RU2000117C1 - Method of licorice dry extract preparing - Google Patents

Abstract

Usage: the invention relates to medicine, namely to the pharmaceutical industry, and relates to a method for producing a dry extract of licorice. The purpose of the invention is to increase the yield of the target product. SUMMARY OF THE INVENTION: extraction of licorice roots and rhizomes at 20-25 ° C and 5.5-5.9 MPa in a sealed container with liquefied ammonia. Next, the micelle is drained and the extract is concentrated by distillation of the extractant with a temperature increase of 5-10 ° C and / or a decrease in pressure. The positive effect is to increase the yield of the product by 12% compared with the prototype.

Description

The invention relates to medicine and can be used to extract medicinal substances from plant materials.

A known method for producing a dry licorice extract by extracting licorice root with an aqueous solution of ammonia, thickening the extract and filtering it.

The disadvantage of this method is the presence of at least traces of toxic extractant in the extract, which requires recrystallization of the target product isolated from the extract, and a low yield of extractives.

The closest to the proposed technical essence and the achieved effect is a method for producing a dry licorice extract by extracting a dry licorice root with a 1% solution of ammonia in a 60-70% aqueous solution of acetone, condensing the extract and filtering it.

This method, in comparison with the previous ones, allows to slightly increase the yield

extractive substances, but also requires recrystallization of the target product due to the presence of at least traces of a toxic extractant in it, and the yield of extractives remains low due to their thermal degradation during distillation of the extractant.

The aim of the invention is to increase the yield of the target product.

The object is achieved in that in the method for producing a dry licorice extract by extracting dry licorice root with ammonia, thickening the extract and filtering it, according to the invention, the extraction is carried out with liquid ammonia.

This allows us to simplify the technology of distillation of the extractant during thickening of the obtained extract, since under normal conditions the extractant exists in the gas phase, which allows the extract to be purified from the extract by holding under normal conditions and to obtain a high quality extract without

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traces of extractant while maintaining the thermolabile target product.

In a preferred embodiment, extraction is carried out at 20-25 ° C and 5.5-5.9 MPa, which corresponds to comfortable working conditions in the room and does not require thermostatting of the extraction tank to ensure the existence of ammonia in a liquefied form, and also allows to obtain the maximum yield of extractive substances.

The method is implemented as follows.

Licorice roots and rhizomes are dried, ground, and then extracted in a sealed container pr 20-25 ° C and 5.5-5.9 MPa. Miscella is drained and thickened with an extract of extract, an extractant, with a temperature increase of 5-10 ° and / or a decrease in pressure. The resulting extract is filtered and sent to isolate the desired product-glycyram or glycyrrhizic acid by known techniques.

Example 1. 200 g of Dry ground licorice root is extracted in an extractor with liquefied ammonia at 20 ° C and 5.5 MPa for 60 minutes. Then the miscella is poured into the evaporator and concentrated by distillation of the extractant at 30 ° C and 5.0 MPa. The resulting dry extract was removed from the evaporator and filtered. Ammonia is distilled into a condenser, where it is liquefied by raising the pressure and lowering the temperature to the initial values, and is reused. After 20 minutes under normal conditions, no trace of the extractant was found in the extract. The filtered extract is sent to isolate glycyrrhizic acid or glyceram from it. which are the target products. Their isolation is carried out according to any

from well-known technologies. The yield of the target product compared with the prototype increased by 12%.

Example 2. The raw material according to example 1

extracted in an extractor with liquefied ammonia at 25 ° C and 5.9 MPa for 60 minutes The miscella is then poured into an evaporator and concentrated by distilling off the solvent by reducing the pressure to 5.5 MPa. The resulting dry extract was removed and filtered, and ammonia was compressed and reused. The amount of glyceram. extracted from the extract by 12.3% more than from the same dose of raw materials by the prototype method.

Example Z. Technological operations were carried out as in example 2, but when the extract was thickened, the temperature was raised to 35 ° C. The output of glyceram increased by 11.8%.

Thus, the proposed method allows to increase the yield of extractives and the target product from the extract due to milder conditions of extraction and thickening of the extract, which allows you to save heat-labile target product, and the extract does not contain toxic extractant.

Claims (3)

SUMMARY OF THE INVENTION 1. A method for producing a dry licorice extract by extracting dried licorice root with ammonia, thickening the extract and filtering it, characterized in that, in order to increase the yield of the target product, the extraction is carried out with liquid ammonia. 2. A method according to claim 1, characterized in that the extraction is carried out at a temperature of 20-25 ° C and a pressure of 5.5-5.9 MPa. 3. The method according to claim 1, characterized in that. that thickening is carried out by increasing the temperature by 5-10 ° C and / or reducing the pressure.