DD153692A5 - Verfahren zur herstellung von benzodiazepinverbindungen - Google Patents

Verfahren zur herstellung von benzodiazepinverbindungen Download PDF

Info

Publication number
DD153692A5
DD153692A5 DD80224618A DD22461880A DD153692A5 DD 153692 A5 DD153692 A5 DD 153692A5 DD 80224618 A DD80224618 A DD 80224618A DD 22461880 A DD22461880 A DD 22461880A DD 153692 A5 DD153692 A5 DD 153692A5
Authority
DD
German Democratic Republic
Prior art keywords
alkyl
hydrogen
cycloalkyl
formula
deep
Prior art date
Application number
DD80224618A
Other languages
German (de)
English (en)
Inventor
Jiban K Chakrabarii
Terrence M Hotten
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of DD153692A5 publication Critical patent/DD153692A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DD80224618A 1979-10-16 1980-10-15 Verfahren zur herstellung von benzodiazepinverbindungen DD153692A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7935846 1979-10-16

Publications (1)

Publication Number Publication Date
DD153692A5 true DD153692A5 (de) 1982-01-27

Family

ID=10508540

Family Applications (1)

Application Number Title Priority Date Filing Date
DD80224618A DD153692A5 (de) 1979-10-16 1980-10-15 Verfahren zur herstellung von benzodiazepinverbindungen

Country Status (33)

Country Link
US (3) US4404137A (fr)
EP (1) EP0027390B1 (fr)
JP (1) JPS5663987A (fr)
KR (2) KR850000471B1 (fr)
AR (2) AR228041A1 (fr)
AT (1) AT373889B (fr)
AU (1) AU538500B2 (fr)
BE (1) BE885729A (fr)
BG (2) BG34907A3 (fr)
CA (1) CA1159056A (fr)
CH (1) CH646700A5 (fr)
CS (1) CS244409B2 (fr)
DD (1) DD153692A5 (fr)
DE (1) DE3068706D1 (fr)
DK (1) DK437480A (fr)
ES (1) ES495948A0 (fr)
FI (1) FI67550C (fr)
FR (1) FR2467851A1 (fr)
GB (1) GB8327127D0 (fr)
GR (1) GR70720B (fr)
HU (1) HU182213B (fr)
IE (1) IE50358B1 (fr)
IL (1) IL61264A (fr)
IT (1) IT1143047B (fr)
LU (1) LU82853A1 (fr)
MX (1) MX6233E (fr)
NZ (1) NZ195248A (fr)
PH (2) PH16288A (fr)
PL (2) PL135044B1 (fr)
PT (1) PT71913B (fr)
RO (2) RO81351B (fr)
YU (1) YU261580A (fr)
ZA (1) ZA806342B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4404137A (en) * 1979-10-16 1983-09-13 Lilly Industries Limited Pyrazolo [3,4-b][1,5]benzodiazepine compounds
US4431589A (en) * 1980-12-11 1984-02-14 Lilly House Benzodiazepine compounds and their use as pharmaceuticals
US4596799A (en) * 1985-01-29 1986-06-24 Ciba-Geigy Corporation 9H-pyrrolo[2,1-c]-1,2,4-triazolo[4,3-a][1,4]benzodiazepines
TW219896B (fr) * 1988-07-07 1994-02-01 Duphar Int Res
GB8819059D0 (en) * 1988-08-11 1988-09-14 Lilly Industries Ltd Benzodiazepine compounds & their use as pharmaceuticals
US5637584A (en) * 1995-03-24 1997-06-10 Eli Lilly And Company Solvate of olanzapine
US5631250A (en) * 1995-03-24 1997-05-20 Eli Lilly And Company Process and solvate of 2-methyl-thieno-benzodiazepine
US20050250767A1 (en) * 2003-01-23 2005-11-10 Weiner David M Use of N-desmethylclozapine to treat human neuropsychiatric disease
KR20050092123A (ko) * 2003-01-23 2005-09-20 아카디아 파마슈티칼스 인코포레이티드 Ｎ-데스메틸클로자핀의 인간의 신경정신성 질환의 치료용도
US20050085463A1 (en) * 2003-01-23 2005-04-21 Weiner David M. Use of N-desmethylclozapine to treat human neuropsychiatric disease
JP2007534656A (ja) * 2003-12-22 2007-11-29 アカディア ファーマシューティカルズ，インコーポレーテッド ムスカリンアゴニストとしてのアミノ置換ジアリール［ａ，ｄ］シクロヘプテン類似体および精神神経疾患の治療方法
EP1756070A2 (fr) * 2004-04-01 2007-02-28 Acadia Pharmaceuticals Inc. Formes cristallines de n-desmethylclozapine
WO2007053618A1 (fr) * 2005-10-31 2007-05-10 Acadia Pharmaceuticals Inc. Promédicaments d'agonistes muscariniques et méthodes de traitement de troubles neuropsychiatriques
JP5438482B2 (ja) * 2009-12-03 2014-03-12 Ｊｕｋｉ株式会社 ミシン、ミシンの縫製データ編集装置及びミシンの縫製データ編集プログラム

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3450694A (en) * 1966-02-23 1969-06-17 Abbott Lab Substituted benzoxazepines and benzothiazepines
US3758479A (en) * 1967-03-22 1973-09-11 Sandoz Ag Nitro and sulphamoyl substituted dibenzodiazepines
DE1795183B1 (de) * 1968-08-20 1972-07-20 Thomae Gmbh Dr K 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-on-derivate und Arzneimittel
CA918659A (en) * 1969-07-31 1973-01-09 Yoshitomi Pharmaceutical Industries 11-(4-substituted-1-piperazinyl)-dibenzo (b,f) (1,4) thiazepines
US4172831A (en) * 1974-11-26 1979-10-30 Lilly Industries Limited Thieno-benzodiazepines
US4115568A (en) * 1974-11-26 1978-09-19 Lilly Industries Limited Thieno[3,2-b]-[1,5]benzodiazepines
US3953430A (en) * 1975-02-24 1976-04-27 American Cyanamid Company Substituted benzodiazepin-10-ones and method of use
US3951981A (en) * 1975-02-24 1976-04-20 American Cyanamid Company Substituted benzodiazepines and method of use
DE2707269A1 (de) * 1977-02-19 1978-08-24 Hoechst Ag Heterocyclische stickstoffverbindungen und verfahren zu ihrer herstellung
DE2707270A1 (de) * 1977-02-19 1978-08-24 Hoechst Ag Pyrazolo-diazepine und verfahren zu ihrer herstellung
US4097597A (en) * 1977-02-23 1978-06-27 Abbott Laboratories Dibenzo b,e! 1,4!diazepines
IT7851496A0 (it) * 1977-10-31 1978-10-13 Sandoz Ag Menti pirazinobenzossazepine loro preparazione e loro impiego quali medica
CH643263A5 (de) * 1979-05-11 1984-05-30 Sandoz Ag Benzodiazepine, ihre herstellung und verwendung.
FI68835C (fi) * 1979-08-03 1985-11-11 Byk Gulden Lomberg Chem Fab Foerfarande foer framstaellning av terapeutiskt anvaendbara 4-minoacyl-1,4,9,10-tetrahydropyrazolo(4,3-b)(1,5)bensodiaz epn-10-oner
US4404137A (en) * 1979-10-16 1983-09-13 Lilly Industries Limited Pyrazolo [3,4-b][1,5]benzodiazepine compounds

Also Published As

Publication number Publication date
IT1143047B (it) 1986-10-22
FI67550C (fi) 1985-04-10
ES8106905A1 (es) 1981-09-16
DE3068706D1 (en) 1984-08-30
RO85822A (fr) 1984-11-25
NZ195248A (en) 1983-11-18
KR850001463A (ko) 1985-03-18
FI803253L (fi) 1981-04-17
ZA806342B (en) 1982-05-26
HU182213B (en) 1983-12-28
PT71913B (en) 1981-08-31
CS244409B2 (en) 1986-07-17
ES495948A0 (es) 1981-09-16
US4486591A (en) 1984-12-04
RO81351B (ro) 1983-02-28
AT373889B (de) 1984-02-27
US4404137A (en) 1983-09-13
IL61264A (en) 1985-08-30
IE50358B1 (en) 1986-04-02
PH17759A (en) 1984-12-05
PH16288A (en) 1983-09-05
AU6325280A (en) 1981-04-30
ATA510180A (de) 1983-07-15
IT8049899A0 (it) 1980-10-14
YU261580A (en) 1983-12-31
AU538500B2 (en) 1984-08-16
PL126824B1 (en) 1983-09-30
BG35042A3 (en) 1983-01-16
KR850000472B1 (ko) 1985-04-08
MX6233E (es) 1985-01-14
CH646700A5 (fr) 1984-12-14
PL231270A1 (fr) 1981-12-23
GR70720B (fr) 1983-01-18
EP0027390A1 (fr) 1981-04-22
GB8327127D0 (en) 1983-11-09
KR850000471B1 (ko) 1985-04-08
EP0027390B1 (fr) 1984-07-25
LU82853A1 (fr) 1982-05-10
RO85822B (ro) 1984-11-30
AR228041A1 (es) 1983-01-14
FI67550B (fi) 1984-12-31
FR2467851B1 (fr) 1985-04-05
IL61264A0 (en) 1980-12-31
KR830004300A (ko) 1983-07-09
AR228101A1 (es) 1983-01-14
US4542131A (en) 1985-09-17
PT71913A (en) 1980-11-01
RO81351A (fr) 1983-02-15
JPS5663987A (en) 1981-05-30
CA1159056A (fr) 1983-12-20
FR2467851A1 (fr) 1981-04-30
BG34907A3 (en) 1983-12-15
DK437480A (da) 1981-04-17
IE802135L (en) 1981-04-16
PL135044B1 (en) 1985-09-30
BE885729A (fr) 1981-04-15
PL227306A1 (fr) 1981-09-18

Similar Documents

Publication Publication Date Title
EP0059391B1 (fr) Imidazodiazépines, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0165904B1 (fr) Composés substitués bicycliques
DD153692A5 (de) Verfahren zur herstellung von benzodiazepinverbindungen
DE69630209T2 (de) Bicyclische benzazepin-derivate als vasopressin-antagonisten
EP0059390B1 (fr) Imidazodiazépines, produits intermédiaires et procédé pour leur préparation ainsi que médicaments les contenant
EP0059389B1 (fr) Imidazodiazépines, procédé pour leur préparation ainsi que médicaments les contenant
DE2552403C2 (de) Thieno[1,5]-benzodiazepine, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Mittel
EP0288431B1 (fr) 3H-1,2,3-triazolo[4,5-d]pyrimidines
DD208153A5 (de) Verfahren zur herstellung von benzodiazepinderivaten
EP0059388B1 (fr) Imidazodiazépines, procédé et produits intermédiaires pour leur préparation ainsi que médicaments les contenant
DD282457A5 (de) Verfahren zur herstellung neuer heterocyclischer derivate
DE2233682A1 (de) 2- eckige klammer auf 3-(subst. aminomethyl)-4-h-1,2,4-triazol-4-yl eckige klammer zu -benzophenone, ein verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel
DE2439209A1 (de) Neue 6-phenyl-s-triazolo eckige klammer auf 4,3-a eckige klammer zu eckige klammer auf 1,3,4 eckige klammer zu benzotriazepine
EP0045519B1 (fr) Pyrrolo-(3,4-d)-benzazépines, procédé et intermédiaires pour leur préparation et compositions pharmaceutiques les contenant
EP0195939B1 (fr) Dérivés de l'imidazodiazépine
EP0129509B1 (fr) Triazolo(2,3-c)(1,3)benzodiazépines, procédé pour leur préparation, compositions pharmaceutiques les contenant et leur application thérapeutique
EP0072029A2 (fr) Triazolobenzazépines, procédé et intermédiaires pour leur fabrication et médicaments les contenant
EP0084155A2 (fr) 1,4-Benzodiazépines (1,2) anellés ainsi qu'un procédé pour leur préparation et médicaments contenant ces composés
DD235261A5 (de) Verfahren zur herstellung von arylderivaten heterovicyclischer verbindungen
DE2435041A1 (de) Neue 8-substituierte 6-aryl-4h-striazolo- eckige klammer auf 3,4c eckige klammer zu-thieno- eckige klammer auf 2,3e eckige klammer zu -1,4-diazepine, verfahren zu ihrer herstellung, ihre verwendung in arzneimitteln sowie zwischenprodukte und verfahren zur herstellung dieser zwischenprodukte
EP0000479A1 (fr) 1-Pipérazinyl-4H-s-triazolo (3,4-c)thiéno (2,3-e)1,4-diazépines, procédé pour leur préparation et médicaments les contenant
DE10042092A1 (de) Antikonvulsiv wirkende 2,5-Dihydro-pyrazolo(3,4-d)pyrimidin-4-one und Verfahren zu deren Darstellung
DE2261693A1 (de) Nitroimidazolyl-triazolo-pyridazine und verfahren zu ihrer herstellung
DE2445430A1 (de) Neue 1-substituierte 6-aryl-4h-striazolo- eckige klammer auf 3,4c eckige klammer zu -thieno- eckige klammer auf 2,3e eckige klammer zu -1,4-diazepine, verfahren zu ihrer herstellung, ihre verwendung in arzneimitteln sowie zwischenprodukte und verfahren zur herstellung dieser zwischenprodukte
CH577982A5 (en) Antiinflammatory quinazoline derivs