DE1923082C3 - Verfahren zur Gewinnung von Polyhydroxyphenylchromanonen (Silymarin I-IV) und Arzneimittel enthaltend das Polyhydroxyphenylchromanon (Silymarin I-IV = Silymarin I-IV-Gruppe)Gemisch - Google Patents

Verfahren zur Gewinnung von Polyhydroxyphenylchromanonen (Silymarin I-IV) und Arzneimittel enthaltend das Polyhydroxyphenylchromanon (Silymarin I-IV = Silymarin I-IV-Gruppe)Gemisch

Info

Publication number
DE1923082C3
DE1923082C3 DE1923082A DE1923082A DE1923082C3 DE 1923082 C3 DE1923082 C3 DE 1923082C3 DE 1923082 A DE1923082 A DE 1923082A DE 1923082 A DE1923082 A DE 1923082A DE 1923082 C3 DE1923082 C3 DE 1923082C3
Authority
DE
Germany
Prior art keywords
silymarin
weight
fruits
mixture
parts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1923082A
Other languages
German (de)
English (en)
Other versions
DE1923082A1 (de
DE1923082B2 (de
Inventor
Des Erfinders Auf Nennung Verzicht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Madaus Holding GmbH
Original Assignee
Dr Madaus GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Madaus GmbH and Co filed Critical Dr Madaus GmbH and Co
Priority to DE1923082A priority Critical patent/DE1923082C3/de
Priority to US00828353A priority patent/US3773932A/en
Priority to CA053,025A priority patent/CA1029735A/en
Priority to GB1257956D priority patent/GB1257956A/en
Priority to LU58751D priority patent/LU58751A1/xx
Priority to CH825169A priority patent/CH541554A/de
Priority to SE6907652*A priority patent/SE371931B/xx
Priority to NL6908301A priority patent/NL6908301A/xx
Priority to BE733911D priority patent/BE733911A/xx
Priority to AT517269A priority patent/AT290723B/de
Priority to ES367906A priority patent/ES367906A1/es
Priority to OA53625A priority patent/OA03888A/xx
Priority to FR6918088A priority patent/FR2010026A1/fr
Priority to IE510/70A priority patent/IE34110B1/xx
Priority to IL34381A priority patent/IL34381A/en
Priority to YU1129/70A priority patent/YU37065B/xx
Priority to PL1970140431A priority patent/PL80560B1/pl
Priority to CS3099A priority patent/CS162722B2/cs
Priority to FI701253A priority patent/FI50932C/fi
Priority to NO01710/70A priority patent/NO130345B/no
Publication of DE1923082A1 publication Critical patent/DE1923082A1/de
Publication of DE1923082B2 publication Critical patent/DE1923082B2/de
Priority to NLAANVRAGE7908046,A priority patent/NL177829C/xx
Application granted granted Critical
Publication of DE1923082C3 publication Critical patent/DE1923082C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/40—Separation, e.g. from natural material; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE1923082A 1968-06-01 1969-05-06 Verfahren zur Gewinnung von Polyhydroxyphenylchromanonen (Silymarin I-IV) und Arzneimittel enthaltend das Polyhydroxyphenylchromanon (Silymarin I-IV = Silymarin I-IV-Gruppe)Gemisch Expired DE1923082C3 (de)

Priority Applications (21)

