DD292000A5 - Pyrimidinyl-piperazinyl-alkylazolderivate mit anxiolitischer und/oder beruhigender aktivitaet - Google Patents

Pyrimidinyl-piperazinyl-alkylazolderivate mit anxiolitischer und/oder beruhigender aktivitaet Download PDF

Info

Publication number
DD292000A5
DD292000A5 DD90337677A DD33767790A DD292000A5 DD 292000 A5 DD292000 A5 DD 292000A5 DD 90337677 A DD90337677 A DD 90337677A DD 33767790 A DD33767790 A DD 33767790A DD 292000 A5 DD292000 A5 DD 292000A5
Authority
DD
German Democratic Republic
Prior art keywords
radical
general formula
piperazinyl
pyrimidinyl
butyl
Prior art date
Application number
DD90337677A
Other languages
German (de)
English (en)
Inventor
Augusto C Pinol
Jordi F Constansa
Juan P Corominas
Original Assignee
������������@���@��K@������k�K@�Kk��
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ������������@���@��K@������k�K@�Kk�� filed Critical ������������@���@��K@������k�K@�Kk��
Publication of DD292000A5 publication Critical patent/DD292000A5/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DD90337677A 1989-02-09 1990-02-08 Pyrimidinyl-piperazinyl-alkylazolderivate mit anxiolitischer und/oder beruhigender aktivitaet DD292000A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8901700A FR2642759B1 (fr) 1989-02-09 1989-02-09 Derives de pyrimidyl-piperazinyl-alkyl azoles avec activite anxiolytique et/ou tranquillisante

Publications (1)

Publication Number Publication Date
DD292000A5 true DD292000A5 (de) 1991-07-18

Family

ID=9378642

Family Applications (1)

Application Number Title Priority Date Filing Date
DD90337677A DD292000A5 (de) 1989-02-09 1990-02-08 Pyrimidinyl-piperazinyl-alkylazolderivate mit anxiolitischer und/oder beruhigender aktivitaet

Country Status (18)

Country Link
US (1) US5128343A (ru)
EP (1) EP0382637B1 (ru)
JP (1) JP2521170B2 (ru)
KR (1) KR950000779B1 (ru)
AT (1) ATE92059T1 (ru)
AU (1) AU623734B2 (ru)
CA (1) CA2009480A1 (ru)
DD (1) DD292000A5 (ru)
DE (1) DE69002341T2 (ru)
DK (1) DK0382637T3 (ru)
ES (1) ES2021941A6 (ru)
FR (1) FR2642759B1 (ru)
HU (1) HU204817B (ru)
NO (1) NO176880C (ru)
PT (1) PT93095B (ru)
RU (1) RU2071474C1 (ru)
YU (1) YU48071B (ru)
ZA (1) ZA90929B (ru)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5219855A (en) * 1988-01-29 1993-06-15 Mitsubishi Kasei Corporation Anxiolytic drug
FR2654621B1 (fr) * 1989-11-22 1994-09-23 Esteve Labor Dr Inhibition du syndrome d'abstinence.
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
US5681956A (en) * 1990-12-28 1997-10-28 Neurogen Corporation 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
US5646281A (en) * 1990-12-28 1997-07-08 Neurogen Corporation Certain 4-piperidino- and piperazinomethyl-2-phenyl imidazole derivatives; dopamine receptor subtype specific ligands
FR2671972B1 (fr) * 1991-01-25 1995-03-03 Esteve Labor Dr Utilisation de derives 1-h-azole-(omega-(4-(2-pyrimidinyl)-1-piperazinyl)-alkyl) pour la preparation de medicaments destines au traitement des troubles des fonctions cognitives.
FR2673628B1 (fr) * 1991-03-07 1993-07-09 Esteve Labor Dr Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles.
FR2701260B1 (fr) * 1993-02-05 1995-05-05 Esteve Labor Dr Dérivés de 2-[4-(4-azolylbutyl)-1-pipérazinyl]-5-hydroxypyrimidine, leur préparation et leur application en tant que médicaments.
FR2705098B1 (fr) * 1993-05-10 1995-08-04 Esteve Labor Dr Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) .
ES2099031B1 (es) * 1995-05-31 1997-12-01 Esteve Labor Dr Nuevos polimorfos de diclorhidrato de lesopitron y sus formas hidratadas, procedimientos de preparacion y composiciones que los contienen.
FR2763950B1 (fr) 1997-06-02 2002-09-20 Esteve Labor Dr 2- {4- [4-(4,5-dichloro-2-methylimidazol-1-yl)butyl] -1- piperazinyl }-5-fluoropyrimidine, sa preparation et son utilisation therapeutique
ES2125206B1 (es) * 1997-07-21 1999-11-16 Esteve Labor Dr Derivados de acil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos.
US6166205A (en) * 1998-09-02 2000-12-26 Neurogen Corporation 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands
US7332494B2 (en) 2000-08-14 2008-02-19 Janssen Pharmaceutica, N.V. Method for treating allergies using substituted pyrazoles
ES2261463T3 (es) 2000-08-14 2006-11-16 Ortho-Mcneil Pharmaceutical, Inc. Pirazoles sustituidos.
ATE324372T1 (de) 2000-08-14 2006-05-15 Ortho Mcneil Pharm Inc Substituierte pyrazole
EP1309591B1 (en) 2000-08-14 2007-01-24 Ortho-McNeil Pharmaceutical, Inc. Substituted pyrazoles
US6369032B1 (en) 2000-09-06 2002-04-09 Ortho-Mcneil Pharmaceutical, Inc. Method for treating allergies
ES2167276B1 (es) * 2000-10-20 2003-04-01 Esteve Labor Dr Nuevos derivados de cianoaril (o cianoheteroaril)-carbonil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487773A (en) * 1981-03-16 1984-12-11 Mead Johnson & Company 1,2,4-Triazol-3-one antidepressants
US4367335A (en) * 1981-08-03 1983-01-04 Mead Johnson & Company Thiazolidinylalkylene piperazine derivatives
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4547499A (en) * 1984-05-10 1985-10-15 The Upjohn Company 2,4-Dihydro-2(omega-aminoalkyl)-1H-[1,2,4]triazolo[3,4-c]benzoxazin-1-one anti-allergy drug compounds, compositions and use
US4675403A (en) * 1985-10-16 1987-06-23 American Home Products Corporation 3-Aminoalkyl derivatives of 5,5-disubstituted hydantoins with psychotropic activity

Also Published As

Publication number Publication date
DK0382637T3 (da) 1993-09-20
DE69002341T2 (de) 1993-12-02
PT93095A (pt) 1990-08-31
RU2071474C1 (ru) 1997-01-10
HUT53100A (en) 1990-09-28
YU25790A (en) 1991-08-31
JP2521170B2 (ja) 1996-07-31
PT93095B (pt) 1995-12-29
AU4919290A (en) 1990-08-16
YU48071B (sh) 1997-01-08
CA2009480A1 (fr) 1990-08-09
KR900012929A (ko) 1990-09-03
NO176880C (no) 1995-06-14
US5128343A (en) 1992-07-07
ES2021941A6 (es) 1991-11-16
HU204817B (en) 1992-02-28
HU900716D0 (en) 1990-04-28
KR950000779B1 (ko) 1995-02-02
FR2642759B1 (fr) 1991-05-17
NO900411D0 (no) 1990-01-29
EP0382637B1 (en) 1993-07-28
ZA90929B (en) 1990-11-28
FR2642759A1 (fr) 1990-08-10
AU623734B2 (en) 1992-05-21
NO900411L (no) 1990-08-10
NO176880B (no) 1995-03-06
DE69002341D1 (de) 1993-09-02
ATE92059T1 (de) 1993-08-15
EP0382637A1 (fr) 1990-08-16
JPH032179A (ja) 1991-01-08

Similar Documents

Publication Publication Date Title
DD292000A5 (de) Pyrimidinyl-piperazinyl-alkylazolderivate mit anxiolitischer und/oder beruhigender aktivitaet
DE69210076T2 (de) Verfahren zur Herstellung von Aryl(oder Heteroaryl)-piperazin-1-butyl-azol-derivaten
DE60121590T2 (de) Pyrazolderivate
DE3788145T2 (de) Piperidinderivate, diese enthaltende pharmazeutische Zusammensetzungen und ihre Verwendung.
DE69132340T2 (de) Kondensiertes pyrazinderivat
DE69529142T2 (de) Tetrahydropyridin-(oder 4-hydroxypiperidin) alkylazole mit sigma und/oder 5ht 1a-rezeptor aktivität
DE3852565T2 (de) Aryl-heteroaryl-karbinol-Derivate mit analgetischer Aktivität.
DE69209679T2 (de) Aryl(oder Heteroaryl)-piperazinyl-alkyl-azol-derivate, ihre Herstellung und ihre Anwendung als Medikament
DE69222595T2 (de) Pyrazolopyrimidone als Wirkstoffe gegen Angina
DE60108900T2 (de) Phenylethenyl- oder phenylethinylderivate als glutamatrezeptorantagonisten
DE69521323T2 (de) Quinoxalindion-nmda rezeptorantagonisten
DE2009020B2 (de) Verfahren zur Herstellung von N-U,l,l-trisubstituierten)-Methylazolen
EP0908456A1 (de) Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
DE2946020A1 (de) Imidazolverbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE69115588T2 (de) Benzimidazolderivate, Verfahren zu deren Herstellung und deren Anwendung als Arzneimittel
DE1946370C3 (de) Substituierte Pyrazol-4-essigsäuren, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
DE60303273T2 (de) Verfahren zur Monomethylierung von stickstoffhaltigen Heterocyclen
DE69203911T2 (de) Antihistaminische und nicht sedierende Benzimidazolderivate, Verfahren zu deren Herstellung und deren Anwendung als Arzneimittel.
DE2834322A1 (de) 4-substituierte pyrazole
DE3889974T2 (de) Pyrazol-Derivate und diese enthaltende Behandlungsmittel für cerebrovaskulare Krankheiten.
DE2023453C3 (de) Pyrazole eckige Klammer auf 3,4-e eckige Klammer zu eckige Klammer auf 1,4 eckige Klammer zu diazepin-7(1H)one
DE1595920B2 (de) 4-(co-Piperazinoalkyl)-pyrazole, ihre Salze und Verfahren zu ihrer Herstellung
DE2052692A1 (de) Isothioharnstoffverbmdungen, ihre Salze mit Sauren, Verfahren zu ihrer Her stellung und ihre Verwendung zur Her stellung von Arzneimitteln
DE1795314A1 (de) N-(Thiazolyl-2)-piperazine
DE69525633T2 (de) Chinoxalinderivate und ihre therapeutische verwendbarkeit