DE15782250T1 - Verfahren zur Entfernung von Bakterien aus Blut unter Verwendung einer hohen Durchflussrate - Google Patents
Verfahren zur Entfernung von Bakterien aus Blut unter Verwendung einer hohen Durchflussrate Download PDFInfo
- Publication number
- DE15782250T1 DE15782250T1 DE15782250.3T DE15782250T DE15782250T1 DE 15782250 T1 DE15782250 T1 DE 15782250T1 DE 15782250 T DE15782250 T DE 15782250T DE 15782250 T1 DE15782250 T1 DE 15782250T1
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- Germany
- Prior art keywords
- bacteria
- sample
- adsorption
- subject
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract 54
- 241000894006 Bacteria Species 0.000 title claims abstract 31
- 210000004369 blood Anatomy 0.000 title claims 6
- 239000008280 blood Substances 0.000 title claims 6
- 238000001179 sorption measurement Methods 0.000 claims abstract 17
- 230000001464 adherent effect Effects 0.000 claims abstract 11
- 230000015572 biosynthetic process Effects 0.000 claims abstract 4
- 239000007787 solid Substances 0.000 claims 9
- 239000011324 bead Substances 0.000 claims 8
- 239000000758 substrate Substances 0.000 claims 7
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 6
- 241000588747 Klebsiella pneumoniae Species 0.000 claims 6
- 229960002897 heparin Drugs 0.000 claims 6
- 241000588724 Escherichia coli Species 0.000 claims 5
- 239000003463 adsorbent Substances 0.000 claims 5
- 150000004676 glycans Chemical class 0.000 claims 5
- 229920000669 heparin Polymers 0.000 claims 5
- 229920001282 polysaccharide Polymers 0.000 claims 5
- 239000005017 polysaccharide Substances 0.000 claims 5
- 229920002971 Heparan sulfate Polymers 0.000 claims 4
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 claims 4
- 238000000502 dialysis Methods 0.000 claims 4
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- 229920000642 polymer Polymers 0.000 claims 4
- 241000191967 Staphylococcus aureus Species 0.000 claims 3
- 230000005660 hydrophilic surface Effects 0.000 claims 3
- 241000588626 Acinetobacter baumannii Species 0.000 claims 2
- 108090000204 Dipeptidase 1 Proteins 0.000 claims 2
- 241000194031 Enterococcus faecium Species 0.000 claims 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 2
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- 241000192125 Firmicutes Species 0.000 claims 2
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 2
- 239000004698 Polyethylene Substances 0.000 claims 2
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- 229920002367 Polyisobutene Polymers 0.000 claims 2
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- 102000006635 beta-lactamase Human genes 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 239000000835 fiber Substances 0.000 claims 2
- 239000012510 hollow fiber Substances 0.000 claims 2
- 229960003085 meticillin Drugs 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims 2
- 229920000573 polyethylene Polymers 0.000 claims 2
- 239000004926 polymethyl methacrylate Substances 0.000 claims 2
- 229920001155 polypropylene Polymers 0.000 claims 2
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- 239000004814 polyurethane Substances 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 238000001228 spectrum Methods 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 125000000311 mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 238000000159 protein binding assay Methods 0.000 claims 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 1
- 238000012876 topography Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
- A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3692—Washing or rinsing blood or blood constituents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/26—Synthetic macromolecular compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
- B01J20/28004—Sorbent size or size distribution, e.g. particle size
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
- B01J20/28016—Particle form
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
- B01J20/28023—Fibres or filaments
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3204—Inorganic carriers, supports or substrates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3206—Organic carriers, supports or substrates
- B01J20/3208—Polymeric carriers, supports or substrates
- B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3206—Organic carriers, supports or substrates
- B01J20/3208—Polymeric carriers, supports or substrates
- B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3268—Macromolecular compounds
- B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
- B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3291—Characterised by the shape of the carrier, the coating or the obtained coated product
- B01J20/3293—Coatings on a core, the core being particle or fiber shaped, e.g. encapsulated particles, coated fibers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/0057—Special media to be introduced, removed or treated retained by adsorption
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/20—Pathogenic agents
- A61M2202/203—Bacteria
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
- B01J2220/62—In a cartridge
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Cell Biology (AREA)
- External Artificial Organs (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461984013P | 2014-04-24 | 2014-04-24 | |
| US201461984013P | 2014-04-24 | ||
| PCT/US2015/026340 WO2015164198A1 (en) | 2014-04-24 | 2015-04-17 | Method for removing bacteria from blood using high flow rate |
| EP15782250.3A EP3134146B1 (en) | 2014-04-24 | 2015-04-17 | Method for removing bacteria from blood using high flow rate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE15782250T1 true DE15782250T1 (de) | 2017-08-10 |
Family
ID=54333028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE15782250.3T Pending DE15782250T1 (de) | 2014-04-24 | 2015-04-17 | Verfahren zur Entfernung von Bakterien aus Blut unter Verwendung einer hohen Durchflussrate |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20170035956A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3134146B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP2017513636A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20170020749A (cg-RX-API-DMAC7.html) |
| CN (1) | CN106255520B (cg-RX-API-DMAC7.html) |
| AU (2) | AU2015250107A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112016024569B1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2946294C (cg-RX-API-DMAC7.html) |
| DE (1) | DE15782250T1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2625351T3 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2016013873A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015164198A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007069983A1 (en) | 2005-12-13 | 2007-06-21 | Exthera Ab | Method for extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein from blood |
| EP2509604B1 (en) | 2009-12-01 | 2021-03-17 | ExThera Medical Corporation | Device for removing cytokines from blood with surface immobilized polysaccharides |
| WO2012112724A1 (en) | 2011-02-15 | 2012-08-23 | Exthera Medical, Llc | Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines |
| DK2861273T3 (da) | 2012-06-13 | 2017-11-27 | Exthera Medical Corp | Anvendelse af heparin og kulhydrater til behandling af cancer. |
| JP6648009B2 (ja) | 2013-06-24 | 2020-02-14 | エクステラ・メディカル・コーポレーション | マンノース被覆基材を含有する血液濾過システム |
| CN105705177B (zh) | 2013-11-08 | 2019-10-22 | 艾克塞拉医疗公司 | 使用吸附介质诊断感染性疾病的方法 |
| DE15782250T1 (de) | 2014-04-24 | 2017-08-10 | Exthera Medical Corporation | Verfahren zur Entfernung von Bakterien aus Blut unter Verwendung einer hohen Durchflussrate |
| AU2015321601B2 (en) | 2014-09-22 | 2020-04-23 | Exthera Medical Corporation | Wearable hemoperfusion device |
| US11911551B2 (en) | 2016-03-02 | 2024-02-27 | Exthera Medical Corporation | Method for treating drug intoxication |
| US10786615B2 (en) | 2016-03-02 | 2020-09-29 | Exthera Medical Corporation | Method for treating drug intoxication |
| AU2017272021B2 (en) * | 2016-05-26 | 2021-09-02 | Cytosorbents Corporation | The use of a Hemocompatible porous polymer bead sorbent for removal of Endotoxemia-inducing molecules |
| US20190329188A1 (en) * | 2016-11-29 | 2019-10-31 | Gambro Lundia Ab | Membrane for the adsorption of bacteria |
| EP3388140A1 (en) * | 2017-04-10 | 2018-10-17 | Gambro Lundia AB | Extracorporeal blood circuit |
| US20190105475A1 (en) * | 2017-10-05 | 2019-04-11 | Minnetronix, Inc. | Systems, catheters, and methods for treating along the central nervous system |
| CN112088023B (zh) | 2018-01-05 | 2024-05-14 | 帕斯艾克斯公司 | 用于捕获和去除流体中的疾病物质的装置 |
| KR20220009400A (ko) | 2019-05-16 | 2022-01-24 | 엑스테라 메디컬 코퍼레이션 | 내피 글리코칼릭스 구조의 조절 방법 |
| KR102419508B1 (ko) * | 2020-10-14 | 2022-07-11 | 대전보건대학교 산학협력단 | 신규한 메티실린-내성 황색포도상구균 검출 방법 및 이의 용도 |
| CA3195376A1 (en) * | 2020-11-30 | 2022-06-02 | Lennart Wilhelm LJUNGGREN | Device for binding and separation of at least one component from a body fluid |
| CN114011389B (zh) * | 2021-12-08 | 2023-10-31 | 广州康盛生物科技股份有限公司 | 一种用于脓毒血症的血液净化材料及其制备方法和应用 |
| KR102863574B1 (ko) * | 2022-12-16 | 2025-09-22 | 서울대학교산학협력단 | 병원 내 2차 감염을 감소시키기 위한 혈액관류장치 |
| JPWO2024177096A1 (cg-RX-API-DMAC7.html) | 2023-02-21 | 2024-08-29 | ||
| WO2025117428A1 (en) * | 2023-11-29 | 2025-06-05 | Exthera Medical Corporation | Fluidized bed extracorporeal treatment device |
| CN120437731B (zh) * | 2025-07-09 | 2025-11-04 | 天津泰达洁净材料有限公司 | 一种熔喷pbt非织造布复合滤材及其制备方法与应用 |
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| KR20220009400A (ko) | 2019-05-16 | 2022-01-24 | 엑스테라 메디컬 코퍼레이션 | 내피 글리코칼릭스 구조의 조절 방법 |
| EP4072613A4 (en) | 2019-12-12 | 2024-06-05 | Stavro Medical, Inc. | SYRINGE-BASED SYSTEMS FOR MANUAL EXTRACORPOREAL BLOOD TREATMENT AND BATCH PROCESSING METHODS |
| WO2021119195A1 (en) | 2019-12-12 | 2021-06-17 | Chawla Lakhmir Singh | Extracorporeal blood treatment systems and methods employing batch processing |
| JP2024514111A (ja) | 2021-04-06 | 2024-03-28 | エクスセラ メディカル コーポレイション | 濾過媒体 |
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2015
- 2015-04-17 DE DE15782250.3T patent/DE15782250T1/de active Pending
- 2015-04-17 CN CN201580020663.2A patent/CN106255520B/zh active Active
- 2015-04-17 EP EP15782250.3A patent/EP3134146B1/en active Active
- 2015-04-17 WO PCT/US2015/026340 patent/WO2015164198A1/en not_active Ceased
- 2015-04-17 CA CA2946294A patent/CA2946294C/en active Active
- 2015-04-17 BR BR112016024569-5A patent/BR112016024569B1/pt active IP Right Grant
- 2015-04-17 KR KR1020167032452A patent/KR20170020749A/ko not_active Ceased
- 2015-04-17 AU AU2015250107A patent/AU2015250107A1/en not_active Abandoned
- 2015-04-17 JP JP2016564198A patent/JP2017513636A/ja not_active Withdrawn
- 2015-04-17 ES ES15782250T patent/ES2625351T3/es active Active
- 2015-04-17 MX MX2016013873A patent/MX2016013873A/es unknown
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2016
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2019
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2020
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- 2020-12-01 JP JP2020199557A patent/JP7184864B2/ja active Active
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2022
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2946294C (en) | 2023-03-21 |
| EP3134146A1 (en) | 2017-03-01 |
| BR112016024569A8 (pt) | 2021-06-01 |
| JP7184864B2 (ja) | 2022-12-06 |
| US11844895B2 (en) | 2023-12-19 |
| MX2016013873A (es) | 2017-03-09 |
| AU2015250107A1 (en) | 2016-11-17 |
| AU2020200029B2 (en) | 2022-07-28 |
| CN106255520A (zh) | 2016-12-21 |
| ES2625351T1 (es) | 2017-07-19 |
| EP3134146B1 (en) | 2024-12-25 |
| JP2017513636A (ja) | 2017-06-01 |
| US20200171233A1 (en) | 2020-06-04 |
| BR112016024569A2 (pt) | 2017-08-15 |
| WO2015164198A1 (en) | 2015-10-29 |
| ES2625351T3 (en) | 2025-04-07 |
| KR20170020749A (ko) | 2017-02-24 |
| BR112016024569B1 (pt) | 2023-01-03 |
| EP3134146A4 (en) | 2018-01-10 |
| AU2020200029A1 (en) | 2020-01-30 |
| CN106255520B (zh) | 2022-08-12 |
| CA2946294A1 (en) | 2015-10-29 |
| JP2022125040A (ja) | 2022-08-26 |
| JP2021045573A (ja) | 2021-03-25 |
| US20170035956A1 (en) | 2017-02-09 |
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