DE1815332C3 - Verfahren zur Bindung von Proteinen, Polypeptiden, Peptiden oder Derivaten derselben an in Wasser unlösliche Polymere mit einer oder mehreren Hydroxyl- oder primären oder sekundären Aminogruppen - Google Patents

Verfahren zur Bindung von Proteinen, Polypeptiden, Peptiden oder Derivaten derselben an in Wasser unlösliche Polymere mit einer oder mehreren Hydroxyl- oder primären oder sekundären Aminogruppen

Info

Publication number
DE1815332C3
DE1815332C3 DE1815332A DE1815332A DE1815332C3 DE 1815332 C3 DE1815332 C3 DE 1815332C3 DE 1815332 A DE1815332 A DE 1815332A DE 1815332 A DE1815332 A DE 1815332A DE 1815332 C3 DE1815332 C3 DE 1815332C3
Authority
DE
Germany
Prior art keywords
cyanate
water
polymer
groups
primary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1815332A
Other languages
German (de)
English (en)
Other versions
DE1815332A1 (de
DE1815332B2 (de
Inventor
Stig Hjalmar Johannes Dr. Akerstroem
Sven Lennart Kagedal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
Pharmacia AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia AB filed Critical Pharmacia AB
Publication of DE1815332A1 publication Critical patent/DE1815332A1/de
Publication of DE1815332B2 publication Critical patent/DE1815332B2/de
Application granted granted Critical
Publication of DE1815332C3 publication Critical patent/DE1815332C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C261/00—Derivatives of cyanic acid
    • C07C261/02—Cyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/06—Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/087—Acrylic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/813—Carrier is a saccharide
    • Y10S530/814—Cellulose or derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/862—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgE or IgD

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE1815332A 1967-12-20 1968-12-18 Verfahren zur Bindung von Proteinen, Polypeptiden, Peptiden oder Derivaten derselben an in Wasser unlösliche Polymere mit einer oder mehreren Hydroxyl- oder primären oder sekundären Aminogruppen Expired DE1815332C3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE17469/67A SE343210B (forum.php) 1967-12-20 1967-12-20

Publications (3)

Publication Number Publication Date
DE1815332A1 DE1815332A1 (de) 1969-07-24
DE1815332B2 DE1815332B2 (de) 1979-08-02
DE1815332C3 true DE1815332C3 (de) 1980-04-03

Family

ID=20303654

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1815332A Expired DE1815332C3 (de) 1967-12-20 1968-12-18 Verfahren zur Bindung von Proteinen, Polypeptiden, Peptiden oder Derivaten derselben an in Wasser unlösliche Polymere mit einer oder mehreren Hydroxyl- oder primären oder sekundären Aminogruppen

Country Status (10)

