DD246318A5 - Neue genetische Sequenzen, die durch die codierten Interferon-Peptide vom Typ I und diese sie produzierende Organismen - Google Patents
Neue genetische Sequenzen, die durch die codierten Interferon-Peptide vom Typ I und diese sie produzierende Organismen Download PDFInfo
- Publication number
- DD246318A5 DD246318A5 DD27937585A DD27937585A DD246318A5 DD 246318 A5 DD246318 A5 DD 246318A5 DD 27937585 A DD27937585 A DD 27937585A DD 27937585 A DD27937585 A DD 27937585A DD 246318 A5 DD246318 A5 DD 246318A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- leu
- ser
- ctg
- arg
- gin
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- 108010014726 Interferon Type I Proteins 0.000 title abstract description 10
- 102000002227 Interferon Type I Human genes 0.000 title abstract description 8
- 230000002068 genetic effect Effects 0.000 title abstract description 3
- 229940047124 interferons Drugs 0.000 claims abstract description 53
- 108091028043 Nucleic acid sequence Proteins 0.000 claims abstract description 27
- 230000014509 gene expression Effects 0.000 claims abstract description 24
- 108090000623 proteins and genes Proteins 0.000 claims description 104
- 108010050904 Interferons Proteins 0.000 claims description 101
- 102000014150 Interferons Human genes 0.000 claims description 94
- 239000012634 fragment Substances 0.000 claims description 90
- 239000013612 plasmid Substances 0.000 claims description 87
- 150000001413 amino acids Chemical class 0.000 claims description 74
- 238000000034 method Methods 0.000 claims description 57
- 229940079322 interferon Drugs 0.000 claims description 56
- 238000002360 preparation method Methods 0.000 claims description 36
- 239000002773 nucleotide Substances 0.000 claims description 29
- 125000003729 nucleotide group Chemical group 0.000 claims description 29
- 108020004999 messenger RNA Proteins 0.000 claims description 25
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- 239000002253 acid Substances 0.000 claims description 15
- 230000008569 process Effects 0.000 claims description 15
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- 235000011056 potassium acetate Nutrition 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 101150059159 proA2 gene Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 239000012857 radioactive material Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 239000012146 running buffer Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229940043230 sarcosine Drugs 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 239000012679 serum free medium Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 108060007951 sulfatase Proteins 0.000 description 1
- 239000010414 supernatant solution Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 108010061238 threonyl-glycine Proteins 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 101150108727 trpl gene Proteins 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 108010073969 valyllysine Proteins 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Plant Pathology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Oncology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3428370A DE3428370A1 (de) | 1984-08-01 | 1984-08-01 | Interferon, genetische sequenzen, die hierfuer codieren, und diese produzierende organismen |
| DE19853505060 DE3505060A1 (de) | 1985-02-14 | 1985-02-14 | Neue interferone vom typ i, genetische sequenzen, die hierfuer codieren, und diese produzierende organismen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD246318A5 true DD246318A5 (de) | 1987-06-03 |
Family
ID=25823496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD27937585A DD246318A5 (de) | 1984-08-01 | 1985-07-29 | Neue genetische Sequenzen, die durch die codierten Interferon-Peptide vom Typ I und diese sie produzierende Organismen |
Country Status (21)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5231176A (en) * | 1984-08-27 | 1993-07-27 | Genentech, Inc. | Distinct family DNA encoding of human leukocyte interferons |
| DE3607835A1 (de) * | 1986-03-10 | 1987-09-24 | Boehringer Ingelheim Int | Hybridinterferone, deren verwendung als arzneimittel und als zwischenprodukte zur herstellung von antikoerpern und deren verwendung sowie verfahren zu ihrer herstellung |
| EP0490233A1 (de) * | 1986-03-10 | 1992-06-17 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Monoclonale Antikörper gegen BgIII-Hybridinterferone, deren Verwendung und Verfahren zu ihrer Herstellung |
| US4863727A (en) * | 1986-04-09 | 1989-09-05 | Cetus Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
| DE3633323A1 (de) * | 1986-10-01 | 1988-04-07 | Boehringer Ingelheim Int | Neue monoklonale antikoerper gegen ifn-omega, verfahren zu ihrer herstellung und deren verwendung zur reinigung sowie zum nachweis von ifn-omega |
| DE3635867A1 (de) * | 1986-10-22 | 1988-05-11 | Boehringer Ingelheim Int | Neue hefeexpressionsvektoren fuer ifn-omega, verfahren zu ihrer herstellung und deren verwendung |
