DE1768470A1 - 1,2-O-Isopropylidin-5-O-benzoyl-3-methyl-alpha-D-ribofuranose und Verfahren zu ihrer Herstellung - Google Patents
1,2-O-Isopropylidin-5-O-benzoyl-3-methyl-alpha-D-ribofuranose und Verfahren zu ihrer HerstellungInfo
- Publication number
- DE1768470A1 DE1768470A1 DE19661768470 DE1768470A DE1768470A1 DE 1768470 A1 DE1768470 A1 DE 1768470A1 DE 19661768470 DE19661768470 DE 19661768470 DE 1768470 A DE1768470 A DE 1768470A DE 1768470 A1 DE1768470 A1 DE 1768470A1
- Authority
- DE
- Germany
- Prior art keywords
- benzoyl
- methyl
- preparation
- ribofuranose
- isopropylidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 2
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 235000013311 vegetables Nutrition 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- JCLFHZLOKITRCE-UHFFFAOYSA-N 4-pentoxyphenol Chemical compound CCCCCOC1=CC=C(O)C=C1 JCLFHZLOKITRCE-UHFFFAOYSA-N 0.000 description 1
- 241001122767 Theaceae Species 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- -1 benzoyl-3-ethyl-D-ribofuranose Chemical compound 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50769765A | 1965-11-15 | 1965-11-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1768470A1 true DE1768470A1 (de) | 1971-05-13 |
Family
ID=24019753
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19661768470 Pending DE1768470A1 (de) | 1965-11-15 | 1966-11-14 | 1,2-O-Isopropylidin-5-O-benzoyl-3-methyl-alpha-D-ribofuranose und Verfahren zu ihrer Herstellung |
| DE19661593110 Pending DE1593110A1 (de) | 1965-11-15 | 1966-11-14 | Ribofuranosen und Verfahren zu deren Herstellung |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19661593110 Pending DE1593110A1 (de) | 1965-11-15 | 1966-11-14 | Ribofuranosen und Verfahren zu deren Herstellung |
Country Status (5)
| Country | Link |
|---|---|
| CH (1) | CH490367A (cs) |
| DE (2) | DE1768470A1 (cs) |
| FR (1) | FR1498856A (cs) |
| GB (1) | GB1163102A (cs) |
| NL (1) | NL6616102A (cs) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| EA200601591A1 (ru) | 2000-05-26 | 2007-02-27 | Айденикс (Кайман) Лимитед | Применение рибонуклеозидных соединений для лечения флавивирусных и пестивирусных инфекций |
| US7138376B2 (en) | 2001-09-28 | 2006-11-21 | Idenix Pharmaceuticals, Inc. | Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides |
| JP2005533824A (ja) | 2002-06-28 | 2005-11-10 | イデニクス（ケイマン）リミテツド | フラビウイルス科感染の治療のための２’−ｃ−メチル−３’−ｏ−ｌ−バリンエステルリボフラノシルシチジン |
| US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| CN101172993A (zh) | 2002-06-28 | 2008-05-07 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷 |
| WO2004003000A2 (en) * | 2002-06-28 | 2004-01-08 | Idenix (Cayman) Limited | 1’-, 2'- and 3'- modified nucleoside derivatives for treating flaviviridae infections |
| CN1849142A (zh) | 2002-11-15 | 2006-10-18 | 埃迪尼克斯(开曼)有限公司 | 2′－支链核苷和黄病毒突变 |
| JP5116972B2 (ja) | 2002-12-12 | 2013-01-09 | イデニクス（ケイマン）リミテツド | ２’−分枝ヌクレオシドの製造方法 |
| JP5254033B2 (ja) | 2005-12-23 | 2013-08-07 | イデニク プハルマセウティカルス，インコーポレイテッド | 分岐型ヌクレオシドを調製するための合成中間体の製造方法 |
-
0
- FR FR1498856D patent/FR1498856A/fr not_active Expired
-
1966
- 1966-11-08 GB GB4992366A patent/GB1163102A/en not_active Expired
- 1966-11-14 CH CH1633566A patent/CH490367A/de not_active IP Right Cessation
- 1966-11-14 DE DE19661768470 patent/DE1768470A1/de active Pending
- 1966-11-14 DE DE19661593110 patent/DE1593110A1/de active Pending
- 1966-11-15 NL NL6616102A patent/NL6616102A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR1498856A (cs) | 1968-01-10 |
| DE1593110A1 (de) | 1970-07-16 |
| NL6616102A (cs) | 1967-05-16 |
| CH490367A (de) | 1970-05-15 |
| GB1163102A (en) | 1969-09-04 |
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