DE19535114A1 - Endoskopsystem mit Fluoreszenzdiagnose - Google Patents
Endoskopsystem mit FluoreszenzdiagnoseInfo
- Publication number
- DE19535114A1 DE19535114A1 DE19535114A DE19535114A DE19535114A1 DE 19535114 A1 DE19535114 A1 DE 19535114A1 DE 19535114 A DE19535114 A DE 19535114A DE 19535114 A DE19535114 A DE 19535114A DE 19535114 A1 DE19535114 A1 DE 19535114A1
- Authority
- DE
- Germany
- Prior art keywords
- light
- image
- endoscope
- endoscope system
- filter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/0638—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements providing two or more wavelengths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00002—Operational features of endoscopes
- A61B1/00043—Operational features of endoscopes provided with output arrangements
- A61B1/00045—Display arrangement
- A61B1/0005—Display arrangement combining images e.g. side-by-side, superimposed or tiled
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00186—Optical arrangements with imaging filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/0646—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements with illumination filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/0661—Endoscope light sources
- A61B1/0669—Endoscope light sources at proximal end of an endoscope
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6852—Catheters
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
- H04N23/50—Constructional details
- H04N23/555—Constructional details for picking-up images in sites, inaccessible due to their dimensions or hazardous conditions, e.g. endoscopes or borescopes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Multimedia (AREA)
- Signal Processing (AREA)
- Endoscopes (AREA)
Description
Claims (35)
eine Lichtquelle zur Beleuchtung des Gewebes mit Licht mehrerer Wellenlängenbereiche, wobei das menschliche Ge webe in Abhängigkeit von der Beleuchtung mit Anregungs licht eines vorbestimmten Wellenlängenbereiches fluores ziert;
ein Bildaufnahmeelementpaar, wobei jedes Element des Bildaufnahmeelementpaars ein einem optischen Bild ent sprechendes Bildsignal abgibt;
ein optisches Objektivsystem zur Erzeugung eines opti schen Bildpaars des Gewebes auf dem Bildaufnahmeelement paar;
ein Fluoreszenzlichtfilter zum Durchlassen von durch das fluoreszierende Gewebe erzeugtem Licht und zur Vermeidung des Durchlasses von Licht einer Wellenlänge innerhalb des vorbestimmten Wellenlängenbereichs, wobei das Filter zwi schen dem einen Element des Paars Bildaufnahmeelemente und dem optischen Objektivsystem angeordnet ist;
Mittel zur Auswahl eines Elements des Bildaufnahmeele mentpaars;
Mittel zum Verarbeiten des von jedem Element des Bildauf nahmeelementpaars abgegebenen Bildsignals; und
Mittel zur Abgabe eines Videosignals entsprechend dem Bildsignal des jeweils ausgewählten Elements des Bildauf nahmeelementpaars.
ein Schaltkreis zum Empfangen von durch das andere Ele ment des Bildaufnahmeelementpaars zugeführten Bildsigna len, wenn das Objekt mit dem roten, grünen und blauen Licht beleuchtet wird; und
ein Schaltkreis zum Verarbeiten der von dem anderen Ele ment des Bildaufnahmeelementpaars übertragenen Bildsigna le und zum Ausgeben des Videosignals dienen.
ein Bildaufnahmeelement zum Aufnehmen eines Bildes des Objekts und zum Abgeben eines Bildsignals entsprechend dem aufgenommenen Bild, wobei das Bildaufnahmeelement Mittel zum Verstärken des Bildsignals enthält;
ein optisches Objektivsystem zum Erzeugen des Objektbil des auf dem Bildaufnahmeelement;
Mittel zum Durchlassen von Licht eines vorbestimmten Wel lenlängenbereiches zu dem Objekt zu dessen Beleuchtung, wobei das Objekt Fluoreszenzlicht eines anderen vorbe stimmten Wellenlängenbereiches in Abhängigkeit von der Beleuchtung mit Licht des ersten vorbestimmten Wellenlän genbereichs erzeugt; und
ein zwischen dem Bildaufnahmeelement und dem optischen Objektivsystem angeordnetes Filter, wobei das Filter Licht des anderen vorbestimmten Wellenlängenbereichs durchläßt und Licht des ersten vorbestimmten Wellenbe reichs sperrt.
ein elektronisches Endoskop zum Aufnehmen eines Bildes eines zu beobachtenden Objektes und zum Abgeben eines dem aufgenommenen Bild entsprechenden Bildsignals;
eine Lichtquelle zur Beleuchtung des Objekts mit Licht eines von mehreren Wellenlängenbereichen, wobei die Lichtquelle das Objekt mit einem Anregungslicht eines vorbestimmten Wellenlängenbereichs beleuchtet, und das Objekt in Abhängigkeit von der Beleuchtung durch das An regungslicht fluoresziert;
ein Lichtleiter-Sichtgerät, das in einen Instrumentenka nal des Endoskops eingesetzt werden kann, wobei das Sichtgerät an einem Rohr eine Licht von dem Objekt kon vergierende und durch das Lichtleiter-Sichtgerät durch lassende Linse enthält;
ein Bildaufnahmeelement zum Aufnehmen des durch das Lichtleiter-Sichtgerät durchgelassenen Lichtes;
ein zwischen einem anderen Ende des Lichtleiter-Sichtge rätes und dem anderen Bildaufnahmeelement vorgesehenes Filter, das von dem fluoreszierenden Objekt abgegebenes Licht durchläßt und Licht des vorbestimmten Wellenlängen bereichs sperrt; und
Mittel zum Empfangen des Bildsignals des einen Bildauf nahmeelements und/oder des anderen Bildaufnahmeelements, und zur Abgabe eines entsprechenden Videosignals.
ein Bildaufnahmeelementpaar zum Aufnehmen von Bildern und Ausgeben von Bildsignalen in Abhängigkeit von den aufge nommenen Bildern;
ein optisches Objektivsystem zur Erzeugung der Bilder auf den Bildaufnahmeelementen;
Mittel zum Durchlassen von Licht eines vorbestimmten Wel lenlängenbereichs zur Beleuchtung des Objekts, das in Ab hängigkeit von der Beleuchtung mit dem Durchlaßlicht fluoresziert; und
ein zwischen einem der Bildaufnahmeelemente und dem opti schen Objektivsystem vorgesehenes Filter, das von dem fluoreszierenden Objekt abgegebenes Licht durchläßt und an dem Objekt reflektiertes Licht sperrt.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP22652194 | 1994-09-21 | ||
JP22652294 | 1994-09-21 | ||
JP6-226523 | 1994-09-21 | ||
JP6-226524 | 1994-09-21 | ||
JP22652494 | 1994-09-21 | ||
JP6-226521 | 1994-09-21 | ||
JP22652394 | 1994-09-21 | ||
JP6-226522 | 1994-09-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE19535114A1 true DE19535114A1 (de) | 1996-03-28 |
DE19535114B4 DE19535114B4 (de) | 2013-09-05 |
Family
ID=27477218
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19535114A Expired - Fee Related DE19535114B4 (de) | 1994-09-21 | 1995-09-21 | Endoskopsystem mit Fluoreszenzdiagnose |
Country Status (2)
Country | Link |
---|---|
US (2) | US6099466A (de) |
DE (1) | DE19535114B4 (de) |
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19639653A1 (de) * | 1996-09-26 | 1998-04-09 | Storz Karl Gmbh & Co | Vorrichtung zur photodynamischen Diagnose |
WO1998049347A1 (en) * | 1997-04-30 | 1998-11-05 | University Of Florida | Methods and materials for detection of gene transfer and expression |
WO1999037204A1 (en) * | 1998-01-26 | 1999-07-29 | Massachusetts Institute Of Technology | Fluorescence imaging endoscope |
EP1099405A1 (de) * | 1999-05-18 | 2001-05-16 | Olympus Optical Co., Ltd. | Endoskop |
EP1101438A1 (de) * | 1999-11-18 | 2001-05-23 | Fuji Photo Film Co., Ltd. | Verfahren und Vorrichtung zur Erzeugung von Fluoreszenzbildern |
US6364829B1 (en) * | 1999-01-26 | 2002-04-02 | Newton Laboratories, Inc. | Autofluorescence imaging system for endoscopy |
EP1477103A1 (de) * | 2002-01-15 | 2004-11-17 | Xillix Technologies Corp. | Fluoreszierende Endoskopie-Videosysteme ohne bewegliche Teile in der Kamera |
US7495233B2 (en) | 2005-03-18 | 2009-02-24 | Siemens Aktiengesellschaft | Fluorescence scanner for molecular signatures |
DE102008011013A1 (de) | 2008-02-25 | 2009-09-03 | Labo Tech Labortechnik Gmbh | Verfahren und Einrichtung zur komplexen Stoffwechselanalyse |
US7846091B2 (en) | 1999-01-26 | 2010-12-07 | Newton Laboratories, Inc. | Autofluorescence imaging system for endoscopy |
EP2319390A1 (de) * | 2000-07-21 | 2011-05-11 | Olympus Corporation | Endoskop |
US8630698B2 (en) | 2005-05-04 | 2014-01-14 | Novadaq Technologies, Inc. | Filter for use with imaging endoscopes |
US9386909B2 (en) | 2006-07-28 | 2016-07-12 | Novadaq Technologies Inc. | System and method for deposition and removal of an optical element on an endoscope objective |
US9642532B2 (en) | 2008-03-18 | 2017-05-09 | Novadaq Technologies Inc. | Imaging system for combined full-color reflectance and near-infrared imaging |
US9814378B2 (en) | 2011-03-08 | 2017-11-14 | Novadaq Technologies Inc. | Full spectrum LED illuminator having a mechanical enclosure and heatsink |
US9877654B2 (en) | 2006-02-07 | 2018-01-30 | Novadaq Technologies Inc. | Near infrared imaging |
US9968244B2 (en) | 2000-07-14 | 2018-05-15 | Novadaq Technologies ULC | Compact fluorescence endoscopy video system |
US10293122B2 (en) | 2016-03-17 | 2019-05-21 | Novadaq Technologies ULC | Endoluminal introducer with contamination avoidance |
US10694151B2 (en) | 2006-12-22 | 2020-06-23 | Novadaq Technologies ULC | Imaging system with a single color image sensor for simultaneous fluorescence and color video endoscopy |
US10869645B2 (en) | 2016-06-14 | 2020-12-22 | Stryker European Operations Limited | Methods and systems for adaptive imaging for low light signal enhancement in medical visualization |
USD916294S1 (en) | 2016-04-28 | 2021-04-13 | Stryker European Operations Limited | Illumination and imaging device |
US10980420B2 (en) | 2016-01-26 | 2021-04-20 | Stryker European Operations Limited | Configurable platform |
US10992848B2 (en) | 2017-02-10 | 2021-04-27 | Novadaq Technologies ULC | Open-field handheld fluorescence imaging systems and methods |
US11930278B2 (en) | 2015-11-13 | 2024-03-12 | Stryker Corporation | Systems and methods for illumination and imaging of a target |
US12028600B2 (en) | 2021-10-04 | 2024-07-02 | Stryker Corporation | Open-field handheld fluorescence imaging systems and methods |
Families Citing this family (118)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7179222B2 (en) * | 1996-11-20 | 2007-02-20 | Olympus Corporation | Fluorescent endoscope system enabling simultaneous achievement of normal light observation based on reflected light and fluorescence observation based on light with wavelengths in infrared spectrum |
JP3309276B2 (ja) | 1999-03-17 | 2002-07-29 | エーカポット・パンナチェート | 蛍光電子内視鏡システム |
US6793652B1 (en) | 1999-06-02 | 2004-09-21 | Power Medical Interventions, Inc. | Electro-mechanical surgical device |
US6716233B1 (en) * | 1999-06-02 | 2004-04-06 | Power Medical Interventions, Inc. | Electromechanical driver and remote surgical instrument attachment having computer assisted control capabilities |
US8229549B2 (en) | 2004-07-09 | 2012-07-24 | Tyco Healthcare Group Lp | Surgical imaging device |
US7695485B2 (en) | 2001-11-30 | 2010-04-13 | Power Medical Interventions, Llc | Surgical device |
US7951071B2 (en) | 1999-06-02 | 2011-05-31 | Tyco Healthcare Group Lp | Moisture-detecting shaft for use with an electro-mechanical surgical device |
US8025199B2 (en) | 2004-02-23 | 2011-09-27 | Tyco Healthcare Group Lp | Surgical cutting and stapling device |
US6498884B1 (en) * | 1999-10-21 | 2002-12-24 | Quickie Vision Llc | Wide-view endoscope compatible with HDTV format |
JP2001125009A (ja) | 1999-10-28 | 2001-05-11 | Asahi Optical Co Ltd | 内視鏡装置 |
DE10055725B4 (de) | 1999-11-11 | 2007-12-27 | Pentax Corp. | Elektronisches Endoskopsystem |
US6635011B1 (en) * | 2000-01-14 | 2003-10-21 | Pentax Corporation | Electronic endoscope system |
