DK45081A - Fremgangsmaade til fremstilling af 2-(2-(1,4-benzodioxanyl) )--imidazolin eller ikke-toxiske syreadditionssalte deraf - Google Patents

Fremgangsmaade til fremstilling af 2-(2-(1,4-benzodioxanyl) )--imidazolin eller ikke-toxiske syreadditionssalte deraf

Info

Publication number
DK45081A
DK45081A DK45081A DK45081A DK45081A DK 45081 A DK45081 A DK 45081A DK 45081 A DK45081 A DK 45081A DK 45081 A DK45081 A DK 45081A DK 45081 A DK45081 A DK 45081A
Authority
DK
Denmark
Prior art keywords
benzodioxanyl
imidazoline
preparation
acid addition
addition salts
Prior art date
Application number
DK45081A
Other languages
English (en)
Other versions
DK160092C (da
DK160092B (da
Inventor
C B Chapleo
P L Myers
Original Assignee
Reckitt & Colmann Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt & Colmann Prod Ltd filed Critical Reckitt & Colmann Prod Ltd
Publication of DK45081A publication Critical patent/DK45081A/da
Publication of DK160092B publication Critical patent/DK160092B/da
Application granted granted Critical
Publication of DK160092C publication Critical patent/DK160092C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
DK045081A 1980-02-04 1981-02-02 Analogifremgangsmaade til fremstilling af 2-(2-(1,4-benzodioxanyl))-2-imidazolin eller ikke-toxiske syreadditionssalte deraf DK160092C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8003636 1980-02-04
GB8003636 1980-02-04

Publications (3)

Publication Number Publication Date
DK45081A true DK45081A (da) 1981-08-05
DK160092B DK160092B (da) 1991-01-28
DK160092C DK160092C (da) 1991-06-24

Family

ID=10511105

Family Applications (1)

Application Number Title Priority Date Filing Date
DK045081A DK160092C (da) 1980-02-04 1981-02-02 Analogifremgangsmaade til fremstilling af 2-(2-(1,4-benzodioxanyl))-2-imidazolin eller ikke-toxiske syreadditionssalte deraf

Country Status (26)

Country Link
US (1) US4818764A (da)
EP (1) EP0033655B1 (da)
JP (1) JPS56122378A (da)
AR (1) AR225794A1 (da)
AT (1) ATE7228T1 (da)
AU (1) AU535320B2 (da)
CA (1) CA1156241A (da)
CS (1) CS254956B2 (da)
DD (1) DD155991A5 (da)
DE (1) DE3163256D1 (da)
DK (1) DK160092C (da)
ES (1) ES8202553A1 (da)
FI (1) FI67543C (da)
GB (1) GB2068376B (da)
GR (1) GR73853B (da)
HU (1) HU187295B (da)
IE (1) IE51736B1 (da)
IL (1) IL62039A (da)
NO (1) NO154882C (da)
NZ (1) NZ196162A (da)
PH (1) PH16249A (da)
PL (1) PL128368B1 (da)
PT (1) PT72435B (da)
SU (1) SU1128837A3 (da)
ZA (1) ZA81666B (da)
ZW (1) ZW2381A1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199469A (en) * 1981-01-30 1984-03-16 Reckitt & Colmann Prod Ltd Benzodioxanyl-2-imidazoline derivatives and pharmaceutical compositions
US4436914A (en) * 1981-08-03 1984-03-13 Kluge Arthur F Benzodioxane-imidazoline compounds as antihypertensives
NZ203680A (en) * 1982-04-17 1985-08-16 Reckitt & Colmann Prod Ltd Imidazolines and pharmaceutical compositions
FR2527208B1 (fr) * 1982-05-19 1985-07-19 Inst Nat Sante Rech Med Isomeres optiques de la (benzodioxanne-1,4 yl-2)-2d-2 imidazoline, leur preparation et leur application en therapeutique
DE3367391D1 (en) * 1982-12-23 1986-12-11 Ici America Inc Chroman compounds
US4634714A (en) * 1983-12-01 1987-01-06 American Home Products Corporation Inhibition of prolactin release by a benzodioxinylimidazoline derivative
US4882343A (en) * 1987-08-28 1989-11-21 G. D. Searle & Co. Biarylalkylimidazole derivatives as anti-depressants
US5240930A (en) * 1987-09-02 1993-08-31 National Research Development Corporation Pharmaceutical compositions for treatment of depression and low blood pressure
GB8720600D0 (en) * 1987-09-02 1987-10-07 Saad Al Damluji Pharmaceutical compositions
FR2698789B1 (fr) * 1992-12-07 1995-03-03 Pf Medicament Utilisation de l'idazoxan et ses dérivés pour la préparation d'un médicament destiné au traitement de la maladie de Parkinson et de son évolution.
FR2700113B1 (fr) * 1993-01-07 1995-03-24 Pf Medicament Utilisation de l'Idazoxan et ses dérivés pour la fabrication de médicaments destinés au traitement des maladies neurodégénératives et en particulier l'évolution de la maladie d'Alzheimer.
US5574059A (en) * 1995-10-27 1996-11-12 Cornell Research Foundation, Inc. Treating disorders mediated by vascular smooth muscle cell proliferation
FR2795727B1 (fr) * 1999-06-29 2001-09-21 Pf Medicament Nouveaux derives benzodioxanne imidazolines fluores, leur preparation et leurs applications en therapeutique
FR2801786B1 (fr) * 1999-12-01 2002-03-01 Fabre Pierre Cosmetique Nouvelles compositions topiques a base d'idazoxan et de cafeine ou de ses derives solubles et leur utilisation comme amincissant et/ou dans le traitement de la cellulite
US20010049368A1 (en) * 2000-02-29 2001-12-06 Reines Scott A. Method for treating or preventing depression
FR2861299B1 (fr) * 2003-10-28 2006-01-27 Pf Medicament Compositions pharmaceutiques a base de derives d'idasoxan sous formes polymorphes
US7595335B2 (en) * 2003-10-28 2009-09-29 Pierre Fabre Medicament Pharmaceutical composition based on idazoxan, salts, hydrates or polymorphs thereof
US8476307B2 (en) * 2003-10-28 2013-07-02 Pierre Fabre Medicament Pharmaceutical composition based on idazoxan, salts, hydrates or polymorphs thereof
WO2023159145A1 (en) * 2022-02-16 2023-08-24 Terran Biosciences, Inc. Deuterated idazoxan and methods of use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2641601A (en) * 1950-11-24 1953-06-09 Hoffmann La Roche Furans and method of preparation
US2979511A (en) * 1959-03-25 1961-04-11 Olin Mathieson Certain 1, 4-benzodioxanyl imidazolines and corresponding pyrimidines and process
JPS5276346A (en) * 1975-12-22 1977-06-27 Sumitomo Bakelite Co Ltd Epoxy resin adhesive composition
DE2862340D1 (en) * 1978-02-01 1983-11-24 Wellcome Found Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof
US4302469A (en) * 1980-09-10 1981-11-24 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
US4301171A (en) * 1980-12-03 1981-11-17 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)benzimidazoles useful as anti-depressants
US4315021A (en) * 1980-12-03 1982-02-09 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles
US4436914A (en) * 1981-08-03 1984-03-13 Kluge Arthur F Benzodioxane-imidazoline compounds as antihypertensives
US4352809A (en) * 1981-09-04 1982-10-05 Smithkline Corporation Method of producing alpha2 antagonism

Also Published As

Publication number Publication date
AU535320B2 (en) 1984-03-15
US4818764A (en) 1989-04-04
JPH0231077B2 (da) 1990-07-11
PT72435B (pt) 1982-01-29
EP0033655B1 (en) 1984-04-25
DE3163256D1 (en) 1984-05-30
GB2068376A (en) 1981-08-12
EP0033655A2 (en) 1981-08-12
HU187295B (en) 1985-12-28
PL229488A1 (da) 1981-10-16
FI810288L (fi) 1981-08-05
NO810351L (no) 1981-08-05
IE810199L (en) 1981-08-04
CS254956B2 (en) 1988-02-15
GB2068376B (en) 1983-06-22
CS73881A2 (en) 1987-07-16
PH16249A (en) 1983-08-16
ZW2381A1 (en) 1981-06-24
NO154882B (no) 1986-09-29
DD155991A5 (de) 1982-07-21
AU6675881A (en) 1981-08-13
CA1156241A (en) 1983-11-01
EP0033655A3 (en) 1981-11-25
IE51736B1 (en) 1987-03-18
ES499034A0 (es) 1982-02-01
SU1128837A3 (ru) 1984-12-07
ATE7228T1 (de) 1984-05-15
ZA81666B (en) 1982-04-28
DK160092C (da) 1991-06-24
PT72435A (en) 1981-03-01
PL128368B1 (en) 1984-01-31
FI67543C (fi) 1985-04-10
GR73853B (da) 1984-05-07
JPS56122378A (en) 1981-09-25
AR225794A1 (es) 1982-04-30
IL62039A (en) 1985-01-31
NO154882C (no) 1987-01-07
IL62039A0 (en) 1981-03-31
DK160092B (da) 1991-01-28
ES8202553A1 (es) 1982-02-01
FI67543B (fi) 1984-12-31
NZ196162A (en) 1983-06-17

Similar Documents

Publication Publication Date Title
DK462380A (da) Analogifremgangsmaade til fremstilling af 2,4-diaminoquinazolin-forbindelser eller syreadditionssalte deraf
DK481879A (da) Fremgangsmaade til fremstilling af 5-(2-imidazolin-2-yl)-aminopyrimidiner eller syreadditionssalte deraf
DK45081A (da) Fremgangsmaade til fremstilling af 2-(2-(1,4-benzodioxanyl) )--imidazolin eller ikke-toxiske syreadditionssalte deraf
DK144010C (da) Analogifremgangsmaade til fremstilling af 2-piperazinyl-6,7-dimethoxyquinazoliner eller syreadditionssalte deraf
DK148795C (da) Anologifremgangsmaade til fremstilling af 3-(2-morpholino-ethyl-amino)-5-phenyl-pyridazin eller farmaceutisk acceptable syreadditionssalte deraf
DK453181A (da) Fremgangsmaade til fremstilling af 2-quanidino-4-heteroaryl-thiazolforbindelser eller syreadditionssalte deraf
DK413783D0 (da) Fremgangsmade til fremstilling af 20-amino-macrolidderivater eller syreadditionssalte deraf
DK53083A (da) Fremgangsmaade til fremstilling af 2-(phenyl-methylen)-cycloalkylaminer og -azetidiner eller syreadditionssalte deraf
DK224281A (da) Fremgangsmaade til fremstilling af 2,2-dimethylpenam-3-carboxylsyre-1,1-dioxid-forbindelser eller salte deraf
DK146281C (da) Analogifremgangsmaade til fremstilling af 2-brom-6-fluor-n-2-imidazolidinyliden-benzamin eller syreadditionssalte heraf
DK134580A (da) Fremgangsmaade til fremstilling af 2,6-diaminonebulariner eller syreadditionssalte deraf
DK157451C (da) Analogifremgangsmaade til fremstilling af 2,4-diamino-6-alkoxybenzyl-5-methylpyridooe2,3-daapyrimidiner eller farmaceutisk acceptable syreadditionssalte deraf
DK165790C (da) Fremgangsmaade til fremstilling af adriamycin-4'-o-derivater eller syreadditionssalte deraf
DK430379A (da) Fremgangsmaade til fremstilling af 2,6-diaminonebulariner eller syreadditionssalte deraf
DK150597C (da) Analogifremgangsmaade til fremstilling af 3,4-bis-substituerede 1,2,5-oxadiazol-2-oxider eller farmakologisk acceptable syreadditionssalte deraf
DK158457C (da) Analogifremgangsmaade til fremstilling af 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaensyre eller salte heraf
DK158227C (da) Analogifremgangsmaade til fremstilling af substituerede imidazooe1,5-aaapyridiner eller 5,6,7,8-tetrahydroderivater deraf eller salte deraf
DK148036C (da) Analogifremgangsmaade til fremstilling af epimere 4''-amino-erythromycin-forbindelser eller syreadditionssalte deraf
DK234182A (da) Fremgangsmaade til fremstilling af heterocyclisk substitueredeamidoximer eller syreadditionssalte deraf
DK144916C (da) Fremgangsmaade til fremstilling af vlb-3-spiro-5"-oxazolidin-2",4"-dion eller ikke-toxiske syreadditionssalte heraf
DK516480A (da) Fremgangsmaade til fremstilling af 2-amino-ethanol-derivater eller syreadditionssalte deraf
DK153539C (da) Fremgangsmaade til fremstilling af 3,3-dimethyl-2-oxosmoersyre eller salte deraf
DK151021C (da) Analogifremgangsmaade til fremstilling af 17,18-dehydro-apovincaminol-3',4',5'-trimethoxybenzoat eller farmaceutisk acceptable syreadditionssalte deraf
DK129380A (da) Fremgangsmaade til fremstilling af 6,7-dialkoxy-1-piperidinophthalazin-forbindelser eller syreadditionssalte deraf
DK258180A (da) Fremgangsmaade til fremstilling af pyridylaminotriazoler eller syreadditionssalte deraf

Legal Events

Date Code Title Description
PBP Patent lapsed