DD246318A5 - Neue genetische Sequenzen, die durch die codierten Interferon-Peptide vom Typ I und diese sie produzierende Organismen - Google Patents
Neue genetische Sequenzen, die durch die codierten Interferon-Peptide vom Typ I und diese sie produzierende Organismen Download PDFInfo
- Publication number
- DD246318A5 DD246318A5 DD27937585A DD27937585A DD246318A5 DD 246318 A5 DD246318 A5 DD 246318A5 DD 27937585 A DD27937585 A DD 27937585A DD 27937585 A DD27937585 A DD 27937585A DD 246318 A5 DD246318 A5 DD 246318A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- leu
- ser
- ctg
- arg
- gin
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- 108010014726 Interferon Type I Proteins 0.000 title abstract description 10
- 102000002227 Interferon Type I Human genes 0.000 title abstract description 8
- 230000002068 genetic effect Effects 0.000 title abstract description 3
- 229940047124 interferons Drugs 0.000 claims abstract description 53
- 108091028043 Nucleic acid sequence Proteins 0.000 claims abstract description 27
- 230000014509 gene expression Effects 0.000 claims abstract description 24
- 108090000623 proteins and genes Proteins 0.000 claims description 104
- 108010050904 Interferons Proteins 0.000 claims description 101
- 102000014150 Interferons Human genes 0.000 claims description 94
- 239000012634 fragment Substances 0.000 claims description 90
- 239000013612 plasmid Substances 0.000 claims description 87
- 150000001413 amino acids Chemical class 0.000 claims description 74
- 238000000034 method Methods 0.000 claims description 57
- 229940079322 interferon Drugs 0.000 claims description 56
- 238000002360 preparation method Methods 0.000 claims description 36
- 239000002773 nucleotide Substances 0.000 claims description 29
- 125000003729 nucleotide group Chemical group 0.000 claims description 29
- 108020004999 messenger RNA Proteins 0.000 claims description 25
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- 239000002253 acid Substances 0.000 claims description 15
- 230000008569 process Effects 0.000 claims description 15
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- 238000012545 processing Methods 0.000 description 1
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- 239000012857 radioactive material Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
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- 229920002477 rna polymer Polymers 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 108060007951 sulfatase Proteins 0.000 description 1
- 239000010414 supernatant solution Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 108010061238 threonyl-glycine Proteins 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 101150108727 trpl gene Proteins 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 108010073969 valyllysine Proteins 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Plant Pathology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Oncology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Electrotherapy Devices (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3428370A DE3428370A1 (de) | 1984-08-01 | 1984-08-01 | Interferon, genetische sequenzen, die hierfuer codieren, und diese produzierende organismen |
| DE19853505060 DE3505060A1 (de) | 1985-02-14 | 1985-02-14 | Neue interferone vom typ i, genetische sequenzen, die hierfuer codieren, und diese produzierende organismen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD246318A5 true DD246318A5 (de) | 1987-06-03 |
Family
ID=25823496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD27937585A DD246318A5 (de) | 1984-08-01 | 1985-07-29 | Neue genetische Sequenzen, die durch die codierten Interferon-Peptide vom Typ I und diese sie produzierende Organismen |
Country Status (21)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5231176A (en) * | 1984-08-27 | 1993-07-27 | Genentech, Inc. | Distinct family DNA encoding of human leukocyte interferons |
| EP0490233A1 (de) * | 1986-03-10 | 1992-06-17 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Monoclonale Antikörper gegen BgIII-Hybridinterferone, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE3607835A1 (de) * | 1986-03-10 | 1987-09-24 | Boehringer Ingelheim Int | Hybridinterferone, deren verwendung als arzneimittel und als zwischenprodukte zur herstellung von antikoerpern und deren verwendung sowie verfahren zu ihrer herstellung |
| US4863727A (en) * | 1986-04-09 | 1989-09-05 | Cetus Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
| DE3633323A1 (de) * | 1986-10-01 | 1988-04-07 | Boehringer Ingelheim Int | Neue monoklonale antikoerper gegen ifn-omega, verfahren zu ihrer herstellung und deren verwendung zur reinigung sowie zum nachweis von ifn-omega |