US8016855B2 (en) | 2002-01-08 | 2011-09-13 | Tyco Healthcare Group Lp | Surgical device |
US6488197B1 (en) | 2000-02-22 | 2002-12-03 | Power Medical Interventions, Inc. | Fluid delivery device for use with anastomosing resecting and stapling instruments |
EP1149555A3 (de) * | 2000-04-24 | 2002-04-17 | Fuji Photo Film Co., Ltd. | Fluoreszierendes Endoskopgerät |
JP2002095634A (ja) * | 2000-09-26 | 2002-04-02 | Fuji Photo Film Co Ltd | 内視鏡装置 |
US6663561B2 (en) | 2000-10-05 | 2003-12-16 | Pentax Corporation | Video endoscope system |
JP2002153414A (ja) | 2000-11-17 | 2002-05-28 | Asahi Optical Co Ltd | 電子内視鏡及び電子内視鏡システム |
US6875165B2 (en) | 2001-02-22 | 2005-04-05 | Retinalabs, Inc. | Method of radiation delivery to the eye |
ATE398413T1 (de) * | 2001-04-20 | 2008-07-15 | Power Med Interventions Inc | Abbildungsvorrichtung |
US7172553B2 (en) * | 2001-05-16 | 2007-02-06 | Olympus Corporation | Endoscope system using normal light and fluorescence |
JP4772235B2 (ja) * | 2001-09-13 | 2011-09-14 | オリンパス株式会社 | 内視鏡装置 |
US6932762B2 (en) * | 2001-09-21 | 2005-08-23 | Fujinon Corporation | Endoscope having red component cut filter |
JP2003190091A (ja) * | 2001-12-26 | 2003-07-08 | Pentax Corp | 蛍光観察用照明プローブ、電子内視鏡システム及び電子内視鏡 |
US9113878B2 (en) | 2002-01-08 | 2015-08-25 | Covidien Lp | Pinion clip for right angle linear cutter |
ATE500777T1 (de) | 2002-01-30 | 2011-03-15 | Tyco Healthcare | Chirurgische bildgebende vorrichtung |
US8620410B2 (en) * | 2002-03-12 | 2013-12-31 | Beth Israel Deaconess Medical Center | Multi-channel medical imaging system |
AU2003218116A1 (en) * | 2002-03-12 | 2003-09-29 | Beth Israel Deaconess Medical Center | Medical imaging systems |
JP2003334162A (ja) * | 2002-03-14 | 2003-11-25 | Olympus Optical Co Ltd | 内視鏡画像処理装置 |
US8614768B2 (en) | 2002-03-18 | 2013-12-24 | Raytheon Company | Miniaturized imaging device including GRIN lens optically coupled to SSID |
US9155544B2 (en) * | 2002-03-20 | 2015-10-13 | P Tech, Llc | Robotic systems and methods |
WO2003105702A2 (en) | 2002-06-14 | 2003-12-24 | Power Medical Interventions, Inc. | Surgical device |
ATE465672T1 (de) | 2002-09-30 | 2010-05-15 | Power Medical Interventions Llc | Eigenständiges sterilisierbares chirurgisches system |
JP4394356B2 (ja) | 2003-02-07 | 2010-01-06 | Hoya株式会社 | 電子内視鏡装置 |
US20040210107A1 (en) * | 2003-03-31 | 2004-10-21 | Pentax Corporation | Endoscope system for fluorescent observation |
JP2007521477A (ja) * | 2003-06-26 | 2007-08-02 | ギブン・イメージング・リミテツド | 生体内検出用の方法、装置、およびシステム |
US8473035B2 (en) * | 2003-09-15 | 2013-06-25 | Beth Israel Deaconess Medical Center | Medical imaging systems |
EP1665978B1 (de) * | 2003-09-19 | 2017-03-08 | Olympus Corporation | Endoskop |
JP4009581B2 (ja) * | 2003-11-18 | 2007-11-14 | オリンパス株式会社 | カプセル型医療システム |
US20050166537A1 (en) * | 2004-02-03 | 2005-08-04 | Geiger Gerard G. | Bird repellant device for use on transparent surface |
WO2005079294A2 (en) | 2004-02-12 | 2005-09-01 | Neo Vista, Inc. | Methods and apparatus for intraocular brachytherapy |
JP4459662B2 (ja) | 2004-03-05 | 2010-04-28 | Hoya株式会社 | 調節機構 |
JP2006006834A (ja) * | 2004-06-29 | 2006-01-12 | Pentax Corp | 電子内視鏡システム |
JP4611674B2 (ja) * | 2004-06-29 | 2011-01-12 | Hoya株式会社 | 電子内視鏡システム |
DE502004009167D1 (de) * | 2004-07-19 | 2009-04-23 | Fraunhofer Ges Forschung | Videoendoskopievorrichtung |
JP4575720B2 (ja) * | 2004-07-23 | 2010-11-04 | Hoya株式会社 | 電子内視鏡システム |
US8289381B2 (en) | 2005-01-05 | 2012-10-16 | Avantis Medical Systems, Inc. | Endoscope with an imaging catheter assembly and method of configuring an endoscope |
US8235887B2 (en) | 2006-01-23 | 2012-08-07 | Avantis Medical Systems, Inc. | Endoscope assembly with retroscope |
JP4598182B2 (ja) * | 2005-01-05 | 2010-12-15 | Hoya株式会社 | 電子内視鏡システム |
