 1979-04-18 1983-01-04 George Wojcik Synthetic adjuvants for stimulation of antigenic responses
US4551532A (en) * 1980-05-08 1985-11-05 Takeda Chemical Industries, Ltd. Ethylene glycol derivatives having anti-protozoan, anti-fungal and anti-tumor activity
US4329302A (en) * 1980-06-27 1982-05-11 Board Of Regents, The University Of Texas System Synthetic phosphoglycerides possessing platelet activating properties
US4504474A (en) * 1980-06-27 1985-03-12 Board Of Regents, The University Of Texas System Synthetic phosphoglycerides possessing platelet activating properties
EP0050327B1 (de) * 1980-10-21 1984-06-20 Roche Diagnostics GmbH Neue schwefelhaltige Phospholipide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
EP0061872B1 (en) * 1981-03-30 1985-08-07 Takeda Chemical Industries, Ltd. Ethyleneglycol derivatives, their production and use
DE3127503A1 (de) * 1981-07-11 1983-02-17 Boehringer Mannheim Gmbh, 6800 Mannheim Neue phospholipide, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
JPS60130428U (ja) * 1984-02-09 1985-08-31 スタンレー電気株式会社 タツチスイツチ付液晶表示パネル
JPS60130429U (ja) * 1984-02-09 1985-08-31 スタンレー電気株式会社 タツチスイツチ付液晶表示パネル
US5061626A (en) * 1986-03-24 1991-10-29 University Of Sydney Antigenic anarogues of platelet activating factor
US5036152A (en) * 1988-03-10 1991-07-30 Hoechst-Roussel Pharmaceuticals Incorporated Alkoxycarbonylalkylphospholipids and alkylaminocarbonylalkylphospholipids
US4888328A (en) * 1988-03-10 1989-12-19 Hoeschst-Roussel Incorporated Alkoxycarbonylalkylphospholipids and alkylaminocarbonylalkylphospholipids
BR0016058A (pt) * 1999-12-03 2003-07-15 Univ California San Diego Compostos de fosfonato
EP1868628B1 (en) 2005-04-08 2014-06-11 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
CN102670628B (zh) 2008-01-25 2015-11-25 奇默里克斯公司 治疗病毒感染的方法
WO2011011519A1 (en) 2009-07-21 2011-01-27 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
EP3216789A1 (en) 2010-02-12 2017-09-13 Chimerix, Inc. Methods of treating viral infection
AU2011248620B2 (en) 2010-04-26 2015-11-26 Chimerix, Inc. Methods of treating retroviral infections and related dosage regimes

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0395849A1 (de) * 1989-03-04 1990-11-07 Roche Diagnostics GmbH /3-(C16-C18)alkansulfinyl- und sulfonyl-2-methoxymethyl-propyl/-(2-trimethylammonio-ethyl)phosphate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US5543402A (en) * 1989-03-04 1996-08-06 Boehringer Mannheim Gmbh [3-(C16 -C18)-alkanesulphinyl and sulphonyl-2-methoxy-methylpropyl]-(2-trimethylammonioethyl) phosphates, processes for the preparation thereof and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FR2081545B1 (OSRAM) 1974-03-22
IE34973L (en) 1971-08-27
IL36299A0 (en) 1971-04-28
NL168518C (nl) 1982-04-16
SE369192B (OSRAM) 1974-08-12
HU162911B (OSRAM) 1973-04-28
CH542247A (de) 1973-09-30
NO134057C (OSRAM) 1976-08-11
PL74270B1 (OSRAM) 1974-10-30
NL7102495A (OSRAM) 1971-08-31
BG17619A3 (bg) 1973-11-10
NO134057B (OSRAM) 1976-05-03
GB1280788A (en) 1972-07-05
ES388446A1 (es) 1973-05-01
IL36299A (en) 1974-12-31
IE34973B1 (en) 1975-10-01
RO58353A (OSRAM) 1975-07-15
ZA711241B (en) 1971-12-29
JPS558995B1 (OSRAM) 1980-03-07
CS152390B2 (OSRAM) 1973-12-19
YU35144B (en) 1980-09-25
FR2081545A1 (OSRAM) 1971-12-03
DE2009341A1 (de) 1971-09-02
BE763578A (fr) 1971-08-26
DE2009341B2 (de) 1978-10-19
DK129352B (da) 1974-09-30
AT299248B (de) 1972-06-12
DK129352C (OSRAM) 1975-03-03
NL168518B (nl) 1981-11-16
US3708558A (en) 1973-01-02
YU34371A (en) 1980-03-15

Similar Documents

Publication Publication Date Title
DE2009341C3 (de) 3-Octadecyloxy-propanol-(l)-phosphorsäure-monocholinester und Verfahren zu dessen Herstellung
DE2051495C3 (de) Trialkylphosphingoldkomplex-Verbindungen von 1- ß -D-Glukopyranosiden und deren Verwendung
DE2009343C3 (de) Verwendung von Lysolecithinen als immunologische Adjuvantien
US2864848A (en) Method of producing l-alpha-glycerylphosphorylcholine
DE1670536B2 (de) Neue 2-Anilino-5-acylamino-pyrimidlne
DE2009342C3 (de) Verwendung von Glycerin-alkyläther-(l)-phosphorsäure-(3)-monocholinestern
DE2431561C2 (de) Cycloalkylphenoxycarbonsäuren, Verfahren zu ihrer Herstellung und Arzneimittel
EP0413700A1 (de) Neue alkylphosphono- und phosphoserine, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
DE2719901C2 (de) 9-Desoxy-9-methylen-16,16-dimethyl-prostaglandinderivat
DE2024299A1 (de) Neue Sulfonamide, Verfahren zu ihrer Herstellung und ihre Verwendung in einem pharmazeutischen Präparat
DE939507C (de) Verfahren zur Herstellung von Bis-(ª‰-chloraethyl)-aminen
DE2437147A1 (de) Phosphin- und phosphit-goldkomplexe und arzneimittel
DE2437146A1 (de) Phosphin-gold-chelate und arzneimittel
DE1620258A1 (de) Verfahren zur Herstellung von Thiaminderivaten
DE1005518B (de) Verfahren zur Herstellung neuer, therapeutisch wertvoller 1,2-Diaryl-3, 5-dioxo-pyrazolidine
DE2909038C2 (de) Neues heterocyclisches derivat als medikament mit wirkung auf das zentralnervensystem und verfahren zu seiner herstellung
DE1816103A1 (de) O-AEthyl-threonin und Derivate davon
DE1543735C (de) alpha Amino omega mtrosohydroxylammosauren
DE2033361A1 (de) Acylpropandiol-(1,3) phosphorsaure chohnester und Verfahren zu deren Her stellung
AT288389B (de) Verfahren zur Herstellung eines neuen Zimtsäureamids
DE1695591A1 (de) Verfahren zur Herstellung von 2-[2-Thienyl-(2)-aethyl]-delta1-pyrrolin und -tetrahydropyridin
KR810001699B1 (ko) 페녹시 알킬아미드의 제조 방법
DE2235400C3 (de) ^Chlor-S-sulfamoyl-anthranilsäuren, deren Salze, Verfahren zur Herstellung dieser Verbindungen und diese Verbindungen enthaltende Arzneimittel
DE2925345A1 (de) Neue phenoxyalkylamide
DE1620675A1 (de) Verfahren zur Herstellung von S-Benzoyloxymethylthiaminverbindungen

Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee