ES2625351T1 - Método para eliminar bacterias de la sangre utilizando caudal alto - Google Patents

Método para eliminar bacterias de la sangre utilizando caudal alto Download PDF

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ES2625351T1
ES2625351T1 ES15782250.3T ES15782250T ES2625351T1 ES 2625351 T1 ES2625351 T1 ES 2625351T1 ES 15782250 T ES15782250 T ES 15782250T ES 2625351 T1 ES2625351 T1 ES 2625351T1
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bacteria
sample
adsorption
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group
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Keith Mccrea
Robert Ward
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Exthera Medical Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3692—Washing or rinsing blood or blood constituents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28016—Particle form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28023—Fibres or filaments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3291—Characterised by the shape of the carrier, the coating or the obtained coated product
    • B01J20/3293—Coatings on a core, the core being particle or fiber shaped, e.g. encapsulated particles, coated fibers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/0057—Special media to be introduced, removed or treated retained by adsorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/20—Pathogenic agents
    • A61M2202/203—Bacteria
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/62—In a cartridge

Abstract

Un método ex vivo para eliminar bacterias de una muestra extraída de un sujeto que se sospecha que está infectado con bacterias, comprendiendo el método: poner en contacto una muestra extraída del sujeto con un medio de adsorción para permitir la formación de un complejo adherente, en el que el complejo adherente comprende bacterias y medio de adsorción; y separar la muestra del complejo adherente para producir la muestra con una cantidad reducida de bacterias.

Claims (48)

  1. 5
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    REIVINDICACIONES
    1. Un metodo ex vivo para eliminar bacterias de una muestra extralda de un sujeto que se sospecha que esta infectado con bacterias, comprendiendo el metodo:
    poner en contacto una muestra extralda del sujeto con un medio de adsorcion para permitir la formacion de un complejo adherente, en el que el complejo adherente comprende bacterias y medio de adsorcion; y separar la muestra del complejo adherente para producir la muestra con una cantidad reducida de bacterias.
  2. 2. El metodo de la reivindicacion 1, en el que la muestra se selecciona del grupo que consiste en sangre entera, suero y plasma.
  3. 3. El metodo de la reivindicacion 2, en el que la muestra es sangre entera.
  4. 4. El metodo de la reivindicacion 1, en el que el medio de adsorcion es un sustrato solido de area superficial alta que tiene una superficie hidrofila desprovista de adsorbente polisacarldico.
  5. 5. El metodo de la reivindicacion 4, en el que el sustrato solido comprende una pluralidad de microesferas polimericas rlgidas.
  6. 6. El metodo de la reivindicacion 5, en el que la microesfera polimerica rlgida es un miembro seleccionado del grupo que consiste en poliuretano, polimetilmetacrilato, polietileno o copollmeros de etileno y otros monomeros, polietilen imina, polipropileno y poliisobutileno.
  7. 7. El metodo de la reivindicacion 4, en el que el sustrato solido comprende una o una pluralidad de fibras huecas.
  8. 8. El metodo de la reivindicacion 4, en el que el sustrato solido comprende fibras solidas o hilo tejido fabricado de fibras solidas.
  9. 9. El metodo de la reivindicacion 4, en el que la superficie hidrofila es una superficie cationica.
  10. 10. El metodo de la reivindicacion 1, en el que el medio de adsorcion tiene un area superficial alta como resultado de una superficie o topografla rugosa.
  11. 11. El metodo de la reivindicacion 4, en el que la superficie hidrofila es una superficie con carga neutra.
  12. 12. El metodo de la reivindicacion 1, en el que las bacterias en la muestra se reducen de aproximadamente aproximadamente 99,9 %.
  13. 13. El metodo de la reivindicacion 12, en el que las bacterias en la muestra se reducen de aproximadamente aproximadamente 40 %.
  14. 14. El metodo de la reivindicacion 1, en el que las bacterias son bacterias gram negativas.
  15. 15. El metodo de la reivindicacion 1, en el que las bacterias son bacterias gram positivas.
  16. 16. El metodo de la reivindicacion 1, en el que las bacterias se seleccionan del grupo que consiste en Escherichia coli, Klebsiella pneumoniae, Escherichia coli resistente a carbapenemo, Klebsiella pneumoniae resistente a carbapenemo y Klebsiella pneumoniae productora de betalactamasa de espectro ampliado, Enterococcus faecium, Acinetobacter baumannii y Staphylococcus aureus resistente a meticilina (SARM).
  17. 17. El metodo de la reivindicacion 1, en el que las bacterias se seleccionan del grupo que consiste en Staphylococcus aureus, Staphylococcus aureus resistente a meticilina (SARM) y Escherichia coli.
  18. 18. El metodo de la reivindicacion 1, en el que la muestra tiene un caudal lineal de aproximadamente 8 cm/min a aproximadamente 1000 cm/min.
  19. 19. El metodo de la reivindicacion 1, en el que la muestra tiene un caudal volumetrico de aproximadamente 50 ml/min a aproximadamente 5 l/min.
  20. 20. Un metodo ex vivo para eliminar bacterias de una muestra extralda de un sujeto que se sospecha que esta infectado con bacterias, en el que se sabe que las bacterias tienen una baja afinidad, o ninguna, por sulfato de heparan, comprendiendo el metodo:
    poner en contacto una muestra extralda del sujeto con un medio de adsorcion para permitir la formacion de un complejo adherente, en el que el medio de adsorcion es un sustrato solido de area superficial alta que tiene al
    20 % a 20 % a
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    menos un adsorbente polisacarldico en su superficie; y
    separar la muestra del complejo adherente para producir la muestra con una cantidad reducida de bacterias.
  21. 21. El metodo de la reivindicacion 20, en el que la muestra se selecciona del grupo que consiste en sangre entera, suero y plasma.
  22. 22. El metodo de la reivindicacion 21, en el que la muestra es sangre entera.
  23. 23. El metodo de la reivindicacion 20, en el que el sustrato solido comprende una pluralidad de microesferas polimericas rlgidas.
  24. 24. El metodo de la reivindicacion 20, en el que el complejo adherente comprende bacterias y el medio de adsorcion.
  25. 25. El metodo de la reivindicacion 23, en el que la microesfera polimerica rlgida es un miembro seleccionado del grupo que consiste en poliuretano, polimetilmetacrilato, polietileno o copollmeros de etileno y otros monomeros, polietilen imina, polipropileno y poliisobutileno.
  26. 26. El metodo de la reivindicacion 20, en el que el sustrato solido comprende una o una pluralidad de fibras huecas.
  27. 27. El metodo de la reivindicacion 20, en el que el al menos un absorbente polisacarldico es un miembro seleccionado del grupo que consiste en heparina, heparan sulfato, acido hialuronico, acido sialico, hidratos de carbono con secuencias de manosa y quitosano.
  28. 28. El metodo de la reivindicacion 27, en el que el al menos un absorbente polisacarldico es heparina o heparan sulfato.
  29. 29. El metodo de la reivindicacion 28, en el que el al menos un absorbente polisacarldico es heparina.
  30. 30. El metodo de la reivindicacion 29, en el que las microesferas se recubren con aproximadamente de 0,27 mg a aproximadamente 10 mg de heparina por gramo de microesfera.
  31. 31. El metodo de la reivindicacion 30, en el que la microesfera se recubre con 2+0,5 mg de heparina por gramo de microesfera.
  32. 32. El metodo de la reivindicacion 20, en el que las bacterias en la muestra se reducen de aproximadamente 20 % a aproximadamente 99,9 %.
  33. 33. El metodo de la reivindicacion 20, en el que las bacterias en la muestra se reducen de aproximadamente 20 % a aproximadamente 40 %.
  34. 34. El metodo de la reivindicacion 20, en el que las bacterias en la muestra fracasan en un ensayo de union a heparina in vitro.
  35. 35. El metodo de la reivindicacion 16, en el que las bacterias son bacterias gram negativas.
  36. 36. El metodo de la reivindicacion 16, en el que las bacterias son bacterias gram positivas.
  37. 37. El metodo de la reivindicacion 20, en el que las bacterias se seleccionan del grupo que consiste en Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Enterococcus faecium, Escherichia coli resistente a carbapenemo, Klebsiella pneumoniae resistente a carbapenemo y Klebsiella pneumoniae productora de betalactamasa de espectro ampliado.
  38. 38. El metodo de la reivindicacion 20, en el que la muestra tiene un caudal lineal de aproximadamente 8 cm/min a aproximadamente 1000 cm/min.
  39. 39. El metodo de la reivindicacion 20, en el que la muestra tiene un caudal volumetrico de aproximadamente 50 ml/min a aproximadamente 5 l/min.
  40. 40. Un metodo ex vivo para eliminar bacterias de una muestra extralda de un sujeto que se somete a dialisis, comprendiendo el metodo:
    poner en contacto una muestra extralda del sujeto con un cartucho de adsorcion que comprende medios de adsorcion, en el que el cartucho de adsorcion esta en serie con un cartucho de dialisis para permitir la formacion de un complejo adherente; y
    separar la muestra del complejo adherente para producir la muestra con una cantidad reducida de bacterias.
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  41. 41. El metodo de la reivindicacion 40, en el que la muestra tiene un volumen de sangre total menor de 200 ml.
  42. 42. El metodo de la reivindicacion 40, en el que el cartucho de adsorcion tiene una altura de columna entre 1 cm-50 cm.
  43. 43. El metodo de la reivindicacion 40, en el que el cartucho de adsorcion tiene un diametro de columna entre 1 cm- 50 cm.
  44. 44. El metodo de la reivindicacion 40, en el que el cartucho de adsorcion es proximal al sujeto en comparacion con el cartucho de dialisis.
  45. 45. El metodo de la reivindicacion 40, en el que el cartucho de adsorcion es distal al sujeto en comparacion con el cartucho de dialisis.
  46. 46. El metodo de la reivindicacion 40, en el que el complejo adherente comprende bacterias y medios de adsorcion.
  47. 47. El metodo de la reivindicacion 40, en el que la muestra tiene un caudal lineal de aproximadamente 8 cm/min a aproximadamente 1000 cm/min.
  48. 48. El metodo de la reivindicacion 40, en el que la muestra tiene un caudal volumetrico de aproximadamente 50 ml/min a aproximadamente 5 l/min.
ES15782250.3T 2014-04-24 2015-04-17 Método para eliminar bacterias de la sangre utilizando caudal alto Pending ES2625351T1 (es)

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US201461984013P 2014-04-24 2014-04-24
US201461984013P 2014-04-24
PCT/US2015/026340 WO2015164198A1 (en) 2014-04-24 2015-04-17 Method for removing bacteria from blood using high flow rate

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EP (1) EP3134146A4 (es)
JP (3) JP2017513636A (es)
KR (1) KR20170020749A (es)
CN (1) CN106255520B (es)
AU (2) AU2015250107A1 (es)
BR (1) BR112016024569B1 (es)
CA (1) CA2946294C (es)
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KR20170020749A (ko) 2017-02-24
CA2946294C (en) 2023-03-21
US20200171233A1 (en) 2020-06-04
AU2020200029A1 (en) 2020-01-30
JP2017513636A (ja) 2017-06-01
US11844895B2 (en) 2023-12-19
AU2015250107A1 (en) 2016-11-17
WO2015164198A1 (en) 2015-10-29
JP2021045573A (ja) 2021-03-25
BR112016024569A8 (pt) 2021-06-01
JP7184864B2 (ja) 2022-12-06
CN106255520B (zh) 2022-08-12
EP3134146A1 (en) 2017-03-01
BR112016024569B1 (pt) 2023-01-03
MX2016013873A (es) 2017-03-09
US20170035956A1 (en) 2017-02-09
JP2022125040A (ja) 2022-08-26
BR112016024569A2 (pt) 2017-08-15
AU2020200029B2 (en) 2022-07-28
EP3134146A4 (en) 2018-01-10
DE15782250T1 (de) 2017-08-10

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