Application Number Priority Date Filing Date Title
DE1923082A DE1923082C3 (de) 1969-05-06 1969-05-06 Verfahren zur Gewinnung von Polyhydroxyphenylchromanonen (Silymarin I-IV) und Arzneimittel enthaltend das Polyhydroxyphenylchromanon (Silymarin I-IV = Silymarin I-IV-Gruppe)Gemisch
US00828353A US3773932A (en) 1968-06-01 1969-05-27 Method for recovering silymarin comprising polyhydroxyphenyl chromanones
CA053,025A CA1029735A (en) 1968-06-01 1969-05-29 Method for recovering polyhydroxyphenyl chromones
LU58751D LU58751A1 (enExample) 1968-06-01 1969-05-30
CH825169A CH541554A (de) 1969-05-06 1969-05-30 Verfahren zur Gewinnung eines Extraktes von Polyhydroxychromanonen aus Silybum marianum Gaertn., mit protektivem und stabilisierendem Effekt auf die Biomembranen
SE6907652*A SE371931B (enExample) 1968-06-01 1969-05-30
NL6908301A NL6908301A (enExample) 1968-06-01 1969-05-30
BE733911D BE733911A (enExample) 1968-06-01 1969-05-30
AT517269A AT290723B (de) 1969-05-06 1969-05-30 Verfahren zur Gewinnung von Polyhydroxyphenylchromonen aus Silybum marianum Gaertn
GB1257956D GB1257956A (enExample) 1968-06-01 1969-05-30
ES367906A ES367906A1 (es) 1969-05-06 1969-05-31 Procedimiento para la obtencion de polihidroxifenil - cre- monas estabilizantes de la estructura celular y el citometa-bolismo.
OA53625A OA03888A (fr) 1968-06-01 1969-06-02 Procédé d'obtenton de polydroxyphénylchromones présentant la propriété de stabiliser la structure cellulaire et le cytométabolisme.
FR6918088A FR2010026A1 (enExample) 1968-06-01 1969-06-02
IE510/70A IE34110B1 (en) 1969-05-06 1970-04-21 Process for obtaining polyhydroxyphenyl-chromones
IL34381A IL34381A (en) 1969-05-06 1970-04-24 Process for obtaining polyhydroxy-phenylchromones which stabilise the cell structure and the cytometabolism
YU1129/70A YU37065B (en) 1969-05-06 1970-05-04 Process for obtaining polyhydroxypheyl chromanes
PL1970140431A PL80560B1 (enExample) 1969-05-06 1970-05-05
CS3099A CS162722B2 (enExample) 1969-05-06 1970-05-05
FI701253A FI50932C (fi) 1969-05-06 1970-05-05 Menetelmä silymariini-ryhmään kuuluvien polyhydroksifenyylikromonien v almistamiseksi, joilla on solurakennetta ja solun aineenvaihduntaa sta biloiva vaikutus ja mahdollisesti silymariinin I erottamiseksi.
NO01710/70A NO130345B (enExample) 1969-05-06 1970-05-05
NLAANVRAGE7908046,A NL177829C (nl) 1968-06-01 1979-11-02 Werkwijze voor het winnen van een of een aantal silymarinen en voor het bereiden van een geneesmiddel dat dit of deze silymarinen bevat en de onder toepassing van deze laatste werkwijze verkregen gevormde geneesmiddelen.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1923082A DE1923082C3 (de) 1969-05-06 1969-05-06 Verfahren zur Gewinnung von Polyhydroxyphenylchromanonen (Silymarin I-IV) und Arzneimittel enthaltend das Polyhydroxyphenylchromanon (Silymarin I-IV = Silymarin I-IV-Gruppe)Gemisch

Publications (3)

Publication Number Publication Date
DE1923082A1 DE1923082A1 (de) 1970-11-19
DE1923082B2 DE1923082B2 (de) 1974-09-19
DE1923082C3 true DE1923082C3 (de) 1985-08-22

Family

ID=5733385

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1923082A Expired DE1923082C3 (de) 1968-06-01 1969-05-06 Verfahren zur Gewinnung von Polyhydroxyphenylchromanonen (Silymarin I-IV) und Arzneimittel enthaltend das Polyhydroxyphenylchromanon (Silymarin I-IV = Silymarin I-IV-Gruppe)Gemisch

Country Status (11)

Country Link
AT (1) AT290723B (enExample)
CH (1) CH541554A (enExample)
CS (1) CS162722B2 (enExample)
DE (1) DE1923082C3 (enExample)
ES (1) ES367906A1 (enExample)
FI (1) FI50932C (enExample)
IE (1) IE34110B1 (enExample)
IL (1) IL34381A (enExample)
NO (1) NO130345B (enExample)
PL (1) PL80560B1 (enExample)
YU (1) YU37065B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2428680C2 (de) * 1974-06-14 1983-02-17 Dr. Madaus & Co, 5000 Köln 1-(2',4',6'-Trihydroxyphenyl)-propandion-(1,2)-Verbindungen, Verfahren zu deren Herstellung und Arzneimittel, die diese Verbindungen enthalten
DE3537656A1 (de) * 1984-11-22 1986-05-22 Dr. Madaus GmbH & Co, 5000 Köln Verfahren zur herstellung von isosilybinfreiem silibinin und arzneimittel, enthaltend silibinin
FR2594691B1 (fr) * 1986-02-24 1990-08-03 Bonne Claude Nouvelles preparations cosmetiques contenant un extrait des fruits de silybum marianum
DE4401902C2 (de) * 1994-01-24 2000-02-03 Madaus Ag Verwendung von Flavolignanen als Adjuvans in der Tumortherapie
EP2959910A1 (de) 2014-06-26 2015-12-30 Bionorica Se Mariendistelextrakt aus Mariendistelfrüchteschalen, Verfahren zur Herstellung und Verwendung
EP4696313A1 (en) 2024-08-13 2026-02-18 WÖRWAG Pharma GmbH & Co.KG Formulation of krill oil and silymarin

Also Published As

Publication number Publication date
CH541554A (de) 1973-09-15
PL80560B1 (enExample) 1975-08-30
YU112970A (en) 1983-04-27
IE34110L (en) 1970-11-06
AT290723B (de) 1971-06-11
ES367906A1 (es) 1971-04-16
CS162722B2 (enExample) 1975-07-15
IL34381A (en) 1973-06-29
NO130345B (enExample) 1974-08-19
IE34110B1 (en) 1975-02-05
YU37065B (en) 1984-08-31
DE1923082A1 (de) 1970-11-19
FI50932B (enExample) 1976-05-31
IL34381A0 (en) 1970-06-17
FI50932C (fi) 1976-09-10
DE1923082B2 (de) 1974-09-19

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Legal Events

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8281 Inventor (new situation)

Free format text: ANTRAG AUF NICHTNENNUNG

C3 Grant after two publication steps (3rd publication)