US8872906B2 (en) | 2005-01-05 | 2014-10-28 | Avantis Medical Systems, Inc. | Endoscope assembly with a polarizing filter |
US8182422B2 (en) | 2005-12-13 | 2012-05-22 | Avantis Medical Systems, Inc. | Endoscope having detachable imaging device and method of using |
US8797392B2 (en) | 2005-01-05 | 2014-08-05 | Avantis Medical Sytems, Inc. | Endoscope assembly with a polarizing filter |
WO2006073186A1 (ja) * | 2005-01-07 | 2006-07-13 | Olympus Medical Systems Corp. | 内視鏡用挿入部 |
JP4354425B2 (ja) * | 2005-04-11 | 2009-10-28 | オリンパスメディカルシステムズ株式会社 | 内視鏡用挿入部及び内視鏡 |
JP4723281B2 (ja) * | 2005-05-16 | 2011-07-13 | Hoya株式会社 | 電子内視鏡システム |
JP4681981B2 (ja) * | 2005-08-18 | 2011-05-11 | Hoya株式会社 | 電子内視鏡装置 |
WO2007059208A2 (en) | 2005-11-15 | 2007-05-24 | Neovista Inc. | Methods and apparatus for intraocular brachytherapy |
US8287446B2 (en) | 2006-04-18 | 2012-10-16 | Avantis Medical Systems, Inc. | Vibratory device, endoscope having such a device, method for configuring an endoscope, and method of reducing looping of an endoscope |
CN101420901B (zh) * | 2006-04-20 | 2012-01-04 | 奥林巴斯医疗株式会社 | 生物体观测系统 |
WO2007136859A2 (en) * | 2006-05-19 | 2007-11-29 | Avantis Medical Systems, Inc. | Device and method for reducing effects of video artifacts |
JP5314841B2 (ja) * | 2006-08-22 | 2013-10-16 | オリンパス株式会社 | 内視鏡装置、及び内視鏡プローブ |
US20080177140A1 (en) * | 2007-01-23 | 2008-07-24 | Xillix Technologies Corp. | Cameras for fluorescence and reflectance imaging |
US8064666B2 (en) | 2007-04-10 | 2011-11-22 | Avantis Medical Systems, Inc. | Method and device for examining or imaging an interior surface of a cavity |
US7835074B2 (en) * | 2007-06-05 | 2010-11-16 | Sterling Lc | Mini-scope for multi-directional imaging |
CA2921566C (en) | 2007-09-21 | 2018-05-22 | Tyco Healthcare Group Lp | Surgical device |
AU2008302043B2 (en) | 2007-09-21 | 2013-06-27 | Covidien Lp | Surgical device |
US20090124854A1 (en) * | 2007-11-09 | 2009-05-14 | Fujifilm Corporation | Image capturing device and image capturing system |
US8169471B2 (en) * | 2007-11-09 | 2012-05-01 | Fujifilm Corporation | Image capturing system, image capturing method, and computer readable medium |
US8169468B2 (en) * | 2008-04-26 | 2012-05-01 | Intuitive Surgical Operations, Inc. | Augmented stereoscopic visualization for a surgical robot |
EP2296756A1 (de) | 2008-06-04 | 2011-03-23 | Neovista, Inc. | Tragbares bestrahlungssystem zum vorschieben eines strahlungsquellendrahtes |
CN102137616B (zh) | 2008-06-18 | 2014-09-10 | 雷神公司 | 确定焦距的透明内窥镜头 |
WO2010014792A2 (en) | 2008-07-30 | 2010-02-04 | Sterling Lc | Method and device for incremental wavelength variation to analyze tissue |
WO2010053916A2 (en) | 2008-11-04 | 2010-05-14 | Sterling Lc | Method and device for wavelength shifted imaging |
US8734333B2 (en) * | 2009-03-18 | 2014-05-27 | Fujifilm Corporation | Endoscope system, endoscope video processor and method of driving endoscope system |
CA2765559C (en) | 2009-06-18 | 2017-09-05 | Peer Medical Ltd. | Multi-camera endoscope |
US11278190B2 (en) | 2009-06-18 | 2022-03-22 | Endochoice, Inc. | Multi-viewing element endoscope |
US11547275B2 (en) | 2009-06-18 | 2023-01-10 | Endochoice, Inc. | Compact multi-viewing element endoscope system |
WO2012038958A2 (en) | 2010-09-20 | 2012-03-29 | Peermedical Ltd. | Multi-camera endoscope having fluid channels |
US11864734B2 (en) | 2009-06-18 | 2024-01-09 | Endochoice, Inc. | Multi-camera endoscope |
US9101287B2 (en) | 2011-03-07 | 2015-08-11 | Endochoice Innovation Center Ltd. | Multi camera endoscope assembly having multiple working channels |
US8926502B2 (en) | 2011-03-07 | 2015-01-06 | Endochoice, Inc. | Multi camera endoscope having a side service channel |
US9642513B2 (en) | 2009-06-18 | 2017-05-09 | Endochoice Inc. | Compact multi-viewing element endoscope system |
