IE34110L - Extracting polyhydroxyphenyl-chromones - Google Patents

Extracting polyhydroxyphenyl-chromones

Info

Publication number
IE34110L
IE34110L IE700510A IE51070A IE34110L IE 34110 L IE34110 L IE 34110L IE 700510 A IE700510 A IE 700510A IE 51070 A IE51070 A IE 51070A IE 34110 L IE34110 L IE 34110L
Authority
IE
Ireland
Prior art keywords
residue
extracting
silymarin
fatty oils
larger part
Prior art date
Application number
IE700510A
Other versions
IE34110B1 (en
Original Assignee
Madaus & Co Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madaus & Co Dr filed Critical Madaus & Co Dr
Publication of IE34110L publication Critical patent/IE34110L/en
Publication of IE34110B1 publication Critical patent/IE34110B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/40—Separation, e.g. from natural material; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea

Abstract

Preparing polyhydroxyphenylchromones from the dried fruits of Silybum marianum Gaertn by removing the larger part of the fatty oils by submitting the fruit to elevated pressure, pref. in helicoid presses and extracting the residue with ethyl acetate. After removing the solvent, the residue is portioned repeatedly between the phases of a solvent system of aqs. methanol/petrol ether to give a final product contng. 70-80% active components. Crystallisation after treatment with active carbon gives then pure silymarin I. Silymarin is a protecting agent and stabilising agent for intracellular biomembranes where cytometabolism takes place. The process is much shorter and economical than existing ones, by eliminating the larger part of fatty oils before extraction. The process gives a high yield of good purity. [DE1923082B2]
IE510/70A 1969-05-06 1970-04-21 Process for obtaining polyhydroxyphenyl-chromones IE34110B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1923082A DE1923082C3 (en) 1969-05-06 1969-05-06 Process for the production of polyhydroxyphenylchromanones (Silymarin I-IV) and medicaments containing the polyhydroxyphenylchromanone (Silymarin I-IV = Silymarin I-IV group) mixture

Publications (2)

Publication Number Publication Date
IE34110L true IE34110L (en) 1970-11-06
IE34110B1 IE34110B1 (en) 1975-02-05

Family

ID=5733385

Family Applications (1)

Application Number Title Priority Date Filing Date
IE510/70A IE34110B1 (en) 1969-05-06 1970-04-21 Process for obtaining polyhydroxyphenyl-chromones

Country Status (11)

Country Link
AT (1) AT290723B (en)
CH (1) CH541554A (en)
CS (1) CS162722B2 (en)
DE (1) DE1923082C3 (en)
ES (1) ES367906A1 (en)
FI (1) FI50932C (en)
IE (1) IE34110B1 (en)
IL (1) IL34381A (en)
NO (1) NO130345B (en)
PL (1) PL80560B1 (en)
YU (1) YU37065B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2428680C2 (en) * 1974-06-14 1983-02-17 Dr. Madaus & Co, 5000 Köln 1- (2 ', 4', 6'-trihydroxyphenyl) propanedione (1,2) compounds, processes for their preparation and pharmaceuticals containing these compounds
DE3537656A1 (en) * 1984-11-22 1986-05-22 Dr. Madaus GmbH & Co, 5000 Köln METHOD FOR PRODUCING ISOSILYBIN-FREE SILIBININE AND MEDICINAL PRODUCTS CONTAINING SILIBININE
FR2594691B1 (en) * 1986-02-24 1990-08-03 Bonne Claude NEW COSMETIC PREPARATIONS CONTAINING EXTRACT OF SILYBUM MARIANUM FRUITS
DE4401902C2 (en) * 1994-01-24 2000-02-03 Madaus Ag Use of flavolignans as an adjuvant in tumor therapy
EP2959910A1 (en) 2014-06-26 2015-12-30 Bionorica Se Milk thistle extract of fruit shells of Silybum marianum, process of manufacture and use

Also Published As

Publication number Publication date
DE1923082A1 (en) 1970-11-19
NO130345B (en) 1974-08-19
CH541554A (en) 1973-09-15
IL34381A0 (en) 1970-06-17
FI50932B (en) 1976-05-31
IL34381A (en) 1973-06-29
ES367906A1 (en) 1971-04-16
DE1923082B2 (en) 1974-09-19
CS162722B2 (en) 1975-07-15
YU37065B (en) 1984-08-31
DE1923082C3 (en) 1985-08-22
FI50932C (en) 1976-09-10
PL80560B1 (en) 1975-08-30
YU112970A (en) 1983-04-27
AT290723B (en) 1971-06-11
IE34110B1 (en) 1975-02-05

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