ES2021941A6 - Procedimiento para la preparacion de nuevos derivados de pirimidinil-piperacinil-alquil azoles. - Google Patents

Procedimiento para la preparacion de nuevos derivados de pirimidinil-piperacinil-alquil azoles.

Info

Publication number
ES2021941A6
ES2021941A6 ES9000369A ES9000369A ES2021941A6 ES 2021941 A6 ES2021941 A6 ES 2021941A6 ES 9000369 A ES9000369 A ES 9000369A ES 9000369 A ES9000369 A ES 9000369A ES 2021941 A6 ES2021941 A6 ES 2021941A6
Authority
ES
Spain
Prior art keywords
radical
represent
general formula
image
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9000369A
Other languages
English (en)
Inventor
Pinol Augusto Colombo
Constansa Jordi Frigola
Corominas Juan Pares
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of ES2021941A6 publication Critical patent/ES2021941A6/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE PIRIMIDINIL-PIPERACINIL-ALQUIL AZOLES, PARTICULARMENTE DE LA FORMULA GENERAL (I), EN EL CUAL SE HACE REACCIONAR UN COMPUESTO DE FORMULA GENERAL (IV) CON UN COMPUESTO DE LA FORMULA GENERAL (V) EFECTUANDOSE LA REACCION EN PRESENCIA DE UN SOLVENTE ADECUADO, COMO DIMETILSULFOXIDO, DIMETILFORMAMIDA, UN ALCOHOL, UN HIDROCARBURO, UN ETER O UNA MEZCLA DE ESTOS SOLVENTES, EN PRESENCIA DE UNA BASE TAL COMO HIDROXIDOS, CARBONATOS O BICARBONATOS DE METALES ALCALINOS O SUS MEZCLAS; LA REACCION DE REALIZA A TEMPERATURAS COMPRENDIDAS ENTRE LA TEMPERATURA AMBIENTE Y LA DE REFLUJO DEL SOLVENTE, ESTANDO EL TIEMPO DE REACCION COMPRENDIDO ENTRE 1 Y 24 HORAS; EL SIGNIFICADO DE LOS SUSTITUYENTES EN LAS ANTERIORES FORMULAS Y OTRAS VARIANTES DEL PROCEDIMIENTO SE INDICAN EN LA DESCRIPCION. LOS COMPUESTOS OBTENIDOS SON UTILIZABLES COMO INTERMEDIOS Y PARA PREPARAR MEDICAMENTOS DE ACCION ANSIOLITICA Y/O TRANQUILIZANTE.
ES9000369A 1989-02-09 1990-02-08 Procedimiento para la preparacion de nuevos derivados de pirimidinil-piperacinil-alquil azoles. Expired - Fee Related ES2021941A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8901700A FR2642759B1 (fr) 1989-02-09 1989-02-09 Derives de pyrimidyl-piperazinyl-alkyl azoles avec activite anxiolytique et/ou tranquillisante

Publications (1)

Publication Number Publication Date
ES2021941A6 true ES2021941A6 (es) 1991-11-16

Family

ID=9378642

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9000369A Expired - Fee Related ES2021941A6 (es) 1989-02-09 1990-02-08 Procedimiento para la preparacion de nuevos derivados de pirimidinil-piperacinil-alquil azoles.

Country Status (18)

Country Link
US (1) US5128343A (es)
EP (1) EP0382637B1 (es)
JP (1) JP2521170B2 (es)
KR (1) KR950000779B1 (es)
AT (1) ATE92059T1 (es)
AU (1) AU623734B2 (es)
CA (1) CA2009480A1 (es)
DD (1) DD292000A5 (es)
DE (1) DE69002341T2 (es)
DK (1) DK0382637T3 (es)
ES (1) ES2021941A6 (es)
FR (1) FR2642759B1 (es)
HU (1) HU204817B (es)
NO (1) NO176880C (es)
PT (1) PT93095B (es)
RU (1) RU2071474C1 (es)
YU (1) YU48071B (es)
ZA (1) ZA90929B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2042385A1 (es) * 1991-01-28 1993-12-01 Esteve Labor Dr Procedimientos de preparacion de derivados de aril (o heteroaril)-piperazinil-alquilazoles.

