DE19955190A1 - Stabile Salze neuartiger Derivate von 3,3-Diphenylpropylaminen - Google Patents

Stabile Salze neuartiger Derivate von 3,3-Diphenylpropylaminen

Info

Publication number
DE19955190A1
DE19955190A1 DE19955190A DE19955190A DE19955190A1 DE 19955190 A1 DE19955190 A1 DE 19955190A1 DE 19955190 A DE19955190 A DE 19955190A DE 19955190 A DE19955190 A DE 19955190A DE 19955190 A1 DE19955190 A1 DE 19955190A1
Authority
DE
Germany
Prior art keywords
acid
compound
formula
diisopropylamino
phenylpropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19955190A
Other languages
German (de)
English (en)
Inventor
Claus Meese
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Pharma GmbH
Original Assignee
Schwarz Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7929277&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE19955190(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schwarz Pharma AG filed Critical Schwarz Pharma AG
Priority to DE19955190A priority Critical patent/DE19955190A1/de
Priority to DE29923134U priority patent/DE29923134U1/de
Priority to PL356766A priority patent/PL201422B1/pl
Priority to DE50013365T priority patent/DE50013365D1/de
Priority to DK06011207T priority patent/DK1690536T3/da
Priority to MXPA02004603A priority patent/MXPA02004603A/es
Priority to DE50015163T priority patent/DE50015163D1/de
Priority to DK04018487T priority patent/DK1481964T3/da
Priority to AU26667/01A priority patent/AU778132B2/en
Priority to AT06011207T priority patent/ATE395056T1/de
Priority to SI200030998T priority patent/SI1690536T1/sl
Priority to CZ20060247A priority patent/CZ302497B6/cs
Priority to SI200030890T priority patent/SI1481964T1/sl
Priority to CA002389749A priority patent/CA2389749C/en
Priority to SK657-2002A priority patent/SK287430B6/sk
Priority to AT00989857T priority patent/ATE286872T1/de
Priority to US10/130,214 priority patent/US6858650B1/en
Priority to PT00989857T priority patent/PT1230209E/pt
Priority to SK5024-2013A priority patent/SK288384B6/sk
Priority to SK5027-2010A priority patent/SK288185B6/sk
Priority to EP06011207A priority patent/EP1690536B1/de
Priority to EP04018487A priority patent/EP1481964B1/de
Priority to CZ20021343A priority patent/CZ302967B6/cs
Priority to DE50009239T priority patent/DE50009239D1/de
Priority to KR10-2002-7006306A priority patent/KR100536095B1/ko
Priority to CNB008157057A priority patent/CN1215045C/zh
Priority to PT04018487T priority patent/PT1481964E/pt
Priority to BRPI0015610A priority patent/BRPI0015610C1/pt
Priority to EP00989857A priority patent/EP1230209B3/de
Priority to PCT/EP2000/011309 priority patent/WO2001035957A1/de
Priority to NZ519230A priority patent/NZ519230A/en
Priority to JP2001537950A priority patent/JP4083431B2/ja
Priority to AT04018487T priority patent/ATE337293T1/de
Priority to KR1020057018318A priority patent/KR100563149B1/ko
Priority to HU0900587A priority patent/HU227608B1/hu
Priority to ES00989857T priority patent/ES2236032T7/es
Priority to EA200200511A priority patent/EA005588B1/ru
Priority to HK02106545.5A priority patent/HK1045148B/zh
Priority to ES04018487T priority patent/ES2270240T3/es
Priority to ES06011207T priority patent/ES2303708T3/es
Priority to HU0204034A priority patent/HU228197B1/hu
Priority to SI200030617T priority patent/SI1230209T1/xx
Priority to UA2002043609A priority patent/UA73324C2/uk
Priority to DK00989857T priority patent/DK1230209T3/da
Priority to IL14956700A priority patent/IL149567A0/xx
Priority to PT06011207T priority patent/PT1690536E/pt
Publication of DE19955190A1 publication Critical patent/DE19955190A1/de
Priority to IS6351A priority patent/IS2124B/xx
Priority to ZA200203315A priority patent/ZA200203315B/xx
Priority to IL149567A priority patent/IL149567A/en
Priority to NO20022314A priority patent/NO323920B1/no
Priority to HK04110231.4A priority patent/HK1067114B/xx
Priority to UAA200500434A priority patent/UA77322C2/uk
Priority to IS8382A priority patent/IS2673B/is
Priority to CY20061101493T priority patent/CY1106204T1/el
Priority to NO20065380A priority patent/NO332637B1/no
Priority to HK07101097.3A priority patent/HK1095736B/xx
Priority to JP2007042774A priority patent/JP2007137895A/ja
Priority to GEAP200710360A priority patent/GEP20084430B/en
Priority to CY20081100712T priority patent/CY1110389T1/el
Priority to JP2010098844A priority patent/JP5650924B2/ja
Priority to JP2010098845A priority patent/JP5503393B2/ja
Priority to JP2011096911A priority patent/JP5290351B2/ja
Priority to JP2013229622A priority patent/JP5717824B2/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Luminescent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
DE19955190A 1999-11-16 1999-11-16 Stabile Salze neuartiger Derivate von 3,3-Diphenylpropylaminen Ceased DE19955190A1 (de)

Priority Applications (63)

Application Number Priority Date Filing Date Title
DE19955190A DE19955190A1 (de) 1999-11-16 1999-11-16 Stabile Salze neuartiger Derivate von 3,3-Diphenylpropylaminen
DE29923134U DE29923134U1 (de) 1999-11-16 1999-11-16 Stabile Salze neuartiger Derviate von 3,3-Diphenylpropylaminen
PL356766A PL201422B1 (pl) 1999-11-16 2000-11-15 Stabilna sól izomaślanu R-(+)-2-(3-(diizopropyloamino-1-fenylopropylo)-4-hydroksymetylofenylowego
DE50013365T DE50013365D1 (de) 1999-11-16 2000-11-15 Stabile Salze neuartiger derivative von 3,3-Diphenylpropylaminen
DK06011207T DK1690536T3 (da) 1999-11-16 2000-11-15 Anvendelse af R-( )-2-(3-diisopropylamino-1-phenylpropyl)4-4-hydroxy-methyl-phenylsobutyrat hydrogenfumarat til behandling af urininkontinens og andre spasmogene lidelser
MXPA02004603A MXPA02004603A (es) 1999-11-16 2000-11-15 Sales estables de nuevos derivados de 3, 3-difenilpropilaminas.
DE50015163T DE50015163D1 (de) 1999-11-16 2000-11-15 Verwendung von r-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxy-methyl-Phenylisobuttersäureester Hydrogenfumarat zur Behandlung von Harndrang-Inkontinenz und anderen spasmogenen Leiden
DK04018487T DK1481964T3 (da) 1999-11-16 2000-11-15 Stabile salte af hidtil ukendte derivater af 3,3-diphenylpropylaminer
AU26667/01A AU778132B2 (en) 1999-11-16 2000-11-15 Stable salts of novel derivatives of 3,3-diphenylpropylamines
AT06011207T ATE395056T1 (de) 1999-11-16 2000-11-15 Verwendung von r-(+)-2-(3-diisopropylamino-1- phenylpropyl)-4-hydroxy-methyl- phenylisobuttersäureester hydrogenfumarat zur behandlung von harndrang-inkontinenz und anderen spasmogenen leiden
SI200030998T SI1690536T1 (sl) 1999-11-16 2000-11-15 Uporaba hidrogenfumarata estra R-(+)-2-(3-diizopropilamino-1-fenilpropil)-4-hidroksi-metil- fenilizomaslene kisline za zdravljenje inkontinence in drugih spazmogenih bolezni
CZ20060247A CZ302497B6 (cs) 1999-11-16 2000-11-15 Deriváty 3,3-difenylpropylaminu, zpusob jejich prípravy a použití
SI200030890T SI1481964T1 (sl) 1999-11-16 2000-11-15 Stabilne soli novovrstnih derivatov 3,3-difenilpropilaminov
CA002389749A CA2389749C (en) 1999-11-16 2000-11-15 Stable salts of novel derivatives of 3,3-diphenylpropylamines
SK657-2002A SK287430B6 (sk) 1999-11-16 2000-11-15 Stabilná soľ derivátov 3,3-difenylpropylamínov, spôsob jej výroby a stabilné medziprodukty na jej výrobu
AT00989857T ATE286872T1 (de) 1999-11-16 2000-11-15 Stabile salze neuartiger derivate von 3,3- diphenylpropylaminen
US10/130,214 US6858650B1 (en) 1999-11-16 2000-11-15 Stable salts of novel derivatives of 3,3-diphenylpropylamines
PT00989857T PT1230209E (pt) 1999-11-16 2000-11-15 Sais estaveis de novos derivados de 3,3-difenilpropilaminas
SK5024-2013A SK288384B6 (sk) 1999-11-16 2000-11-15 Deriváty 3,3-difenylpropylamínov a spôsob ich výroby
SK5027-2010A SK288185B6 (sk) 1999-11-16 2000-11-15 Stabilné soli derivátov 3,3-difenylpropylamínov
EP06011207A EP1690536B1 (de) 1999-11-16 2000-11-15 Verwendung von r-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxy-methyl-Phenylisobuttersäureester Hydrogenfumarat zur Behandlung von Harndrang-Inkontinenz und anderen spasmogenen Leiden
EP04018487A EP1481964B1 (de) 1999-11-16 2000-11-15 Stabile Salze neuartiger derivative von 3,3-Diphenylpropylaminen
CZ20021343A CZ302967B6 (cs) 1999-11-16 2000-11-15 Krystalické deriváty 3,3-difenylpropylaminu a zpusob jejich výroby
DE50009239T DE50009239D1 (de) 1999-11-16 2000-11-15 Stabile salze neuartiger derivate von 3,3-diphenylpropylaminen
KR10-2002-7006306A KR100536095B1 (ko) 1999-11-16 2000-11-15 3,3-디페닐-프로필아민의 신규한 유도체의 안정한 염
CNB008157057A CN1215045C (zh) 1999-11-16 2000-11-15 3,3－二苯基丙胺类化合物的新衍生物的稳定盐
PT04018487T PT1481964E (pt) 1999-11-16 2000-11-15 Sais estáveis de novos derivados de 3,3-difenilpropilaminas
BRPI0015610A BRPI0015610C1 (pt) 1999-11-16 2000-11-15 composto derivado de 3,3-difenilpropilamina, processo para preparação do mesmo, utilização de intermediários na obtenção do referido composto
EP00989857A EP1230209B3 (de) 1999-11-16 2000-11-15 Stabile salze neuartiger derivate von 3,3-diphenylpropylaminen
PCT/EP2000/011309 WO2001035957A1 (de) 1999-11-16 2000-11-15 Stabile salze neuartiger derivate von 3,3-diphenylpropylaminen
NZ519230A NZ519230A (en) 1999-11-16 2000-11-15 Stable salts of novel derivatives of 3,3-diphenylpropylamines
