DE19782097T1 - Zusammensetzungen und Verfahren zur Immobilisierung von Nucleinsäuren an feste Träger - Google Patents
Zusammensetzungen und Verfahren zur Immobilisierung von Nucleinsäuren an feste TrägerInfo
- Publication number
- DE19782097T1 DE19782097T1 DE19782097T DE19782097T DE19782097T1 DE 19782097 T1 DE19782097 T1 DE 19782097T1 DE 19782097 T DE19782097 T DE 19782097T DE 19782097 T DE19782097 T DE 19782097T DE 19782097 T1 DE19782097 T1 DE 19782097T1
- Authority
- DE
- Germany
- Prior art keywords
- compositions
- methods
- nucleic acids
- solid support
- solid supports
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0244—Drop counters; Drop formers using pins
- B01L3/0255—Drop counters; Drop formers using pins characterized by the form or material of the pin tip
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
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- C07F9/2429—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of arylalkanols
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- C—CHEMISTRY; METALLURGY
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
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- Immunology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/746,036 US5900481A (en) | 1996-11-06 | 1996-11-06 | Bead linkers for immobilizing nucleic acids to solid supports |
| US08/787,639 US6024925A (en) | 1997-01-23 | 1997-01-23 | Systems and methods for preparing low volume analyte array elements |
| US08/786,988 US7285422B1 (en) | 1997-01-23 | 1997-01-23 | Systems and methods for preparing and analyzing low volume analyte array elements |
| US08/933,792 US6133436A (en) | 1996-11-06 | 1997-09-19 | Beads bound to a solid support and to nucleic acids |
| PCT/US1997/020194 WO1998020019A1 (en) | 1996-11-06 | 1997-11-06 | Compositions and methods for immobilizing nucleic acids to solid supports |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19782097T1 true DE19782097T1 (de) | 1999-10-14 |
Family
ID=27505632
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19782097T Ceased DE19782097T1 (de) | 1996-11-06 | 1997-11-06 | Zusammensetzungen und Verfahren zur Immobilisierung von Nucleinsäuren an feste Träger |
| DE69706187T Revoked DE69706187T2 (de) | 1996-11-06 | 1997-11-06 | Zusammensetzungen und verfahren zur immobilisierung von nukleinsäure auf festträgern |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69706187T Revoked DE69706187T2 (de) | 1996-11-06 | 1997-11-06 | Zusammensetzungen und verfahren zur immobilisierung von nukleinsäure auf festträgern |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0937097B1 (enExample) |
| JP (1) | JP4963139B2 (enExample) |
| AT (1) | ATE204290T1 (enExample) |
| AU (1) | AU746737B2 (enExample) |
| CA (1) | CA2267070A1 (enExample) |
| DE (2) | DE19782097T1 (enExample) |
| NO (1) | NO992167L (enExample) |
| WO (1) | WO1998020019A1 (enExample) |
Families Citing this family (136)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5795714A (en) | 1992-11-06 | 1998-08-18 | Trustees Of Boston University | Method for replicating an array of nucleic acid probes |
| US6436635B1 (en) | 1992-11-06 | 2002-08-20 | Boston University | Solid phase sequencing of double-stranded nucleic acids |
| DE69433811T2 (de) | 1993-01-07 | 2005-06-23 | Sequenom, Inc., San Diego | Dns - sequenzierung durch massenspektronomie |
| US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| US5830655A (en) | 1995-05-22 | 1998-11-03 | Sri International | Oligonucleotide sizing using cleavable primers |
| US6146854A (en) * | 1995-08-31 | 2000-11-14 | Sequenom, Inc. | Filtration processes, kits and devices for isolating plasmids |
| US6022688A (en) | 1996-05-13 | 2000-02-08 | Sequenom, Inc. | Method for dissociating biotin complexes |
| US5777324A (en) | 1996-09-19 | 1998-07-07 | Sequenom, Inc. | Method and apparatus for maldi analysis |
| CA2270132A1 (en) | 1996-11-06 | 1998-05-14 | Sequenom, Inc. | Dna diagnostics based on mass spectrometry |
| US6133436A (en) | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids |
| US6635452B1 (en) | 1996-12-10 | 2003-10-21 | Sequenom Inc. | Releasable nonvolatile mass label molecules |
| US6207370B1 (en) | 1997-09-02 | 2001-03-27 | Sequenom, Inc. | Diagnostics based on mass spectrometric detection of translated target polypeptides |
| US6287772B1 (en) | 1998-04-29 | 2001-09-11 | Boston Probes, Inc. | Methods, kits and compositions for detecting and quantitating target sequences |
| US7875440B2 (en) | 1998-05-01 | 2011-01-25 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
| US6780591B2 (en) | 1998-05-01 | 2004-08-24 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
| US6780981B1 (en) | 1998-05-15 | 2004-08-24 | Oxford Gene Technology Ip Limited | Libraries of oligomers labeled with different tags |
| WO1999067641A2 (en) * | 1998-06-24 | 1999-12-29 | Illumina, Inc. | Decoding of array sensors with microspheres |
| EP1105529B2 (en) * | 1998-07-30 | 2013-05-29 | Illumina Cambridge Limited | Arrayed biomolecules and their use in sequencing |
| GB0002310D0 (en) * | 2000-02-01 | 2000-03-22 | Solexa Ltd | Polynucleotide sequencing |
| US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
| DE19854946C2 (de) * | 1998-11-27 | 2002-01-03 | Guenter Von Kiedrowski | Klonieren und Kopieren an Oberflächen |
| JP2000157272A (ja) * | 1998-12-01 | 2000-06-13 | Hitachi Software Eng Co Ltd | バイオチップ及びその製造方法 |
| US6441152B1 (en) | 1998-12-08 | 2002-08-27 | Boston Probes, Inc. | Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices |
| US6429027B1 (en) * | 1998-12-28 | 2002-08-06 | Illumina, Inc. | Composite arrays utilizing microspheres |
| US6514768B1 (en) | 1999-01-29 | 2003-02-04 | Surmodics, Inc. | Replicable probe array |
| EP1434055B1 (en) | 1999-02-16 | 2006-09-27 | Applera Corporation | Bead dispensing system |
| US6225061B1 (en) | 1999-03-10 | 2001-05-01 | Sequenom, Inc. | Systems and methods for performing reactions in an unsealed environment |
| US20020009394A1 (en) | 1999-04-02 | 2002-01-24 | Hubert Koster | Automated process line |
| US7501245B2 (en) | 1999-06-28 | 2009-03-10 | Helicos Biosciences Corp. | Methods and apparatuses for analyzing polynucleotide sequences |
| US6818395B1 (en) | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
| US6274320B1 (en) * | 1999-09-16 | 2001-08-14 | Curagen Corporation | Method of sequencing a nucleic acid |
| US7244559B2 (en) | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| US7211390B2 (en) | 1999-09-16 | 2007-05-01 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| ATE444532T1 (de) | 1999-10-13 | 2009-10-15 | Sequenom Inc | Verfahren zur identifizierung von polymorphen genetischen markern |
| US7917301B1 (en) | 2000-09-19 | 2011-03-29 | Sequenom, Inc. | Method and device for identifying a biological sample |
| US20030190644A1 (en) | 1999-10-13 | 2003-10-09 | Andreas Braun | Methods for generating databases and databases for identifying polymorphic genetic markers |
| AU2622101A (en) * | 1999-11-02 | 2001-05-14 | Celine Hu | Molecular microarrays and methods for production and use thereof |
| GB0002389D0 (en) | 2000-02-02 | 2000-03-22 | Solexa Ltd | Molecular arrays |
| AU3986501A (en) | 2000-02-23 | 2001-09-03 | Zyomyx Inc | Chips having elevated sample surfaces |
| US6958214B2 (en) | 2000-07-10 | 2005-10-25 | Sequenom, Inc. | Polymorphic kinase anchor proteins and nucleic acids encoding the same |
| JP3453604B2 (ja) | 2000-07-27 | 2003-10-06 | 北陸先端科学技術大学院大学長 | 新規なバイオチップ及びその作製方法 |
| WO2002055199A2 (en) * | 2000-10-30 | 2002-07-18 | Sequenom Inc | Method and apparatus for delivery of submicroliter volumes onto a substrate |
| US7026163B1 (en) | 2001-02-23 | 2006-04-11 | Mayo Foundation For Medical Education And Research | Sulfotransferase sequence variants |
| ES2593683T3 (es) * | 2001-03-09 | 2016-12-12 | Trovagene, Inc. | Sondas conjugadas y detección óptica de analitos |
| CA2440754A1 (en) | 2001-03-12 | 2002-09-19 | Stephen Quake | Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension |
| US20020155587A1 (en) | 2001-04-20 | 2002-10-24 | Sequenom, Inc. | System and method for testing a biological sample |
| US7056731B1 (en) | 2001-06-22 | 2006-06-06 | Mayo Foundation For Medical Education And Research | Sulfotransferase SULT2A1 sequence variants |
| CA2652991A1 (en) | 2001-07-16 | 2003-11-13 | Caprotec Bioanalytics Gmbh | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions |
| US7517496B2 (en) | 2001-07-17 | 2009-04-14 | Bio-Rad Laboratories, Inc. | Latex based adsorbent chip |
| EP1483794A4 (en) * | 2001-07-17 | 2006-05-03 | Ciphergen Biosystems Inc | ADSORBENT CHIP BASED ON LATEX |
| US20030113233A1 (en) | 2001-10-26 | 2003-06-19 | Elizabeth Nanthakumar | Resin dispensing device |
| US20030087425A1 (en) * | 2001-11-07 | 2003-05-08 | Eggers Mitchell D | Sample carrier |
| US7584240B2 (en) * | 2001-11-07 | 2009-09-01 | Genvault Corporation | Automated biological sample archive for storage, retrieval and analysis of large numbers of samples for remote clients |
| US7186551B1 (en) | 2001-11-14 | 2007-03-06 | Mayo Foundation For Medical Education And Research | 3′-phosphoadenosine -5′-phosphosulfate synthetase 2 (PAPSS2) sequence variants |
| US7067311B1 (en) | 2001-11-14 | 2006-06-27 | Mayo Foundation For Medical Education And Research | 3′-phosphoadenosine-5′-phosphosulfate synthetase 1 (PAPSS1) sequence variants |
| SI1458888T1 (sl) | 2001-12-10 | 2011-07-29 | Novartis Ag | Metode zdravljenja psihoze in shizofrenije na osnovi polimorfizmov gena cntf |
| US7288641B1 (en) | 2002-01-30 | 2007-10-30 | Mayo Foundation For Medical Education And Research | Sulfotransferase 1E1 sequence variants |
| US7432342B2 (en) | 2002-05-03 | 2008-10-07 | Sequenom, Inc. | Kinase anchor protein muteins, peptides thereof and related documents |
| JP3685774B2 (ja) * | 2002-05-30 | 2005-08-24 | 日立ソフトウエアエンジニアリング株式会社 | スポットピン |
| US7011971B2 (en) * | 2002-06-03 | 2006-03-14 | Eastman Kodak Company | Method of making random array of microspheres using enzyme digestion |
| DE10235302A1 (de) * | 2002-08-01 | 2004-02-12 | Henkel Kgaa | Verfahren zur Herstellung perl- bzw. kugelförmiger magnetischer Partikel auf Acrylsäuresbasis zur Aufreinigung biologischer Substanzen |
| US8277753B2 (en) | 2002-08-23 | 2012-10-02 | Life Technologies Corporation | Microfluidic transfer pin |
| US7371523B1 (en) | 2003-01-09 | 2008-05-13 | Mayo Foundation For Medical Education And Research | Phenylethanolamine-N-methyltransferase sequence variants |
| WO2004064972A2 (en) | 2003-01-16 | 2004-08-05 | Hk Pharmaceuticals, Inc. | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions |
| US7425624B1 (en) | 2003-01-21 | 2008-09-16 | Mayo Foundation For Medical Education And Research | Sulfotransferase 1A3 sequence variants |
| CA2513535C (en) | 2003-01-29 | 2012-06-12 | 454 Corporation | Bead emulsion nucleic acid amplification |
| US7575865B2 (en) | 2003-01-29 | 2009-08-18 | 454 Life Sciences Corporation | Methods of amplifying and sequencing nucleic acids |
| WO2004072268A2 (en) | 2003-02-12 | 2004-08-26 | Mayo Foundation For Medical Education And Research | Pkhdl1, a homolog of the autosomal recessive kidney disease gene |
