DE1953914A1 - Verfahren zum Herstellen von Koernern mit einer gesteuerten Freigabe von einem in ihnen enthaltenen aktiven Stoff - Google Patents
Verfahren zum Herstellen von Koernern mit einer gesteuerten Freigabe von einem in ihnen enthaltenen aktiven StoffInfo
- Publication number
- DE1953914A1 DE1953914A1 DE19691953914 DE1953914A DE1953914A1 DE 1953914 A1 DE1953914 A1 DE 1953914A1 DE 19691953914 DE19691953914 DE 19691953914 DE 1953914 A DE1953914 A DE 1953914A DE 1953914 A1 DE1953914 A1 DE 1953914A1
- Authority
- DE
- Germany
- Prior art keywords
- grains
- spherical
- active substance
- film
- controlled release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 19
- 239000013543 active substance Substances 0.000 title claims description 14
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 230000008569 process Effects 0.000 title claims description 3
- 238000013270 controlled release Methods 0.000 title claims 3
- 239000000126 substance Substances 0.000 claims description 12
- 239000008187 granular material Substances 0.000 claims description 11
- 239000000025 natural resin Substances 0.000 claims description 4
- 238000007493 shaping process Methods 0.000 claims description 4
- 229920003002 synthetic resin Polymers 0.000 claims description 4
- 239000000057 synthetic resin Substances 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 239000004744 fabric Substances 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000000750 progressive effect Effects 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 235000009579 balsamo Nutrition 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2018869 | 1969-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1953914A1 true DE1953914A1 (de) | 1971-02-11 |
Family
ID=11164545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19691953914 Pending DE1953914A1 (de) | 1969-07-28 | 1969-10-27 | Verfahren zum Herstellen von Koernern mit einer gesteuerten Freigabe von einem in ihnen enthaltenen aktiven Stoff |
Country Status (11)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1561204A (en) * | 1977-06-01 | 1980-02-13 | Ici Ltd | Sustained release pharmaceutical composition |
| US4618487A (en) * | 1984-07-06 | 1986-10-21 | Alza Corporation | Device for administering calcium ascorbate |
| IT1227336B (it) * | 1987-09-11 | 1991-04-08 | Squibb & Sons Inc | Composizione farmaceutica contenente un carico elevato di medicamento e procedimento per la sua preparazione |
| GB8805695D0 (en) * | 1988-03-10 | 1988-04-07 | Nycomed As | Enteric coated spheroidal granules |
| DE19808634A1 (de) * | 1998-02-24 | 1999-08-26 | Schering Ag | Mantel für eine pharmazeutische Zusammensetzung |
-
1969
- 1969-09-29 CA CA063562A patent/CA935093A/en not_active Expired
- 1969-09-30 GB GB1251115D patent/GB1251115A/en not_active Expired
- 1969-10-03 FR FR6934276A patent/FR2053190A1/fr active Pending
- 1969-10-27 DE DE19691953914 patent/DE1953914A1/de active Pending
- 1969-11-25 CH CH1750669A patent/CH538883A/it not_active IP Right Cessation
-
1970
- 1970-07-21 LU LU61380A patent/LU61380A1/xx unknown
- 1970-07-22 ZA ZA705024A patent/ZA705024B/xx unknown
- 1970-07-22 BE BE753766D patent/BE753766A/xx not_active IP Right Cessation
- 1970-07-22 AT AT667370A patent/AT306929B/de not_active IP Right Cessation
- 1970-07-24 NL NL7011021A patent/NL7011021A/xx unknown
- 1970-07-27 ES ES382529A patent/ES382529A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1251115A (enrdf_load_stackoverflow) | 1971-10-27 |
| AT306929B (de) | 1973-04-25 |
| CA935093A (en) | 1973-10-09 |
| CH538883A (it) | 1973-07-15 |
| BE753766A (fr) | 1970-12-31 |
| ES382529A1 (es) | 1973-04-16 |
| FR2053190A1 (enrdf_load_stackoverflow) | 1971-04-16 |
| LU61380A1 (enrdf_load_stackoverflow) | 1970-09-21 |
| NL7011021A (enrdf_load_stackoverflow) | 1971-02-01 |
| ZA705024B (en) | 1971-04-28 |
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