GB1163102A - D-Ribofuranose Derivatives - Google Patents

D-Ribofuranose Derivatives

Info

Publication number
GB1163102A
GB1163102A GB4992366A GB4992366A GB1163102A GB 1163102 A GB1163102 A GB 1163102A GB 4992366 A GB4992366 A GB 4992366A GB 4992366 A GB4992366 A GB 4992366A GB 1163102 A GB1163102 A GB 1163102A
Authority
GB
United Kingdom
Prior art keywords
radical
alkyl
acylating
haloaroyloxy
alkoxyaroyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4992366A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1163102A publication Critical patent/GB1163102A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)

Abstract

1,163,102. D - Ribofuranose derivatives. MERCK & CO. Inc. 8 Nov., 1966 [15 Nov., 1965], No. 49923/66. Heading C2C. Novel D-ribofuranose derivatives of the Formulµ I and III where R is a C 1-4 alkyl radical, X is a halogen atom or a hydroxy, C 1-4 alkoxy, alkanoyloxy, aroyloxy, alkoxyaroyloxy, haloaroyloxy or nitrobenzoyloxy radical and each of R<SP>1</SP>, R<SP>11</SP> and R<SP>111</SP> is a hydrogen atom, or an alkanoyl, aroyl, alkoxyaroyl, haloaroyl or nitrobenzoyl radical provided that, in Formula I, when X is an alkanoyloxy, aroyloxy, alkoxyaroyloxy, haloaroyloxy or nitrobenzoyloxy radical R<SP>1</SP>, R<SP>11</SP> and R<SP>111</SP> are not hydrogen atoms, are obtained by treating 5-O-R<SP>1</SP>-1,2-O-alkylidene-D-erythro- 3-pentulofuranoses with C 1-4 alkyl magnesium halides to give compounds of Formula III in which R<SP>11</SP> is a hydrogen atom, and, if desired, converting these to other compounds of the above formulµ by (a) subjecting them to acid alcoholysis to produce C 1-4 -alkyl-5-O-R<SP>1</SP>-3- C 1-4 alkyl-D-ribofuranoses, acylating these and subjecting the acylated products to hydrolysis or halogen replacement reactions, or (b) acylating them, hydrolysing the isopropylidene group and further acylating the products.
GB4992366A 1965-11-15 1966-11-08 D-Ribofuranose Derivatives Expired GB1163102A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50769765A 1965-11-15 1965-11-15

Publications (1)

Publication Number Publication Date
GB1163102A true GB1163102A (en) 1969-09-04

Family

ID=24019753

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4992366A Expired GB1163102A (en) 1965-11-15 1966-11-08 D-Ribofuranose Derivatives

Country Status (5)

Country Link
CH (1) CH490367A (en)
DE (2) DE1768470A1 (en)
FR (1) FR1498856A (en)
GB (1) GB1163102A (en)
NL (1) NL6616102A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004003000A3 (en) * 2002-06-28 2004-11-04 Idenix Cayman Ltd 1’-, 2'- and 3'- modified nucleoside derivatives for treating flaviviridae infections
US7138376B2 (en) 2001-09-28 2006-11-21 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides
US7192936B2 (en) 2002-06-28 2007-03-20 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7625875B2 (en) 2002-06-28 2009-12-01 Idenix Pharmaceuticals, Inc. 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7781576B2 (en) 2005-12-23 2010-08-24 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
US7824851B2 (en) 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
US8299038B2 (en) 2000-05-23 2012-10-30 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus
US8343937B2 (en) 2000-05-26 2013-01-01 Idenix Pharmaceuticals, Inc. Methods and compositions for treating flaviviruses and pestiviruses

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8299038B2 (en) 2000-05-23 2012-10-30 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus
US10758557B2 (en) 2000-05-23 2020-09-01 Idenix Pharmaceuticals Llc Methods and compositions for treating hepatitis C virus
US10363265B2 (en) 2000-05-23 2019-07-30 Idenix Pharmaceuticals Llc Methods and compositions for treating hepatitis C virus
US9968628B2 (en) 2000-05-26 2018-05-15 Idenix Pharmaceuticals Llc Methods and compositions for treating flaviviruses and pestiviruses
US8343937B2 (en) 2000-05-26 2013-01-01 Idenix Pharmaceuticals, Inc. Methods and compositions for treating flaviviruses and pestiviruses
US7138376B2 (en) 2001-09-28 2006-11-21 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides
US7384924B2 (en) 2002-06-28 2008-06-10 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7625875B2 (en) 2002-06-28 2009-12-01 Idenix Pharmaceuticals, Inc. 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7635689B2 (en) 2002-06-28 2009-12-22 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7662798B2 (en) 2002-06-28 2010-02-16 Idenix Pharmaceuticals, Inc. 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7547704B2 (en) 2002-06-28 2009-06-16 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
WO2004003000A3 (en) * 2002-06-28 2004-11-04 Idenix Cayman Ltd 1’-, 2'- and 3'- modified nucleoside derivatives for treating flaviviridae infections
US7365057B2 (en) 2002-06-28 2008-04-29 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flavivridae infections
US7192936B2 (en) 2002-06-28 2007-03-20 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7824851B2 (en) 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
US8674085B2 (en) 2002-11-15 2014-03-18 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
US10525072B2 (en) 2002-11-15 2020-01-07 Idenix Pharmaceuticals Llc 2′-branched nucleosides and flaviviridae mutation
US7781576B2 (en) 2005-12-23 2010-08-24 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides

Also Published As

Publication number Publication date
NL6616102A (en) 1967-05-16
CH490367A (en) 1970-05-15
DE1768470A1 (en) 1971-05-13
FR1498856A (en) 1968-01-10
DE1593110A1 (en) 1970-07-16

Similar Documents

Publication Publication Date Title
AU556761B2 (en) Vector for corne- or brevi-bacterial hosts
GB1163102A (en) D-Ribofuranose Derivatives
GB1451569A (en) 2,7,10,15,18,23-hexamethyltetracosane and process for preparing it
GB1354507A (en) Process for the production of ethers or alcohols
GB1231228A (en)
GB1420052A (en) Dialkyl thionocarbamate method
GB1187825A (en) Ribofuranosyl Derivatives
GB1301816A (en)
GB1142710A (en) p-alkoxy-piperidine-amides
GB1154414A (en) Preparation of 3,17-Disubstituted Androstane Compounds
GB1165060A (en) New N,N-Diglycidyl-Bis-Hydantoinyl Methane Derivatives, Process for their Production, and Use
GB1227692A (en)
GB1355667A (en) Alpha-beta-unsaturated delta-lactones and process for the pre paration
GB1270784A (en) Processes for carrying out chemical reactions initiated by free-radicals using 1,2-diaryl-1,2-dicyano-ethane compounds as radical initiators
GB932325A (en) Estrane derivatives
ES2000304A6 (en) Process for the valorization, in the form of perbrominated products, of underbrominated products produced as solutions
GB1127295A (en) Process for preparing equilin
GB1143930A (en) Process for the preparation of an acid fluoride and of corresponding esters
GB1275283A (en) A-nor steroids
GB1215162A (en) 9,11-oxido-steroids
GB1289918A (en)
GB1227693A (en)
GB1292715A (en) 03-polycarbonalkyl-18-norpregnenes
GB1504134A (en) 2-bromo-6beta-fluoro-pregnane compounds
GB1257564A (en)

Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees