DD297915A5 - Neue zusammensetzungen auf der grundlage von imipramin - Google Patents
Neue zusammensetzungen auf der grundlage von imipramin Download PDFInfo
- Publication number
- DD297915A5 DD297915A5 DD90340952A DD34095290A DD297915A5 DD 297915 A5 DD297915 A5 DD 297915A5 DD 90340952 A DD90340952 A DD 90340952A DD 34095290 A DD34095290 A DD 34095290A DD 297915 A5 DD297915 A5 DD 297915A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- cyclodextrin
- imipramine
- derivatives
- pct
- trimipramine
- Prior art date
Links
- BCGWQEUPMDMJNV-UHFFFAOYSA-N imipramine Chemical compound C1CC2=CC=CC=C2N(CCCN(C)C)C2=CC=CC=C21 BCGWQEUPMDMJNV-UHFFFAOYSA-N 0.000 title claims abstract description 17
- 239000000203 mixture Substances 0.000 title claims description 11
- 229920000858 Cyclodextrin Polymers 0.000 claims abstract description 18
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229960004801 imipramine Drugs 0.000 claims abstract description 12
- 150000001875 compounds Chemical class 0.000 claims abstract description 5
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 239000001116 FEMA 4028 Substances 0.000 claims description 6
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 6
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 6
- 229960004853 betadex Drugs 0.000 claims description 6
- 235000019658 bitter taste Nutrition 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 3
- 239000008247 solid mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 10
- ZSCDBOWYZJWBIY-UHFFFAOYSA-N trimipramine Chemical compound C1CC2=CC=CC=C2N(CC(CN(C)C)C)C2=CC=CC=C21 ZSCDBOWYZJWBIY-UHFFFAOYSA-N 0.000 description 10
- 229960002431 trimipramine Drugs 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 3
- 238000001035 drying Methods 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000007493 shaping process Methods 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 230000009967 tasteless effect Effects 0.000 description 2
- 101100440640 Drosophila melanogaster conu gene Proteins 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000012084 conversion product Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- -1 flavorings Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 description 1
- 229940080345 gamma-cyclodextrin Drugs 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 229940041597 tofranil Drugs 0.000 description 1
- 229960002835 trimipramine maleate Drugs 0.000 description 1
- YDGHCKHAXOUQOS-BTJKTKAUSA-N trimipramine maleate Chemical compound [O-]C(=O)\C=C/C([O-])=O.C1CC2=CC=CC=C2[NH+](CC(C[NH+](C)C)C)C2=CC=CC=C21 YDGHCKHAXOUQOS-BTJKTKAUSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Materials For Medical Uses (AREA)
- Filtering Materials (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8906781A FR2647343B1 (fr) | 1989-05-24 | 1989-05-24 | Nouvelle forme pharmaceutique poreuse et sa preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD297915A5 true DD297915A5 (de) | 1992-01-30 |
Family
ID=9381955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD90340952A DD297915A5 (de) | 1989-05-24 | 1990-05-23 | Neue zusammensetzungen auf der grundlage von imipramin |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5244881A (forum.php) |
| EP (2) | EP0399902B1 (forum.php) |
| JP (1) | JP2948271B2 (forum.php) |
| KR (1) | KR0163423B1 (forum.php) |
| AT (2) | ATE83663T1 (forum.php) |
| AU (2) | AU631888B2 (forum.php) |
| CA (2) | CA2017360A1 (forum.php) |
| DD (1) | DD297915A5 (forum.php) |
| DE (2) | DE69000641T2 (forum.php) |
| DK (2) | DK0399902T3 (forum.php) |
| ES (2) | ES2054289T3 (forum.php) |
| FI (1) | FI103712B1 (forum.php) |
| FR (1) | FR2647343B1 (forum.php) |
| GR (1) | GR3006655T3 (forum.php) |
| IE (2) | IE64370B1 (forum.php) |
| IL (2) | IL94460A0 (forum.php) |
| NO (1) | NO180517C (forum.php) |
| NZ (2) | NZ233766A (forum.php) |
| PL (1) | PL285327A1 (forum.php) |
| PT (2) | PT94139B (forum.php) |
| TW (1) | TW257672B (forum.php) |
| WO (1) | WO1990014089A1 (forum.php) |
| YU (1) | YU100790A (forum.php) |
| ZA (2) | ZA903895B (forum.php) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69231457T2 (de) * | 1991-06-21 | 2001-05-23 | Takeda Chemical Industries Ltd | Zyklodextrin-Zusammensetzung enthaltend Fumagillol-Derivate |
| KR100256147B1 (ko) | 1991-12-24 | 2000-08-01 | 오노다 마사요시 | 구강내 붕해성 제제 및 이의 제조방법 |
| GB9318880D0 (en) * | 1993-09-11 | 1993-10-27 | Smithkline Beecham Plc | Pharmaceutical composition |
| CA2190598A1 (en) * | 1994-05-27 | 1995-12-07 | Lawrence John Penkler | Pharmaceutical composition |
| US6471992B1 (en) * | 1997-02-20 | 2002-10-29 | Therics, Inc. | Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same |
| BE1011251A3 (fr) * | 1997-07-03 | 1999-06-01 | Ucb Sa | Compositions pharmaceutiques administrables par voie orale, comprenant une substance active et une cyclodextrine. |
| TW527195B (en) | 1997-10-09 | 2003-04-11 | Ssp Co Ltd | Fast-soluble solid pharmaceutical combinations |
| JP4644364B2 (ja) * | 1998-02-05 | 2011-03-02 | ノバルティス アーゲー | エポシロン組成物 |
| IT1304190B1 (it) * | 1998-12-18 | 2001-03-08 | Euphar Group Srl | Clatrati di deidroepiandrosterone e relative composizionifarmaceutiche |
| US6287603B1 (en) * | 1999-09-16 | 2001-09-11 | Nestec S.A. | Cyclodextrin flavor delivery systems |
| PL212123B1 (pl) | 2002-01-15 | 2012-08-31 | Ucb Farchim Sa | Doustna kompozycja farmaceutyczna |
| US7759506B2 (en) | 2002-02-25 | 2010-07-20 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
| HUP0500134A3 (en) | 2002-02-25 | 2009-12-28 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
| DE10239531A1 (de) * | 2002-08-23 | 2004-03-04 | Gulbins, Erich, Prof. Dr. | Prophylaxe und Therapie von Infektionserkrankungen |
| DE10248314A1 (de) * | 2002-10-16 | 2004-04-29 | Dr. Suwelack Skin & Health Care Ag | Verwendung von Formkörpern zur äußeren Anwendung |
| FR2876910B1 (fr) * | 2004-10-21 | 2007-04-13 | Pierre Fabre Medicament Sa | Complexe comprenant la mequitazine, une cyclodextrine et un agent d'interaction |
| NZ561664A (en) | 2005-02-24 | 2011-02-25 | Diffusion Pharmaceuticals Llc | Trans carotenoids, their synthesis, formulation and uses |
| DE102005041860A1 (de) * | 2005-09-02 | 2007-03-08 | Schering Ag | Nanopartikulärer Einschluss- und Ladungskomplex für pharmazeutische Formulierungen |
| US8293804B2 (en) | 2007-04-13 | 2012-10-23 | Diffusion Pharmaceuticals Llc | Use of bipolar trans carotenoids as a pretreatment and in the treatment of peripheral vascular disease |
| JP2009091309A (ja) * | 2007-10-10 | 2009-04-30 | Japan Organo Co Ltd | バコパモニエラエキスを含有する組成物およびその製造方法ならびに飲食品 |
| EA201070544A1 (ru) | 2007-10-31 | 2010-12-30 | Диффьюжн Фармасьютикалз Ллс | Новый класс терапевтических веществ, усиливающих диффузию низкомолекулярных соединений |
| BRPI0918906A2 (pt) * | 2008-09-05 | 2015-12-01 | Mcneil Ppc Inc | método para a produção de comprimidos de cetirizina |
| US10130689B2 (en) | 2009-06-22 | 2018-11-20 | Diffusion Pharmaceuticals Llc | Diffusion enhancing compounds and their use alone or with thrombolytics |
| US8974822B2 (en) | 2010-06-02 | 2015-03-10 | Diffusion Pharmaceuticals Llc | Oral formulations of bipolar trans carotenoids |
| WO2012037117A1 (en) * | 2010-09-13 | 2012-03-22 | Bev-Rx, Inc. | Aqueous drug delivery system comprising off - flavor masking agent |
| RU2609198C1 (ru) * | 2016-01-25 | 2017-01-30 | Закрытое Акционерное Общество "БИОКОМ" | Твердая лекарственная форма имипрамина немедленного высвобождения и способ ее получения |
| JP7032320B2 (ja) | 2016-03-24 | 2022-03-08 | ディフュージョン・ファーマシューティカルズ・エルエルシー | 癌を処置するための、化学療法及び放射線療法を伴う二極性トランスカロテノイドの使用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5443570B2 (forum.php) * | 1972-10-27 | 1979-12-20 | ||