JP2001537950A JP4083431B2 (ja) 1999-11-16 2000-11-15 ３，３−ジフェニルプロピルアミン類の新規誘導体の安定な塩
AT04018487T ATE337293T1 (de) 1999-11-16 2000-11-15 Stabile salze neuartiger derivative von 3,3- diphenylpropylaminen
KR1020057018318A KR100563149B1 (ko) 1999-11-16 2000-11-15 3,3-디페닐-프로필아민의 신규한 유도체의 안정한 염
HU0900587A HU227608B1 (en) 1999-11-16 2000-11-15 Stable salts of 3,3-diphenylpropylamines and preparation thereof
ES00989857T ES2236032T7 (es) 1999-11-16 2000-11-15 Sales estables de nuevos derivados de 3,3-difenil-propil-aminas.
EA200200511A EA005588B1 (ru) 1999-11-16 2000-11-15 Соли производных 3,3-дифенилпропиламинов
HK02106545.5A HK1045148B (zh) 1999-11-16 2000-11-15 3，3-二苯丙胺的全新衍生物的穩定的鹽
ES04018487T ES2270240T3 (es) 1999-11-16 2000-11-15 Sales estables de nuevos derivados de 3,3-difenil-propil-aminas.
ES06011207T ES2303708T3 (es) 1999-11-16 2000-11-15 Utilizacion del hidrogeno-fumarato del r-(+)-ester 2-(3-diisopropilamino-1-fenil-propil)-4-hidroximetil-fenilico de acido isobutirico para el tratamiento de la incontinencia urinaria y de otras dolencias espasmogenas.
HU0204034A HU228197B1 (en) 1999-11-16 2000-11-15 Stable salts of 3,3-diphenylpropylamines derivatives and preparation thereof
SI200030617T SI1230209T1 (en) 1999-11-16 2000-11-15 Stable salts of novel derivatives of 3,3-diphenylpropylamines
UA2002043609A UA73324C2 (uk) 1999-11-16 2000-11-15 Стійкі солі похідних 3,3-дифенілпропіламінів та спосіб їх одержання (варіанти)
DK00989857T DK1230209T3 (da) 1999-11-16 2000-11-15 Stabile salte af hidtil ukendte derivater af 3,3-diphenylpropylaminer
IL14956700A IL149567A0 (en) 1999-11-16 2000-11-15 Stable salts of novel derivatives of 3,3-diphenylpropylamines
PT06011207T PT1690536E (pt) 1999-11-16 2000-11-15 Utilização do sal hidrogenofumarato de isobutirato de r-(+)-2-(3 diisopropilamino-1-fenilpropil)-4-hidroxi-metilfenilo para tratamento de incontinência urinária e outros estados espástico-dolorosos
IS6351A IS2124B (is) 1999-11-16 2002-04-19 Stöðug sölt af nýjum afleiðum af 3,3-dífenýlprópýlamínum
ZA200203315A ZA200203315B (en) 1999-11-16 2002-04-25 Stable salts of novel derivatives of 3,3-diphenylpropylamines.
IL149567A IL149567A (en) 1999-11-16 2002-05-09 Stable salts of derivatives 3,3 - diphenylpropylamines
NO20022314A NO323920B1 (no) 1999-11-16 2002-05-15 Stabile forbindelser av nye derivater av 3,3-difenylpropylaminer, fremgangsmåte for fremstilling derav og nye mellomprodukter
HK04110231.4A HK1067114B (en) 1999-11-16 2002-09-05 Stable salts of novel derivatives of 3,3-diphenylpropylamines
UAA200500434A UA77322C2 (en) 1999-11-16 2005-01-17 Hydrofumarate of r-(+) -2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenylisobutirate ester, method for its production and intermediates
IS8382A IS2673B (is) 1999-11-16 2006-03-29 R-(+)-2-(3-díísóprópýlamínó-1-fenýlprópýl)-4-hýdroxýmetýlfenýlísóbútýrat vetnisfúmarat og notkun þar á til framleiðslu á lyfjum
CY20061101493T CY1106204T1 (el) 1999-11-16 2006-10-18 Σταθepα αλατα καινοφανων παραγωγων 3,3-διφαινυλοπροπυλαμινων
NO20065380A NO332637B1 (no) 1999-11-16 2006-11-22 Anvendelse av R-(+)-2-(3-diisopropylamino-1-fenylpropyl)-4-hydroksymetyl-fenylisosmørsyreester- hydrogenfumarat for fremstilling av et medikament for behandling av urininkontinens og andre spasmogeniske sykdommer og farmasøytisk formulering derav
HK07101097.3A HK1095736B (en) 1999-11-16 2007-01-31 Use of r-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxy-methyl-phenylisobutyric acid ester hydrogenfumarate for the treatment of urinary incontinence and other spasmogenic disorders
JP2007042774A JP2007137895A (ja) 1999-11-16 2007-02-22 ３，３−ジフェニルプロピルアミン類の新規誘導体の安定な塩
GEAP200710360A GEP20084430B (OSRAM) 1999-11-16 2007-11-07
CY20081100712T CY1110389T1 (el) 1999-11-16 2008-07-08 Χρηση του οξινου φουμαρικου r-(+)-2-(3-διισοπροπυλαμινο-1-φαινυλοπροπυλο)-4-υδροξυ-μεθυλο-φαινυλισοβουτυρικου εστερα για τη θεραπεια της επιτακτικης ακρατειας ουρων και αλλων σπασμογενων παθησεων
JP2010098844A JP5650924B2 (ja) 1999-11-16 2010-04-22 ３，３−ジフェニルプロピルアミン類の新規誘導体の安定な塩
JP2010098845A JP5503393B2 (ja) 1999-11-16 2010-04-22 ３，３−ジフェニルプロピルアミン類の新規誘導体の安定な塩
JP2011096911A JP5290351B2 (ja) 1999-11-16 2011-04-25 ３，３−ジフェニルプロピルアミン類の新規誘導体の安定な塩
JP2013229622A JP5717824B2 (ja) 1999-11-16 2013-11-05 ３，３−ジフェニルプロピルアミン類の新規誘導体の安定な塩

