CS254956B2 - Method of 2-(2-/1,4-benzodioxanyl/)2-imidazoline preparation - Google Patents

Method of 2-(2-/1,4-benzodioxanyl/)2-imidazoline preparation Download PDF

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Publication number
CS254956B2
CS254956B2 CS81738A CS73881A CS254956B2 CS 254956 B2 CS254956 B2 CS 254956B2 CS 81738 A CS81738 A CS 81738A CS 73881 A CS73881 A CS 73881A CS 254956 B2 CS254956 B2 CS 254956B2
Authority
CS
Czechoslovakia
Prior art keywords
compound
imidazoline
presynaptic
benzodioxanyl
formula
Prior art date
Application number
CS81738A
Other languages
Czech (cs)
English (en)
Other versions
CS73881A2 (en
Inventor
Christopher B Chapleo
Peter L Myers
Original Assignee
Reckitt & Colmann Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt & Colmann Prod Ltd filed Critical Reckitt & Colmann Prod Ltd
Publication of CS73881A2 publication Critical patent/CS73881A2/cs
Publication of CS254956B2 publication Critical patent/CS254956B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
CS81738A 1980-02-04 1981-02-02 Method of 2-(2-/1,4-benzodioxanyl/)2-imidazoline preparation CS254956B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8003636 1980-02-04

Publications (2)

Publication Number Publication Date
CS73881A2 CS73881A2 (en) 1987-07-16
CS254956B2 true CS254956B2 (en) 1988-02-15

Family

ID=10511105

Family Applications (1)

Application Number Title Priority Date Filing Date
CS81738A CS254956B2 (en) 1980-02-04 1981-02-02 Method of 2-(2-/1,4-benzodioxanyl/)2-imidazoline preparation

Country Status (26)

Country Link
US (1) US4818764A (da)
EP (1) EP0033655B1 (da)
JP (1) JPS56122378A (da)
AR (1) AR225794A1 (da)
AT (1) ATE7228T1 (da)
AU (1) AU535320B2 (da)
CA (1) CA1156241A (da)
CS (1) CS254956B2 (da)
DD (1) DD155991A5 (da)
DE (1) DE3163256D1 (da)
DK (1) DK160092C (da)
ES (1) ES499034A0 (da)
FI (1) FI67543C (da)
GB (1) GB2068376B (da)
GR (1) GR73853B (da)
HU (1) HU187295B (da)
IE (1) IE51736B1 (da)
IL (1) IL62039A (da)
NO (1) NO154882C (da)
NZ (1) NZ196162A (da)
PH (1) PH16249A (da)
PL (1) PL128368B1 (da)
PT (1) PT72435B (da)
SU (1) SU1128837A3 (da)
ZA (1) ZA81666B (da)
ZW (1) ZW2381A1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199469A (en) * 1981-01-30 1984-03-16 Reckitt & Colmann Prod Ltd Benzodioxanyl-2-imidazoline derivatives and pharmaceutical compositions
US4436914A (en) * 1981-08-03 1984-03-13 Kluge Arthur F Benzodioxane-imidazoline compounds as antihypertensives
NZ203680A (en) * 1982-04-17 1985-08-16 Reckitt & Colmann Prod Ltd Imidazolines and pharmaceutical compositions
FR2527208B1 (fr) * 1982-05-19 1985-07-19 Inst Nat Sante Rech Med Isomeres optiques de la (benzodioxanne-1,4 yl-2)-2d-2 imidazoline, leur preparation et leur application en therapeutique
ATE23337T1 (de) * 1982-12-23 1986-11-15 Ici America Inc Chromanverbindungen.
US4634714A (en) * 1983-12-01 1987-01-06 American Home Products Corporation Inhibition of prolactin release by a benzodioxinylimidazoline derivative
US4882343A (en) * 1987-08-28 1989-11-21 G. D. Searle & Co. Biarylalkylimidazole derivatives as anti-depressants
US5240930A (en) * 1987-09-02 1993-08-31 National Research Development Corporation Pharmaceutical compositions for treatment of depression and low blood pressure
GB8720600D0 (en) * 1987-09-02 1987-10-07 Saad Al Damluji Pharmaceutical compositions
FR2698789B1 (fr) * 1992-12-07 1995-03-03 Pf Medicament Utilisation de l'idazoxan et ses dérivés pour la préparation d'un médicament destiné au traitement de la maladie de Parkinson et de son évolution.
FR2700113B1 (fr) * 1993-01-07 1995-03-24 Pf Medicament Utilisation de l'Idazoxan et ses dérivés pour la fabrication de médicaments destinés au traitement des maladies neurodégénératives et en particulier l'évolution de la maladie d'Alzheimer.
US5574059A (en) * 1995-10-27 1996-11-12 Cornell Research Foundation, Inc. Treating disorders mediated by vascular smooth muscle cell proliferation
FR2795727B1 (fr) * 1999-06-29 2001-09-21 Pf Medicament Nouveaux derives benzodioxanne imidazolines fluores, leur preparation et leurs applications en therapeutique
FR2801786B1 (fr) * 1999-12-01 2002-03-01 Fabre Pierre Cosmetique Nouvelles compositions topiques a base d'idazoxan et de cafeine ou de ses derives solubles et leur utilisation comme amincissant et/ou dans le traitement de la cellulite
WO2001064223A1 (en) * 2000-02-29 2001-09-07 Merck Frosst Canada & Co. Method for treating or preventing depression
US8476307B2 (en) * 2003-10-28 2013-07-02 Pierre Fabre Medicament Pharmaceutical composition based on idazoxan, salts, hydrates or polymorphs thereof
US7595335B2 (en) * 2003-10-28 2009-09-29 Pierre Fabre Medicament Pharmaceutical composition based on idazoxan, salts, hydrates or polymorphs thereof
FR2861299B1 (fr) * 2003-10-28 2006-01-27 Pf Medicament Compositions pharmaceutiques a base de derives d'idasoxan sous formes polymorphes
WO2023159145A1 (en) * 2022-02-16 2023-08-24 Terran Biosciences, Inc. Deuterated idazoxan and methods of use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2641601A (en) * 1950-11-24 1953-06-09 Hoffmann La Roche Furans and method of preparation
US2979511A (en) * 1959-03-25 1961-04-11 Olin Mathieson Certain 1, 4-benzodioxanyl imidazolines and corresponding pyrimidines and process
JPS5276346A (en) * 1975-12-22 1977-06-27 Sumitomo Bakelite Co Ltd Epoxy resin adhesive composition
EP0003732B1 (en) * 1978-02-01 1983-10-19 The Wellcome Foundation Limited Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof
US4302469A (en) * 1980-09-10 1981-11-24 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
US4315021A (en) * 1980-12-03 1982-02-09 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles
US4301171A (en) * 1980-12-03 1981-11-17 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)benzimidazoles useful as anti-depressants
US4436914A (en) * 1981-08-03 1984-03-13 Kluge Arthur F Benzodioxane-imidazoline compounds as antihypertensives
US4352809A (en) * 1981-09-04 1982-10-05 Smithkline Corporation Method of producing alpha2 antagonism

Also Published As

Publication number Publication date
IL62039A (en) 1985-01-31
JPS56122378A (en) 1981-09-25
NO810351L (no) 1981-08-05
PT72435A (en) 1981-03-01
DK160092B (da) 1991-01-28
ATE7228T1 (de) 1984-05-15
NO154882C (no) 1987-01-07
PH16249A (en) 1983-08-16
FI67543C (fi) 1985-04-10
EP0033655B1 (en) 1984-04-25
IE51736B1 (en) 1987-03-18
DD155991A5 (de) 1982-07-21
ES8202553A1 (es) 1982-02-01
PL229488A1 (da) 1981-10-16
AU6675881A (en) 1981-08-13
IE810199L (en) 1981-08-04
CA1156241A (en) 1983-11-01
JPH0231077B2 (da) 1990-07-11
AU535320B2 (en) 1984-03-15
AR225794A1 (es) 1982-04-30
EP0033655A3 (en) 1981-11-25
GB2068376B (en) 1983-06-22
DK45081A (da) 1981-08-05
FI810288L (fi) 1981-08-05
EP0033655A2 (en) 1981-08-12
GB2068376A (en) 1981-08-12
NZ196162A (en) 1983-06-17
ZW2381A1 (en) 1981-06-24
SU1128837A3 (ru) 1984-12-07
PT72435B (pt) 1982-01-29
HU187295B (en) 1985-12-28
DE3163256D1 (en) 1984-05-30
GR73853B (da) 1984-05-07
ZA81666B (en) 1982-04-28
US4818764A (en) 1989-04-04
FI67543B (fi) 1984-12-31
ES499034A0 (es) 1982-02-01
DK160092C (da) 1991-06-24
CS73881A2 (en) 1987-07-16
NO154882B (no) 1986-09-29
PL128368B1 (en) 1984-01-31
IL62039A0 (en) 1981-03-31

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