DE19900471A1 - Imidazo[4,5c]-pyridin-4-on-derivate - Google Patents

Imidazo[4,5c]-pyridin-4-on-derivate

Info

Publication number
DE19900471A1
DE19900471A1 DE19900471A DE19900471A DE19900471A1 DE 19900471 A1 DE19900471 A1 DE 19900471A1 DE 19900471 A DE19900471 A DE 19900471A DE 19900471 A DE19900471 A DE 19900471A DE 19900471 A1 DE19900471 A1 DE 19900471A1
Authority
DE
Germany
Prior art keywords
formula
compounds
group
salts
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19900471A
Other languages
German (de)
English (en)
Inventor
Werner Mederski
Horst Juraszyk
Hanns Wurziger
Christos Tsaklakidis
Dieter Dorsch
Sabine Bernotat-Danielowski
Guido Melzer
Soheila Anzali
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Priority to DE19900471A priority Critical patent/DE19900471A1/de
Priority to CN99815465A priority patent/CN1333772A/zh
Priority to HU0105054A priority patent/HUP0105054A3/hu
Priority to EP99964639A priority patent/EP1149099A2/de
Priority to PCT/EP1999/010236 priority patent/WO2000040583A2/de
Priority to AU30417/00A priority patent/AU3041700A/en
Priority to PL99349341A priority patent/PL349341A1/xx
Priority to KR1020017007074A priority patent/KR20010086085A/ko
Priority to BR9916774-3A priority patent/BR9916774A/pt
Priority to CZ20012407A priority patent/CZ20012407A3/cs
Priority to SK944-2001A priority patent/SK9442001A3/sk
Priority to CA002357771A priority patent/CA2357771A1/en
Priority to JP2000592291A priority patent/JP2002534429A/ja
Priority to ARP000100062A priority patent/AR022220A1/es
Publication of DE19900471A1 publication Critical patent/DE19900471A1/de
Priority to NO20013384A priority patent/NO20013384L/no
Priority to ZA200106454A priority patent/ZA200106454B/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE19900471A 1999-01-08 1999-01-08 Imidazo[4,5c]-pyridin-4-on-derivate Withdrawn DE19900471A1 (de)

Priority Applications (16)

Application Number Priority Date Filing Date Title
DE19900471A DE19900471A1 (de) 1999-01-08 1999-01-08 Imidazo[4,5c]-pyridin-4-on-derivate
KR1020017007074A KR20010086085A (ko) 1999-01-08 1999-12-21 이미다조[４,５-ｃ]-피리딘-４-온-유도체
SK944-2001A SK9442001A3 (en) 1999-01-08 1999-12-21 Imidazo[4,5-c]-pyridine-4-on-derivatives, process for the preparation thereof, use thereof and pharmaceutical composition comprising same
EP99964639A EP1149099A2 (de) 1999-01-08 1999-12-21 Imidazo[4,5-c]-pyridin-4-on-derivate
PCT/EP1999/010236 WO2000040583A2 (de) 1999-01-08 1999-12-21 Imidazo[4,5-c]-pyridin-4-on-derivate
AU30417/00A AU3041700A (en) 1999-01-08 1999-12-21 Imidazo(4,5-c)-pyridine-4-on-derivatives
PL99349341A PL349341A1 (en) 1999-01-08 1999-12-21 Imidazo[4,5-c]-pyridine-4-on-derivatives
CN99815465A CN1333772A (zh) 1999-01-08 1999-12-21 咪唑并(4,5－c)吡啶－4－酮衍生物
BR9916774-3A BR9916774A (pt) 1999-01-08 1999-12-21 Derivados de imidazo[4,5-c]piridina-4-ona
CZ20012407A CZ20012407A3 (cs) 1999-01-08 1999-12-21 Derivát imidazol [4,5-c]pyridin-4-onu, způsob jeho přípravy, jeho pouľití a farmaceutický prostředek, který ho obsahuje
HU0105054A HUP0105054A3 (en) 1999-01-08 1999-12-21 Imidazo[4,5-c]-pyridine-4-on-derivatives, pharmaceutical compositions containing them and process for their preparation
CA002357771A CA2357771A1 (en) 1999-01-08 1999-12-21 Imidazo[4,5-c]-pyridine-4-one derivatives
JP2000592291A JP2002534429A (ja) 1999-01-08 1999-12-21 イミダゾ［４，５−ｃ］ピリジン−４−オン誘導体
ARP000100062A AR022220A1 (es) 1999-01-08 2000-01-07 Derivados de la imidazo[4,5-c]-piridin-4-ona, un procedimiento para su preparacion, el empleo de los mismos para preparar un medicamento, los medicamentosa base de estos compuestos, las composiciones farmaceuticas que contienen estos compuestos y un procedimiento para preparar estas composiciones fa
NO20013384A NO20013384L (no) 1999-01-08 2001-07-06 Imidazo[4,5-c]pyridin-4-on-derivater
ZA200106454A ZA200106454B (en) 1999-01-08 2001-08-06 Imidazo[4,5-c]-pyridine-4-on-derivatives.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19900471A DE19900471A1 (de) 1999-01-08 1999-01-08 Imidazo[4,5c]-pyridin-4-on-derivate

Publications (1)

Publication Number Publication Date
DE19900471A1 true DE19900471A1 (de) 2000-07-13

Family

ID=7893790

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19900471A Withdrawn DE19900471A1 (de) 1999-01-08 1999-01-08 Imidazo[4,5c]-pyridin-4-on-derivate

Country Status (16)

Country Link
EP (1) EP1149099A2 (zh)
JP (1) JP2002534429A (zh)
KR (1) KR20010086085A (zh)
CN (1) CN1333772A (zh)
AR (1) AR022220A1 (zh)
AU (1) AU3041700A (zh)
BR (1) BR9916774A (zh)
CA (1) CA2357771A1 (zh)
CZ (1) CZ20012407A3 (zh)
DE (1) DE19900471A1 (zh)
HU (1) HUP0105054A3 (zh)
NO (1) NO20013384L (zh)
PL (1) PL349341A1 (zh)
SK (1) SK9442001A3 (zh)
WO (1) WO2000040583A2 (zh)
ZA (1) ZA200106454B (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007009883A1 (en) * 2005-07-15 2007-01-25 F. Hoffmann-La Roche Ag Novel heteroaryl fused cyclic amines
EP2982668A2 (en) 2002-12-03 2016-02-10 Pharmacyclics LLC 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors for the treatment of thromboembolic disorders

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1140941T1 (en) 1998-12-23 2005-04-30 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor xa inhibitors
NZ523184A (en) * 2000-06-23 2004-06-25 Bristol Myers Squibb Pharma Co 1 - (heteroaryl-phenyl) - condensed pyrazol derivatives as factor Xa inhibitors
CA2447488A1 (en) 2001-05-22 2002-11-28 Irina Jacobson Bicyclic inhibitors of factor xa
GB0215293D0 (en) 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
GB0225399D0 (en) * 2002-10-31 2002-12-11 Merck Sharp & Dohme Therapeutic agents
US20050222198A1 (en) 2003-12-22 2005-10-06 K.U. Leuven Research & Development, Gerhard Puerstinger And Gilead Sciences, Inc. Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment
EP1841765B1 (en) 2004-12-21 2009-03-25 Gilead Sciences, Inc. Imidazo[4,5-c]pyridine compound and method of antiviral treatment
ZA200802857B (en) 2005-09-14 2009-09-30 Takeda Pharmaceutical Dipeptidyl peptidase inhibitors for treating diabetes
KR101368988B1 (ko) 2005-09-16 2014-02-28 다케다 야쿠힌 고교 가부시키가이샤 디펩티딜 펩티다제 억제제
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7754720B2 (en) 2006-07-07 2010-07-13 Gilead Sciences, Inc. Pyridazine compound and use thereof
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
UA99466C2 (en) 2007-07-06 2012-08-27 Гилиад Сайенсиз, Инк. Crystalline pyridazine compound
CN107074846B (zh) * 2014-08-12 2020-05-19 先正达参股股份有限公司 具有含硫取代基的杀有害生物活性杂环衍生物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW219935B (zh) * 1991-12-25 1994-02-01 Mitsubishi Chemicals Co Ltd
CA2309347A1 (en) * 1997-12-01 1999-06-10 Merck & Co., Inc. Thrombin inhibitors

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2982668A2 (en) 2002-12-03 2016-02-10 Pharmacyclics LLC 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors for the treatment of thromboembolic disorders
WO2007009883A1 (en) * 2005-07-15 2007-01-25 F. Hoffmann-La Roche Ag Novel heteroaryl fused cyclic amines
US7417144B2 (en) 2005-07-15 2008-08-26 Hoffman-La Roche Inc. Factor Xa inhibitors

Also Published As

Publication number Publication date
SK9442001A3 (en) 2002-05-09
NO20013384D0 (no) 2001-07-06
WO2000040583A2 (de) 2000-07-13
AR022220A1 (es) 2002-09-04
NO20013384L (no) 2001-07-06
CZ20012407A3 (cs) 2001-12-12
PL349341A1 (en) 2002-07-15
HUP0105054A2 (hu) 2002-05-29
CN1333772A (zh) 2002-01-30
ZA200106454B (en) 2002-11-06
BR9916774A (pt) 2001-10-30
KR20010086085A (ko) 2001-09-07
AU3041700A (en) 2000-07-24
EP1149099A2 (de) 2001-10-31
JP2002534429A (ja) 2002-10-15
CA2357771A1 (en) 2000-07-13
WO2000040583A3 (de) 2000-09-21
HUP0105054A3 (en) 2002-12-28

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Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee