DE1955638A1 - Verfahren zur Herstellung von wasserunloeslichen Enzym- und Antigenpraeparaten hoher Aktivitaet und Stabilitaet - Google Patents
Verfahren zur Herstellung von wasserunloeslichen Enzym- und Antigenpraeparaten hoher Aktivitaet und StabilitaetInfo
- Publication number
- DE1955638A1 DE1955638A1 DE19691955638 DE1955638A DE1955638A1 DE 1955638 A1 DE1955638 A1 DE 1955638A1 DE 19691955638 DE19691955638 DE 19691955638 DE 1955638 A DE1955638 A DE 1955638A DE 1955638 A1 DE1955638 A1 DE 1955638A1
- Authority
- DE
- Germany
- Prior art keywords
- water
- enzyme
- antigen
- stability
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004190 Enzymes Human genes 0.000 title claims description 35
- 108090000790 Enzymes Proteins 0.000 title claims description 35
- 239000000427 antigen Substances 0.000 title claims description 33
- 102000036639 antigens Human genes 0.000 title claims description 33
- 108091007433 antigens Proteins 0.000 title claims description 33
- 238000000034 method Methods 0.000 title claims description 19
- 230000000694 effects Effects 0.000 title claims description 17
- 238000002360 preparation method Methods 0.000 title claims description 16
- 230000008569 process Effects 0.000 title claims description 10
- 238000004519 manufacturing process Methods 0.000 title claims description 8
- 239000000178 monomer Substances 0.000 claims description 15
- 239000000126 substance Substances 0.000 claims description 11
- 238000006116 polymerization reaction Methods 0.000 claims description 6
- 239000000243 solution Substances 0.000 claims description 6
- 230000005855 radiation Effects 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 238000004132 cross linking Methods 0.000 claims description 4
- 229920000742 Cotton Polymers 0.000 claims description 2
- 239000004793 Polystyrene Substances 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- 229920001807 Urea-formaldehyde Polymers 0.000 claims description 2
- 239000006260 foam Substances 0.000 claims description 2
- ODGAOXROABLFNM-UHFFFAOYSA-N polynoxylin Chemical compound O=C.NC(N)=O ODGAOXROABLFNM-UHFFFAOYSA-N 0.000 claims description 2
- 229920002223 polystyrene Polymers 0.000 claims description 2
- 229920002635 polyurethane Polymers 0.000 claims description 2
- 239000004814 polyurethane Substances 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 2
- 239000004800 polyvinyl chloride Substances 0.000 claims description 2
- 102000004142 Trypsin Human genes 0.000 description 6
- 108090000631 Trypsin Proteins 0.000 description 6
- 239000012588 trypsin Substances 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000029087 digestion Effects 0.000 description 4
- 229910021538 borax Inorganic materials 0.000 description 3
- 239000003999 initiator Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000004328 sodium tetraborate Substances 0.000 description 3
- 235000010339 sodium tetraborate Nutrition 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 230000001079 digestive effect Effects 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000012966 redox initiator Substances 0.000 description 2
- QPRMGHKASRLPJP-UHFFFAOYSA-N 12-(5-hydroxy-6-methylpiperidin-2-yl)dodecan-2-one Chemical compound CC1NC(CCCCCCCCCCC(C)=O)CCC1O QPRMGHKASRLPJP-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- OGPQOSAKRHKIHW-UHFFFAOYSA-N Cassin Natural products CC(CCCCCCCCCC1CCC(O)C(C)N1)C(=O)C OGPQOSAKRHKIHW-UHFFFAOYSA-N 0.000 description 1
- 229920005830 Polyurethane Foam Polymers 0.000 description 1
- 206010057040 Temperature intolerance Diseases 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000000274 adsorptive effect Effects 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 229920006037 cross link polymer Polymers 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 230000008543 heat sensitivity Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000007040 multi-step synthesis reaction Methods 0.000 description 1
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 description 1
- 230000006855 networking Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000011496 polyurethane foam Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 235000021262 sour milk Nutrition 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2/00—Processes of polymerisation
