DE3163256D1 - Imidazoline derivative, its salts, process for preparation and pharmaceutical compositions thereof - Google Patents

Imidazoline derivative, its salts, process for preparation and pharmaceutical compositions thereof

Info

Publication number
DE3163256D1
DE3163256D1 DE8181300427T DE3163256T DE3163256D1 DE 3163256 D1 DE3163256 D1 DE 3163256D1 DE 8181300427 T DE8181300427 T DE 8181300427T DE 3163256 T DE3163256 T DE 3163256T DE 3163256 D1 DE3163256 D1 DE 3163256D1
Authority
DE
Germany
Prior art keywords
salts
preparation
pharmaceutical compositions
imidazoline derivative
imidazoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181300427T
Other languages
German (de)
Inventor
Christopher Bourne Chapleo
Peter Leslie Myers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Reckitt and Colman Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt and Colman Products Ltd filed Critical Reckitt and Colman Products Ltd
Application granted granted Critical
Publication of DE3163256D1 publication Critical patent/DE3163256D1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
DE8181300427T 1980-02-04 1981-02-02 Imidazoline derivative, its salts, process for preparation and pharmaceutical compositions thereof Expired DE3163256D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8003636 1980-02-04

Publications (1)

Publication Number Publication Date
DE3163256D1 true DE3163256D1 (en) 1984-05-30

Family

ID=10511105

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181300427T Expired DE3163256D1 (en) 1980-02-04 1981-02-02 Imidazoline derivative, its salts, process for preparation and pharmaceutical compositions thereof

Country Status (26)

Country Link
US (1) US4818764A (en)
EP (1) EP0033655B1 (en)
JP (1) JPS56122378A (en)
AR (1) AR225794A1 (en)
AT (1) ATE7228T1 (en)
AU (1) AU535320B2 (en)
CA (1) CA1156241A (en)
CS (1) CS254956B2 (en)
DD (1) DD155991A5 (en)
DE (1) DE3163256D1 (en)
DK (1) DK160092C (en)
ES (1) ES8202553A1 (en)
FI (1) FI67543C (en)
GB (1) GB2068376B (en)
GR (1) GR73853B (en)
HU (1) HU187295B (en)
IE (1) IE51736B1 (en)
IL (1) IL62039A (en)
NO (1) NO154882C (en)
NZ (1) NZ196162A (en)
PH (1) PH16249A (en)
PL (1) PL128368B1 (en)
PT (1) PT72435B (en)
SU (1) SU1128837A3 (en)
ZA (1) ZA81666B (en)
ZW (1) ZW2381A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199469A (en) * 1981-01-30 1984-03-16 Reckitt & Colmann Prod Ltd Benzodioxanyl-2-imidazoline derivatives and pharmaceutical compositions
US4436914A (en) * 1981-08-03 1984-03-13 Kluge Arthur F Benzodioxane-imidazoline compounds as antihypertensives
NZ203680A (en) * 1982-04-17 1985-08-16 Reckitt & Colmann Prod Ltd Imidazolines and pharmaceutical compositions
FR2527208B1 (en) * 1982-05-19 1985-07-19 Inst Nat Sante Rech Med OPTICAL ISOMERS OF (BENZODIOXAN-1,4 YL-2) -2D-2 IMIDAZOLINE, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS
EP0115142B1 (en) * 1982-12-23 1986-11-05 Ici Americas Inc. Chroman compounds
US4634714A (en) * 1983-12-01 1987-01-06 American Home Products Corporation Inhibition of prolactin release by a benzodioxinylimidazoline derivative
US4882343A (en) * 1987-08-28 1989-11-21 G. D. Searle & Co. Biarylalkylimidazole derivatives as anti-depressants
GB8720600D0 (en) * 1987-09-02 1987-10-07 Saad Al Damluji Pharmaceutical compositions
US5240930A (en) * 1987-09-02 1993-08-31 National Research Development Corporation Pharmaceutical compositions for treatment of depression and low blood pressure
FR2698789B1 (en) * 1992-12-07 1995-03-03 Pf Medicament Use of idazoxan and its derivatives for the preparation of a medicament intended for the treatment of Parkinson's disease and its evolution.
FR2700113B1 (en) * 1993-01-07 1995-03-24 Pf Medicament Use of Idazoxan and its derivatives for the manufacture of medicaments intended for the treatment of neurodegenerative diseases and in particular the evolution of Alzheimer's disease.
US5574059A (en) * 1995-10-27 1996-11-12 Cornell Research Foundation, Inc. Treating disorders mediated by vascular smooth muscle cell proliferation
FR2795727B1 (en) * 1999-06-29 2001-09-21 Pf Medicament NOVEL BENZODIOXANE IMIDAZOLINE FLUORINATED DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATIONS
FR2801786B1 (en) * 1999-12-01 2002-03-01 Fabre Pierre Cosmetique NOVEL TOPICAL COMPOSITIONS BASED ON IDAZOXAN AND CAFFEINE OR ITS SOLUBLE DERIVATIVES AND THEIR USE AS SLIMMERS AND / OR IN THE TREATMENT OF CELLULITE
WO2001064223A1 (en) * 2000-02-29 2001-09-07 Merck Frosst Canada & Co. Method for treating or preventing depression
US8476307B2 (en) * 2003-10-28 2013-07-02 Pierre Fabre Medicament Pharmaceutical composition based on idazoxan, salts, hydrates or polymorphs thereof
US7595335B2 (en) * 2003-10-28 2009-09-29 Pierre Fabre Medicament Pharmaceutical composition based on idazoxan, salts, hydrates or polymorphs thereof
FR2861299B1 (en) 2003-10-28 2006-01-27 Pf Medicament PHARMACEUTICAL COMPOSITIONS BASED ON IDASOXAN DERIVATIVES IN POLYMORPHIC FORMS
WO2023159145A1 (en) * 2022-02-16 2023-08-24 Terran Biosciences, Inc. Deuterated idazoxan and methods of use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2641601A (en) * 1950-11-24 1953-06-09 Hoffmann La Roche Furans and method of preparation
US2979511A (en) * 1959-03-25 1961-04-11 Olin Mathieson Certain 1, 4-benzodioxanyl imidazolines and corresponding pyrimidines and process
JPS5276346A (en) * 1975-12-22 1977-06-27 Sumitomo Bakelite Co Ltd Epoxy resin adhesive composition
EP0003732B1 (en) * 1978-02-01 1983-10-19 The Wellcome Foundation Limited Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof
US4302469A (en) * 1980-09-10 1981-11-24 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
US4301171A (en) * 1980-12-03 1981-11-17 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)benzimidazoles useful as anti-depressants
US4315021A (en) * 1980-12-03 1982-02-09 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles
US4436914A (en) * 1981-08-03 1984-03-13 Kluge Arthur F Benzodioxane-imidazoline compounds as antihypertensives
US4352809A (en) * 1981-09-04 1982-10-05 Smithkline Corporation Method of producing alpha2 antagonism