Country Link
US (1) US3788948A (forum.php)
JP (1) JPS4928031B1 (forum.php)
BE (1) BE725872A (forum.php)
CH (1) CH503707A (forum.php)
DE (1) DE1815332C3 (forum.php)
FR (1) FR1595332A (forum.php)
GB (1) GB1247896A (forum.php)
IT (1) IT959324B (forum.php)
NL (1) NL6818410A (forum.php)
SE (1) SE343210B (forum.php)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3980772A (en) * 1969-12-02 1976-09-14 Baxter Laboratories, Inc. Methods of dissolving blood clots and the like with streptokinase chemically bonded to a carbohydrate matrix
CA1042600A (en) * 1972-05-03 1978-11-14 Louis L. Wood Crosslinked hydrophilic polyurethane foams
DE2322533C2 (de) * 1972-11-06 1986-08-28 Pharmacia AB, Uppsala Verfahren zum Binden von Immunoglobulin und Hilfsmittel zur Durchführung des Verfahrens
CA1023287A (en) * 1972-12-08 1977-12-27 Boehringer Mannheim G.M.B.H. Process for the preparation of carrier-bound proteins
US3925344A (en) * 1973-04-11 1975-12-09 Community Blood Council Plasma protein substitute
US3876501A (en) * 1973-05-17 1975-04-08 Baxter Laboratories Inc Binding enzymes to activated water-soluble carbohydrates
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US3949064A (en) * 1973-10-26 1976-04-06 Baxter Laboratories, Inc. Method of detecting antigens or antibodies
CH594367A5 (forum.php) * 1974-05-17 1978-01-13 Brenner Beat Max
US4046633A (en) * 1974-07-01 1977-09-06 University Of Utah Direct renin assay system and method
US3963691A (en) * 1974-10-07 1976-06-15 Merck & Co., Inc. Synthetic antigens of luteinizing hormone releasing hormone
US4001401A (en) * 1975-02-02 1977-01-04 Alza Corporation Blood substitute and blood plasma expander comprising polyhemoglobin
US4009264A (en) * 1975-03-03 1977-02-22 Meito Sangyo Kabushiki Kaisha Complexes of polysaccharides or derivatives thereof with reduced glutathione and process for preparing said complexes
US4046513A (en) * 1976-06-30 1977-09-06 Miles Laboratories, Inc. Printed reagent test devices and method of making same
US4197220A (en) * 1976-08-27 1980-04-08 California Institute Of Technology Impregnated metal-polymeric functional beads
US4108975A (en) * 1977-03-04 1978-08-22 Becton, Dickinson And Company Radioimmunoassay system
US4140662A (en) * 1977-03-25 1979-02-20 Ortho Diagnostics, Inc. Attachment of proteins to inert particles
GB1604249A (en) * 1977-05-31 1981-12-02 Kolehmainen S Selective measurement of somatic and microbial cells
US4229537A (en) * 1978-02-09 1980-10-21 New York University Preparation of trichloro-s-triazine activated supports for coupling ligands
US4289748A (en) * 1979-05-31 1981-09-15 United States Of America Ultrasensitive enzymatic radioimmunoassay method
SE445116B (sv) * 1979-09-12 1986-06-02 Pharmacia Fine Chemicals Ab Sett att odla celler pa mikroberare med fibronektinytskikt
JPS5670028A (en) * 1979-11-12 1981-06-11 Teijin Ltd Polymer bonding with albumin
US4441943A (en) * 1981-05-18 1984-04-10 Hri Inc. Polypeptides as chemical tagging materials
JPS57190003A (en) * 1981-05-18 1982-11-22 Asahi Chem Ind Co Ltd Wholly porous activated gel
US4560653A (en) * 1983-06-06 1985-12-24 W. R. Grace & Co. Process for preparing L-aspartic acid
US4496689A (en) * 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US4478938A (en) * 1984-03-02 1984-10-23 The Dow Chemical Company Process for crosslinking polyamines
US5206344A (en) * 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
US4766106A (en) * 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4894226A (en) * 1986-11-14 1990-01-16 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polyproline conjugation
US4847325A (en) * 1988-01-20 1989-07-11 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5565519A (en) * 1988-11-21 1996-10-15 Collagen Corporation Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications
US5306500A (en) * 1988-11-21 1994-04-26 Collagen Corporation Method of augmenting tissue with collagen-polymer conjugates
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
CZ277766B6 (en) * 1990-01-04 1993-04-14 Vnii Textilno Biologically active material and process for preparing thereof
US5595732A (en) * 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
DK130991D0 (da) * 1991-07-04 1991-07-04 Immunodex K S Polymere konjugater
US5382657A (en) * 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
US5849301A (en) * 1993-09-22 1998-12-15 Henry M. Jackson Foundation For The Advancement Of Military Medicine Producing immunogenic constructs using soluable carbohydrates activated via organic cyanylating reagents
EP0720485B1 (en) * 1993-09-22 2003-11-19 Henry M. Jackson Foundation For The Advancement Of Military Medicine Method of activating soluble carbohydrate using novel cyanylating reagents for the production of immunogenic constructs
DE122009000055I1 (de) * 1995-03-22 2009-12-31 Jackson H M Found Military Med Herstellung von immunogenen konstrukten unter verwendung von löslichen kohlehydraten, die durch organische cyanylierungs-reagenzien aktiviert wurden
CA2215933C (en) * 1995-03-22 2009-10-13 Andrew Lees Producing immunogenic constructs using soluble carbohydrates activated via organic cyanylating reagents
US6833408B2 (en) * 1995-12-18 2004-12-21 Cohesion Technologies, Inc. Methods for tissue repair using adhesive materials
US6458889B1 (en) 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
DK0876165T3 (da) 1995-12-18 2007-08-06 Angiotech Biomaterials Corp Tværbundne polymersammensætninger og fremgangsmåder til deres fremstilling
US7883693B2 (en) * 1995-12-18 2011-02-08 Angiodevice International Gmbh Compositions and systems for forming crosslinked biomaterials and methods of preparation of use
US6309646B1 (en) 1996-05-09 2001-10-30 The Henry M. Jackson Foundation For The Advancement Of Military Medicine Protein-polysaccharide conjugate vaccines and other immunological reagents prepared using homobifunctional and heterobifunctional vinylsulfones, and processes for preparing the conjugates
ATE364654T1 (de) 1998-08-28 2007-07-15 Amylin Pharmaceuticals Inc Polyamideketten von genauer länge und deren konjugate mit proteinen
DE60331367D1 (de) * 2002-12-30 2010-04-01 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
WO2004060405A2 (en) * 2002-12-30 2004-07-22 Angiotech International Ag Tissue reactive compounds and compositions and uses thereof
BRPI0510477B1 (pt) 2004-04-28 2023-01-17 Angiotech Biomaterials Corporation Método para formar um gel e dispositivo para uso em aplicações médicas
WO2006015365A1 (en) * 2004-07-30 2006-02-09 Mount Sinai School Of Medicine Of New York University Npc1l1 and npc1l1 inhibitors and methods of use thereof
US8303973B2 (en) 2004-09-17 2012-11-06 Angiotech Pharmaceuticals (Us), Inc. Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use

Also Published As

Publication number Publication date
FR1595332A (forum.php) 1970-06-08
SE343210B (forum.php) 1972-03-06
BE725872A (forum.php) 1969-06-20
IT959324B (it) 1973-11-10
DE1815332A1 (de) 1969-07-24
CH503707A (fr) 1971-02-28
JPS4928031B1 (forum.php) 1974-07-23
US3788948A (en) 1974-01-29
GB1247896A (en) 1971-09-29
DE1815332B2 (de) 1979-08-02
NL6818410A (forum.php) 1969-06-24

Similar Documents

Publication Publication Date Title
DE1815332C3 (de) Verfahren zur Bindung von Proteinen, Polypeptiden, Peptiden oder Derivaten derselben an in Wasser unlösliche Polymere mit einer oder mehreren Hydroxyl- oder primären oder sekundären Aminogruppen
DE2319495C2 (de) Verfahren zum selektiven, reversiblen Binden von Biomolekülen an ein Adsorbens in einer chromatographischen Säule
DE2910998A1 (de) Verfahren zur herstellung von gebundenes enzym enthaltenden produkten und deren verwendung
DE2661112C2 (de) Verfahren zur Herstellung eines unlöslichen Trägers
DE2839170C2 (de) Chromatographisches Material
DE2631656C2 (de) Verwendung eines Hydroxysuccinimidoester-Derivats zur Bindung von biologisch aktiven Proteinen aneinander und/oder an flüssige oder feste Trägerstoffe
DE2402809C2 (de) Verfahren zur Herstellung eines mit Bromcyan aktivierten, trockenen hydrophilen polymeren Trägers für biologisch wirksame Verbindungen
DE2516935B2 (de) Mit silanen gepfropfte kieselsaeure und ihre verwendung
DE2805056A1 (de) Aktivierte grundmasse und verfahren zu ihrer herstellung
CH654016A5 (de) Verfahren zur fixierung von biologisch aktivem protein oder von substrat von biologisch aktivem protein an polyamid.
DE2154436C3 (de) Als Partricin-methylester (SPA-S-160) bezeichneter Antibiotikakomplex mit Polyenstruktur
DD143262A1 (de) Verfahren zur herstellung eines polymeren,zur bindung von nucleophilen gruppen aktivierten traegers
DE69522564T2 (de) Alkalibeständiges proteinadsorbens
DE3025226C2 (de) Pterinderivate und ihre Verwendung zur radioimmunologischen Bestimmung von Pterinen
DE1925230C3 (de) Verfahren zur Herstellung des Antibiotikums Streptozotocin
DE2501840C3 (de) Verfahren zur Unlöslichmachung eines Enzyms
DE3889041T2 (de) Herstellung von Immunonähe-Katalysatoren.
DE2925681A1 (de) Verfahren zur reinigung von rohem kallikrein
DE2061009A1 (de) Verfahren zur Fixierung von Polymeren
DE69130530T2 (de) Methode zur bildung eines aminosäurehydantoinderivats unter verwendung eines n-substituierten ketenimins als aktivator
CH624112A5 (forum.php)
DE3022723C2 (forum.php)
DE1445847C3 (de) Cephalosporansäurederivate, deren Salze und Herstellung
DE1770882C3 (de) Natürliche oder synthetische organische, freie Hydroxylgruppen aufweisende Polymere, Verfahren zu deren Herstellung und deren Verwendung
DE1445828C (de) N-(7,2-Thienylacetamidoceph-3-em-3ylmethyl)-pyridinium-4-carboxylat und Verfahren zu dessen Herstellung

Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee