CZ404291A3 - Indole derivatives, process of their preparation and pharmaceutical compositions containing thereof - Google Patents

Indole derivatives, process of their preparation and pharmaceutical compositions containing thereof Download PDF

Info

Publication number
CZ404291A3
CZ404291A3 CS914042A CS404291A CZ404291A3 CZ 404291 A3 CZ404291 A3 CZ 404291A3 CS 914042 A CS914042 A CS 914042A CS 404291 A CS404291 A CS 404291A CZ 404291 A3 CZ404291 A3 CZ 404291A3
Authority
CZ
Czechia
Prior art keywords
formula
compound
methyl
pharmaceutically acceptable
indole
Prior art date
Application number
CS914042A
Other languages
Czech (cs)
English (en)
Inventor
Alexander William Oxford
Martin Richard Owen
Darko Butina
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878719167A external-priority patent/GB8719167D0/en
Priority claimed from GB888814002A external-priority patent/GB8814002D0/en
Priority claimed from GB888814481A external-priority patent/GB8814481D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of CZ404291A3 publication Critical patent/CZ404291A3/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CS914042A 1987-08-13 1991-12-23 Indole derivatives, process of their preparation and pharmaceutical compositions containing thereof CZ404291A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB878719167A GB8719167D0 (en) 1987-08-13 1987-08-13 Chemical compounds
GB888814002A GB8814002D0 (en) 1988-06-14 1988-06-14 Chemical compounds
GB888814481A GB8814481D0 (en) 1988-06-17 1988-06-17 Chemical compounds

Publications (1)

Publication Number Publication Date
CZ404291A3 true CZ404291A3 (en) 1993-04-14

Family

ID=27263551

Family Applications (1)

Application Number Title Priority Date Filing Date
CS914042A CZ404291A3 (en) 1987-08-13 1991-12-23 Indole derivatives, process of their preparation and pharmaceutical compositions containing thereof

Country Status (28)

