JP4963139B2 - 固体支持体に核酸を固定化するための組成物および方法 - Google Patents

固体支持体に核酸を固定化するための組成物および方法 Download PDF

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JP4963139B2
JP4963139B2 JP52176498A JP52176498A JP4963139B2 JP 4963139 B2 JP4963139 B2 JP 4963139B2 JP 52176498 A JP52176498 A JP 52176498A JP 52176498 A JP52176498 A JP 52176498A JP 4963139 B2 JP4963139 B2 JP 4963139B2
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bead
nucleic acid
solid support
pairing
beads
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JP2001501967A5 (enExample
JP2001501967A (ja
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ラフ,デイビツド・エム
ケスター,フーベルト
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シークエノム・インコーポレーテツド
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Priority claimed from US08/746,036 external-priority patent/US5900481A/en
Priority claimed from US08/787,639 external-priority patent/US6024925A/en
Priority claimed from US08/786,988 external-priority patent/US7285422B1/en
Priority claimed from US08/933,792 external-priority patent/US6133436A/en
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US08/746,036 US5900481A (en) 1996-11-06 1996-11-06 Bead linkers for immobilizing nucleic acids to solid supports
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US08/787,639 1997-01-23
US08/787,639 US6024925A (en) 1997-01-23 1997-01-23 Systems and methods for preparing low volume analyte array elements
US08/786,988 US7285422B1 (en) 1997-01-23 1997-01-23 Systems and methods for preparing and analyzing low volume analyte array elements
US08/933,792 US6133436A (en) 1996-11-06 1997-09-19 Beads bound to a solid support and to nucleic acids
US08/933,792 1997-09-19
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Families Citing this family (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795714A (en) 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
US6436635B1 (en) 1992-11-06 2002-08-20 Boston University Solid phase sequencing of double-stranded nucleic acids
DE69433811T2 (de) 1993-01-07 2005-06-23 Sequenom, Inc., San Diego Dns - sequenzierung durch massenspektronomie
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US6146854A (en) * 1995-08-31 2000-11-14 Sequenom, Inc. Filtration processes, kits and devices for isolating plasmids
US6022688A (en) 1996-05-13 2000-02-08 Sequenom, Inc. Method for dissociating biotin complexes
US5777324A (en) 1996-09-19 1998-07-07 Sequenom, Inc. Method and apparatus for maldi analysis
CA2270132A1 (en) 1996-11-06 1998-05-14 Sequenom, Inc. Dna diagnostics based on mass spectrometry
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US6635452B1 (en) 1996-12-10 2003-10-21 Sequenom Inc. Releasable nonvolatile mass label molecules
US6207370B1 (en) 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
US6287772B1 (en) 1998-04-29 2001-09-11 Boston Probes, Inc. Methods, kits and compositions for detecting and quantitating target sequences
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6780981B1 (en) 1998-05-15 2004-08-24 Oxford Gene Technology Ip Limited Libraries of oligomers labeled with different tags
WO1999067641A2 (en) * 1998-06-24 1999-12-29 Illumina, Inc. Decoding of array sensors with microspheres
EP1105529B2 (en) * 1998-07-30 2013-05-29 Illumina Cambridge Limited Arrayed biomolecules and their use in sequencing
GB0002310D0 (en) * 2000-02-01 2000-03-22 Solexa Ltd Polynucleotide sequencing
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
DE19854946C2 (de) * 1998-11-27 2002-01-03 Guenter Von Kiedrowski Klonieren und Kopieren an Oberflächen
JP2000157272A (ja) * 1998-12-01 2000-06-13 Hitachi Software Eng Co Ltd バイオチップ及びその製造方法
US6441152B1 (en) 1998-12-08 2002-08-27 Boston Probes, Inc. Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices
US6429027B1 (en) * 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US6514768B1 (en) 1999-01-29 2003-02-04 Surmodics, Inc. Replicable probe array
EP1434055B1 (en) 1999-02-16 2006-09-27 Applera Corporation Bead dispensing system
US6225061B1 (en) 1999-03-10 2001-05-01 Sequenom, Inc. Systems and methods for performing reactions in an unsealed environment
US20020009394A1 (en) 1999-04-02 2002-01-24 Hubert Koster Automated process line
US7501245B2 (en) 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US6274320B1 (en) * 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
ATE444532T1 (de) 1999-10-13 2009-10-15 Sequenom Inc Verfahren zur identifizierung von polymorphen genetischen markern
US7917301B1 (en) 2000-09-19 2011-03-29 Sequenom, Inc. Method and device for identifying a biological sample
US20030190644A1 (en) 1999-10-13 2003-10-09 Andreas Braun Methods for generating databases and databases for identifying polymorphic genetic markers
AU2622101A (en) * 1999-11-02 2001-05-14 Celine Hu Molecular microarrays and methods for production and use thereof
GB0002389D0 (en) 2000-02-02 2000-03-22 Solexa Ltd Molecular arrays
AU3986501A (en) 2000-02-23 2001-09-03 Zyomyx Inc Chips having elevated sample surfaces
US6958214B2 (en) 2000-07-10 2005-10-25 Sequenom, Inc. Polymorphic kinase anchor proteins and nucleic acids encoding the same
JP3453604B2 (ja) 2000-07-27 2003-10-06 北陸先端科学技術大学院大学長 新規なバイオチップ及びその作製方法
WO2002055199A2 (en) * 2000-10-30 2002-07-18 Sequenom Inc Method and apparatus for delivery of submicroliter volumes onto a substrate
US7026163B1 (en) 2001-02-23 2006-04-11 Mayo Foundation For Medical Education And Research Sulfotransferase sequence variants
ES2593683T3 (es) * 2001-03-09 2016-12-12 Trovagene, Inc. Sondas conjugadas y detección óptica de analitos
CA2440754A1 (en) 2001-03-12 2002-09-19 Stephen Quake Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension
US20020155587A1 (en) 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
US7056731B1 (en) 2001-06-22 2006-06-06 Mayo Foundation For Medical Education And Research Sulfotransferase SULT2A1 sequence variants
CA2652991A1 (en) 2001-07-16 2003-11-13 Caprotec Bioanalytics Gmbh Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US7517496B2 (en) 2001-07-17 2009-04-14 Bio-Rad Laboratories, Inc. Latex based adsorbent chip
EP1483794A4 (en) * 2001-07-17 2006-05-03 Ciphergen Biosystems Inc ADSORBENT CHIP BASED ON LATEX
US20030113233A1 (en) 2001-10-26 2003-06-19 Elizabeth Nanthakumar Resin dispensing device
US20030087425A1 (en) * 2001-11-07 2003-05-08 Eggers Mitchell D Sample carrier
US7584240B2 (en) * 2001-11-07 2009-09-01 Genvault Corporation Automated biological sample archive for storage, retrieval and analysis of large numbers of samples for remote clients
US7186551B1 (en) 2001-11-14 2007-03-06 Mayo Foundation For Medical Education And Research 3′-phosphoadenosine -5′-phosphosulfate synthetase 2 (PAPSS2) sequence variants
US7067311B1 (en) 2001-11-14 2006-06-27 Mayo Foundation For Medical Education And Research 3′-phosphoadenosine-5′-phosphosulfate synthetase 1 (PAPSS1) sequence variants
SI1458888T1 (sl) 2001-12-10 2011-07-29 Novartis Ag Metode zdravljenja psihoze in shizofrenije na osnovi polimorfizmov gena cntf
US7288641B1 (en) 2002-01-30 2007-10-30 Mayo Foundation For Medical Education And Research Sulfotransferase 1E1 sequence variants
US7432342B2 (en) 2002-05-03 2008-10-07 Sequenom, Inc. Kinase anchor protein muteins, peptides thereof and related documents
JP3685774B2 (ja) * 2002-05-30 2005-08-24 日立ソフトウエアエンジニアリング株式会社 スポットピン
US7011971B2 (en) * 2002-06-03 2006-03-14 Eastman Kodak Company Method of making random array of microspheres using enzyme digestion
DE10235302A1 (de) * 2002-08-01 2004-02-12 Henkel Kgaa Verfahren zur Herstellung perl- bzw. kugelförmiger magnetischer Partikel auf Acrylsäuresbasis zur Aufreinigung biologischer Substanzen
US8277753B2 (en) 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
US7371523B1 (en) 2003-01-09 2008-05-13 Mayo Foundation For Medical Education And Research Phenylethanolamine-N-methyltransferase sequence variants
WO2004064972A2 (en) 2003-01-16 2004-08-05 Hk Pharmaceuticals, Inc. Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US7425624B1 (en) 2003-01-21 2008-09-16 Mayo Foundation For Medical Education And Research Sulfotransferase 1A3 sequence variants
CA2513535C (en) 2003-01-29 2012-06-12 454 Corporation Bead emulsion nucleic acid amplification
US7575865B2 (en) 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
WO2004072268A2 (en) 2003-02-12 2004-08-26 Mayo Foundation For Medical Education And Research Pkhdl1, a homolog of the autosomal recessive kidney disease gene
US8688385B2 (en) 2003-02-20 2014-04-01 Mayo Foundation For Medical Education And Research Methods for selecting initial doses of psychotropic medications based on a CYP2D6 genotype
JP5348840B2 (ja) 2003-02-20 2013-11-20 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ 薬物を選択する方法
US7250290B1 (en) 2003-04-15 2007-07-31 Mayo Foundation For Medical Education And Research Arsenic methyltransferase sequence variants
WO2005012578A1 (en) 2003-07-31 2005-02-10 Sequenom, Inc. Methods for high level multiplexed polymerase chain reactions and homogeneous mass extension reactions for genotyping of polymorphisms
US9394565B2 (en) 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis
JP4286094B2 (ja) * 2003-09-24 2009-06-24 オリンパス株式会社 生体関連物質の反応装置
JP2005114576A (ja) * 2003-10-08 2005-04-28 Hitachi Software Eng Co Ltd 両親媒性分子固定化ビーズ、その製造方法、及びキャピラリビーズアレイのビーズ配列方法
GB0326073D0 (en) 2003-11-07 2003-12-10 Solexa Ltd Improvements in or relating to polynucleotide arrays
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
TW200533919A (en) * 2003-12-08 2005-10-16 Oxford Gene Tech Ip Ltd Derivatived molecules for mass spectrometry
EP1506959A3 (en) * 2004-09-22 2005-07-27 Oxford Gene Technology Ip Limited Derivatised molecules for mass spectrometry
DE602005020421D1 (de) 2004-02-19 2010-05-20 Helicos Biosciences Corp Verfahren zur analyse von polynukleotidsequenzen
US7608394B2 (en) 2004-03-26 2009-10-27 Sequenom, Inc. Methods and compositions for phenotype identification based on nucleic acid methylation
AU2005230936B2 (en) 2004-03-26 2010-08-05 Agena Bioscience, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
JP2008509226A (ja) 2004-05-24 2008-03-27 ジェンボールト コーポレイション 回収可能な形式での安定なタンパク質保管および安定な核酸保管
DE602005027700D1 (de) 2004-05-25 2011-06-09 Helicos Biosciences Corp Verfahren zur nukleinsäureimmobilisierung
US7476734B2 (en) 2005-12-06 2009-01-13 Helicos Biosciences Corporation Nucleotide analogs
JP2006028060A (ja) * 2004-07-14 2006-02-02 Canon Inc Dna担持体、この製造方法及びこれを用いた捕集システム
JP3927580B2 (ja) * 2004-12-09 2007-06-13 住友ベークライト株式会社 Dna鎖伸長方法、dna鎖増幅方法およびdna鎖伸長用マイクロアレイ
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
US7482120B2 (en) 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
US7858306B2 (en) 2005-07-07 2010-12-28 Mayo Foundation For Medical Education And Research HSD3B1 sequence variants
US7390894B2 (en) 2005-07-07 2008-06-24 Mayo Foundation For Medical Education And Research Glutathione S-transferase sequence variants
US7485711B2 (en) 2005-08-12 2009-02-03 Mayo Foundation For Medical Education And Research CYP19A1 polymorphisms
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
US7397546B2 (en) 2006-03-08 2008-07-08 Helicos Biosciences Corporation Systems and methods for reducing detected intensity non-uniformity in a laser beam
US10522240B2 (en) 2006-05-03 2019-12-31 Population Bio, Inc. Evaluating genetic disorders
US7702468B2 (en) 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
WO2007140417A2 (en) 2006-05-31 2007-12-06 Sequenom, Inc. Methods and compositions for the extraction and amplification of nucleic acid from a sample
US8293481B2 (en) 2006-11-10 2012-10-23 Mayo Foundation For Medical Education And Research Biomarkers for chronic vascular dysfunction
WO2009039122A2 (en) 2007-09-17 2009-03-26 Sequenom, Inc. Integrated robotic sample transfer device
CN102177237B (zh) 2008-09-12 2013-10-30 金沃特公司 用于贮存和稳定生物分子的基质和介质
US20100089287A1 (en) 2008-09-25 2010-04-15 Thames Shelby F Soy protein adhesive and uses thereof
WO2010067372A1 (en) 2008-12-11 2010-06-17 Ramot At Tel-Aviv University Ltd. Genetic markers of schizophrenia
JP5457222B2 (ja) 2009-02-25 2014-04-02 エフ.ホフマン−ラ ロシュ アーゲー 小型化ハイスループット核酸分析
EP3211095B1 (en) 2009-04-03 2019-01-02 Sequenom, Inc. Nucleic acid preparation compositions and methods
EP2503337B1 (en) 2009-11-17 2016-08-24 Asahi Kasei Kabushiki Kaisha Organic colored microparticles and diagnostic reagent kit containing the same
WO2011100503A1 (en) 2010-02-11 2011-08-18 Dana Farber Cancer Institute, Inc. Methods for predicting likelihood of responding to treatment
US8563705B2 (en) 2010-05-12 2013-10-22 Mayo Foundation For Medical Education And Research Ribonucleic acid binding motif protein 20 sequence variants
EP2601609B1 (en) 2010-08-02 2017-05-17 Population Bio, Inc. Compositions and methods for discovery of causative mutations in genetic disorders
CN102321622B (zh) * 2011-08-04 2016-03-30 盛司潼 一种引物-固相载体复合物及其制备和用于测序的方法
WO2013045505A1 (en) 2011-09-28 2013-04-04 Novartis Ag Biomarkers for raas combination therapy
EP2766483B1 (en) 2011-10-10 2022-03-23 The Hospital For Sick Children Methods and compositions for screening and treating developmental disorders
EP2773779B1 (en) 2011-11-04 2020-10-14 Population Bio, Inc. Methods and compositions for diagnosing, prognosing, and treating neurological conditions
WO2013120018A1 (en) 2012-02-09 2013-08-15 Population Diagnostics, Inc. Methods and compositions for screening and treating developmental disorders
DK2895621T3 (da) 2012-09-14 2020-11-30 Population Bio Inc Fremgangsmåder og sammensætning til diagnosticering, prognose og behandling af neurologiske tilstande
EP2900835B1 (en) 2012-09-27 2025-04-30 Population Bio, Inc. Method for screening and treating developmental disorders
WO2014134144A1 (en) 2013-02-28 2014-09-04 The General Hospital Corporation Mirna profiling compositions and methods of use