| US8688385B2 (en) | 2003-02-20 | 2014-04-01 | Mayo Foundation For Medical Education And Research | Methods for selecting initial doses of psychotropic medications based on a CYP2D6 genotype |
| JP5348840B2 (ja) | 2003-02-20 | 2013-11-20 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | 薬物を選択する方法 |
| US7250290B1 (en) | 2003-04-15 | 2007-07-31 | Mayo Foundation For Medical Education And Research | Arsenic methyltransferase sequence variants |
| WO2005012578A1 (en) | 2003-07-31 | 2005-02-10 | Sequenom, Inc. | Methods for high level multiplexed polymerase chain reactions and homogeneous mass extension reactions for genotyping of polymorphisms |
| US9394565B2 (en) | 2003-09-05 | 2016-07-19 | Agena Bioscience, Inc. | Allele-specific sequence variation analysis |
| JP4286094B2 (ja) * | 2003-09-24 | 2009-06-24 | オリンパス株式会社 | 生体関連物質の反応装置 |
| JP2005114576A (ja) * | 2003-10-08 | 2005-04-28 | Hitachi Software Eng Co Ltd | 両親媒性分子固定化ビーズ、その製造方法、及びキャピラリビーズアレイのビーズ配列方法 |
| GB0326073D0 (en) | 2003-11-07 | 2003-12-10 | Solexa Ltd | Improvements in or relating to polynucleotide arrays |
| US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
| TW200533919A (en) * | 2003-12-08 | 2005-10-16 | Oxford Gene Tech Ip Ltd | Derivatived molecules for mass spectrometry |
| EP1506959A3 (en) * | 2004-09-22 | 2005-07-27 | Oxford Gene Technology Ip Limited | Derivatised molecules for mass spectrometry |
| DE602005020421D1 (de) | 2004-02-19 | 2010-05-20 | Helicos Biosciences Corp | Verfahren zur analyse von polynukleotidsequenzen |
| US7608394B2 (en) | 2004-03-26 | 2009-10-27 | Sequenom, Inc. | Methods and compositions for phenotype identification based on nucleic acid methylation |
| AU2005230936B2 (en) | 2004-03-26 | 2010-08-05 | Agena Bioscience, Inc. | Base specific cleavage of methylation-specific amplification products in combination with mass analysis |
| JP2008509226A (ja) | 2004-05-24 | 2008-03-27 | ジェンボールト コーポレイション | 回収可能な形式での安定なタンパク質保管および安定な核酸保管 |
| DE602005027700D1 (de) | 2004-05-25 | 2011-06-09 | Helicos Biosciences Corp | Verfahren zur nukleinsäureimmobilisierung |
| US7476734B2 (en) | 2005-12-06 | 2009-01-13 | Helicos Biosciences Corporation | Nucleotide analogs |
| JP2006028060A (ja) * | 2004-07-14 | 2006-02-02 | Canon Inc | Dna担持体、この製造方法及びこれを用いた捕集システム |
| JP3927580B2 (ja) * | 2004-12-09 | 2007-06-13 | 住友ベークライト株式会社 | Dna鎖伸長方法、dna鎖増幅方法およびdna鎖伸長用マイクロアレイ |
| US7220549B2 (en) | 2004-12-30 | 2007-05-22 | Helicos Biosciences Corporation | Stabilizing a nucleic acid for nucleic acid sequencing |
| US7482120B2 (en) | 2005-01-28 | 2009-01-27 | Helicos Biosciences Corporation | Methods and compositions for improving fidelity in a nucleic acid synthesis reaction |
| US7858306B2 (en) | 2005-07-07 | 2010-12-28 | Mayo Foundation For Medical Education And Research | HSD3B1 sequence variants |
| US7390894B2 (en) | 2005-07-07 | 2008-06-24 | Mayo Foundation For Medical Education And Research | Glutathione S-transferase sequence variants |
| US7485711B2 (en) | 2005-08-12 | 2009-02-03 | Mayo Foundation For Medical Education And Research | CYP19A1 polymorphisms |
| US7666593B2 (en) | 2005-08-26 | 2010-02-23 | Helicos Biosciences Corporation | Single molecule sequencing of captured nucleic acids |
| US7397546B2 (en) | 2006-03-08 | 2008-07-08 | Helicos Biosciences Corporation | Systems and methods for reducing detected intensity non-uniformity in a laser beam |
| US10522240B2 (en) | 2006-05-03 | 2019-12-31 | Population Bio, Inc. | Evaluating genetic disorders |
| US7702468B2 (en) | 2006-05-03 | 2010-04-20 | Population Diagnostics, Inc. | Evaluating genetic disorders |