| IE45770B1 (en) * | 1976-10-06 | 1982-11-17 | Wyeth John & Brother Ltd | Pharmaceutical dosage forms |
| US4165382A (en) * | 1977-10-17 | 1979-08-21 | Jose Pozuelo | Method of pharmacologically treating schizophrenia with alpha-methyl-para-tyrosine |
| US4284555A (en) * | 1979-04-27 | 1981-08-18 | Schering Corporation | 7-Chloro-8(substituted amino carbonyloxy)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
| US4349472A (en) * | 1979-04-27 | 1982-09-14 | Schering Corporation | (S)-8(1-Adamantanecarbonyloxy)-7-chloro-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine |
| US4477378A (en) * | 1980-02-05 | 1984-10-16 | Schering Corp. | Esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
| WO1986003198A1 (en) * | 1984-11-27 | 1986-06-05 | Dainippon Pharmaceutical Co., Ltd. | 2-(1-piperazinyl)-4-substituted phenylquinoline derivatives, process for their preparation, and medicinal composition containing same |
| GB8506792D0 (en) * | 1985-03-15 | 1985-04-17 | Janssen Pharmaceutica Nv | Derivatives of y-cyclodextrin |
| GB8613688D0 (en) * | 1986-06-05 | 1986-07-09 | Euro Celtique Sa | Pharmaceutical composition |
-
1989
- 1989-05-24 FR FR8906781A patent/FR2647343B1/fr not_active Expired - Fee Related
-
1990
- 1990-05-21 ZA ZA903895A patent/ZA903895B/xx unknown
- 1990-05-21 IE IE182190A patent/IE64370B1/en not_active IP Right Cessation
- 1990-05-21 IL IL94460A patent/IL94460A0/xx unknown
- 1990-05-21 IL IL9445990A patent/IL94459A/en not_active IP Right Cessation
- 1990-05-22 EP EP90401369A patent/EP0399902B1/fr not_active Expired - Lifetime
- 1990-05-22 DE DE9090401370T patent/DE69000641T2/de not_active Expired - Fee Related
- 1990-05-22 AU AU57433/90A patent/AU631888B2/en not_active Ceased
- 1990-05-22 ES ES90401370T patent/ES2054289T3/es not_active Expired - Lifetime
- 1990-05-22 AT AT90401370T patent/ATE83663T1/de not_active IP Right Cessation
- 1990-05-22 US US07/776,344 patent/US5244881A/en not_active Expired - Fee Related
- 1990-05-22 DK DK90401369.5T patent/DK0399902T3/da active
- 1990-05-22 DE DE90401369T patent/DE69005359T2/de not_active Expired - Lifetime
- 1990-05-22 DK DK90401370.3T patent/DK0399903T3/da active
- 1990-05-22 ES ES90401369T patent/ES2062437T3/es not_active Expired - Lifetime
- 1990-05-22 NZ NZ233766A patent/NZ233766A/xx unknown
- 1990-05-22 AT AT90401369T patent/ATE98867T1/de not_active IP Right Cessation
- 1990-05-22 AU AU55828/90A patent/AU623779B2/en not_active Ceased
- 1990-05-22 WO PCT/FR1990/000359 patent/WO1990014089A1/fr unknown
- 1990-05-22 KR KR1019900007369A patent/KR0163423B1/ko not_active Expired - Fee Related
- 1990-05-22 EP EP90401370A patent/EP0399903B1/fr not_active Expired - Lifetime
- 1990-05-23 ZA ZA903978A patent/ZA903978B/xx unknown
- 1990-05-23 CA CA002017360A patent/CA2017360A1/fr not_active Abandoned
- 1990-05-23 NO NO902280A patent/NO180517C/no unknown
- 1990-05-23 DD DD90340952A patent/DD297915A5/de not_active IP Right Cessation
- 1990-05-23 PT PT94139A patent/PT94139B/pt not_active IP Right Cessation
- 1990-05-23 YU YU01007/90A patent/YU100790A/xx unknown
- 1990-05-23 CA CA002017355A patent/CA2017355A1/fr not_active Abandoned
- 1990-05-23 IE IE186290A patent/IE63317B1/en not_active IP Right Cessation
- 1990-05-23 JP JP2131437A patent/JP2948271B2/ja not_active Expired - Lifetime
- 1990-05-23 FI FI902553A patent/FI103712B1/fi not_active IP Right Cessation
- 1990-05-23 NZ NZ233784A patent/NZ233784A/xx unknown
- 1990-05-23 PT PT94138A patent/PT94138B/pt not_active IP Right Cessation
- 1990-05-24 PL PL28532790A patent/PL285327A1/xx unknown
- 1990-05-30 TW TW079104379A patent/TW257672B/zh active
-
1992
- 1992-12-24 GR GR920401770T patent/GR3006655T3/el unknown
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