DE19717904A1 - Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie - Google Patents

Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie

Info

Publication number
DE19717904A1
DE19717904A1 DE19717904A DE19717904A DE19717904A1 DE 19717904 A1 DE19717904 A1 DE 19717904A1 DE 19717904 A DE19717904 A DE 19717904A DE 19717904 A DE19717904 A DE 19717904A DE 19717904 A1 DE19717904 A1 DE 19717904A1
Authority
DE
Germany
Prior art keywords
dye
general formula
chain
acid
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19717904A
Other languages
German (de)
English (en)
Inventor
Kai Dr Licha
Bjoern Riefke
Wolfhard Dr Dr Semmler
Wolfgang Dr Wrasidlo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Institut fuer Diagnostikforschung GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut fuer Diagnostikforschung GmbH filed Critical Institut fuer Diagnostikforschung GmbH
Priority to DE19717904A priority Critical patent/DE19717904A1/de
Priority to KR1019997009757A priority patent/KR100613306B1/ko
Priority to HU0003132A priority patent/HU226812B1/hu
Priority to PT98929212T priority patent/PT988060E/pt
Priority to DE59814030T priority patent/DE59814030D1/de
Priority to CA002287262A priority patent/CA2287262C/en
Priority to PCT/DE1998/001001 priority patent/WO1998047538A2/de
Priority to CN98804489A priority patent/CN1253507A/zh
Priority to JP54471598A priority patent/JP5118790B2/ja
Priority to AT98929212T priority patent/ATE364404T1/de
Priority to ES98929212T priority patent/ES2289786T3/es
Priority to US09/403,418 priority patent/US6534041B1/en
Priority to DK98929212T priority patent/DK0988060T3/da
Priority to AU79057/98A priority patent/AU733757B2/en
Priority to EP98929212A priority patent/EP0988060B1/de
Publication of DE19717904A1 publication Critical patent/DE19717904A1/de
Priority to NO19995181A priority patent/NO327495B1/no
Priority to CY20071101174T priority patent/CY1106860T1/el
Priority to JP2010014564A priority patent/JP2010116413A/ja
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0058—Antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/583—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with non-fluorescent dye label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19717904A 1997-04-23 1997-04-23 Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie Ceased DE19717904A1 (de)

Priority Applications (18)

Application Number Priority Date Filing Date Title
DE19717904A DE19717904A1 (de) 1997-04-23 1997-04-23 Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
AT98929212T ATE364404T1 (de) 1997-04-23 1998-04-02 Säurelabile und enzymatisch spaltbare farbstoffkonstrukte zur diagnostik mit nahinfrarotlicht und zur therapie
ES98929212T ES2289786T3 (es) 1997-04-23 1998-04-02 Construcciones artificiales de colorantes inestables frente a los acidos y disociables enzimaticamente para el diagnostico con luz del infrarrojo proximo y para la terapia.
PT98929212T PT988060E (pt) 1997-04-23 1998-04-02 ''compostos corantes lábeis na presença de ácidos e dissociáveis enzimaticamente para o diagnóstico com luz de infravermelhos próximos e para o uso em terapia''
DE59814030T DE59814030D1 (de) 1997-04-23 1998-04-02 Säurelabile und enzymatisch spaltbare farbstoffkonstrukte zur diagnostik mit nahinfrarotlicht und zur therapie
CA002287262A CA2287262C (en) 1997-04-23 1998-04-02 Acid-labile and enzymatically divisible dye compounds for diagnosis with near infrared light and for therapy
PCT/DE1998/001001 WO1998047538A2 (de) 1997-04-23 1998-04-02 Säurelabile und enzymatisch spaltbare farbstoffkonstrukte zur diagnostik mit nahinfrarotlicht und zur therapie
CN98804489A CN1253507A (zh) 1997-04-23 1998-04-02 用于用近红外光诊断和用于治疗的酸不稳定的及可酶裂解的染料结构
JP54471598A JP5118790B2 (ja) 1997-04-23 1998-04-02 近赤外線を用いた診断法および治療のための酸不安定性で酵素的に分割可能な染料構造体
KR1019997009757A KR100613306B1 (ko) 1997-04-23 1998-04-02 근적외선에 의한 진단 및 치료를 위한 산 불안정성 및 효소 분해성 염료 화합물
HU0003132A HU226812B1 (en) 1997-04-23 1998-04-02 Enzymatically divisible dye compounds for diagnosis with near infrared light
US09/403,418 US6534041B1 (en) 1997-04-23 1998-04-02 Acid-labile and enzymatically divisible dye compounds for diagnosis with near infrared light and for therapy
DK98929212T DK0988060T3 (da) 1997-04-23 1998-04-02 Syrelabile og enzymatisk spaltelige farvestofforbindelser til diagnose med nærinfrarödt lys og til terapi
AU79057/98A AU733757B2 (en) 1997-04-23 1998-04-02 Acid-labile and enzymatically cleavable dye constructs for diagnosis with near-infrared light and for treatment
EP98929212A EP0988060B1 (de) 1997-04-23 1998-04-02 Säurelabile und enzymatisch spaltbare farbstoffkonstrukte zur diagnostik mit nahinfrarotlicht und zur therapie
NO19995181A NO327495B1 (no) 1997-04-23 1999-10-22 Syrelabile og enzymatisk spaltbare fargestofforbindelser for diagnostikk med naerinfrarodt lys og for terapi, og optisk, diagnostisk middel.
CY20071101174T CY1106860T1 (el) 1997-04-23 2007-09-12 Δομες χρωστικων ευαισθητες σε οξεα και διασπωμενες ενζυμικα για τη διαγνωστικη με ακτινοβολια εγγυς υπερυθρου και για τη θεραπεια
JP2010014564A JP2010116413A (ja) 1997-04-23 2010-01-26 近赤外線を用いた診断法および治療のための酸不安定性で酵素的に分割可能な染料構造体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19717904A DE19717904A1 (de) 1997-04-23 1997-04-23 Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie

Publications (1)

Publication Number Publication Date
DE19717904A1 true DE19717904A1 (de) 1998-10-29

Family

ID=7827982

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19717904A Ceased DE19717904A1 (de) 1997-04-23 1997-04-23 Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
DE59814030T Expired - Lifetime DE59814030D1 (de) 1997-04-23 1998-04-02 Säurelabile und enzymatisch spaltbare farbstoffkonstrukte zur diagnostik mit nahinfrarotlicht und zur therapie

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59814030T Expired - Lifetime DE59814030D1 (de) 1997-04-23 1998-04-02 Säurelabile und enzymatisch spaltbare farbstoffkonstrukte zur diagnostik mit nahinfrarotlicht und zur therapie

Country Status (16)

Country Link
US (1) US6534041B1 (https=)
EP (1) EP0988060B1 (https=)
JP (2) JP5118790B2 (https=)
KR (1) KR100613306B1 (https=)
CN (1) CN1253507A (https=)
AT (1) ATE364404T1 (https=)
AU (1) AU733757B2 (https=)
CA (1) CA2287262C (https=)
CY (1) CY1106860T1 (https=)
DE (2) DE19717904A1 (https=)
DK (1) DK0988060T3 (https=)
ES (1) ES2289786T3 (https=)
HU (1) HU226812B1 (https=)
NO (1) NO327495B1 (https=)
PT (1) PT988060E (https=)
WO (1) WO1998047538A2 (https=)

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19917713A1 (de) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik
DE10046215A1 (de) * 2000-09-19 2002-04-04 Inst Chemo Biosensorik Fluorochrome und deren Verwendung
WO2001089584A3 (en) * 2000-05-23 2002-05-02 Amersham Health As Contrast agents
WO2007002332A3 (en) * 2005-06-21 2007-04-26 Mallinckrodt Inc Optical imaging contrast agents
US7745640B2 (en) 2005-12-05 2010-06-29 Dyomics Gmbh Hydrophilic labels for biomolecules
US7951959B2 (en) 2008-09-17 2011-05-31 Thermo Fisher Scientific (Milwaukee) LLC Hydrophilic labels for biomolecules
WO2013009475A1 (en) * 2011-07-11 2013-01-17 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Photosensitizing antibody-phuorophore conjugates
US8524239B2 (en) 2010-07-09 2013-09-03 The United States of America as represented by the Secrectary, Department of Health and Human Services Photosensitizing antibody-fluorophore conjugates
US8889884B1 (en) 2011-07-14 2014-11-18 Pierce Biotechnology, Inc. Phosphine derivatives of fluorescent compounds
US9249307B2 (en) 2011-08-16 2016-02-02 Pierce Biotechnology, Inc. Benzocyanine compounds
US9676787B2 (en) 2012-08-28 2017-06-13 Pierce Biotechnology, Inc. Benzopyrylium compounds
US9751868B2 (en) 2012-02-28 2017-09-05 Pierce Biotechnology, Inc. Benzocyanine compounds
WO2017214165A1 (en) * 2016-06-06 2017-12-14 Sony Corporation Ionic polymers comprising fluorescent or colored reporter groups
US10000467B2 (en) 2012-03-02 2018-06-19 Pierce Biotechnology, Inc. Cyanine compounds
US10036754B2 (en) 2014-01-16 2018-07-31 Sony Corporation Water soluble fluorescent or colored dyes and methods for their use
US10351551B2 (en) 2010-12-21 2019-07-16 Pierce Biotechnology, Inc. Fluorescent compounds
US10435563B2 (en) 2013-08-22 2019-10-08 Sony Corporation Water soluble fluorescent or colored dyes and methods for their use
US10830678B2 (en) 2014-08-08 2020-11-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Photo-controlled removal of targets in vitro and in vivo
US10865310B2 (en) 2015-05-11 2020-12-15 Sony Corporation Of America Ultra bright dimeric or polymeric dyes
US10866244B2 (en) 2016-04-06 2020-12-15 Sony Corporation Of America Ultra bright dimeric or polymeric dyes with spacing linker groups
US11013803B2 (en) 2015-08-07 2021-05-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Near infrared photoimmunotherapy (NIR-PIT) of suppressor cells to treat cancer
US11084932B2 (en) 2015-02-26 2021-08-10 Sony Group Corporation Phenylethynylnaphthalene dyes and methods for their use
US11141483B2 (en) 2015-08-18 2021-10-12 Rakuten Medical, Inc. Methods for manufacturing phthalocyanine dye conjugates and stable conjugates
US11142647B2 (en) 2016-04-01 2021-10-12 Sony Group Corporation Ultra bright dimeric or polymeric dyes
US11147875B2 (en) 2015-08-18 2021-10-19 Rakuten Medical, Inc. Compositions, combinations and related methods for photoimmunotherapy
US11827661B2 (en) 2015-02-26 2023-11-28 Sony Group Corporation Water soluble fluorescent or colored dyes comprising conjugating groups

Families Citing this family (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
DE19717904A1 (de) * 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
US6592847B1 (en) 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
US6083486A (en) * 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
US7547721B1 (en) 1998-09-18 2009-06-16 Bayer Schering Pharma Ag Near infrared fluorescent contrast agent and fluorescence imaging
JP2000095758A (ja) * 1998-09-18 2000-04-04 Schering Ag 近赤外蛍光造影剤および蛍光造影方法
US7175953B2 (en) 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
US6114350A (en) * 1999-04-19 2000-09-05 Nen Life Science Products, Inc. Cyanine dyes and synthesis methods thereof
FR2793414B1 (fr) * 1999-05-10 2003-05-23 Centre Nat Rech Scient Conjugue acide nucleique-anticorps pour delivrer un acide nucleique etranger dans les cellules
US7597878B2 (en) * 2000-09-19 2009-10-06 Li-Cor, Inc. Optical fluorescent imaging
US6673334B1 (en) * 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
US20070092450A1 (en) * 2000-10-16 2007-04-26 Mallinckrodt Inc. Tissue-specific exogenous optical agents
US6716413B1 (en) * 2000-10-16 2004-04-06 Mallinckrodt, Inc. Indole compounds as tissue-specific exogenous optical agents
US20040180809A1 (en) * 2000-10-16 2004-09-16 Mallinckrodt Inc. Tissue-specific exogenous optical agents
US7383076B2 (en) 2000-11-27 2008-06-03 The General Hospital Corporation Fluorescence-mediated molecular tomography
US6984373B2 (en) 2000-12-23 2006-01-10 Dyax Corp. Fibrin binding moieties useful as imaging agents
US20030044353A1 (en) * 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
US20030031627A1 (en) * 2001-07-31 2003-02-13 Mallinckrodt Inc. Internal image antibodies for optical imaging and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US20050100963A1 (en) 2002-03-01 2005-05-12 Dyax Corporation KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
CA2666005C (en) 2002-03-01 2016-01-19 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
AU2003225763A1 (en) * 2002-03-11 2003-09-29 Visen Medical, Inc. Optical imaging probes
GB0208989D0 (en) 2002-04-19 2002-05-29 Amersham Biosciences Uk Ltd Methods for measuring enzyme activity
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
DE60323766D1 (de) * 2003-01-24 2008-11-06 Bayer Schering Pharma Ag En konjugate mit biomolekülen für fluoreszenzdiagnose
PT2949658T (pt) 2003-03-03 2018-10-18 Bracco Suisse Sa Péptidos que ligam especificamente o recetor de hgf (cmet) e utilizações dos mesmos
US20050106100A1 (en) * 2003-09-03 2005-05-19 Harris Thomas D. Compounds containing matrix metalloproteinase substrates and methods of their use
JP2005170812A (ja) * 2003-12-09 2005-06-30 Konica Minolta Medical & Graphic Inc 蛍光造影剤及び蛍光造影方法
US7018775B2 (en) * 2003-12-15 2006-03-28 Eastman Kodak Company Infrared absorbing N-alkylsulfate cyanine compounds
WO2007005491A1 (en) * 2005-06-30 2007-01-11 Bristol-Myers Squibb Pharma Company Hydrazide conjugates as imaging agents
US8227621B2 (en) * 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
EP1745739A3 (en) * 2005-07-14 2009-04-22 Bundesrepublik Deutschland, vertr. d.d. Bundes- ministerium f. Wirtschaft- und Technologie, dieses vertr. d.d. Präs. d. Phys.-Techn. Bundesanstalt Optical imaging of rheumatoid arthritis
JP5416970B2 (ja) 2005-09-02 2014-02-12 ビセン メディカル， インコーポレイテッド ニコチン酸及びピコリン酸誘導近赤外線蛍光団
CN101296927A (zh) 2005-09-02 2008-10-29 Visen医药公司 生物相容的含n,n-二取代磺酰胺的荧光染料标记
US7947256B2 (en) * 2005-09-02 2011-05-24 Visen Medical, Inc. Biocompatible fluorescent imaging agents
US20070148094A1 (en) * 2005-12-22 2007-06-28 Uzgiris Egidijus E Polymeric imaging agents and medical imaging methods
WO2007136413A2 (en) 2005-12-22 2007-11-29 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
US7741045B2 (en) * 2006-11-16 2010-06-22 General Electric Company Sequential analysis of biological samples
US9201063B2 (en) * 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
US7629125B2 (en) * 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
WO2008073458A2 (en) 2006-12-11 2008-06-19 Bracco Imaging S.P.A. Fibrin-binding peptides and conjugates thereof
US8221721B2 (en) * 2007-02-09 2012-07-17 Visen Medical, Inc. Polycyclo dyes and use thereof
WO2008109832A2 (en) * 2007-03-08 2008-09-12 Visen Medical, Inc. Viable near-infrared fluorochrome labeled cells and methods of making and using same
US7906106B2 (en) * 2007-06-27 2011-03-15 General Electric Company In vivo cell trafficking
US8021647B2 (en) * 2007-06-29 2011-09-20 General Electric Company In vivo optical imaging
ES2658852T3 (es) 2008-01-18 2018-03-12 Visen Medical, Inc. Agentes de imaginología fluorescentes
CA2758415C (en) 2008-04-14 2019-06-04 The General Hospital Corporation Plectin-1 targeted agents for detection and treatment of pancreatic ductal adenocarcinoma
EP2147684A1 (en) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Diagnostic Agents Selective Against Metalloproteases
US20110280806A1 (en) * 2008-11-20 2011-11-17 Robert James Domett Nairne Dye conjugate imaging agents
US8864821B2 (en) 2008-11-26 2014-10-21 Visen Medical, Inc. Methods and compositions for identifying subjects at risk of developing stent thrombosis
CN102459469A (zh) * 2009-04-17 2012-05-16 利康股份有限公司 用取代的花青染料进行荧光成像
EP2435096A1 (en) 2009-05-27 2012-04-04 Lumicell Diagnostics, Inc. Methods and systems for spatially identifying abnormal cells
US9155471B2 (en) 2009-05-27 2015-10-13 Lumicell, Inc'. Methods and systems for spatially identifying abnormal cells
CA2766861A1 (en) 2009-07-09 2011-01-13 F. Hoffmann-La Roche Ag In vivo tumor vasculature imaging
US20120230918A1 (en) 2009-07-28 2012-09-13 Hoffmann-La-Roche Inc. Non-invasive in vivo optical imaging method
WO2011025950A2 (en) 2009-08-28 2011-03-03 Visen Medical, Inc. Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique
WO2011038006A1 (en) 2009-09-22 2011-03-31 Visen Medical, Inc. Systems and methods for virtual index-matching of diffusive media
US9677125B2 (en) * 2009-10-21 2017-06-13 General Electric Company Detection of plurality of targets in biological samples
RU2012148816A (ru) 2010-05-07 2014-06-20 Ф. Хоффманн-Ля Рош Аг Метод диагностики для определения клеток ex vivo
WO2012003334A2 (en) * 2010-06-30 2012-01-05 Case Western Reserve University Molecular probes for imaging of myelin
US9012242B2 (en) 2010-09-20 2015-04-21 Caliper Life Sciences Multivalent fluorescent probes
EP2630196B1 (en) 2010-10-20 2017-09-06 Li-Cor, Inc. Cyanine dyes and their conjugates
EP2633080B1 (en) 2010-10-29 2018-12-05 President and Fellows of Harvard College Method of detecting targets using fluorescently labelled nucleic acid nanotube probes
WO2012061403A1 (en) * 2010-11-02 2012-05-10 Life Technologies Corporation Modified hydrocyanine dyes for the detection of reactive oxygen species
US9314304B2 (en) 2010-12-08 2016-04-19 Lumicell, Inc. Methods and system for image guided cell ablation with microscopic resolution
US20140099264A1 (en) 2011-03-07 2014-04-10 F. Hoffman-La Roche Ag Means and methods for in vivo testing of therapeutic antibodies
JP6385060B2 (ja) 2011-03-07 2018-09-05 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 治療的に活性な抗体のインビボにおける選択
EP2689024B1 (en) 2011-03-25 2016-01-13 Almac Sciences (Scotland) Limited Enzyme assays
AU2012253502C1 (en) 2011-05-09 2017-12-14 Visen Medical, Inc. Carbonic anhydrase targeting agents and methods of using same
