DE112012005176B4 - Verfahren zum Synthetisieren von 1-(2-FluorbenzyI)-1H-pyrazolo[3,4-b]pyridin-3-formamidin-hydrochlorid - Google Patents

Verfahren zum Synthetisieren von 1-(2-FluorbenzyI)-1H-pyrazolo[3,4-b]pyridin-3-formamidin-hydrochlorid Download PDF

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Publication number
DE112012005176B4
DE112012005176B4 DE112012005176.9T DE112012005176T DE112012005176B4 DE 112012005176 B4 DE112012005176 B4 DE 112012005176B4 DE 112012005176 T DE112012005176 T DE 112012005176T DE 112012005176 B4 DE112012005176 B4 DE 112012005176B4
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Prior art keywords
compound
pyridine
pyrazolo
reaction
fluorobenzyl
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German (de)
English (en)
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DE112012005176T5 (de
Inventor
Jin Li
Xiaoyu Yang
Jingwei Zhu
Minmin Yang
Xihan Wu
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Pharmablock Sciences (Nanjing) Inc
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Pharmablock Sciences (Nanjing) Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE112012005176.9T 2011-12-12 2012-11-28 Verfahren zum Synthetisieren von 1-(2-FluorbenzyI)-1H-pyrazolo[3,4-b]pyridin-3-formamidin-hydrochlorid Active DE112012005176B4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201110414004.0 2011-12-12
CN201110414004.0A CN102491974B (zh) 2011-12-12 2011-12-12 1-（2-氟苄基）-1H-吡唑并[3，4-b]吡啶-3-甲脒盐酸盐的合成方法
PCT/CN2012/085451 WO2013086935A1 (zh) 2011-12-12 2012-11-28 1-（2-氟苄基）-1H -吡唑并[3，4- b]吡啶-3 -甲脒盐酸盐的合成方法

Publications (2)

Publication Number Publication Date
DE112012005176T5 DE112012005176T5 (de) 2014-08-28
DE112012005176B4 true DE112012005176B4 (de) 2018-10-11

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DE112012005176.9T Active DE112012005176B4 (de) 2011-12-12 2012-11-28 Verfahren zum Synthetisieren von 1-(2-FluorbenzyI)-1H-pyrazolo[3,4-b]pyridin-3-formamidin-hydrochlorid

Country Status (7)

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US (1) US8957210B2 (enExample)
JP (1) JP5791825B2 (enExample)
CN (1) CN102491974B (enExample)
DE (1) DE112012005176B4 (enExample)
IL (1) IL233066B (enExample)
IN (1) IN2014DN05281A (enExample)
WO (1) WO2013086935A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102491974B (zh) 2011-12-12 2013-08-07 南京药石药物研发有限公司 1-（2-氟苄基）-1H-吡唑并[3，4-b]吡啶-3-甲脒盐酸盐的合成方法
CN104086545A (zh) * 2014-07-29 2014-10-08 安徽联创药物化学有限公司 1-(2-氟苄基)-1H-吡唑并[3,4-b]吡啶-3-甲脒盐酸盐的合成方法
CN105237531A (zh) * 2015-10-15 2016-01-13 湖南华腾制药有限公司 一种利奥西呱中间体的制备方法及其中间体化合物
KR20180094965A (ko) 2015-12-14 2018-08-24 아이언우드 파마슈티컬스, 인코포레이티드 위장 괄약근 기능장애의 치료를 위한 sGC 자극제의 용도
WO2018111795A2 (en) 2016-12-13 2018-06-21 Ironwood Pharmaceuticals, Inc. Use of sgc stimulators for the treatment of esophageal motility disorders
US12220414B2 (en) 2018-07-11 2025-02-11 Tisento Therapeutics Inc. Use of sGC stimulators for the treatment of mitochondrial disorders
CN117510403A (zh) * 2022-07-29 2024-02-06 阿里生物新材料（常州）有限公司 一种3-乙基-吡啶-2-甲脒盐酸盐的合成方法
CN115947689B (zh) * 2022-09-23 2025-08-29 湖南华腾制药有限公司 一种连续流微反应器合成利奥西呱中间体的方法
CN117024334A (zh) * 2023-07-20 2023-11-10 重庆医药高等专科学校 一种2-氟-3-羟基吡啶的合成方法

Citations (3)

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Publication number Priority date Publication date Assignee Title
US20020173514A1 (en) 2000-11-22 2002-11-21 Johannes-Peter Stasch Pyridine-substituted pyrazolopyridine derivatives
WO2003095451A1 (de) 2002-05-08 2003-11-20 Bayer Healthcare Ag Carbamat-substituierte pyrazolopyridine
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung

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AR072657A1 (es) * 2008-02-29 2010-09-15 Genentech Inc Compuestos inhibidores de raf y metodos para su uso
CA2742306A1 (en) * 2008-11-03 2010-05-06 Chemocentryx, Inc. Compounds for the treatment of osteoporosis and cancers
CN101648909B (zh) * 2009-09-14 2011-10-05 南京第一农药集团有限公司 一种氯代吡啶在无配体钯催化下制备氰基吡啶的方法
US20110225969A1 (en) 2010-03-19 2011-09-22 Gm Global Technology Operations, Inc. Compressor bypass to exhaust for particulate trap regeneration
ES2549979T3 (es) * 2010-05-26 2015-11-03 Adverio Pharma Gmbh El uso de estimuladores de la sGC, activadores de la sGC, solos y en combinaciones con inhibidores de la PDE5 para el tratamiento de esclerosis sistémica (EcS)
UA107112C2 (uk) * 2010-05-27 2014-11-25 Мерк Шарп Енд Доме Корп. Активатори розчинної гуанілатциклази
EA022375B1 (ru) * 2011-04-22 2015-12-30 Пфайзер Инк. ПРОИЗВОДНЫЕ ПИРАЗОЛОСПИРОКЕТОНОВ ДЛЯ ПРИМЕНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ АЦЕТИЛ-КоА-КАРБОКСИЛАЗ
BR112014005110A2 (pt) * 2011-09-02 2017-04-18 Bayer Ip Gmbh pirimidinas aneladas substituídas e utilização das mesmas
CN102491974B (zh) 2011-12-12 2013-08-07 南京药石药物研发有限公司 1-（2-氟苄基）-1H-吡唑并[3，4-b]吡啶-3-甲脒盐酸盐的合成方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020173514A1 (en) 2000-11-22 2002-11-21 Johannes-Peter Stasch Pyridine-substituted pyrazolopyridine derivatives
WO2003095451A1 (de) 2002-05-08 2003-11-20 Bayer Healthcare Ag Carbamat-substituierte pyrazolopyridine
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung

Also Published As

Publication number Publication date
IL233066B (en) 2019-01-31
CN102491974A (zh) 2012-06-13
IL233066A0 (en) 2014-07-31
IN2014DN05281A (enExample) 2015-04-03
US8957210B2 (en) 2015-02-17
JP2015500248A (ja) 2015-01-05
US20140309425A1 (en) 2014-10-16
DE112012005176T5 (de) 2014-08-28
JP5791825B2 (ja) 2015-10-07
WO2013086935A1 (zh) 2013-06-20
CN102491974B (zh) 2013-08-07

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