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19955190A DE19955190A1 (de) 1999-11-16 1999-11-16 Stabile Salze neuartiger Derivate von 3,3-Diphenylpropylaminen

Publications (1)

Publication Number Publication Date
DE19955190A1 true DE19955190A1 (de) 2001-06-21

Family

ID=7929277

Family Applications (5)

Application Number Title Priority Date Filing Date
DE19955190A Ceased DE19955190A1 (de) 1999-11-16 1999-11-16 Stabile Salze neuartiger Derivate von 3,3-Diphenylpropylaminen
DE29923134U Expired - Lifetime DE29923134U1 (de) 1999-11-16 1999-11-16 Stabile Salze neuartiger Derviate von 3,3-Diphenylpropylaminen
DE50009239T Expired - Lifetime DE50009239D1 (de) 1999-11-16 2000-11-15 Stabile salze neuartiger derivate von 3,3-diphenylpropylaminen
DE50015163T Expired - Lifetime DE50015163D1 (de) 1999-11-16 2000-11-15 Verwendung von r-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxy-methyl-Phenylisobuttersäureester Hydrogenfumarat zur Behandlung von Harndrang-Inkontinenz und anderen spasmogenen Leiden
DE50013365T Expired - Lifetime DE50013365D1 (de) 1999-11-16 2000-11-15 Stabile Salze neuartiger derivative von 3,3-Diphenylpropylaminen

Family Applications After (4)

Application Number Title Priority Date Filing Date
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DE50009239T Expired - Lifetime DE50009239D1 (de) 1999-11-16 2000-11-15 Stabile salze neuartiger derivate von 3,3-diphenylpropylaminen
DE50015163T Expired - Lifetime DE50015163D1 (de) 1999-11-16 2000-11-15 Verwendung von r-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxy-methyl-Phenylisobuttersäureester Hydrogenfumarat zur Behandlung von Harndrang-Inkontinenz und anderen spasmogenen Leiden
DE50013365T Expired - Lifetime DE50013365D1 (de) 1999-11-16 2000-11-15 Stabile Salze neuartiger derivative von 3,3-Diphenylpropylaminen

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010010464A3 (en) * 2008-07-21 2010-12-23 Actavis Group Ptc Ehf Fesoterodine comprising a reduced amount of dehydroxyfesoterodine