Country Link
US (1) US4997841A (de)
EP (1) EP0303507B1 (de)
JP (1) JPH0633252B2 (de)
KR (1) KR0131327B1 (de)
AT (1) ATE92057T1 (de)
AU (1) AU611469B2 (de)
CA (1) CA1310968C (de)
CY (1) CY1728A (de)
CZ (1) CZ404291A3 (de)
DE (2) DE3882614T2 (de)
DK (1) DK172696B1 (de)
ES (1) ES2058292T3 (de)
FI (1) FI92397C (de)
GB (1) GB2208646B (de)
HK (1) HK86793A (de)
HU (1) HU211576A9 (de)
IE (1) IE61488B1 (de)
IL (1) IL87437A0 (de)
LU (1) LU90160I2 (de)
LV (1) LV5736B4 (de)
NL (1) NL970035I2 (de)
NO (2) NO174052C (de)
NZ (1) NZ225820A (de)
PH (1) PH24976A (de)
PT (1) PT88255B (de)
SG (1) SG65393G (de)
SK (1) SK281495B6 (de)
UY (1) UY23657A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
GB8903036D0 (en) * 1989-02-10 1989-03-30 Glaxo Group Ltd Chemical compounds
AU646871B2 (en) * 1990-06-07 1994-03-10 Astrazeneca Uk Limited Therapeutic heterocyclic compounds
DK152090D0 (da) * 1990-06-22 1990-06-22 Lundbaek A S H Piperidylsubstituerede indolderivater
US5643784A (en) * 1990-12-04 1997-07-01 H, Lundbeck A/S Indan derivatives
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
TW222631B (de) * 1991-07-15 1994-04-21 Duphar Int Res
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
CA2141810A1 (en) * 1992-08-05 1994-02-17 Ian A. Cliffe Amide derivatives
GB9320115D0 (en) * 1993-09-29 1993-11-17 Glaxo Group Ltd Process
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
FR2731224B1 (fr) * 1995-03-02 1997-05-30 Pf Medicament Nouveaux derives bi-tryptaminiques sulfonamides, leur procede de preparation et leur utilisation a titre de medicaments
FR2731222A1 (fr) * 1995-03-02 1996-09-06 Pf Medicament Nouveaux derives de piperazine aminoindoles cycliques, leur procede de preparation et leur utilisation a titre de medicaments
CZ288897A3 (cs) * 1995-03-20 1998-02-18 Eli Lilly And Company V poloze 5-substituovaný 3-(1,2,3,6-tetrahydropyridin-4-yl)indol a 3-(piperidin-4-yl)indol a farmaceutický prostředek, který je obsahuje
AU2104097A (en) * 1996-03-13 1997-10-01 Glaxo Group Limited Medicaments comprising 5ht1-like receptor agonists with an increased absorption
AR013669A1 (es) * 1997-10-07 2001-01-10 Smithkline Beecham Corp Compuestos y metodos
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
PT1305307E (pt) 2000-07-21 2004-09-30 Lundbeck & Co As H Derivados de indole eficazes no tratamento de doencas do sistema nervoso central
EP1341777B1 (de) * 2000-11-29 2007-09-26 Eli Lilly And Company 1-(2-m-methansulfonamidophenylethyl)-4-(m-trifluoromethylphenyl)piperazine und ihre akzeptablen pharmazeutischen salze und solvate und ihre verwendung zur behandlung von inkontinenz
US8329734B2 (en) 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
CA2529528A1 (en) 2003-06-20 2004-12-29 Ronald Aung-Din Topical therapy for the treatment of migraines, muscle sprains, muscle spasm, spasticity and related conditions
MX2007005845A (es) * 2004-11-24 2007-07-04 Alcon Inc Metodo para entregar rocio nasal.
ATE502921T1 (de) * 2006-10-19 2011-04-15 Auspex Pharmaceuticals Inc Substituierte indole
WO2008056378A2 (en) * 2006-11-09 2008-05-15 Natco Pharma Limited Novel process for the preparation of naratriptan hydrochloride
WO2008072257A2 (en) * 2006-12-12 2008-06-19 Ind-Swift Laboratories Limited Process for the preparation of indole derivatives
WO2009016466A2 (en) * 2007-07-30 2009-02-05 Orchid Chemicals & Pharmaceuticals Limited A process for the preparation of naratriptan hydrochloride
WO2009118753A2 (en) * 2008-03-07 2009-10-01 Usv Limited Process for preparation of naratriptan hydrochloride
WO2010005507A1 (en) 2008-06-30 2010-01-14 Afgin Pharma, Llc Topical regional neuro-affective therapy
WO2010004580A2 (en) * 2008-07-11 2010-01-14 Ind-Swift Laboratories Limited Process for preparing indole derivatives
WO2010084507A2 (en) * 2008-07-15 2010-07-29 Sun Pharmaceutical Industries Ltd. Process for the preparation of n-methyl-2-[3-(1-methyl-4-piperidyl)-1h-indol-5-yl]-ethanesulfonamide and its acid addition salts
KR20120084286A (ko) 2009-08-20 2012-07-27 시플라 리미티드 나라트립탄의 합성방법
CN102276581B (zh) * 2011-08-05 2013-06-12 上海师范大学 N-取代四氢吡啶连吲哚类化合物及其制备方法及应用
CN107530318A (zh) 2015-03-02 2018-01-02 阿福金制药有限责任公司 用大麻素的局部区域神经影响性疗法
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
EP3766483A1 (de) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispergierbare pulverzusammensetzung mit einem triptan