| WO2007140417A2 (en) | 2006-05-31 | 2007-12-06 | Sequenom, Inc. | Methods and compositions for the extraction and amplification of nucleic acid from a sample |
| US8293481B2 (en) | 2006-11-10 | 2012-10-23 | Mayo Foundation For Medical Education And Research | Biomarkers for chronic vascular dysfunction |
| WO2009039122A2 (en) | 2007-09-17 | 2009-03-26 | Sequenom, Inc. | Integrated robotic sample transfer device |
| CN102177237B (zh) | 2008-09-12 | 2013-10-30 | 金沃特公司 | 用于贮存和稳定生物分子的基质和介质 |
| US20100089287A1 (en) | 2008-09-25 | 2010-04-15 | Thames Shelby F | Soy protein adhesive and uses thereof |
| WO2010067372A1 (en) | 2008-12-11 | 2010-06-17 | Ramot At Tel-Aviv University Ltd. | Genetic markers of schizophrenia |
| JP5457222B2 (ja) | 2009-02-25 | 2014-04-02 | エフ.ホフマン−ラ ロシュ アーゲー | 小型化ハイスループット核酸分析 |
| EP3211095B1 (en) | 2009-04-03 | 2019-01-02 | Sequenom, Inc. | Nucleic acid preparation compositions and methods |
| EP2503337B1 (en) | 2009-11-17 | 2016-08-24 | Asahi Kasei Kabushiki Kaisha | Organic colored microparticles and diagnostic reagent kit containing the same |
| WO2011100503A1 (en) | 2010-02-11 | 2011-08-18 | Dana Farber Cancer Institute, Inc. | Methods for predicting likelihood of responding to treatment |
| US8563705B2 (en) | 2010-05-12 | 2013-10-22 | Mayo Foundation For Medical Education And Research | Ribonucleic acid binding motif protein 20 sequence variants |
| EP2601609B1 (en) | 2010-08-02 | 2017-05-17 | Population Bio, Inc. | Compositions and methods for discovery of causative mutations in genetic disorders |
| CN102321622B (zh) * | 2011-08-04 | 2016-03-30 | 盛司潼 | 一种引物-固相载体复合物及其制备和用于测序的方法 |
| WO2013045505A1 (en) | 2011-09-28 | 2013-04-04 | Novartis Ag | Biomarkers for raas combination therapy |
| EP2766483B1 (en) | 2011-10-10 | 2022-03-23 | The Hospital For Sick Children | Methods and compositions for screening and treating developmental disorders |
| EP2773779B1 (en) | 2011-11-04 | 2020-10-14 | Population Bio, Inc. | Methods and compositions for diagnosing, prognosing, and treating neurological conditions |
| WO2013120018A1 (en) | 2012-02-09 | 2013-08-15 | Population Diagnostics, Inc. | Methods and compositions for screening and treating developmental disorders |
| DK2895621T3 (da) | 2012-09-14 | 2020-11-30 | Population Bio Inc | Fremgangsmåder og sammensætning til diagnosticering, prognose og behandling af neurologiske tilstande |
| EP2900835B1 (en) | 2012-09-27 | 2025-04-30 | Population Bio, Inc. | Method for screening and treating developmental disorders |
| WO2014134144A1 (en) | 2013-02-28 | 2014-09-04 | The General Hospital Corporation | Mirna profiling compositions and methods of use |
| EP3511422B1 (en) | 2013-11-12 | 2022-12-28 | Population Bio, Inc. | Methods and compositions for diagnosing, prognosing, and treating endometriosis |
| WO2015094992A1 (en) | 2013-12-17 | 2015-06-25 | Merck Sharp & Dohme Corp. | Ifn-gamma gene signature biomarkers of tumor response to pd-1 antagonists |
| US10724096B2 (en) | 2014-09-05 | 2020-07-28 | Population Bio, Inc. | Methods and compositions for inhibiting and treating neurological conditions |
| EP3230498B1 (en) | 2014-12-09 | 2023-01-18 | Merck Sharp & Dohme LLC | System and methods for deriving gene signature biomarkers of response to pd-1 antagonists |
| PL3650458T3 (pl) | 2015-02-24 | 2023-11-06 | City Of Hope | Platformy do analiz przesiewowych bibliotek kodowanych chemicznie i adresowanych przestrzennie |
| WO2016168133A1 (en) | 2015-04-17 | 2016-10-20 | Merck Sharp & Dohme Corp. | Blood-based biomarkers of tumor sensitivity to pd-1 antagonists |
| CA2992987A1 (en) | 2015-07-23 | 2017-01-26 | Merck Sharp & Dohme Corp. | Genetic markers associated with response to crth2 receptor antagonists |
| EP3124619B1 (en) | 2015-07-31 | 2019-03-06 | Menicon Co., Ltd | Reagents, method and kit for across and within dog breed glaucoma diagnosis |
| US11725232B2 (en) | 2016-10-31 | 2023-08-15 | The Hong Kong University Of Science And Technology | Compositions, methods and kits for detection of genetic variants for alzheimer's disease |
| AU2017375590A1 (en) | 2016-12-14 | 2019-06-13 | Beijing Genomics Institute At Shenzhen | Human genetic markers associated with response to treatments that target Clostridium difficile toxin B |
| US10240205B2 (en) | 2017-02-03 | 2019-03-26 | Population Bio, Inc. | Methods for assessing risk of developing a viral disease using a genetic test |
| EP4063859A1 (en) | 2017-04-28 | 2022-09-28 | Merck Sharp & Dohme Corp. | Biomarkers for cancer therapeutics |
| WO2019051253A1 (en) * | 2017-09-08 | 2019-03-14 | Sigma-Aldrich Co. Llc | DNA MODIFIED POLYMERASES |
| AU2019231794A1 (en) * | 2018-03-08 | 2020-10-29 | Pathogendx, Inc. | Microarray based multiplex pathogen analysis and uses thereof |
| WO2019236053A1 (en) * | 2018-06-04 | 2019-12-12 | Hewlett-Packard Development Company, L.P. | Ejection subassembly pitches to match nanowell spacing |
| CA3108807A1 (en) | 2018-08-08 | 2020-02-13 | Pml Screening, Llc | Methods for assessing the risk of developing progressive multifocal leukoencephalopathy caused by john cunningham virus by genetic testing |
| FI3846824T3 (fi) | 2018-09-07 | 2025-09-25 | Massachusetts Gen Hospital | Koostumuksia ja menetelmiä immuunitarkistuspisteen estämiseen |
| CN115461471B (zh) * | 2020-04-30 | 2025-08-15 | 南京金斯瑞生物科技有限公司 | 一种芯片表面连接体及其制备方法和应用 |
| JPWO2022050418A1 (enExample) * | 2020-09-07 | 2022-03-10 | ||
| EP4460583A1 (en) | 2022-01-03 | 2024-11-13 | Checkmate Pharmaceuticals, Inc. | Transcriptional biomarkers for response to innate immune activators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4797355A (en) * | 1985-06-13 | 1989-01-10 | Amgen Inc. | Methods for attaching polynucleotides to supports |
| ES2099699T3 (es) * | 1989-05-02 | 1997-06-01 | Abbott Lab | Fijacion covalente de los miembros de union especificos a las fases solidas. |
| EP0455905B1 (en) * | 1990-05-11 | 1998-06-17 | Microprobe Corporation | Dipsticks for nucleic acid hybridization assays and methods for covalently immobilizing oligonucleotides |
| US5993935A (en) * | 1991-10-11 | 1999-11-30 | 3M Innovative Properties Company | Covalently reactive particles incorporated in a continous porous matrix |
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- 1997-11-06 AU AU52472/98A patent/AU746737B2/en not_active Ceased
- 1997-11-06 JP JP52176498A patent/JP4963139B2/ja not_active Expired - Fee Related
- 1997-11-06 AT AT97947374T patent/ATE204290T1/de not_active IP Right Cessation
- 1997-11-06 WO PCT/US1997/020194 patent/WO1998020019A1/en not_active Ceased
- 1997-11-06 CA CA002267070A patent/CA2267070A1/en not_active Abandoned
- 1997-11-06 DE DE69706187T patent/DE69706187T2/de not_active Revoked
- 1997-11-06 EP EP97947374A patent/EP0937097B1/en not_active Revoked
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1999
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Also Published As
| Publication number | Publication date |
|---|---|
| DE69706187D1 (de) | 2001-09-20 |
| CA2267070A1 (en) | 1998-05-14 |
| EP0937097B1 (en) | 2001-08-16 |
| AU746737B2 (en) | 2002-05-02 |
| ATE204290T1 (de) | 2001-09-15 |
| WO1998020019A1 (en) | 1998-05-14 |
| HK1020197A1 (en) | 2000-03-31 |
| JP2001501967A (ja) | 2001-02-13 |
| NO992167L (no) | 1999-07-05 |
| AU5247298A (en) | 1998-05-29 |
| JP4963139B2 (ja) | 2012-06-27 |
| NO992167D0 (no) | 1999-05-04 |
| EP0937097A1 (en) | 1999-08-25 |
| DE69706187T2 (de) | 2002-04-11 |
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