US9872609B2 (en) | 2009-06-18 | 2018-01-23 | Endochoice Innovation Center Ltd. | Multi-camera endoscope |
US9706903B2 (en) | 2009-06-18 | 2017-07-18 | Endochoice, Inc. | Multiple viewing elements endoscope system with modular imaging units |
US9713417B2 (en) | 2009-06-18 | 2017-07-25 | Endochoice, Inc. | Image capture assembly for use in a multi-viewing elements endoscope |
US9492063B2 (en) | 2009-06-18 | 2016-11-15 | Endochoice Innovation Center Ltd. | Multi-viewing element endoscope |
US9101268B2 (en) | 2009-06-18 | 2015-08-11 | Endochoice Innovation Center Ltd. | Multi-camera endoscope |
US10165929B2 (en) | 2009-06-18 | 2019-01-01 | Endochoice, Inc. | Compact multi-viewing element endoscope system |
US9901244B2 (en) | 2009-06-18 | 2018-02-27 | Endochoice, Inc. | Circuit board assembly of a multiple viewing elements endoscope |
US9402533B2 (en) | 2011-03-07 | 2016-08-02 | Endochoice Innovation Center Ltd. | Endoscope circuit board assembly |
WO2012056453A2 (en) | 2010-10-28 | 2012-05-03 | Peermedical Ltd. | Optical systems for multi-sensor endoscopes |
JP5371858B2 (ja) | 2009-09-29 | 2013-12-18 | 富士フイルム株式会社 | 電子内視鏡装置 |
WO2011041730A2 (en) | 2009-10-01 | 2011-04-07 | Jacobsen Stephen C | Light diffusion apparatus |
WO2011041720A2 (en) | 2009-10-01 | 2011-04-07 | Jacobsen Stephen C | Method and apparatus for manipulating movement of a micro-catheter |
WO2011041728A2 (en) | 2009-10-01 | 2011-04-07 | Jacobsen Stephen C | Needle delivered imaging device |
US8828028B2 (en) | 2009-11-03 | 2014-09-09 | Raytheon Company | Suture device and method for closing a planar opening |
WO2011055614A1 (ja) * | 2009-11-06 | 2011-05-12 | オリンパスメディカルシステムズ株式会社 | 内視鏡システム |
US9560953B2 (en) | 2010-09-20 | 2017-02-07 | Endochoice, Inc. | Operational interface in a multi-viewing element endoscope |
JP5604248B2 (ja) * | 2010-09-28 | 2014-10-08 | 富士フイルム株式会社 | 内視鏡画像表示装置 |
JP5133386B2 (ja) * | 2010-10-12 | 2013-01-30 | 富士フイルム株式会社 | 内視鏡装置 |
EP3522215A1 (de) | 2010-12-09 | 2019-08-07 | EndoChoice Innovation Center Ltd. | Flexible elektronische leiterplatte für ein mehrkamera-endoskop |
US11889986B2 (en) | 2010-12-09 | 2024-02-06 | Endochoice, Inc. | Flexible electronic circuit board for a multi-camera endoscope |
EP3747343A1 (de) | 2010-12-09 | 2020-12-09 | EndoChoice, Inc. | Multikameraendoskop mit flexibler elektronischer leiterplatte |
EP3228236A1 (de) | 2011-02-07 | 2017-10-11 | Endochoice Innovation Center Ltd. | Mehrteilige abdeckung für ein mehrkamera-endoskop |
US8900126B2 (en) | 2011-03-23 | 2014-12-02 | United Sciences, Llc | Optical scanning device |
EP2604175B1 (de) | 2011-12-13 | 2019-11-20 | EndoChoice Innovation Center Ltd. | Endoskop mit entfernbarer Spitze |
CA2798729A1 (en) | 2011-12-13 | 2013-06-13 | Peermedical Ltd. | Rotatable connector for an endoscope |
US8900125B2 (en) | 2012-03-12 | 2014-12-02 | United Sciences, Llc | Otoscanning with 3D modeling |
US9560954B2 (en) | 2012-07-24 | 2017-02-07 | Endochoice, Inc. | Connector for use with endoscope |
JP2014128394A (ja) | 2012-12-28 | 2014-07-10 | Hoya Corp | 内視鏡装置 |
US9986899B2 (en) | 2013-03-28 | 2018-06-05 | Endochoice, Inc. | Manifold for a multiple viewing elements endoscope |
US9993142B2 (en) | 2013-03-28 | 2018-06-12 | Endochoice, Inc. | Fluid distribution device for a multiple viewing elements endoscope |
US10499794B2 (en) | 2013-05-09 | 2019-12-10 | Endochoice, Inc. | Operational interface in a multi-viewing element endoscope |
US10602918B2 (en) | 2013-12-31 | 2020-03-31 | Karl Storz Imaging, Inc. | Switching between white light imaging and excitation light imaging leaving last video frame displayed |
US20150282749A1 (en) * | 2014-04-05 | 2015-10-08 | Surgisense Corporation | Apparatus, systems, and methods for mapping of tissue oxygenation |
