DD155991A5 - Verfahren zur herstellung von imidazolin-derivaten - Google Patents

Verfahren zur herstellung von imidazolin-derivaten Download PDF

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Publication number
DD155991A5
DD155991A5 DD81227377A DD22737781A DD155991A5 DD 155991 A5 DD155991 A5 DD 155991A5 DD 81227377 A DD81227377 A DD 81227377A DD 22737781 A DD22737781 A DD 22737781A DD 155991 A5 DD155991 A5 DD 155991A5
Authority
DD
German Democratic Republic
Prior art keywords
compound
formula
imidazoline
presynaptic
clonidine
Prior art date
Application number
DD81227377A
Other languages
German (de)
English (en)
Inventor
Christopher B Chapleo
Peter L Myers
Original Assignee
Reckitt & Colmann Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt & Colmann Prod Ltd filed Critical Reckitt & Colmann Prod Ltd
Publication of DD155991A5 publication Critical patent/DD155991A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DD81227377A 1980-02-04 1981-02-02 Verfahren zur herstellung von imidazolin-derivaten DD155991A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8003636 1980-02-04

Publications (1)

Publication Number Publication Date
DD155991A5 true DD155991A5 (de) 1982-07-21

Family

ID=10511105

Family Applications (1)

Application Number Title Priority Date Filing Date
DD81227377A DD155991A5 (de) 1980-02-04 1981-02-02 Verfahren zur herstellung von imidazolin-derivaten

Country Status (26)

Country Link
US (1) US4818764A (no)
EP (1) EP0033655B1 (no)
JP (1) JPS56122378A (no)
AR (1) AR225794A1 (no)
AT (1) ATE7228T1 (no)
AU (1) AU535320B2 (no)
CA (1) CA1156241A (no)
CS (1) CS254956B2 (no)
DD (1) DD155991A5 (no)
DE (1) DE3163256D1 (no)
DK (1) DK160092C (no)
ES (1) ES499034A0 (no)
FI (1) FI67543C (no)
GB (1) GB2068376B (no)
GR (1) GR73853B (no)
HU (1) HU187295B (no)
IE (1) IE51736B1 (no)
IL (1) IL62039A (no)
NO (1) NO154882C (no)
NZ (1) NZ196162A (no)
PH (1) PH16249A (no)
PL (1) PL128368B1 (no)
PT (1) PT72435B (no)
SU (1) SU1128837A3 (no)
ZA (1) ZA81666B (no)
ZW (1) ZW2381A1 (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199469A (en) * 1981-01-30 1984-03-16 Reckitt & Colmann Prod Ltd Benzodioxanyl-2-imidazoline derivatives and pharmaceutical compositions
US4436914A (en) * 1981-08-03 1984-03-13 Kluge Arthur F Benzodioxane-imidazoline compounds as antihypertensives
NZ203680A (en) * 1982-04-17 1985-08-16 Reckitt & Colmann Prod Ltd Imidazolines and pharmaceutical compositions
FR2527208B1 (fr) * 1982-05-19 1985-07-19 Inst Nat Sante Rech Med Isomeres optiques de la (benzodioxanne-1,4 yl-2)-2d-2 imidazoline, leur preparation et leur application en therapeutique
DE3367391D1 (en) * 1982-12-23 1986-12-11 Ici America Inc Chroman compounds
US4634714A (en) * 1983-12-01 1987-01-06 American Home Products Corporation Inhibition of prolactin release by a benzodioxinylimidazoline derivative
US4882343A (en) * 1987-08-28 1989-11-21 G. D. Searle & Co. Biarylalkylimidazole derivatives as anti-depressants
GB8720600D0 (en) * 1987-09-02 1987-10-07 Saad Al Damluji Pharmaceutical compositions
US5240930A (en) * 1987-09-02 1993-08-31 National Research Development Corporation Pharmaceutical compositions for treatment of depression and low blood pressure
FR2698789B1 (fr) * 1992-12-07 1995-03-03 Pf Medicament Utilisation de l'idazoxan et ses dérivés pour la préparation d'un médicament destiné au traitement de la maladie de Parkinson et de son évolution.
FR2700113B1 (fr) * 1993-01-07 1995-03-24 Pf Medicament Utilisation de l'Idazoxan et ses dérivés pour la fabrication de médicaments destinés au traitement des maladies neurodégénératives et en particulier l'évolution de la maladie d'Alzheimer.
US5574059A (en) * 1995-10-27 1996-11-12 Cornell Research Foundation, Inc. Treating disorders mediated by vascular smooth muscle cell proliferation
FR2795727B1 (fr) * 1999-06-29 2001-09-21 Pf Medicament Nouveaux derives benzodioxanne imidazolines fluores, leur preparation et leurs applications en therapeutique
FR2801786B1 (fr) * 1999-12-01 2002-03-01 Fabre Pierre Cosmetique Nouvelles compositions topiques a base d'idazoxan et de cafeine ou de ses derives solubles et leur utilisation comme amincissant et/ou dans le traitement de la cellulite
AU2001243297A1 (en) * 2000-02-29 2001-09-12 Merck Frosst Canada And Co. Method for treating or preventing depression
US7595335B2 (en) * 2003-10-28 2009-09-29 Pierre Fabre Medicament Pharmaceutical composition based on idazoxan, salts, hydrates or polymorphs thereof
FR2861299B1 (fr) * 2003-10-28 2006-01-27 Pf Medicament Compositions pharmaceutiques a base de derives d'idasoxan sous formes polymorphes
US8476307B2 (en) * 2003-10-28 2013-07-02 Pierre Fabre Medicament Pharmaceutical composition based on idazoxan, salts, hydrates or polymorphs thereof
WO2023159145A1 (en) * 2022-02-16 2023-08-24 Terran Biosciences, Inc. Deuterated idazoxan and methods of use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2641601A (en) * 1950-11-24 1953-06-09 Hoffmann La Roche Furans and method of preparation
US2979511A (en) * 1959-03-25 1961-04-11 Olin Mathieson Certain 1, 4-benzodioxanyl imidazolines and corresponding pyrimidines and process
JPS5276346A (en) * 1975-12-22 1977-06-27 Sumitomo Bakelite Co Ltd Epoxy resin adhesive composition
DE2862340D1 (en) * 1978-02-01 1983-11-24 Wellcome Found Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof
US4302469A (en) * 1980-09-10 1981-11-24 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
US4301171A (en) * 1980-12-03 1981-11-17 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)benzimidazoles useful as anti-depressants
US4315021A (en) * 1980-12-03 1982-02-09 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles
US4436914A (en) * 1981-08-03 1984-03-13 Kluge Arthur F Benzodioxane-imidazoline compounds as antihypertensives
US4352809A (en) * 1981-09-04 1982-10-05 Smithkline Corporation Method of producing alpha2 antagonism