US9610370B2 (en) * 2011-10-07 2017-04-04 University Of Virginia Patent Foundation Compositions and methods for tumor imaging and targeting by a class of organic heptamethine cyanine dyes that possess dual nuclear and near-infrared properties
US9375493B2 (en) 2012-03-30 2016-06-28 Visen Medical, Inc. Bacterial imaging agents and methods of using same
EP2831179B1 (en) * 2012-03-30 2016-04-20 Life Technologies Corporation Modified nucleic acid binding cyanine dyes for the detection of reactive oxygen species
JP6370785B2 (ja) 2012-08-15 2018-08-08 ビセン メディカル， インコーポレイテッド 前立腺がんイメージングのための前立腺特異的抗原薬剤およびその使用方法
CN104853669B (zh) 2012-10-15 2017-07-21 文森医学公司 具有荧光及生物发光源的交叉形态加权特征的漫射介质成像的系统、方法及设备
AU2013334635B2 (en) 2012-10-24 2018-12-06 Becton, Dickinson And Company Hydroxamate substituted azaindoline-cyanine dyes and bioconjugates of the same
NL2010040C2 (en) * 2012-12-21 2014-06-24 Internat Inst For Diagnostic And Analitical Affairs B V Cleavable coating material having microbial functionality.
WO2014165216A1 (en) * 2013-03-12 2014-10-09 The Trustees Of The University Of Pennsylvania Diagnosing and treating cancer
US10791937B2 (en) 2013-03-14 2020-10-06 Lumicell, Inc. Medical imaging device and methods of use
WO2014149069A1 (en) * 2013-03-15 2014-09-25 Purdue Research Foundation Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
JP6606487B2 (ja) 2013-03-15 2019-11-13 ビセン メディカル， インコーポレイテッド ｉｎｖｉｔｒｏおよびｉｎｖｉｖｏイメージングおよび検出のための置換シラキサンテニウム赤色〜近赤外蛍光色素
CN105339436B (zh) 2013-03-15 2018-05-25 文森医学公司 4,4-二取代环己基桥连七甲川花菁染料及其应用
AU2014296253A1 (en) 2013-07-30 2016-02-04 President And Fellows Of Harvard College Quantitative DNA-based imaging and super-resolution imaging
US10471163B2 (en) 2013-09-13 2019-11-12 The General Hospital Corporation Activatable fibrin-binding probes
JP6681334B2 (ja) 2013-12-31 2020-04-15 メモリアル スローン ケタリング キャンサー センター リアルタイムの蛍光源のマルチチャネル撮像のためのシステム、方法、および装置
EP4245859A3 (en) 2014-03-11 2023-11-08 President and Fellows of Harvard College High-throughput and highly multiplexed imaging with programmable nucleic acid probes
EP2944326B1 (en) * 2014-05-16 2018-11-21 Cyanagen Srl Tricarbocyanine-cyclodextrin-conjugates and their use for the diagnosis of kidney diseases
JP6751715B2 (ja) 2014-12-15 2020-09-09 メモリアル スローン ケタリング キャンサー センター 神経結合選択性が増強された環状ペプチド、当該環状ペプチドと結合したナノ粒子、およびリアルタイムｉｎ ｖｉｖｏ神経組織撮像ための当該環状ペプチドの使用
US10124111B2 (en) 2015-02-24 2018-11-13 The Board Of Trustees Of The Leland Stanford Junior University Small molecule dye for molecular imaging and photothermal therapy
US20180224461A1 (en) 2015-08-07 2018-08-09 President And Fellows Of Harvard College Super resolution imaging of protein-protein interactions
CN105199430B (zh) * 2015-11-05 2017-03-22 济宁博联生物科技有限公司 一种上皮组织染色剂及其制备方法
CN108495655A (zh) 2015-12-15 2018-09-04 纪念斯隆凯特琳癌症中心 用于组织区分例如用于术中可视化的成像系统和方法
US11434377B2 (en) 2016-04-01 2022-09-06 Sony Corporation Ultra bright dimeric or polymeric dyes with rigid spacing groups
US11370922B2 (en) 2016-05-10 2022-06-28 Sony Corporation Ultra bright polymeric dyes with peptide backbones
WO2017197014A2 (en) 2016-05-10 2017-11-16 Sony Corporation Compositions comprising a polymeric dye and a cyclodextrin and uses thereof
KR102526802B1 (ko) 2016-05-11 2023-05-02 소니그룹주식회사 초고명도 이량체성 또는 중합체성 염료
JP7312929B2 (ja) 2016-07-29 2023-07-24 ソニーグループ株式会社 超明色二量体またはポリマー色素およびその調製のための方法
EP3548096B1 (en) 2016-11-30 2024-11-20 Memorial Sloan Kettering Cancer Center Inhibitor-functionalized ultrasmall nanoparticles and methods thereof
JP2020504600A (ja) 2016-12-09 2020-02-13 アルティヴュー， インク． 標識化核酸イメージング剤を使用した多重イメージングのための改善された方法
EP3568689B1 (en) 2017-01-10 2025-09-03 Sun Chemical Corporation In-line coating weight and radiant energy exposure measurement
JP7551056B2 (ja) 2017-10-05 2024-09-17 ソニーグループ株式会社 プログラマブルなポリマー薬物
CN111093711A (zh) 2017-10-05 2020-05-01 索尼公司 可编程的树枝状药物
CN111836645A (zh) 2017-11-16 2020-10-27 索尼公司 可编程的聚合药物
US12194104B2 (en) 2018-01-12 2025-01-14 Sony Group Corporation Phosphoalkyl ribose polymers comprising biologically active compounds
EP3737419B1 (en) 2018-01-12 2024-04-10 Sony Group Corporation Phosphoalkyl polymers comprising biologically active compounds
CN111565756A (zh) 2018-01-12 2020-08-21 索尼公司 包含生物活性化合物的具有刚性间隔基团的聚合物
US11874280B2 (en) 2018-03-19 2024-01-16 Sony Group Corporation Use of divalent metals for enhancement of fluorescent signals
KR102864292B1 (ko) 2018-03-21 2025-09-26 소니그룹주식회사 링커 군을 갖는 중합체성 텐덤 염료
CN111970960A (zh) 2018-03-30 2020-11-20 珀金埃尔默健康科学有限公司 使用短波红外(swir)投影层析成像对解剖器官和内含物进行3d重建的系统和方法
US12006438B2 (en) 2018-06-27 2024-06-11 Sony Group Corporation Polymeric dyes with linker groups comprising deoxyribose
EP3820944A1 (en) 2018-07-13 2021-05-19 Sony Corporation Polymeric dyes having a backbone comprising organophosphate units
KR102132885B1 (ko) * 2018-09-03 2020-07-10 (주)씨바이오멕스 생체물질과 연결될 수 있는 양쪽성 형광물질
WO2021062176A2 (en) 2019-09-26 2021-04-01 Sony Corporation Polymeric tandem dyes with linker groups
EP4038081A1 (en) 2019-09-30 2022-08-10 Sony Group Corporation Nucleotide probes
KR102336507B1 (ko) * 2020-02-21 2021-12-06 한림대학교 산학협력단 국소뇌산소포화도를 이용한 지연성 뇌허혈 진단 방법
KR102369155B1 (ko) * 2020-07-07 2022-02-28 한림대학교 산학협력단 근적외선 분광분석법을 이용한 지연성 뇌허혈 진단 방법
CN112062797B (zh) * 2020-08-19 2021-09-21 华南理工大学 一种二聚体前药及其制备方法和应用
WO2022125564A1 (en) 2020-12-07 2022-06-16 Sony Group Corporation Spacing linker group design for brightness enhancement in dimeric or polymeric dyes
EP4015004A1 (en) 2020-12-18 2022-06-22 Phi Pharma SA Proteoglycan specific branched peptides
CN114748640B (zh) * 2022-05-06 2024-02-09 南方医科大学珠江医院 一种pH响应性的siRNA递送系统
EP4573360B1 (en) 2023-01-26 2026-01-14 Sun Chemical Corporation Fluorescent ink and imaging system for defect detection on printed photosensitive objects
WO2025107185A1 (zh) * 2023-11-22 2025-05-30 中国科学院深圳先进技术研究院 一种载体、靶向纳米颗粒及其制备方法和应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU583854B2 (en) 1984-09-13 1989-05-11 Cytogen Corporation Antibody therapeutic agent conjugates
US5569587A (en) * 1986-04-18 1996-10-29 Carnegie Mellon University Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes
US5066490A (en) * 1988-06-01 1991-11-19 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Protein crosslinking reagents cleavable within acidified intracellular vesicles
CA2048089A1 (en) * 1990-09-17 1992-03-18 Wolfgang A. Wrasidlo Chemical conjugation of morpholino anthracyclines to antibodies
JPH07145148A (ja) 1992-06-02 1995-06-06 Bio Sensor Kenkyusho:Kk ポリメチン系化合物およびそれを用いる測定方法
GB9310978D0 (en) * 1993-05-27 1993-07-14 Zeneca Ltd Compounds
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
KR100397020B1 (ko) * 1995-01-30 2004-04-29 다이이치 가가쿠 야쿠힝 가부시키가이샤 진단용마커
US5741657A (en) * 1995-03-20 1998-04-21 The Regents Of The University Of California Fluorogenic substrates for β-lactamase and methods of use
IT1276833B1 (it) * 1995-10-09 1997-11-03 Sorin Biomedica Cardio Spa Coloranti fluorescenti della famiglia della solfo benz e indocianina
DE19539409C2 (de) * 1995-10-11 1999-02-18 Diagnostikforschung Inst Kontrastmittel für die Nahinfrarot-Diagnostik
JP2000508709A (ja) * 1996-04-19 2000-07-11 アマーシャム・ファルマシア・バイオテック・ユーケイ・リミテッド スクアラート染料類および蛍光配列決定法におけるそれらの使用
DE19649971A1 (de) * 1996-11-19 1998-05-28 Diagnostikforschung Inst Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung)
DE19717904A1 (de) * 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
EP1636177A2 (en) 2003-02-28 2006-03-22 Shell Internationale Research Maatschappij B.V. Process for preparing organic hydroperoxides