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5219855A (en) * 1988-01-29 1993-06-15 Mitsubishi Kasei Corporation Anxiolytic drug
FR2654621B1 (fr) * 1989-11-22 1994-09-23 Esteve Labor Dr Inhibition du syndrome d'abstinence.
US5681956A (en) * 1990-12-28 1997-10-28 Neurogen Corporation 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
US5633377A (en) * 1990-12-28 1997-05-27 Neurogen Corporation 4-piperidino- and piperazinomethyl-2-cyclohexyl imidazole derivatives; dopamine receptor subtype specific ligands
FR2671972B1 (fr) * 1991-01-25 1995-03-03 Esteve Labor Dr Utilisation de derives 1-h-azole-(omega-(4-(2-pyrimidinyl)-1-piperazinyl)-alkyl) pour la preparation de medicaments destines au traitement des troubles des fonctions cognitives.
FR2673628B1 (fr) * 1991-03-07 1993-07-09 Esteve Labor Dr Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles.
FR2701260B1 (fr) * 1993-02-05 1995-05-05 Esteve Labor Dr Dérivés de 2-[4-(4-azolylbutyl)-1-pipérazinyl]-5-hydroxypyrimidine, leur préparation et leur application en tant que médicaments.
FR2705098B1 (fr) * 1993-05-10 1995-08-04 Esteve Labor Dr Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) .
ES2099031B1 (es) * 1995-05-31 1997-12-01 Esteve Labor Dr Nuevos polimorfos de diclorhidrato de lesopitron y sus formas hidratadas, procedimientos de preparacion y composiciones que los contienen.
FR2763950B1 (fr) * 1997-06-02 2002-09-20 Esteve Labor Dr 2- {4- [4-(4,5-dichloro-2-methylimidazol-1-yl)butyl] -1- piperazinyl }-5-fluoropyrimidine, sa preparation et son utilisation therapeutique
ES2125206B1 (es) * 1997-07-21 1999-11-16 Esteve Labor Dr Derivados de acil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos.
US6166205A (en) * 1998-09-02 2000-12-26 Neurogen Corporation 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands
EP1309592B9 (en) 2000-08-14 2007-02-28 Ortho-McNeil Pharmaceutical, Inc. Substituted pyrazoles
AU8645401A (en) 2000-08-14 2002-02-25 Ortho Mcneil Pharm Inc Substituted pyrazoles
DK1309591T3 (da) 2000-08-14 2007-03-26 Ortho Mcneil Pharm Inc Substituerede pyrazoler
US7332494B2 (en) 2000-08-14 2008-02-19 Janssen Pharmaceutica, N.V. Method for treating allergies using substituted pyrazoles
MXPA03001960A (es) 2000-09-06 2004-03-18 Johnson & Johnson Un metodo para tratar alergias.
ES2167276B1 (es) * 2000-10-20 2003-04-01 Esteve Labor Dr Nuevos derivados de cianoaril (o cianoheteroaril)-carbonil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487773A (en) * 1981-03-16 1984-12-11 Mead Johnson & Company 1,2,4-Triazol-3-one antidepressants
US4367335A (en) * 1981-08-03 1983-01-04 Mead Johnson & Company Thiazolidinylalkylene piperazine derivatives
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4547499A (en) * 1984-05-10 1985-10-15 The Upjohn Company 2,4-Dihydro-2(omega-aminoalkyl)-1H-[1,2,4]triazolo[3,4-c]benzoxazin-1-one anti-allergy drug compounds, compositions and use
US4675403A (en) * 1985-10-16 1987-06-23 American Home Products Corporation 3-Aminoalkyl derivatives of 5,5-disubstituted hydantoins with psychotropic activity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2042385A1 (es) * 1991-01-28 1993-12-01 Esteve Labor Dr Procedimientos de preparacion de derivados de aril (o heteroaril)-piperazinil-alquilazoles.

Also Published As

Publication number Publication date
JP2521170B2 (ja) 1996-07-31
ATE92059T1 (de) 1993-08-15
NO176880B (no) 1995-03-06
ZA90929B (en) 1990-11-28
NO900411L (no) 1990-08-10
AU4919290A (en) 1990-08-16
DD292000A5 (de) 1991-07-18
AU623734B2 (en) 1992-05-21
PT93095A (pt) 1990-08-31
CA2009480A1 (fr) 1990-08-09
KR900012929A (ko) 1990-09-03
EP0382637B1 (en) 1993-07-28
YU25790A (en) 1991-08-31
US5128343A (en) 1992-07-07
FR2642759B1 (fr) 1991-05-17
EP0382637A1 (fr) 1990-08-16
DE69002341D1 (de) 1993-09-02
NO900411D0 (no) 1990-01-29
KR950000779B1 (ko) 1995-02-02
YU48071B (sh) 1997-01-08
DE69002341T2 (de) 1993-12-02
RU2071474C1 (ru) 1997-01-10
HU900716D0 (en) 1990-04-28
JPH032179A (ja) 1991-01-08
HU204817B (en) 1992-02-28
DK0382637T3 (da) 1993-09-20
PT93095B (pt) 1995-12-29
NO176880C (no) 1995-06-14
FR2642759A1 (fr) 1990-08-10
HUT53100A (en) 1990-09-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040916