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0957073A1 (en) * 1998-05-12 1999-11-17 Schwarz Pharma Ag Novel derivatives of 3,3-diphenylpropylamines
DE19955190A1 (de) * 1999-11-16 2001-06-21 Sanol Arznei Schwarz Gmbh Stabile Salze neuartiger Derivate von 3,3-Diphenylpropylaminen
DE10028443C1 (de) * 2000-06-14 2002-05-29 Sanol Arznei Schwarz Gmbh Verfahren zur Herstellung von 3,3-Diarylpropylaminen, (R,S)- und (R)-4-Phenyl-2-chromanon-6-carbonsäure sowie (R)-4-Phenyl-2-chromanon-carbonsäure-cinchonidinsalz und deren Verwendung zur Herstellung eines rechtsdrehenden Hydroxybenzylalkohols und von pharmazeutischen Zusammensetzungen
DE10315878B4 (de) 2003-04-08 2009-06-04 Schwarz Pharma Ag Vorrichtung zur transdermalen Verabreichung von Fesoterodin und Verwendung
DE10315917A1 (de) * 2003-04-08 2004-11-18 Schwarz Pharma Ag Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
WO2005012227A2 (en) * 2003-08-05 2005-02-10 Ranbaxy Laboratories Limited Process for preparation of 2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethyl-phenol, a metabolite of tolterodine
ES2235648B1 (es) * 2003-12-22 2006-11-01 Ragactives, S.L. Procedimiento para la obtencion de tolterodina.
US8034823B2 (en) * 2005-02-22 2011-10-11 Savvipharm Inc Method of increasing drug oral bioavailability and compositions of less toxic orotate salts
KR100647068B1 (ko) 2005-09-15 2006-11-23 하나제약 주식회사 라세믹ｎ,ｎ-디이소프로필-3-(2-히드록시-5-메틸페닐)-3-페닐프로판아민의 제조방법
DK2029567T3 (da) * 2006-05-24 2010-11-29 Pfizer Ltd Fremgangsmåde til frembringelse af benzopyran-2-ol-derivater
BRPI0711881B1 (pt) * 2006-05-31 2016-09-27 Schwarz Pharma Ltd síntese de hidroximetil fenóis substituídos
EP1862449A1 (en) * 2006-05-31 2007-12-05 Schwarz Pharma Ltd. A shortened synthesis of substituted hydroxymethyl phenols
IES20060424A2 (en) * 2006-06-08 2007-10-31 Schwarz Pharma Ltd Accelerated synthesis of (3-Diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)phenol and its phenolic monoesters
US7807715B2 (en) 2006-06-09 2010-10-05 Ucb Pharma Gmbh Pharmaceutical compositions comprising fesoterodine
CA2648333C (en) * 2006-06-09 2014-04-29 Schwarz Pharma Ltd Synthesis of phenolic esters of hydroxymethyl phenols
ATE517619T1 (de) * 2006-06-09 2011-08-15 Ucb Pharma Gmbh Stabilisierte pharmazeutische zusammensetzung mit fesoterodin
IES20060435A2 (en) * 2006-06-12 2007-12-12 Schwarz Pharma Ltd Shortened synthesis using paraformaldehyde or trioxane
AU2007260267B2 (en) 2006-06-12 2012-09-06 Ucb Pharma Gmbh New chiral intermediate, process for producing the same and its use in the manufacture of tolterodine, fesoterodine, or the active metabolite thereof
US20100217034A1 (en) * 2007-09-21 2010-08-26 Actavis Group Ptc Ehf Process for the Preparation of Fesoterodine
US20100297241A1 (en) * 2007-10-01 2010-11-25 Actavis Group Ptc Ehf Amorphous Fesoterodine Fumarate
EP2294047A2 (en) * 2008-04-04 2011-03-16 Actavis Group PTC EHF Novel mandelate salt of fesoterodine
IT1392082B1 (it) * 2008-12-10 2012-02-09 Chemi Spa Nuove forme solide della fesoterodina fumarato
PL2416761T3 (pl) 2009-05-11 2015-07-31 Ratiopharm Gmbh Desfezoterodyna w postaci soli kwasu winowego
IT1394217B1 (it) 2009-05-15 2012-06-01 Chemi Spa Metodo di preparazione di fesoterodina e/o fesoterodina fumarato.
IT1394219B1 (it) * 2009-05-15 2012-06-01 Chemi Spa Metodo di preparazione di fesoterodina fumarato di elevata purezza.
KR20120053027A (ko) 2009-09-03 2012-05-24 테바 기오기스제르갸르 자르트쾨렌 뮈쾨되 레스즈베니타르사사그 페소테로딘 푸마레이트 및 페소테로딘 염기의 결정형
IT1396373B1 (it) * 2009-10-29 2012-11-19 Dipharma Francis Srl Procedimento per la preparazione di fesoterodina.
EP2316432A1 (de) 2009-10-30 2011-05-04 ratiopharm GmbH Zusammensetzung enthaltend Fesoterodin und Ballaststoffe
US20110124903A1 (en) * 2009-11-20 2011-05-26 Actavis Group Ptc Ehf Solid state forms of fesoterodine intermediates
IT1397521B1 (it) * 2009-12-21 2013-01-16 Dipharma Francis Srl Procedimento per la preparazione di fesoterodina con un basso contenuto di impurezze.
IT1397920B1 (it) * 2010-02-08 2013-02-04 Dipharma Francis Srl Forma cristallina di fesoterodina fumarato e procedimento per la sua preparazione
WO2011117884A1 (en) 2010-03-22 2011-09-29 Cadila Healthcare Limited Stable pharmaceutical compositions comprising fesoterodine
JP5812500B2 (ja) 2010-04-30 2015-11-17 メルク・シャープ・エンド・ドーム・コーポレイション 新規なβ３アドレナリン作動性受容体アゴニスト
WO2011141932A2 (en) 2010-05-11 2011-11-17 Intas Pharmaceuticals Limited Process for preparation of phenolic monoesters of hydroxymethyl phenols
WO2011145019A1 (en) * 2010-05-17 2011-11-24 Orchid Chemicals And Pharmaceuticals Limited Improved process for diphenylpropylamine derivatives
IT1401451B1 (it) 2010-06-10 2013-07-26 Chemi Spa Nuovo processo di preparazione di 2-idrossi-4-fenil-3,4-diidro-2h-cromen-6-il-metanolo e (r)-2-[3-(diisopropilammino)-1-fenilpropil]-4-(idrossimetil)fenolo.
WO2011158257A1 (en) 2010-06-18 2011-12-22 Panacea Biotec Ltd Preparation process of fesoterodine and intermediates
WO2012025941A2 (en) 2010-08-25 2012-03-01 Cadila Healthcare Limited Processes for the preparation of fesoterodine
IT1403094B1 (it) 2010-12-09 2013-10-04 Dipharma Francis Srl Procedimento per la preparazione di fesoterodina o un suo sale
WO2012098560A2 (en) * 2011-01-17 2012-07-26 Msn Laboratories Limited Process for the preparation of muscarinic receptor antagonist
TWI590821B (zh) 2011-01-18 2017-07-11 輝瑞有限公司 固體分子分散液
EP2508175A1 (en) 2011-04-08 2012-10-10 LEK Pharmaceuticals d.d. Pharmaceutical composition comprising fesoterodine or a salt or a solvate thereof
EP2508173A1 (en) 2011-04-08 2012-10-10 LEK Pharmaceuticals d.d. Stabilized pharmaceutical composition comprising fesoterodine
US9422228B2 (en) 2012-05-04 2016-08-23 Crystal Pharma, S.A.U. Process for the preparation of optically pure fesoterodine derivatives
ITMI20121232A1 (it) 2012-07-16 2014-01-17 Cambrex Profarmaco Milano Srl Procedimento per la preparazione di 2-(3-n,n-diisopropilamino-1-fenilpropil)-4-idrossimetil-fenolo e suoi derivati
TR201721437A2 (tr) 2017-12-25 2019-07-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Fesoterodi̇ni̇n modi̇fi̇ye salim sağlayan formülasyonlari
CN116472262A (zh) * 2020-10-27 2023-07-21 威娜德国有限责任公司 化妆品级品质的2-甲氧基甲基-对苯二胺