Cited By (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19917713A1 (de) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik
WO2001089584A3 (en) * 2000-05-23 2002-05-02 Amersham Health As Contrast agents
DE10046215A1 (de) * 2000-09-19 2002-04-04 Inst Chemo Biosensorik Fluorochrome und deren Verwendung
DE10046215B4 (de) * 2000-09-19 2004-04-15 Institut für Chemo- und Biosensorik Münster e.V. i.Ins. Fluorochrome und deren Verwendung
WO2007002332A3 (en) * 2005-06-21 2007-04-26 Mallinckrodt Inc Optical imaging contrast agents
US7745640B2 (en) 2005-12-05 2010-06-29 Dyomics Gmbh Hydrophilic labels for biomolecules
US7951959B2 (en) 2008-09-17 2011-05-31 Thermo Fisher Scientific (Milwaukee) LLC Hydrophilic labels for biomolecules
US11364298B2 (en) 2010-07-09 2022-06-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Photosensitizing antibody-fluorophore conjugates
US11364297B2 (en) 2010-07-09 2022-06-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Photosensitizing antibody-fluorophore conjugates
US10537641B2 (en) 2010-07-09 2020-01-21 The Usa As Represented By The Secretary, Department Of Health And Human Services Photosensitizing antibody-fluorophore conjugates
US10538590B2 (en) 2010-07-09 2020-01-21 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Photosensitizing antibody-fluorophore conjugates
US9358306B2 (en) 2010-07-09 2016-06-07 The United States of America, as rep. by the Secretary, Dept. of Health and Human Services Photosensitizing antibody-fluorophore conjugates
US8524239B2 (en) 2010-07-09 2013-09-03 The United States of America as represented by the Secrectary, Department of Health and Human Services Photosensitizing antibody-fluorophore conjugates
US12296013B2 (en) 2010-07-09 2025-05-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Photosensitizing antibody-fluorophore conjugates
US11053222B2 (en) 2010-12-21 2021-07-06 Pierce Biotechnology, Inc. Fluorescent compounds
US10351551B2 (en) 2010-12-21 2019-07-16 Pierce Biotechnology, Inc. Fluorescent compounds
WO2013009475A1 (en) * 2011-07-11 2013-01-17 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Photosensitizing antibody-phuorophore conjugates
US9365598B2 (en) 2011-07-14 2016-06-14 Pierce Biotechnology, Inc. Phosphine derivatives of fluorescent compounds
US8889884B1 (en) 2011-07-14 2014-11-18 Pierce Biotechnology, Inc. Phosphine derivatives of fluorescent compounds
US10730857B2 (en) 2011-08-16 2020-08-04 Pierce Biotechnology, Inc. Benzocyanine compounds
US10125120B2 (en) 2011-08-16 2018-11-13 Pierce Biotechnology, Inc. Benzocyanine compounds
US9249307B2 (en) 2011-08-16 2016-02-02 Pierce Biotechnology, Inc. Benzocyanine compounds
US10526317B2 (en) 2012-02-28 2020-01-07 Pierce Biotechnology, Inc. Benzocyanine compounds
US9751868B2 (en) 2012-02-28 2017-09-05 Pierce Biotechnology, Inc. Benzocyanine compounds
US10696653B2 (en) 2012-03-02 2020-06-30 Pierce Biotechnology, Inc. Cyanine compounds
US10000467B2 (en) 2012-03-02 2018-06-19 Pierce Biotechnology, Inc. Cyanine compounds
US10174045B2 (en) 2012-08-28 2019-01-08 Pierce Biotechnology, Inc. Benzopyrylium compounds
US9676787B2 (en) 2012-08-28 2017-06-13 Pierce Biotechnology, Inc. Benzopyrylium compounds
US10435563B2 (en) 2013-08-22 2019-10-08 Sony Corporation Water soluble fluorescent or colored dyes and methods for their use
US10036754B2 (en) 2014-01-16 2018-07-31 Sony Corporation Water soluble fluorescent or colored dyes and methods for their use
US10830678B2 (en) 2014-08-08 2020-11-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Photo-controlled removal of targets in vitro and in vivo
US11781955B2 (en) 2014-08-08 2023-10-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Photo-controlled removal of targets in vitro and in vivo
US11827661B2 (en) 2015-02-26 2023-11-28 Sony Group Corporation Water soluble fluorescent or colored dyes comprising conjugating groups
US11084932B2 (en) 2015-02-26 2021-08-10 Sony Group Corporation Phenylethynylnaphthalene dyes and methods for their use
US10865310B2 (en) 2015-05-11 2020-12-15 Sony Corporation Of America Ultra bright dimeric or polymeric dyes
US11013803B2 (en) 2015-08-07 2021-05-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Near infrared photoimmunotherapy (NIR-PIT) of suppressor cells to treat cancer
US11147875B2 (en) 2015-08-18 2021-10-19 Rakuten Medical, Inc. Compositions, combinations and related methods for photoimmunotherapy
US11154620B2 (en) 2015-08-18 2021-10-26 Rakuten Medical, Inc. Compositions, combinations and related methods for photoimmunotherapy
US11141483B2 (en) 2015-08-18 2021-10-12 Rakuten Medical, Inc. Methods for manufacturing phthalocyanine dye conjugates and stable conjugates
US12491249B2 (en) 2015-08-18 2025-12-09 Rakuten Medical, Inc. Methods for manufacturing phthalocyanine dye conjugates and stable conjugates
US11142647B2 (en) 2016-04-01 2021-10-12 Sony Group Corporation Ultra bright dimeric or polymeric dyes
US11981820B2 (en) 2016-04-01 2024-05-14 Sony Group Corporation Ultra bright dimeric or polymeric dyes
US10866244B2 (en) 2016-04-06 2020-12-15 Sony Corporation Of America Ultra bright dimeric or polymeric dyes with spacing linker groups
WO2017214165A1 (en) * 2016-06-06 2017-12-14 Sony Corporation Ionic polymers comprising fluorescent or colored reporter groups

Also Published As

Publication number Publication date
EP0988060A2 (de) 2000-03-29
HUP0003132A2 (hu) 2001-01-29
KR100613306B1 (ko) 2006-08-17
PT988060E (pt) 2007-08-17
KR20010020183A (ko) 2001-03-15
AU7905798A (en) 1998-11-13
CN1253507A (zh) 2000-05-17
JP5118790B2 (ja) 2013-01-16
CA2287262C (en) 2007-02-06
EP0988060B1 (de) 2007-06-13
NO995181L (no) 1999-10-22
AU733757B2 (en) 2001-05-24
CY1106860T1 (el) 2012-05-23
US6534041B1 (en) 2003-03-18
ATE364404T1 (de) 2007-07-15
ES2289786T3 (es) 2008-02-01
JP2010116413A (ja) 2010-05-27
NO995181D0 (no) 1999-10-22
WO1998047538A2 (de) 1998-10-29
HU226812B1 (en) 2009-11-30
DK0988060T3 (da) 2007-10-15
WO1998047538A3 (de) 1999-01-21
CA2287262A1 (en) 1998-10-29
DE59814030D1 (de) 2007-07-26
HUP0003132A3 (en) 2003-03-28
JP2001521530A (ja) 2001-11-06
NO327495B1 (no) 2009-07-20

Similar Documents

Publication Publication Date Title
EP0988060B1 (de) Säurelabile und enzymatisch spaltbare farbstoffkonstrukte zur diagnostik mit nahinfrarotlicht und zur therapie
EP1181940B1 (de) Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
EP2035505B1 (en) Optical fluorescent imaging using cyanine dyes
US5672333A (en) Delta1,6 bicyclo 4,4,0! functional dyes for contrast enhancement in optical imaging
DE60109740T2 (de) Verfahren zur vermeidung von fluoreszenzlöschung
DE19649971A1 (de) Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung)
US20040171827A1 (en) Phthalocyanine dyes
DE60106389T2 (de) Vielseitige hydrophile farbstoffe
DE60109741T2 (de) Verfahren zur vermeidung von fluoreszenzlöschung
EP1088559A2 (de) Galenische Formulierungen
EP0991428B1 (en) Delta1,2 bicyclo 4,4,0] functional dyes for contrast enhancement in optical imaging
US5723104A (en) Monocyclic functional dyes for contrast enhancement in optical imaging
EP1214099A1 (de) Antikörper-farbstoffkonjugate gegen zielstrukturen der angiogenese zur intraoperativen tumorranddarstellung
DE10302787A1 (de) Hydrophile, Thiol-reaktive Cyaninfarbstoffe und deren Konjugate mit Biomolekülen für die Fluoreszenzdiagnostik
HK1027035A (en) Acid-labile and enzymatically divisible dye compounds for diagnosis with near infrared light and for therapy
DE19817517A1 (de) Neue Benzylguanidinderivate für die Therapie, In-vivo- und In-vitro-Diagnostik
DE19948650A1 (de) Galenische Formulierungen

Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8131 Rejection