Also Published As

Publication number Publication date
DK45081A (da) 1981-08-05
IL62039A (en) 1985-01-31
ZW2381A1 (en) 1981-06-24
NO154882B (no) 1986-09-29
ZA81666B (en) 1982-04-28
PL128368B1 (en) 1984-01-31
GR73853B (no) 1984-05-07
FI810288L (fi) 1981-08-05
JPH0231077B2 (no) 1990-07-11
EP0033655B1 (en) 1984-04-25
PT72435B (pt) 1982-01-29
NO810351L (no) 1981-08-05
SU1128837A3 (ru) 1984-12-07
PT72435A (en) 1981-03-01
AU6675881A (en) 1981-08-13
IL62039A0 (en) 1981-03-31
ES8202553A1 (es) 1982-02-01
GB2068376B (en) 1983-06-22
ATE7228T1 (de) 1984-05-15
PL229488A1 (no) 1981-10-16
CA1156241A (en) 1983-11-01
GB2068376A (en) 1981-08-12
EP0033655A3 (en) 1981-11-25
CS254956B2 (en) 1988-02-15
AU535320B2 (en) 1984-03-15
DE3163256D1 (en) 1984-05-30
PH16249A (en) 1983-08-16
DK160092B (da) 1991-01-28
CS73881A2 (en) 1987-07-16
ES499034A0 (es) 1982-02-01
FI67543B (fi) 1984-12-31
IE810199L (en) 1981-08-04
DK160092C (da) 1991-06-24
EP0033655A2 (en) 1981-08-12
JPS56122378A (en) 1981-09-25
HU187295B (en) 1985-12-28
US4818764A (en) 1989-04-04
FI67543C (fi) 1985-04-10
NZ196162A (en) 1983-06-17
IE51736B1 (en) 1987-03-18
NO154882C (no) 1987-01-07
AR225794A1 (es) 1982-04-30

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