ES2021941A6 - Procedimiento para la preparacion de nuevos derivados de pirimidinil-piperacinil-alquil azoles. - Google Patents
Procedimiento para la preparacion de nuevos derivados de pirimidinil-piperacinil-alquil azoles.Info
- Publication number
- ES2021941A6 ES2021941A6 ES9000369A ES9000369A ES2021941A6 ES 2021941 A6 ES2021941 A6 ES 2021941A6 ES 9000369 A ES9000369 A ES 9000369A ES 9000369 A ES9000369 A ES 9000369A ES 2021941 A6 ES2021941 A6 ES 2021941A6
- Authority
- ES
- Spain
- Prior art keywords
- radical
- represent
- general formula
- image
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE PIRIMIDINIL-PIPERACINIL-ALQUIL AZOLES, PARTICULARMENTE DE LA FORMULA GENERAL (I), EN EL CUAL SE HACE REACCIONAR UN COMPUESTO DE FORMULA GENERAL (IV) CON UN COMPUESTO DE LA FORMULA GENERAL (V) EFECTUANDOSE LA REACCION EN PRESENCIA DE UN SOLVENTE ADECUADO, COMO DIMETILSULFOXIDO, DIMETILFORMAMIDA, UN ALCOHOL, UN HIDROCARBURO, UN ETER O UNA MEZCLA DE ESTOS SOLVENTES, EN PRESENCIA DE UNA BASE TAL COMO HIDROXIDOS, CARBONATOS O BICARBONATOS DE METALES ALCALINOS O SUS MEZCLAS; LA REACCION DE REALIZA A TEMPERATURAS COMPRENDIDAS ENTRE LA TEMPERATURA AMBIENTE Y LA DE REFLUJO DEL SOLVENTE, ESTANDO EL TIEMPO DE REACCION COMPRENDIDO ENTRE 1 Y 24 HORAS; EL SIGNIFICADO DE LOS SUSTITUYENTES EN LAS ANTERIORES FORMULAS Y OTRAS VARIANTES DEL PROCEDIMIENTO SE INDICAN EN LA DESCRIPCION. LOS COMPUESTOS OBTENIDOS SON UTILIZABLES COMO INTERMEDIOS Y PARA PREPARAR MEDICAMENTOS DE ACCION ANSIOLITICA Y/O TRANQUILIZANTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8901700A FR2642759B1 (fr) | 1989-02-09 | 1989-02-09 | Derives de pyrimidyl-piperazinyl-alkyl azoles avec activite anxiolytique et/ou tranquillisante |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2021941A6 true ES2021941A6 (es) | 1991-11-16 |
Family
ID=9378642
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9000369A Expired - Fee Related ES2021941A6 (es) | 1989-02-09 | 1990-02-08 | Procedimiento para la preparacion de nuevos derivados de pirimidinil-piperacinil-alquil azoles. |
Country Status (18)
Country | Link |
---|---|
US (1) | US5128343A (es) |
EP (1) | EP0382637B1 (es) |
JP (1) | JP2521170B2 (es) |
KR (1) | KR950000779B1 (es) |
AT (1) | ATE92059T1 (es) |
AU (1) | AU623734B2 (es) |
CA (1) | CA2009480A1 (es) |
DD (1) | DD292000A5 (es) |
DE (1) | DE69002341T2 (es) |
DK (1) | DK0382637T3 (es) |
ES (1) | ES2021941A6 (es) |
FR (1) | FR2642759B1 (es) |
HU (1) | HU204817B (es) |
NO (1) | NO176880C (es) |
PT (1) | PT93095B (es) |
RU (1) | RU2071474C1 (es) |
YU (1) | YU48071B (es) |
ZA (1) | ZA90929B (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2042385A1 (es) * | 1991-01-28 | 1993-12-01 | Esteve Labor Dr | Procedimientos de preparacion de derivados de aril (o heteroaril)-piperazinil-alquilazoles. |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5219855A (en) * | 1988-01-29 | 1993-06-15 | Mitsubishi Kasei Corporation | Anxiolytic drug |
FR2654621B1 (fr) * | 1989-11-22 | 1994-09-23 | Esteve Labor Dr | Inhibition du syndrome d'abstinence. |
US5681956A (en) * | 1990-12-28 | 1997-10-28 | Neurogen Corporation | 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands |
US5633377A (en) * | 1990-12-28 | 1997-05-27 | Neurogen Corporation | 4-piperidino- and piperazinomethyl-2-cyclohexyl imidazole derivatives; dopamine receptor subtype specific ligands |
FR2671972B1 (fr) * | 1991-01-25 | 1995-03-03 | Esteve Labor Dr | Utilisation de derives 1-h-azole-(omega-(4-(2-pyrimidinyl)-1-piperazinyl)-alkyl) pour la preparation de medicaments destines au traitement des troubles des fonctions cognitives. |
FR2673628B1 (fr) * | 1991-03-07 | 1993-07-09 | Esteve Labor Dr | Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles. |
FR2701260B1 (fr) * | 1993-02-05 | 1995-05-05 | Esteve Labor Dr | Dérivés de 2-[4-(4-azolylbutyl)-1-pipérazinyl]-5-hydroxypyrimidine, leur préparation et leur application en tant que médicaments. |
FR2705098B1 (fr) * | 1993-05-10 | 1995-08-04 | Esteve Labor Dr | Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) . |
ES2099031B1 (es) * | 1995-05-31 | 1997-12-01 | Esteve Labor Dr | Nuevos polimorfos de diclorhidrato de lesopitron y sus formas hidratadas, procedimientos de preparacion y composiciones que los contienen. |
FR2763950B1 (fr) * | 1997-06-02 | 2002-09-20 | Esteve Labor Dr | 2- {4- [4-(4,5-dichloro-2-methylimidazol-1-yl)butyl] -1- piperazinyl }-5-fluoropyrimidine, sa preparation et son utilisation therapeutique |
ES2125206B1 (es) * | 1997-07-21 | 1999-11-16 | Esteve Labor Dr | Derivados de acil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos. |
US6166205A (en) * | 1998-09-02 | 2000-12-26 | Neurogen Corporation | 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands |
EP1309592B9 (en) | 2000-08-14 | 2007-02-28 | Ortho-McNeil Pharmaceutical, Inc. | Substituted pyrazoles |
AU8645401A (en) | 2000-08-14 | 2002-02-25 | Ortho Mcneil Pharm Inc | Substituted pyrazoles |
DK1309591T3 (da) | 2000-08-14 | 2007-03-26 | Ortho Mcneil Pharm Inc | Substituerede pyrazoler |
US7332494B2 (en) | 2000-08-14 | 2008-02-19 | Janssen Pharmaceutica, N.V. | Method for treating allergies using substituted pyrazoles |
MXPA03001960A (es) | 2000-09-06 | 2004-03-18 | Johnson & Johnson | Un metodo para tratar alergias. |
ES2167276B1 (es) * | 2000-10-20 | 2003-04-01 | Esteve Labor Dr | Nuevos derivados de cianoaril (o cianoheteroaril)-carbonil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos. |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4487773A (en) * | 1981-03-16 | 1984-12-11 | Mead Johnson & Company | 1,2,4-Triazol-3-one antidepressants |
US4367335A (en) * | 1981-08-03 | 1983-01-04 | Mead Johnson & Company | Thiazolidinylalkylene piperazine derivatives |
DE3321969A1 (de) * | 1983-06-18 | 1984-12-20 | Troponwerke GmbH & Co KG, 5000 Köln | 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
US4547499A (en) * | 1984-05-10 | 1985-10-15 | The Upjohn Company | 2,4-Dihydro-2(omega-aminoalkyl)-1H-[1,2,4]triazolo[3,4-c]benzoxazin-1-one anti-allergy drug compounds, compositions and use |
US4675403A (en) * | 1985-10-16 | 1987-06-23 | American Home Products Corporation | 3-Aminoalkyl derivatives of 5,5-disubstituted hydantoins with psychotropic activity |
-
1989
- 1989-02-09 FR FR8901700A patent/FR2642759B1/fr not_active Expired - Lifetime
-
1990
- 1990-01-29 NO NO900411A patent/NO176880C/no not_active IP Right Cessation
- 1990-02-07 DE DE90400337T patent/DE69002341T2/de not_active Expired - Fee Related
- 1990-02-07 DK DK90400337.3T patent/DK0382637T3/da active
- 1990-02-07 AU AU49192/90A patent/AU623734B2/en not_active Ceased
- 1990-02-07 US US07/476,815 patent/US5128343A/en not_active Expired - Fee Related
- 1990-02-07 CA CA002009480A patent/CA2009480A1/fr not_active Abandoned
- 1990-02-07 AT AT90400337T patent/ATE92059T1/de not_active IP Right Cessation
- 1990-02-07 EP EP90400337A patent/EP0382637B1/en not_active Expired - Lifetime
- 1990-02-08 JP JP2031353A patent/JP2521170B2/ja not_active Expired - Lifetime
- 1990-02-08 ZA ZA90929A patent/ZA90929B/xx unknown
- 1990-02-08 DD DD90337677A patent/DD292000A5/de unknown
- 1990-02-08 HU HU90716A patent/HU204817B/hu not_active IP Right Cessation
- 1990-02-08 PT PT93095A patent/PT93095B/pt not_active IP Right Cessation
- 1990-02-08 ES ES9000369A patent/ES2021941A6/es not_active Expired - Fee Related
- 1990-02-08 KR KR1019900001536A patent/KR950000779B1/ko not_active IP Right Cessation
- 1990-02-09 YU YU25790A patent/YU48071B/sh unknown
-
1991
- 1991-09-18 RU SU915001503A patent/RU2071474C1/ru active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2042385A1 (es) * | 1991-01-28 | 1993-12-01 | Esteve Labor Dr | Procedimientos de preparacion de derivados de aril (o heteroaril)-piperazinil-alquilazoles. |
Also Published As
Publication number | Publication date |
---|---|
JP2521170B2 (ja) | 1996-07-31 |
ATE92059T1 (de) | 1993-08-15 |
NO176880B (no) | 1995-03-06 |
ZA90929B (en) | 1990-11-28 |
NO900411L (no) | 1990-08-10 |
AU4919290A (en) | 1990-08-16 |
DD292000A5 (de) | 1991-07-18 |
AU623734B2 (en) | 1992-05-21 |
PT93095A (pt) | 1990-08-31 |
CA2009480A1 (fr) | 1990-08-09 |
KR900012929A (ko) | 1990-09-03 |
EP0382637B1 (en) | 1993-07-28 |
YU25790A (en) | 1991-08-31 |
US5128343A (en) | 1992-07-07 |
FR2642759B1 (fr) | 1991-05-17 |
EP0382637A1 (fr) | 1990-08-16 |
DE69002341D1 (de) | 1993-09-02 |
NO900411D0 (no) | 1990-01-29 |
KR950000779B1 (ko) | 1995-02-02 |
YU48071B (sh) | 1997-01-08 |
DE69002341T2 (de) | 1993-12-02 |
RU2071474C1 (ru) | 1997-01-10 |
HU900716D0 (en) | 1990-04-28 |
JPH032179A (ja) | 1991-01-08 |
HU204817B (en) | 1992-02-28 |
DK0382637T3 (da) | 1993-09-20 |
PT93095B (pt) | 1995-12-29 |
NO176880C (no) | 1995-06-14 |
FR2642759A1 (fr) | 1990-08-10 |
HUT53100A (en) | 1990-09-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20040916 |