YU48071B - DERIVTI (w/4-(2-PIRIMIDINIL)-1-PIPERAZINIL/ALKIL)-1H-AZOLA I POSTUPAK NJIHOVOG DOBIJANJA - Google Patents
DERIVTI (w/4-(2-PIRIMIDINIL)-1-PIPERAZINIL/ALKIL)-1H-AZOLA I POSTUPAK NJIHOVOG DOBIJANJAInfo
- Publication number
- YU48071B YU48071B YU25790A YU25790A YU48071B YU 48071 B YU48071 B YU 48071B YU 25790 A YU25790 A YU 25790A YU 25790 A YU25790 A YU 25790A YU 48071 B YU48071 B YU 48071B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- radical
- represent
- general formula
- image
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivti w/4-(2-pirimidinil)-1-piperazinil/-alkil/-1H-azola, naznačen time, što odgovaraju opštoj formuli I u kojoj R1 predstavlja atom vodonika ili halogen, n može da ima vrednosti 1 do 6 i Het predstavlja azol ili jedan od njegovih derivata, odabranih od imidazola, indazola, tetrahidroin-dazola, pirazola i pirazolina koji može da se predstavi opštom formulom II u kojoj A i B, uvek različiti, predstavljaju atom ugljenika ili atom azota, isprekidana linija ukazuje eventualno prisustvo dvogube veze izmedju položaja 4 i 5, i R2, R3 i R4, isti ili različiti, koji mogu isto tako da obrazuju deo drugog prstena, aromatskog ili nearomatskog, predstavljaju atom vodonika, halogen, niži alkil radikal, nitro radikal, hidroksi radikal, okso radikal, akoksi radikal, cijano radikal, karboksilni radikal, karboksamido radikal, alkil kar-boksilni radikal, aril radikal ili sustituisani aril, sulfonski radikal, sulfonamido radikal, supstituisan ili ne na amino grupi, amino radikal ili supstituisani amino opšte formule III u kojoj R5 ili R6, isti ili različiti, predstavljaju atom vodonika, alkil radikal, aril radikal, heteroaril radikal, alkenil radikal, alkilkarboksi radikal, arilkarboksi radikal, alkilsulfonil radikal ili arilsulfonil radikal. Prijava sadrži još 1 nezavisan i 1 zavisan zahtev.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8901700A FR2642759B1 (fr) | 1989-02-09 | 1989-02-09 | Derives de pyrimidyl-piperazinyl-alkyl azoles avec activite anxiolytique et/ou tranquillisante |
Publications (2)
Publication Number | Publication Date |
---|---|
YU25790A YU25790A (en) | 1991-08-31 |
YU48071B true YU48071B (sh) | 1997-01-08 |
Family
ID=9378642
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU25790A YU48071B (sh) | 1989-02-09 | 1990-02-09 | DERIVTI (w/4-(2-PIRIMIDINIL)-1-PIPERAZINIL/ALKIL)-1H-AZOLA I POSTUPAK NJIHOVOG DOBIJANJA |
Country Status (18)
Country | Link |
---|---|
US (1) | US5128343A (sh) |
EP (1) | EP0382637B1 (sh) |
JP (1) | JP2521170B2 (sh) |
KR (1) | KR950000779B1 (sh) |
AT (1) | ATE92059T1 (sh) |
AU (1) | AU623734B2 (sh) |
CA (1) | CA2009480A1 (sh) |
DD (1) | DD292000A5 (sh) |
DE (1) | DE69002341T2 (sh) |
DK (1) | DK0382637T3 (sh) |
ES (1) | ES2021941A6 (sh) |
FR (1) | FR2642759B1 (sh) |
HU (1) | HU204817B (sh) |
NO (1) | NO176880C (sh) |
PT (1) | PT93095B (sh) |
RU (1) | RU2071474C1 (sh) |
YU (1) | YU48071B (sh) |
ZA (1) | ZA90929B (sh) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5219855A (en) * | 1988-01-29 | 1993-06-15 | Mitsubishi Kasei Corporation | Anxiolytic drug |
FR2654621B1 (fr) * | 1989-11-22 | 1994-09-23 | Esteve Labor Dr | Inhibition du syndrome d'abstinence. |
FR2672052B1 (fr) * | 1991-01-28 | 1995-05-24 | Esteve Labor Dr | Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments. |
US5681956A (en) * | 1990-12-28 | 1997-10-28 | Neurogen Corporation | 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands |
US5646281A (en) | 1990-12-28 | 1997-07-08 | Neurogen Corporation | Certain 4-piperidino- and piperazinomethyl-2-phenyl imidazole derivatives; dopamine receptor subtype specific ligands |
FR2671972B1 (fr) * | 1991-01-25 | 1995-03-03 | Esteve Labor Dr | Utilisation de derives 1-h-azole-(omega-(4-(2-pyrimidinyl)-1-piperazinyl)-alkyl) pour la preparation de medicaments destines au traitement des troubles des fonctions cognitives. |
FR2673628B1 (fr) * | 1991-03-07 | 1993-07-09 | Esteve Labor Dr | Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles. |
FR2701260B1 (fr) * | 1993-02-05 | 1995-05-05 | Esteve Labor Dr | Dérivés de 2-[4-(4-azolylbutyl)-1-pipérazinyl]-5-hydroxypyrimidine, leur préparation et leur application en tant que médicaments. |
FR2705098B1 (fr) * | 1993-05-10 | 1995-08-04 | Esteve Labor Dr | Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) . |
ES2099031B1 (es) * | 1995-05-31 | 1997-12-01 | Esteve Labor Dr | Nuevos polimorfos de diclorhidrato de lesopitron y sus formas hidratadas, procedimientos de preparacion y composiciones que los contienen. |
FR2763950B1 (fr) * | 1997-06-02 | 2002-09-20 | Esteve Labor Dr | 2- {4- [4-(4,5-dichloro-2-methylimidazol-1-yl)butyl] -1- piperazinyl }-5-fluoropyrimidine, sa preparation et son utilisation therapeutique |
ES2125206B1 (es) | 1997-07-21 | 1999-11-16 | Esteve Labor Dr | Derivados de acil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos. |
US6166205A (en) * | 1998-09-02 | 2000-12-26 | Neurogen Corporation | 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands |
US6953793B2 (en) | 2000-08-14 | 2005-10-11 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted pyrazoles |
US7332494B2 (en) | 2000-08-14 | 2008-02-19 | Janssen Pharmaceutica, N.V. | Method for treating allergies using substituted pyrazoles |
ES2281434T3 (es) | 2000-08-14 | 2007-10-01 | Ortho-Mcneil Pharmaceutical, Inc. | Pirazoles sustituidos. |
AU2001284823B2 (en) | 2000-08-14 | 2006-11-30 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted pyrazoles |
AU2001288714A1 (en) | 2000-09-06 | 2002-03-22 | Ortho-Mcneil Pharmaceutical, Inc. | A method for treating allergies |
ES2167276B1 (es) * | 2000-10-20 | 2003-04-01 | Esteve Labor Dr | Nuevos derivados de cianoaril (o cianoheteroaril)-carbonil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos. |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4487773A (en) * | 1981-03-16 | 1984-12-11 | Mead Johnson & Company | 1,2,4-Triazol-3-one antidepressants |
US4367335A (en) * | 1981-08-03 | 1983-01-04 | Mead Johnson & Company | Thiazolidinylalkylene piperazine derivatives |
DE3321969A1 (de) * | 1983-06-18 | 1984-12-20 | Troponwerke GmbH & Co KG, 5000 Köln | 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
US4547499A (en) * | 1984-05-10 | 1985-10-15 | The Upjohn Company | 2,4-Dihydro-2(omega-aminoalkyl)-1H-[1,2,4]triazolo[3,4-c]benzoxazin-1-one anti-allergy drug compounds, compositions and use |
US4675403A (en) * | 1985-10-16 | 1987-06-23 | American Home Products Corporation | 3-Aminoalkyl derivatives of 5,5-disubstituted hydantoins with psychotropic activity |
-
1989
- 1989-02-09 FR FR8901700A patent/FR2642759B1/fr not_active Expired - Lifetime
-
1990
- 1990-01-29 NO NO900411A patent/NO176880C/no not_active IP Right Cessation
- 1990-02-07 DK DK90400337.3T patent/DK0382637T3/da active
- 1990-02-07 CA CA002009480A patent/CA2009480A1/fr not_active Abandoned
- 1990-02-07 US US07/476,815 patent/US5128343A/en not_active Expired - Fee Related
- 1990-02-07 AU AU49192/90A patent/AU623734B2/en not_active Ceased
- 1990-02-07 AT AT90400337T patent/ATE92059T1/de not_active IP Right Cessation
- 1990-02-07 DE DE90400337T patent/DE69002341T2/de not_active Expired - Fee Related
- 1990-02-07 EP EP90400337A patent/EP0382637B1/en not_active Expired - Lifetime
- 1990-02-08 DD DD90337677A patent/DD292000A5/de unknown
- 1990-02-08 ES ES9000369A patent/ES2021941A6/es not_active Expired - Fee Related
- 1990-02-08 ZA ZA90929A patent/ZA90929B/xx unknown
- 1990-02-08 HU HU90716A patent/HU204817B/hu not_active IP Right Cessation
- 1990-02-08 JP JP2031353A patent/JP2521170B2/ja not_active Expired - Lifetime
- 1990-02-08 PT PT93095A patent/PT93095B/pt not_active IP Right Cessation
- 1990-02-08 KR KR1019900001536A patent/KR950000779B1/ko not_active IP Right Cessation
- 1990-02-09 YU YU25790A patent/YU48071B/sh unknown
-
1991
- 1991-09-18 RU SU915001503A patent/RU2071474C1/ru active
Also Published As
Publication number | Publication date |
---|---|
EP0382637A1 (fr) | 1990-08-16 |
PT93095B (pt) | 1995-12-29 |
ZA90929B (en) | 1990-11-28 |
ES2021941A6 (es) | 1991-11-16 |
KR900012929A (ko) | 1990-09-03 |
US5128343A (en) | 1992-07-07 |
HU900716D0 (en) | 1990-04-28 |
JP2521170B2 (ja) | 1996-07-31 |
NO176880C (no) | 1995-06-14 |
HUT53100A (en) | 1990-09-28 |
DE69002341D1 (de) | 1993-09-02 |
NO900411D0 (no) | 1990-01-29 |
FR2642759B1 (fr) | 1991-05-17 |
DK0382637T3 (da) | 1993-09-20 |
NO176880B (no) | 1995-03-06 |
HU204817B (en) | 1992-02-28 |
KR950000779B1 (ko) | 1995-02-02 |
PT93095A (pt) | 1990-08-31 |
RU2071474C1 (ru) | 1997-01-10 |
ATE92059T1 (de) | 1993-08-15 |
NO900411L (no) | 1990-08-10 |
AU623734B2 (en) | 1992-05-21 |
CA2009480A1 (fr) | 1990-08-09 |
JPH032179A (ja) | 1991-01-08 |
YU25790A (en) | 1991-08-31 |
EP0382637B1 (en) | 1993-07-28 |
DD292000A5 (de) | 1991-07-18 |
FR2642759A1 (fr) | 1990-08-10 |
AU4919290A (en) | 1990-08-16 |
DE69002341T2 (de) | 1993-12-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
YU48071B (sh) | DERIVTI (w/4-(2-PIRIMIDINIL)-1-PIPERAZINIL/ALKIL)-1H-AZOLA I POSTUPAK NJIHOVOG DOBIJANJA | |
KR920018046A (ko) | 아릴(또는 헤테로아릴)피페라지닐부틸아졸 유도체의 제조방법 | |
DE69413542D1 (de) | Perhydroisoindolderivate als substanz p antagonisten | |
ES2167371T3 (es) | Derivados de 1h-3-aril-pirrolidin-2,4-diona espirociclicos substituidos. | |
ATE243697T1 (de) | Substitutierte heterozyclische derivate als crf antagonisten | |
HK1086269A1 (en) | 2-iminopyrrolidine derivatives | |
ATE170856T1 (de) | Indolderivate als thromboxane a2 antagonisten | |
TR199901665T2 (xx) | 4-(3-Heterosiklil-1-Benzoil) Pirazol ve herbisit olarak kullan�mlar� | |
ATE212991T1 (de) | Thiazolidinedione- und oxazolidinedione-derivate mit antidiabetischen, hypolipidämischen und anti hypertensiven eigenschaften | |
KR930004262A (ko) | 메타노안트라센 화합물 | |
ES2078876A1 (es) | Una composicion herbicida a base de fenilpirazol 3-sustituidos. | |
KR910009268A (ko) | 금단 증후군의 억제 | |
DK100190D0 (da) | Hydantoinderivater | |
KR930004234A (ko) | 메타노안트라센 화합물 | |
ATE269862T1 (de) | Substituierte thiazolidinedione und oxazolidinedione mit antidiabetischen, hypolipidämischen und antihypertensiven eigenschaften | |
Rooney et al. | 5-Aryl-4-hydroxy-3 (2H)-isothiazolone 1, 1-dioxide derivatives. Synthesis and carbon-13 NMR characterization | |
DE69403896D1 (de) | 4-amino-2-(hetero)aryl-butanamide verwenbar als 5-ht1a-antagonisten | |
FI942798A0 (fi) | Loracarbef-hydrokloridi-C1-C3-alkoholisolvaatit ja niiden käyttö | |
SE8703254L (sv) | Syntes av 4-amino-1,2-hydrokarbyl-pyrazolidiner via 4-nitroanaloger |