Also Published As

Publication number Publication date
NO810351L (en) 1981-08-05
EP0033655A2 (en) 1981-08-12
CS254956B2 (en) 1988-02-15
NZ196162A (en) 1983-06-17
GB2068376A (en) 1981-08-12
AR225794A1 (en) 1982-04-30
AU535320B2 (en) 1984-03-15
CA1156241A (en) 1983-11-01
GB2068376B (en) 1983-06-22
DK160092C (en) 1991-06-24
JPS56122378A (en) 1981-09-25
HU187295B (en) 1985-12-28
IE51736B1 (en) 1987-03-18
GR73853B (en) 1984-05-07
EP0033655B1 (en) 1984-04-25
DK160092B (en) 1991-01-28
ZW2381A1 (en) 1981-06-24
FI67543C (en) 1985-04-10
DK45081A (en) 1981-08-05
DD155991A5 (en) 1982-07-21
ZA81666B (en) 1982-04-28
US4818764A (en) 1989-04-04
AU6675881A (en) 1981-08-13
FI810288L (en) 1981-08-05
SU1128837A3 (en) 1984-12-07
PT72435A (en) 1981-03-01
FI67543B (en) 1984-12-31
NO154882C (en) 1987-01-07
CS73881A2 (en) 1987-07-16
ES499034A0 (en) 1982-02-01
IE810199L (en) 1981-08-04
PL229488A1 (en) 1981-10-16
EP0033655A3 (en) 1981-11-25
IL62039A0 (en) 1981-03-31
ES8202553A1 (en) 1982-02-01
JPH0231077B2 (en) 1990-07-11
PL128368B1 (en) 1984-01-31
IL62039A (en) 1985-01-31
PT72435B (en) 1982-01-29
NO154882B (en) 1986-09-29
PH16249A (en) 1983-08-16
ATE7228T1 (en) 1984-05-15

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: PIERRE FABRE MEDICAMENT S.A., CASTRES, FR

8328 Change in the person/name/address of the agent

Free format text: JUNG, E., DIPL.-CHEM. DR.PHIL. SCHIRDEWAHN, J., DIPL.-PHYS. DR.RER.NAT. GERNHARDT, C., DIPL.-ING., PAT.-ANWAELTE, 80803 MUENCHEN

8339 Ceased/non-payment of the annual fee