| DE3635867A1 (de) * | 1986-10-22 | 1988-05-11 | Boehringer Ingelheim Int | Neue hefeexpressionsvektoren fuer ifn-omega, verfahren zu ihrer herstellung und deren verwendung |
| JP2001523480A (ja) | 1997-11-20 | 2001-11-27 | バイカル インコーポレイテッド | サイトカイン発現ポリヌクレオチドおよびそれらの組成物を用いた癌の処置 |
| WO2000040273A2 (en) * | 1999-01-08 | 2000-07-13 | Vical Incorporated | Treatment of viral diseases using an interferon omega expressing polynucleotide |
| KR100938026B1 (ko) * | 2002-03-07 | 2010-01-21 | 아이드게노쉬쉐 테흐니쉐 호흐슐레 쥬리히 | 원핵 숙주에서 재조합 글리코실화 단백질의 생산방법 및생산계 |
| CA2477794C (en) | 2002-03-07 | 2013-08-20 | Eidgenoessische Technische Hochschule Zuerich | System and method for the production of recombinant glycosylated proteins in a prokaryotic host |
| JP4674702B2 (ja) | 2003-04-09 | 2011-04-20 | バイオジェネリクス エージー | グリコペギレ−ション法およびその方法により生成されたタンパク質／ペプチド |
| WO2004096852A1 (fr) * | 2003-04-25 | 2004-11-11 | The Institute Of Microbiology And Epidemiology, Academy Of Military Medical Sciemces, Pla | Interferon$g(v) humain recombinant, son procede d'expression et ses utilisations |
| CA2607595C (en) | 2005-05-11 | 2018-11-27 | Eth Zuerich | Recombinant n-glycosylated proteins from procaryotic cells |
| PT2257307T (pt) | 2008-02-20 | 2018-10-22 | Glaxosmithkline Biologicals Sa | Bioconjugados preparados a partir de proteínas n-glicosiladas recombinantes de células procariotas |
| TR201803015T4 (tr) | 2009-11-19 | 2018-03-21 | Glaxosmithkline Biologicals Sa | Prokaryotik hücrelerde immünojenik polisakaridler üreten biyosentetik sistem. |
| CN103079591B (zh) | 2010-05-06 | 2017-07-28 | 格林考瓦因有限公司 | 荚膜革兰氏阳性细菌生物缀合物疫苗 |
| WO2013024156A2 (en) | 2011-08-17 | 2013-02-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combinations of anti-hcv-entry factor antibodies and interferons for the treatment and the prevention of hcv infection |
| WO2013024158A1 (en) | 2011-08-17 | 2013-02-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combinations of protein kinase inhibitors and interferons or of protein kinase inhibitors and direct acting antivirals for the treatment and the prevention of hcv infection |
| WO2014033266A1 (en) | 2012-08-31 | 2014-03-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-sr-bi antibodies for the inhibition of hepatitis c virus infection |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1217440A (en) * | 1982-08-18 | 1987-02-03 | Michael A. Innis | INTERFERON .alpha. 6L |
| AU1946283A (en) * | 1982-08-18 | 1984-03-07 | Cetus Corporation | Interferon-alpha 6l |
| DE3247922A1 (de) * | 1982-12-24 | 1984-06-28 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Dna-sequenzen, deren herstellung, diese sequenzen enthaltende plasmide und deren verwendung zur synthese eukaryotischer genprodukte in prokaryoten |
| EP0174143B1 (en) * | 1984-08-27 | 1989-11-08 | Genentech, Inc. | Novel, distinct family of human leukocyte interferons, compositions containing them, methods for their production, and dna and transfected hosts therefor |
-
1985
- 1985-07-24 EP EP85109284A patent/EP0170204B1/de not_active Expired - Lifetime
- 1985-07-24 AT AT85109284T patent/ATE67786T1/de not_active IP Right Cessation
- 1985-07-24 DE DE8585109284T patent/DE3584198D1/de not_active Expired - Lifetime
- 1985-07-29 DD DD27937585A patent/DD246318A5/de not_active IP Right Cessation
- 1985-07-29 AU AU45549/85A patent/AU600653B2/en not_active Expired
- 1985-07-29 GR GR851866A patent/GR851866B/el unknown
- 1985-07-30 ES ES545725A patent/ES8609475A1/es not_active Expired
- 1985-07-30 DK DK198503463A patent/DK175194B1/da not_active IP Right Cessation
- 1985-07-30 NO NO853012A patent/NO177863C/no not_active IP Right Cessation
- 1985-07-30 IL IL75963A patent/IL75963A/xx not_active IP Right Cessation
- 1985-07-31 FI FI852956A patent/FI90667C/fi not_active IP Right Cessation
- 1985-07-31 CA CA000487921A patent/CA1340184C/en not_active Expired - Lifetime
- 1985-07-31 KR KR1019850005511A patent/KR0136799B1/ko not_active Expired - Lifetime
- 1985-07-31 IE IE190685A patent/IE58942B1/en not_active IP Right Cessation
- 1985-07-31 HU HU852942A patent/HU205779B/hu unknown
- 1985-07-31 NZ NZ212937A patent/NZ212937A/xx unknown
- 1985-07-31 JP JP60169667A patent/JP2566909B2/ja not_active Expired - Lifetime
- 1985-08-01 PT PT80901A patent/PT80901B/pt unknown
-
1986
- 1986-02-26 ES ES552431A patent/ES8708013A1/es not_active Expired
-
1992
- 1992-06-26 MX MX9203645A patent/MX9203645A/es unknown
-
1993
- 1993-08-27 JP JP5212933A patent/JP2567195B2/ja not_active Expired - Lifetime
-
1994
- 1994-01-25 BG BG098417A patent/BG60445B2/bg unknown
-
1996
- 1996-10-10 HK HK187896A patent/HK187896A/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
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| ENJ | Ceased due to non-payment of renewal fee |