EP3205257B1 (de) * | 2016-02-15 | 2022-11-16 | Leica Instruments (Singapore) Pte Ltd | Beleuchtungsfilter für ein beleuchtungsfiltersystem eines chirurgischen, multispektralen fluoreszenzmikroskops mit einem räumlichen filtermuster |
EP3753470A4 (de) * | 2018-03-15 | 2021-03-24 | Sony Olympus Medical Solutions Inc. | Medizinisches beobachtungssystem |
JP7346357B2 (ja) * | 2020-06-01 | 2023-09-19 | 富士フイルム株式会社 | 内視鏡システム |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE31815E (en) | 1979-08-20 | 1985-01-29 | Philips Medical Systems, Inc. | Method and apparatus for detecting the presence of caries in teeth using visible luminescence |
JPS5940830A (ja) * | 1982-08-31 | 1984-03-06 | 浜松ホトニクス株式会社 | レ−ザ光パルスを用いた癌の診断装置 |
JPS60256443A (ja) * | 1984-05-31 | 1985-12-18 | オムロン株式会社 | 画像計測装置 |
US5318024A (en) | 1985-03-22 | 1994-06-07 | Massachusetts Institute Of Technology | Laser endoscope for spectroscopic imaging |
JP2679014B2 (ja) * | 1986-03-19 | 1997-11-19 | オリンパス光学工業株式会社 | 電子内視鏡装置 |
JPS62247232A (ja) * | 1986-04-21 | 1987-10-28 | Agency Of Ind Science & Technol | 蛍光測定装置 |
JPS6379632A (ja) * | 1986-09-25 | 1988-04-09 | 株式会社東芝 | 電子内視鏡装置 |
JPS63122421A (ja) * | 1986-11-12 | 1988-05-26 | 株式会社東芝 | 内視鏡装置 |
US5255087A (en) * | 1986-11-29 | 1993-10-19 | Olympus Optical Co., Ltd. | Imaging apparatus and endoscope apparatus using the same |
DE3740318A1 (de) * | 1986-11-29 | 1988-07-28 | Olympus Optical Co | Abbildungseinrichtung und ein diese einrichtung verwendendes endoskop |
US4983019A (en) * | 1987-05-06 | 1991-01-08 | Olympus Optical Co., Ltd. | Endoscope light source apparatus |
US5088492A (en) * | 1987-09-16 | 1992-02-18 | Olympus Optical Co., Ltd. | Radioactive ray detecting endoscope |
JP2721690B2 (ja) | 1987-09-24 | 1998-03-04 | マサチユセツツ・インスチチユート・オブ・テクノロジー | 画像形成のためのカテーテルシステム |
JPH0796005B2 (ja) * | 1987-10-27 | 1995-10-18 | オリンパス光学工業株式会社 | 内視鏡装置 |
JPH0220816A (ja) * | 1988-04-08 | 1990-01-24 | Olympus Optical Co Ltd | 内視鏡用光源装置 |
JP2862099B2 (ja) * | 1990-10-12 | 1999-02-24 | 旭光学工業株式会社 | 早期癌診断装置 |
JP3164609B2 (ja) * | 1990-10-31 | 2001-05-08 | オリンパス光学工業株式会社 | 内視鏡装置 |
JP2814409B2 (ja) * | 1990-11-30 | 1998-10-22 | 日立ソフトウェアエンジニアリング 株式会社 | 多色泳動パターン読み取り装置 |
JPH04307024A (ja) * | 1991-04-02 | 1992-10-29 | Olympus Optical Co Ltd | 電子内視鏡装置 |
CA2042075C (en) | 1991-05-08 | 2001-01-23 | Branko Palcic | Endoscopic imaging system |
JPH05228098A (ja) * | 1992-02-20 | 1993-09-07 | Asahi Optical Co Ltd | 測温内視鏡 |
US5315383A (en) * | 1992-02-27 | 1994-05-24 | Olympus Optical Co., Ltd. | Endoscope system |
US5381784A (en) * | 1992-09-30 | 1995-01-17 | Adair; Edwin L. | Stereoscopic endoscope |
US5550582A (en) * | 1993-03-19 | 1996-08-27 | Olympus Optical Co., Ltd. | Endoscope-image processing apparatus for performing image processing of emphasis in endoscope image by pigment concentration distribution |
US5413108A (en) * | 1993-04-21 | 1995-05-09 | The Research Foundation Of City College Of New York | Method and apparatus for mapping a tissue sample for and distinguishing different regions thereof based on luminescence measurements of cancer-indicative native fluorophor |
US5749830A (en) * | 1993-12-03 | 1998-05-12 | Olympus Optical Co., Ltd. | Fluorescent endoscope apparatus |
-
1995
- 1995-09-21 DE DE19535114A patent/DE19535114B4/de not_active Expired - Fee Related
-
1997
- 1997-11-10 US US08/966,581 patent/US6099466A/en not_active Expired - Lifetime
-
1999
- 1999-11-30 US US09/450,510 patent/US6471636B1/en not_active Expired - Fee Related
Cited By (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19639653A1 (de) * | 1996-09-26 | 1998-04-09 | Storz Karl Gmbh & Co | Vorrichtung zur photodynamischen Diagnose |