- C08F2/44—Polymerisation in the presence of compounding ingredients, e.g. plasticisers, dyestuffs, fillers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F291/00—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups C08F251/00 - C08F289/00
- C08F291/18—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups C08F251/00 - C08F289/00 on to irradiated or oxidised macromolecules
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Dispersion Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUMU000413 | 1968-11-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1955638A1 true DE1955638A1 (de) | 1970-06-11 |
Family
ID=10999655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19691955638 Pending DE1955638A1 (de) | 1968-11-06 | 1969-11-05 | Verfahren zur Herstellung von wasserunloeslichen Enzym- und Antigenpraeparaten hoher Aktivitaet und Stabilitaet |
Country Status (5)
| Country | Link |
|---|---|
| AT (1) | AT298375B (enrdf_load_stackoverflow) |
| AU (1) | AU531596B2 (enrdf_load_stackoverflow) |
| DE (1) | DE1955638A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2024804A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1238280A (enrdf_load_stackoverflow) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4891267A (enrdf_load_stackoverflow) * | 1972-03-09 | 1973-11-28 | ||
| JPS4891270A (enrdf_load_stackoverflow) * | 1972-03-09 | 1973-11-28 | ||
| US3933587A (en) * | 1972-12-07 | 1976-01-20 | Agency Of Industrial Science & Technology | Method for production of immobilized enzyme |
| DE2605797A1 (de) * | 1975-02-18 | 1976-08-26 | Uop Inc | Immobilisiertes enzym und verfahren zu dessen herstellung |
| DE2633259A1 (de) * | 1975-07-23 | 1977-01-27 | Japan Atomic Energy Res Inst | Verfahren zur herstellung von unbeweglich gemachten enzymen |
| DE2703834A1 (de) * | 1976-01-31 | 1977-08-11 | Japan Atomic Energy Res Inst | Verfahren zur herstellung einer unloeslich gemachte enzyme und/oder unloeslich gemachte bakterienzellen enthaltenden zusammensetzung |
| DE10220975C1 (de) * | 2002-05-11 | 2003-09-04 | Juri Oll | Werkzeug zum Nacharbeiten von Putz |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1141249B (it) * | 1980-02-28 | 1986-10-01 | Italfarmaco Spa | Procedimento per la preparazione di copolimeri di polisaccaridi supprotanti attivita' enzimatica,e copolimeri cosi' ottenuti |
| EP0048109B1 (en) * | 1980-09-11 | 1985-11-06 | United Kingdom Atomic Energy Authority | Improvements in or relating to composite materials |
| DE3111474A1 (de) * | 1981-03-24 | 1982-10-07 | Behringwerke Ag, 3550 Marburg | "mittel zur immunologischen diagnose sowie verfahren zu seiner herstellung" |
| AUPP536598A0 (en) | 1998-08-20 | 1998-09-10 | Worsley Alumina Pty Ltd | Organic impurity removal process for bayer liquors |
-
1969
- 1969-10-31 GB GB5358869A patent/GB1238280A/en not_active Expired
- 1969-11-05 DE DE19691955638 patent/DE1955638A1/de active Pending
- 1969-11-05 AT AT1041169A patent/AT298375B/de not_active IP Right Cessation
- 1969-11-05 FR FR6938038A patent/FR2024804A1/fr active Pending
-
1979
- 1979-11-08 AU AU52626/79A patent/AU531596B2/en not_active Ceased
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4891267A (enrdf_load_stackoverflow) * | 1972-03-09 | 1973-11-28 | ||
| JPS4891270A (enrdf_load_stackoverflow) * | 1972-03-09 | 1973-11-28 | ||
| US3933587A (en) * | 1972-12-07 | 1976-01-20 | Agency Of Industrial Science & Technology | Method for production of immobilized enzyme |
| DE2605797A1 (de) * | 1975-02-18 | 1976-08-26 | Uop Inc | Immobilisiertes enzym und verfahren zu dessen herstellung |
| DE2633259A1 (de) * | 1975-07-23 | 1977-01-27 | Japan Atomic Energy Res Inst | Verfahren zur herstellung von unbeweglich gemachten enzymen |
| DE2703834A1 (de) * | 1976-01-31 | 1977-08-11 | Japan Atomic Energy Res Inst | Verfahren zur herstellung einer unloeslich gemachte enzyme und/oder unloeslich gemachte bakterienzellen enthaltenden zusammensetzung |
| DE10220975C1 (de) * | 2002-05-11 | 2003-09-04 | Juri Oll | Werkzeug zum Nacharbeiten von Putz |
Also Published As
| Publication number | Publication date |
|---|---|
| AT298375B (de) | 1972-05-10 |
| GB1238280A (enrdf_load_stackoverflow) | 1971-07-07 |
| FR2024804A1 (enrdf_load_stackoverflow) | 1970-09-04 |
| AU531596B2 (en) | 1983-09-01 |
| AU5262679A (en) | 1980-05-15 |
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