CZ303736B6 - Slouceniny a prostredky pro zavádení aktivních cinidel - Google Patents
Slouceniny a prostredky pro zavádení aktivních cinidel Download PDFInfo
- Publication number
- CZ303736B6 CZ303736B6 CZ20030275A CZ2003275A CZ303736B6 CZ 303736 B6 CZ303736 B6 CZ 303736B6 CZ 20030275 A CZ20030275 A CZ 20030275A CZ 2003275 A CZ2003275 A CZ 2003275A CZ 303736 B6 CZ303736 B6 CZ 303736B6
- Authority
- CZ
- Czechia
- Prior art keywords
- active agent
- pharmaceutical composition
- biologically active
- chloro
- amino
- Prior art date
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- 239000013543 active substance Substances 0.000 title claims abstract description 87
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- GCVGCXMTCJMBHY-UHFFFAOYSA-N 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoic acid Chemical compound OC(=O)CCCNC(=O)C1=CC=C(Cl)C=C1O GCVGCXMTCJMBHY-UHFFFAOYSA-N 0.000 claims abstract description 15
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- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical group N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims description 6
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Classifications
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
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- A—HUMAN NECESSITIES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
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| US21489300P | 2000-06-29 | 2000-06-29 |
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| CZ303736B6 true CZ303736B6 (cs) | 2013-04-17 |
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| CZ20030275A CZ303736B6 (cs) | 2000-06-29 | 2001-06-29 | Slouceniny a prostredky pro zavádení aktivních cinidel |
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| CN (1) | CN100482637C (fr) |
| AT (1) | ATE391708T1 (fr) |
| AU (3) | AU2001273153B2 (fr) |
| BR (1) | BR0112311A (fr) |
| CA (1) | CA2411754C (fr) |
| CY (1) | CY1108532T1 (fr) |
| CZ (1) | CZ303736B6 (fr) |
| DE (1) | DE60133555T2 (fr) |
| DK (1) | DK1299348T3 (fr) |
| ES (1) | ES2306719T3 (fr) |
| HK (1) | HK1054918A1 (fr) |
| IL (1) | IL153297A0 (fr) |
| MX (1) | MXPA02012855A (fr) |
| NZ (1) | NZ523017A (fr) |
| PT (1) | PT1299348E (fr) |
| RU (1) | RU2326110C2 (fr) |
| SK (1) | SK1182003A3 (fr) |
| UA (1) | UA80248C2 (fr) |
| WO (1) | WO2002002509A1 (fr) |
| ZA (1) | ZA200209946B (fr) |
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| US6358504B1 (en) * | 1997-02-07 | 2002-03-19 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US7495030B2 (en) * | 2000-09-06 | 2009-02-24 | Emisphere Technologies, Inc. | (5-(2-hydroxy-4-chlorobenzoyl) aminovaleric acid and salts thereof and compositions containing the same for delivering active agents |
| AU2002352974A1 (en) * | 2001-11-29 | 2003-06-10 | Emisphere Technologies, Inc. | Formulations for oral administration of cromolyn sodium |
| US20030198666A1 (en) | 2002-01-07 | 2003-10-23 | Richat Abbas | Oral insulin therapy |
| ES2664189T3 (es) | 2002-01-09 | 2018-04-18 | Emisphere Technologies, Inc. | Polimorfos de 4-(4-cloro-2-hidroxibenzoil)aminobutanoato de sodio |
| ES2614603T3 (es) | 2002-02-20 | 2017-06-01 | Emisphere Technologies, Inc. | Procedimiento de administración de moléculas GLP-1 |
| NZ541058A (en) | 2003-01-06 | 2008-06-30 | Emisphere Tech Inc | Night-time oral insulin therapy |
| JP2006519881A (ja) * | 2003-03-06 | 2006-08-31 | エミスフィアー テクノロジーズ インコーポレイテッド | 経口インスリン治療及びプロトコール |
| WO2004080401A2 (fr) * | 2003-03-06 | 2004-09-23 | Emisphere Technologies, Inc. | Insulinotherapies orales et protocole |
| US7318925B2 (en) * | 2003-08-08 | 2008-01-15 | Amgen Fremont, Inc. | Methods of use for antibodies against parathyroid hormone |
| ES2321088T3 (es) | 2003-08-08 | 2009-06-02 | Amgen Fremont Inc. | Anticuerpos dirigidos frente a la hormona paratiroidea (pth) y usos de los mismos. |
| ES2278346T3 (es) | 2003-08-20 | 2007-08-01 | Eli Lilly And Company | Compuestos, procedimientos y formulaciones para suministro oral de un compuesto peptido (glp)-1 del tipo de glucagon o un peptido agonista (glp)-4 del receptor 4 de melacortina (mc4). |
| CA2530983C (fr) | 2003-08-20 | 2012-09-25 | Eli Lilly And Company | Composes, procedes et preparations destines a l'apport oral d'un compose peptidique de type glucagon (glp-1) ou d'un peptide agoniste du recepteur 4 de melanocortine (mc4) |
| US20050203001A1 (en) | 2004-03-05 | 2005-09-15 | Emisphere Technologies, Inc. | Oral insulin therapies and protocol |
| US20090029911A1 (en) * | 2003-09-25 | 2009-01-29 | Ashley Martin Williams | Liquid Human Growth Hormone Formulation Containing Polyethylene Glycol |
| US20060286129A1 (en) | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
| EP1750729A2 (fr) | 2004-05-06 | 2007-02-14 | Emisphere Technologies, Inc. | Forme de dosage solide d'heparine mouillee |
| NZ551241A (en) | 2004-05-14 | 2010-08-27 | Emisphere Tech Inc | Aryl ketone compounds and compositions for delivering active agents |
| CA2565188C (fr) | 2004-05-14 | 2014-03-04 | Emisphere Technologies, Inc. | Composes et compositions pour administration d'agents actifs |
| BRPI0510906A (pt) | 2004-05-19 | 2007-11-06 | Emisphere Tech Inc | composição farmacêutica tópica, composição para administração tópica e seu uso |
| JP5122954B2 (ja) | 2004-05-19 | 2013-01-16 | エミスフェアー・テクノロジーズ・インク | アシクロビル製剤 |
| WO2006017541A2 (fr) * | 2004-08-03 | 2006-02-16 | Emisphere Technologies, Inc. | Association d'insuline et d'un biguanide pour administration orale contre le diabète |
| JP4636839B2 (ja) * | 2004-09-24 | 2011-02-23 | パナソニック株式会社 | 電子デバイス |
| GB0427603D0 (en) * | 2004-12-16 | 2005-01-19 | Novartis Ag | Organic compounds |
| GB0427600D0 (en) * | 2004-12-16 | 2005-01-19 | Novartis Ag | Organic compounds |
| NZ556373A (en) | 2004-12-29 | 2010-01-29 | Emisphere Tech Inc | Pharmaceutical formulations of gallium salts |
| WO2006076692A1 (fr) * | 2005-01-12 | 2006-07-20 | Emisphere Technologies, Inc. | Compositions pour l'administration orale de l'hormone parathyroide |
| US8975227B2 (en) | 2005-07-15 | 2015-03-10 | Emisphere Technologies, Inc. | Intraoral dosage forms of glucagon |
| CN101296694A (zh) * | 2005-11-04 | 2008-10-29 | 真塔公司 | 药物镓组合物和方法 |
| US8927015B2 (en) | 2006-04-12 | 2015-01-06 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
| WO2007133944A2 (fr) | 2006-05-09 | 2007-11-22 | Emisphere Technologies, Inc. | Administration topique d'acyclovir |
| JP5475443B2 (ja) | 2006-06-28 | 2014-04-16 | エミスフェアー・テクノロジーズ・インク | 硝酸ガリウム製剤 |
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