WO1998049347A1 (en) * | 1997-04-30 | 1998-11-05 | University Of Florida | Methods and materials for detection of gene transfer and expression |
AU752829B2 (en) * | 1998-01-26 | 2002-10-03 | Brigham And Women's Hospital | Fluorescence imaging endoscope |
US6537211B1 (en) | 1998-01-26 | 2003-03-25 | Massachusetts Institute Of Technology | Flourescence imaging endoscope |
WO1999037204A1 (en) * | 1998-01-26 | 1999-07-29 | Massachusetts Institute Of Technology | Fluorescence imaging endoscope |
US7235045B2 (en) | 1998-01-26 | 2007-06-26 | Massachusetts Institute Of Technology | Fluorescence imaging endoscope |
US6364829B1 (en) * | 1999-01-26 | 2002-04-02 | Newton Laboratories, Inc. | Autofluorescence imaging system for endoscopy |
US7846091B2 (en) | 1999-01-26 | 2010-12-07 | Newton Laboratories, Inc. | Autofluorescence imaging system for endoscopy |
EP1099405A1 (de) * | 1999-05-18 | 2001-05-16 | Olympus Optical Co., Ltd. | Endoskop |
EP1099405A4 (de) * | 1999-05-18 | 2004-05-19 | Olympus Optical Co | Endoskop |
US6902527B1 (en) | 1999-05-18 | 2005-06-07 | Olympus Corporation | Endoscope system with charge multiplying imaging device and automatic gain control |
US7258663B2 (en) | 1999-05-18 | 2007-08-21 | Olympus Corporation | Endoscope system with irradiated light switching feature |
EP1101438A1 (de) * | 1999-11-18 | 2001-05-23 | Fuji Photo Film Co., Ltd. | Verfahren und Vorrichtung zur Erzeugung von Fluoreszenzbildern |
US9968244B2 (en) | 2000-07-14 | 2018-05-15 | Novadaq Technologies ULC | Compact fluorescence endoscopy video system |
EP2319390A1 (de) * | 2000-07-21 | 2011-05-11 | Olympus Corporation | Endoskop |
EP1520508A1 (de) * | 2002-01-15 | 2005-04-06 | Xillix Technologies Corp. | Fluoreszierende endoskopie-videosysteme ohne bewegliche teile in der kamera |
US10182709B2 (en) | 2002-01-15 | 2019-01-22 | Novadaq Technologies ULC | Filter for use with imaging endoscopes |
US6899675B2 (en) | 2002-01-15 | 2005-05-31 | Xillix Technologies Corp. | Fluorescence endoscopy video systems with no moving parts in the camera |
EP1477103A1 (de) * | 2002-01-15 | 2004-11-17 | Xillix Technologies Corp. | Fluoreszierende Endoskopie-Videosysteme ohne bewegliche Teile in der Kamera |
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US8630698B2 (en) | 2005-05-04 | 2014-01-14 | Novadaq Technologies, Inc. | Filter for use with imaging endoscopes |
US9877654B2 (en) | 2006-02-07 | 2018-01-30 | Novadaq Technologies Inc. | Near infrared imaging |
US9386909B2 (en) | 2006-07-28 | 2016-07-12 | Novadaq Technologies Inc. | System and method for deposition and removal of an optical element on an endoscope objective |
US10694151B2 (en) | 2006-12-22 | 2020-06-23 | Novadaq Technologies ULC | Imaging system with a single color image sensor for simultaneous fluorescence and color video endoscopy |
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US11025867B2 (en) | 2006-12-22 | 2021-06-01 | Stryker European Operations Limited | Imaging systems and methods for displaying fluorescence and visible images |
US10694152B2 (en) | 2006-12-22 | 2020-06-23 | Novadaq Technologies ULC | Imaging systems and methods for displaying fluorescence and visible images |
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DE102008011013A1 (de) | 2008-02-25 | 2009-09-03 | Labo Tech Labortechnik Gmbh | Verfahren und Einrichtung zur komplexen Stoffwechselanalyse |
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US9642532B2 (en) | 2008-03-18 | 2017-05-09 | Novadaq Technologies Inc. | Imaging system for combined full-color reflectance and near-infrared imaging |
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US6471636B1 (en) | 2002-10-29 |
US6099466A (en) | 2000-08-08 |
DE19535114B4 (de) | 2013-09-05 |
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