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2362628A1 (fr) * 1976-08-26 1978-03-24 Roussel Uclaf Nouveaux derives du piperidyl-indole et leurs sels, procede de preparation et application a titre de medicaments
FR2421899A1 (fr) * 1978-01-16 1979-11-02 Roussel Uclaf Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits
IT1170387B (it) * 1982-06-07 1987-06-03 Glaxo Group Ltd Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono
FR2533924A1 (fr) * 1982-10-05 1984-04-06 Roussel Uclaf Nouveaux derives du 4-(1h-indol-3-yl)a-methyl piperidine-1-ethanol, leurs sels, le procede de preparation, l'application a titre de medicaments et les compositions les renfermant
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
HU196752B (en) * 1983-12-06 1989-01-30 Glaxo Group Ltd Process for production of medical compositions containing indole-derivatives and these compounds
DE3419935A1 (de) * 1984-05-28 1985-11-28 Merck Patent Gmbh, 6100 Darmstadt Verwendung von hydroxyindolderivaten bei der senkung des blutdrucks
GB2162522B (en) * 1984-08-01 1988-02-24 Glaxo Group Ltd An indole derivative
US4548939A (en) * 1984-10-01 1985-10-22 Janssen Pharmaceutica N. V. 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
US4785016A (en) * 1984-12-04 1988-11-15 Glaxo Group Limited Indole derivatives
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
GB8903036D0 (en) * 1989-02-10 1989-03-30 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
GB2208646B (en) 1991-06-26
SK404291A3 (en) 2000-09-12
IE882477L (en) 1989-02-13
CA1310968C (en) 1992-12-01
GB8819200D0 (en) 1988-09-14
SG65393G (en) 1993-08-06
PT88255A (pt) 1989-06-30
DE19775082I2 (de) 2006-04-27
FI883744A0 (fi) 1988-08-12
DE3882614T2 (de) 1993-11-18
ES2058292T3 (es) 1994-11-01
NL970035I1 (nl) 1997-11-03
AU611469B2 (en) 1991-06-13
KR0131327B1 (en) 1998-04-17
PT88255B (pt) 1995-03-01
AU2069288A (en) 1989-02-16
PH24976A (en) 1990-12-26
DK455488A (da) 1989-02-14
FI883744A (fi) 1989-02-14
NO174052B (no) 1993-11-29
DK455488D0 (da) 1988-08-12
EP0303507B1 (de) 1993-07-28
LU90160I2 (fr) 1998-01-14
EP0303507A3 (en) 1990-09-19
EP0303507A2 (de) 1989-02-15
UY23657A1 (es) 1994-02-25
FI92397C (fi) 1994-11-10
DE3882614D1 (de) 1993-09-02
NO883587D0 (no) 1988-08-12
HU211576A9 (en) 1995-12-28
FI92397B (fi) 1994-07-29
NO1998008I1 (no) 1998-02-05
HK86793A (en) 1993-08-27
NZ225820A (en) 1990-09-26
IE61488B1 (en) 1994-11-02
NL970035I2 (nl) 1998-01-05
KR890003731A (ko) 1989-04-17
GB2208646A (en) 1989-04-12
LV5736A4 (lv) 1996-06-20
CY1728A (en) 1994-05-06
ATE92057T1 (de) 1993-08-15
DK172696B1 (da) 1999-05-31
JPH01207288A (ja) 1989-08-21
LV5736B4 (lv) 1997-06-20
IL87437A0 (en) 1989-01-31
NO883587L (no) 1989-02-14
SK281495B6 (sk) 2001-04-09
JPH0633252B2 (ja) 1994-05-02
US4997841A (en) 1991-03-05
NO174052C (no) 1994-03-09

Similar Documents

Publication Publication Date Title
CZ404291A3 (en) Indole derivatives, process of their preparation and pharmaceutical compositions containing thereof
JP2941309B2 (ja) 化合物
US5066660A (en) Indole derivatives
US5637611A (en) Medicaments
US5629430A (en) Trifluoromethylpyrroloindolecarboxylic acid ester and process for production thereof
CZ280530B6 (cs) Indolový derivát, způsob výroby a farmaceutické prostředky s jeho obsahem
JPH0329069B2 (de)
JPS63146874A (ja) インドール誘導体
US5001135A (en) Indole derivatives
US5098915A (en) Substituted N-benzylpiperidine amides
JP2001504501A (ja) ５−ｈｔ▲下１ｄ▼レセプターのリガンドとしての５−シクロインドール化合物
HUT72752A (en) Benzofuran derivatives, process for their preparation and pharmaceutical compositions containing them
WO2006115245A1 (ja) ４－エチニルイソキノリン誘導体及びこれを含有する医薬
US5770611A (en) Indole derivatives as 5HT1 -like agonists
US5210090A (en) Substituted N-benzylpiperidine amides and cardiac regulatory compositions thereof
CN1022243C (zh) 吲哚衍生物的制备方法
JPH08231504A (ja) ２−（２−インドリルエチルアミノ）−１−（３−置換フェニル）エタノール誘導体

Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic