DE1695970C3 - Lincomycin-2-phosphat und Clindamycin-2-phosphat, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel - Google Patents

Lincomycin-2-phosphat und Clindamycin-2-phosphat, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel

Info

Publication number
DE1695970C3
DE1695970C3 DE1695970A DE1695970A DE1695970C3 DE 1695970 C3 DE1695970 C3 DE 1695970C3 DE 1695970 A DE1695970 A DE 1695970A DE 1695970 A DE1695970 A DE 1695970A DE 1695970 C3 DE1695970 C3 DE 1695970C3
Authority
DE
Germany
Prior art keywords
lincomycin
phosphate
water
trityl
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1695970A
Other languages
German (de)
English (en)
Other versions
DE1695970B2 (de
DE1695970A1 (de
Inventor
Donald Joseph Portage Mich. Lamb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of DE1695970A1 publication Critical patent/DE1695970A1/de
Publication of DE1695970B2 publication Critical patent/DE1695970B2/de
Application granted granted Critical
Publication of DE1695970C3 publication Critical patent/DE1695970C3/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C07H15/16—Lincomycin; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrrole Compounds (AREA)
DE1695970A 1966-12-16 1967-12-13 Lincomycin-2-phosphat und Clindamycin-2-phosphat, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel Expired DE1695970C3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60211666A 1966-12-16 1966-12-16

Publications (3)

Publication Number Publication Date
DE1695970A1 DE1695970A1 (de) 1971-05-19
DE1695970B2 DE1695970B2 (de) 1981-05-27
DE1695970C3 true DE1695970C3 (de) 1982-02-25

Family

ID=24410033

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1695970A Expired DE1695970C3 (de) 1966-12-16 1967-12-13 Lincomycin-2-phosphat und Clindamycin-2-phosphat, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel

Country Status (18)

Country Link
US (1) US3487068A (fr)
AT (1) AT285812B (fr)
CH (1) CH509350A (fr)
DE (1) DE1695970C3 (fr)
DK (1) DK141731B (fr)
ES (1) ES347382A1 (fr)
FI (1) FI52459C (fr)
FR (2) FR1561983A (fr)
GB (1) GB1211380A (fr)
GR (1) GR36639B (fr)
IL (1) IL28910A (fr)
MY (1) MY7400034A (fr)
NL (1) NL149503B (fr)
OA (1) OA02551A (fr)
PL (1) PL79277B1 (fr)
SE (1) SE325272B (fr)
SU (1) SU511014A3 (fr)
YU (1) YU33879B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3671647A (en) * 1971-03-24 1972-06-20 Upjohn Co Lincomycin 3-nucleotides and the salts thereof
US3892729A (en) * 1971-06-23 1975-07-01 Upjohn Co 1{40 (Beta-hydroxyethyl)-1{40 -demethyl clindamycin 2-phosphates
GB1465209A (en) * 1973-12-17 1977-02-23 Upjohn Co Clindamycin2-phosphates
US4386079A (en) * 1981-11-23 1983-05-31 The Upjohn Company Method of treating depression
US4621075A (en) * 1984-11-28 1986-11-04 The Procter & Gamble Company Gel-form topical antibiotic compositions
US4895934A (en) * 1988-08-22 1990-01-23 E. I. Du Pont De Nemours And Company Process for the preparation of clindamycin phosphate
US4849515A (en) * 1988-08-22 1989-07-18 E. I. Du Pont De Nemours And Company Clindamycin-2-phosphoryl benzylate
US5182374A (en) * 1990-03-21 1993-01-26 American Cyanamid Company Clindamycin phosphate synthesis
MXPA04001964A (es) * 2001-08-28 2004-06-07 Pharmacia Corp Base libre de clindamicina cristalina.
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
NZ541526A (en) 2003-01-24 2008-03-28 Stiefel Res Australia Pty Ltd Clindamycin phosphate foam
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
PL2206494T3 (pl) 2006-03-31 2016-06-30 Stiefel Res Australia Pty Ltd Spienialny żel zawiesinowy
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
CN103483399B (zh) * 2013-08-27 2016-04-20 河南天方药业股份有限公司 一种克林霉素磷酸酯的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3288780A (en) * 1962-01-30 1966-11-29 Ajinomoto Kk Process for preparing 5'-ribonucleotides
NL126431C (fr) * 1963-02-21 1900-01-01
US3282920A (en) * 1963-03-19 1966-11-01 Asahi Chemical Ind Method for producing 5'-nucleotides
US3338882A (en) * 1965-06-28 1967-08-29 Upjohn Co 2'-and 3'-phosphates of 1-beta-d-arabinofuranosylcytosine

Also Published As

Publication number Publication date
DE1695970B2 (de) 1981-05-27
GB1211380A (en) 1970-11-04
NL149503B (nl) 1976-05-17
DK141731C (fr) 1980-12-22
NL6716856A (fr) 1968-06-17
MY7400034A (en) 1974-12-31
YU33879B (en) 1978-06-30
FR1561983A (fr) 1969-04-04
FI52459B (fr) 1977-05-31
DK141731B (da) 1980-06-02
CH509350A (de) 1971-06-30
IL28910A (en) 1971-08-25
AT285812B (de) 1970-11-10
PL79277B1 (fr) 1975-06-30
YU228467A (en) 1977-12-31
ES347382A1 (es) 1969-01-16
US3487068A (en) 1969-12-30
OA02551A (fr) 1970-05-05
DE1695970A1 (de) 1971-05-19
SU511014A3 (ru) 1976-04-15
FR8429M (fr) 1971-07-08
GR36639B (el) 1969-02-28
FI52459C (fi) 1977-09-12
SE325272B (fr) 1970-06-29

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