| EP1032428B1 (en) | 1997-11-20 | 2003-06-18 | Vical Incorporated | Treatment of cancer using cytokine-expressing polynucleotides and compositions therefor |
| WO2000040273A2 (en) * | 1999-01-08 | 2000-07-13 | Vical Incorporated | Treatment of viral diseases using an interferon omega expressing polynucleotide |
| KR100938026B1 (ko) * | 2002-03-07 | 2010-01-21 | 아이드게노쉬쉐 테흐니쉐 호흐슐레 쥬리히 | 원핵 숙주에서 재조합 글리코실화 단백질의 생산방법 및생산계 |
| ES2258214T3 (es) | 2002-03-07 | 2006-08-16 | Eidgenossische Technische Hochschule Zurich | Sistema y procedimiento para la produccion de proteinas glucosiladas recombinantes en un huesped procariotico. |
| PL1615945T3 (pl) | 2003-04-09 | 2012-03-30 | Ratiopharm Gmbh | Sposoby glikopegylacji i białka/peptydy wytwarzane tymi sposobami |
| WO2004096852A1 (fr) * | 2003-04-25 | 2004-11-11 | The Institute Of Microbiology And Epidemiology, Academy Of Military Medical Sciemces, Pla | Interferon$g(v) humain recombinant, son procede d'expression et ses utilisations |
| DK1888761T3 (da) | 2005-05-11 | 2010-11-01 | Eth Zuerich | Rekombinante N-glycosylerede proteiner fra prokaryote celler |
| SI2257307T1 (sl) | 2008-02-20 | 2018-09-28 | Glaxosmithkline Biologicals S.A. | Biokonjugati, izdelani iz rekombinantnih N-glikoziliranih proteinov iz prokariontskih celic |
| ES2660227T3 (es) | 2009-11-19 | 2018-03-21 | Glaxosmithkline Biologicals S.A. | Sistema biosintético que produce polisacáridos inmunogénicos en células procariotas |
| US8871491B2 (en) | 2010-05-06 | 2014-10-28 | Glycovaxyn Ag | Capsular gram-positive bacteria bioconjugate vaccines |
| WO2013024158A1 (en) | 2011-08-17 | 2013-02-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combinations of protein kinase inhibitors and interferons or of protein kinase inhibitors and direct acting antivirals for the treatment and the prevention of hcv infection |
| WO2013024156A2 (en) | 2011-08-17 | 2013-02-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combinations of anti-hcv-entry factor antibodies and interferons for the treatment and the prevention of hcv infection |
| WO2014033266A1 (en) | 2012-08-31 | 2014-03-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-sr-bi antibodies for the inhibition of hepatitis c virus infection |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1946283A (en) * | 1982-08-18 | 1984-03-07 | Cetus Corporation | Interferon-alpha 6l |
| CA1217440A (en) * | 1982-08-18 | 1987-02-03 | Michael A. Innis | INTERFERON .alpha. 6L |
| DE3247922A1 (de) * | 1982-12-24 | 1984-06-28 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Dna-sequenzen, deren herstellung, diese sequenzen enthaltende plasmide und deren verwendung zur synthese eukaryotischer genprodukte in prokaryoten |
| ATE47864T1 (de) * | 1984-08-27 | 1989-11-15 | Genentech Inc | Verschiedenartige familie von menschlichen leukozyten-interferonen, zusammensetzungen, die diese enthalten, verfahren zu ihrer herstellung, sowie dna und transfektierte wirte hierfuer. |
-
1985
- 1985-07-24 AT AT85109284T patent/ATE67786T1/de not_active IP Right Cessation
- 1985-07-24 EP EP85109284A patent/EP0170204B1/de not_active Expired - Lifetime
- 1985-07-24 DE DE8585109284T patent/DE3584198D1/de not_active Expired - Lifetime
- 1985-07-29 DD DD27937585A patent/DD246318A5/de not_active IP Right Cessation
- 1985-07-29 AU AU45549/85A patent/AU600653B2/en not_active Expired
- 1985-07-29 GR GR851866A patent/GR851866B/el unknown
- 1985-07-30 IL IL75963A patent/IL75963A/xx not_active IP Right Cessation
- 1985-07-30 DK DK198503463A patent/DK175194B1/da not_active IP Right Cessation
- 1985-07-30 ES ES545725A patent/ES8609475A1/es not_active Expired
- 1985-07-30 NO NO853012A patent/NO177863C/no not_active IP Right Cessation
- 1985-07-31 KR KR1019850005511A patent/KR0136799B1/ko not_active Expired - Lifetime
- 1985-07-31 FI FI852956A patent/FI90667C/fi not_active IP Right Cessation
- 1985-07-31 IE IE190685A patent/IE58942B1/en not_active IP Right Cessation
- 1985-07-31 HU HU852942A patent/HU205779B/hu unknown
- 1985-07-31 JP JP60169667A patent/JP2566909B2/ja not_active Expired - Lifetime
- 1985-07-31 NZ NZ212937A patent/NZ212937A/xx unknown
- 1985-07-31 CA CA000487921A patent/CA1340184C/en not_active Expired - Lifetime
- 1985-08-01 PT PT80901A patent/PT80901B/pt unknown
-
1986
- 1986-02-26 ES ES552431A patent/ES8708013A1/es not_active Expired
-
1992
- 1992-06-26 MX MX9203645A patent/MX9203645A/es unknown
-
1993
- 1993-08-27 JP JP5212933A patent/JP2567195B2/ja not_active Expired - Lifetime
-
1994
- 1994-01-25 BG BG098417A patent/BG60445B2/bg unknown
-
1996
- 1996-10-10 HK HK187896A patent/HK187896A/xx not_active IP Right Cessation
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| Date | Code | Title | Description |
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| ENJ | Ceased due to non-payment of renewal fee |