EP3511422B1 (en) 2013-11-12 2022-12-28 Population Bio, Inc. Methods and compositions for diagnosing, prognosing, and treating endometriosis
WO2015094992A1 (en) 2013-12-17 2015-06-25 Merck Sharp & Dohme Corp. Ifn-gamma gene signature biomarkers of tumor response to pd-1 antagonists
US10724096B2 (en) 2014-09-05 2020-07-28 Population Bio, Inc. Methods and compositions for inhibiting and treating neurological conditions
EP3230498B1 (en) 2014-12-09 2023-01-18 Merck Sharp & Dohme LLC System and methods for deriving gene signature biomarkers of response to pd-1 antagonists
PL3650458T3 (pl) 2015-02-24 2023-11-06 City Of Hope Platformy do analiz przesiewowych bibliotek kodowanych chemicznie i adresowanych przestrzennie
WO2016168133A1 (en) 2015-04-17 2016-10-20 Merck Sharp & Dohme Corp. Blood-based biomarkers of tumor sensitivity to pd-1 antagonists
CA2992987A1 (en) 2015-07-23 2017-01-26 Merck Sharp & Dohme Corp. Genetic markers associated with response to crth2 receptor antagonists
EP3124619B1 (en) 2015-07-31 2019-03-06 Menicon Co., Ltd Reagents, method and kit for across and within dog breed glaucoma diagnosis
US11725232B2 (en) 2016-10-31 2023-08-15 The Hong Kong University Of Science And Technology Compositions, methods and kits for detection of genetic variants for alzheimer's disease
AU2017375590A1 (en) 2016-12-14 2019-06-13 Beijing Genomics Institute At Shenzhen Human genetic markers associated with response to treatments that target Clostridium difficile toxin B
US10240205B2 (en) 2017-02-03 2019-03-26 Population Bio, Inc. Methods for assessing risk of developing a viral disease using a genetic test
EP4063859A1 (en) 2017-04-28 2022-09-28 Merck Sharp & Dohme Corp. Biomarkers for cancer therapeutics
WO2019051253A1 (en) * 2017-09-08 2019-03-14 Sigma-Aldrich Co. Llc DNA MODIFIED POLYMERASES
AU2019231794A1 (en) * 2018-03-08 2020-10-29 Pathogendx, Inc. Microarray based multiplex pathogen analysis and uses thereof
WO2019236053A1 (en) * 2018-06-04 2019-12-12 Hewlett-Packard Development Company, L.P. Ejection subassembly pitches to match nanowell spacing
CA3108807A1 (en) 2018-08-08 2020-02-13 Pml Screening, Llc Methods for assessing the risk of developing progressive multifocal leukoencephalopathy caused by john cunningham virus by genetic testing
FI3846824T3 (fi) 2018-09-07 2025-09-25 Massachusetts Gen Hospital Koostumuksia ja menetelmiä immuunitarkistuspisteen estämiseen
CN115461471B (zh) * 2020-04-30 2025-08-15 南京金斯瑞生物科技有限公司 一种芯片表面连接体及其制备方法和应用
JPWO2022050418A1 (enExample) * 2020-09-07 2022-03-10
EP4460583A1 (en) 2022-01-03 2024-11-13 Checkmate Pharmaceuticals, Inc. Transcriptional biomarkers for response to innate immune activators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797355A (en) * 1985-06-13 1989-01-10 Amgen Inc. Methods for attaching polynucleotides to supports
ES2099699T3 (es) * 1989-05-02 1997-06-01 Abbott Lab Fijacion covalente de los miembros de union especificos a las fases solidas.
EP0455905B1 (en) * 1990-05-11 1998-06-17 Microprobe Corporation Dipsticks for nucleic acid hybridization assays and methods for covalently immobilizing oligonucleotides
US5993935A (en) * 1991-10-11 1999-11-30 3M Innovative Properties Company Covalently reactive particles incorporated in a continous porous matrix

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ATE204290T1 (de) 2001-09-15
DE19782097T1 (de) 1999-10-14
WO1998020019A1 (en) 1998-05-14
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