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR75395B (OSRAM) * 1980-11-14 1984-07-13 Lilly Co Eli
IL66831A0 (en) * 1981-10-05 1982-12-31 Kefalas As Indane derivatives
SE8800207D0 (sv) * 1988-01-22 1988-01-22 Kabivitrum Ab Nya aminer, deras anvendning och framstellning
ATE140213T1 (de) * 1990-03-08 1996-07-15 Fujisawa Pharmaceutical Co N-monosubstituierte cyclopentenylamine, ein verfahren zu ihrer herstellung, und ihre verwendung als medikament
JPH0483431A (ja) * 1990-07-26 1992-03-17 Seiko Epson Corp 選択呼出受信機
SE9203318D0 (sv) * 1992-11-06 1992-11-06 Kabi Pharmacia Ab Novel 3,3-diphenylpropylamines, their use and preparation
SE9701144D0 (sv) * 1997-03-27 1997-03-27 Pharmacia & Upjohn Ab Novel compounds, their use and preparation
EP0957073A1 (en) * 1998-05-12 1999-11-17 Schwarz Pharma Ag Novel derivatives of 3,3-diphenylpropylamines
DE19955190A1 (de) * 1999-11-16 2001-06-21 Sanol Arznei Schwarz Gmbh Stabile Salze neuartiger Derivate von 3,3-Diphenylpropylaminen

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010010464A3 (en) * 2008-07-21 2010-12-23 Actavis Group Ptc Ehf Fesoterodine comprising a reduced amount of dehydroxyfesoterodine

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