CZ289641B6 - Imunokonjugát, způsob jeho přípravy a farmaceutický prostředek, který ho obsahuje - Google Patents

Imunokonjugát, způsob jeho přípravy a farmaceutický prostředek, který ho obsahuje Download PDF

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Publication number
CZ289641B6
CZ289641B6 CZ19952375A CZ237595A CZ289641B6 CZ 289641 B6 CZ289641 B6 CZ 289641B6 CZ 19952375 A CZ19952375 A CZ 19952375A CZ 237595 A CZ237595 A CZ 237595A CZ 289641 B6 CZ289641 B6 CZ 289641B6
Authority
CZ
Czechia
Prior art keywords
antibody
immunoconjugate
mab
fragment
heavy chain
Prior art date
Application number
CZ19952375A
Other languages
Czech (cs)
English (en)
Other versions
CZ237595A3 (en
Inventor
Wolfgang Hölzer
Hoegen Ilka Dr. Von
Wolfgang Dr. Strittmatter
Siegfried Dr. Matzku
Original Assignee
MERCK Patent Gesellschaft mit beschränkter Haftung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MERCK Patent Gesellschaft mit beschränkter Haftung filed Critical MERCK Patent Gesellschaft mit beschränkter Haftung
Publication of CZ237595A3 publication Critical patent/CZ237595A3/cs
Publication of CZ289641B6 publication Critical patent/CZ289641B6/cs

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CZ19952375A 1994-09-16 1995-09-14 Imunokonjugát, způsob jeho přípravy a farmaceutický prostředek, který ho obsahuje CZ289641B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP94114572 1994-09-16

Publications (2)

Publication Number Publication Date
CZ237595A3 CZ237595A3 (en) 1996-04-17
CZ289641B6 true CZ289641B6 (cs) 2002-03-13

Family

ID=8216289

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ19952375A CZ289641B6 (cs) 1994-09-16 1995-09-14 Imunokonjugát, způsob jeho přípravy a farmaceutický prostředek, který ho obsahuje

Country Status (20)

Country Link
US (1) US5824782A (hu)
EP (1) EP0706799B1 (hu)
JP (2) JP3865802B2 (hu)
KR (1) KR100386171B1 (hu)
CN (1) CN1123185A (hu)
AT (1) ATE208633T1 (hu)
AU (1) AU702184B2 (hu)
CA (1) CA2158322C (hu)
CZ (1) CZ289641B6 (hu)
DE (1) DE69523857T2 (hu)
DK (1) DK0706799T3 (hu)
ES (1) ES2167391T3 (hu)
HU (1) HU221989B1 (hu)
NO (1) NO315976B1 (hu)
PL (1) PL182636B1 (hu)
PT (1) PT706799E (hu)
RU (1) RU2157701C2 (hu)
SK (1) SK282263B6 (hu)
UA (1) UA40611C2 (hu)
ZA (1) ZA957808B (hu)

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Also Published As

Publication number Publication date
UA40611C2 (uk) 2001-08-15
AU3053395A (en) 1996-03-28
EP0706799A2 (en) 1996-04-17
PL310493A1 (en) 1996-03-18
JPH0899901A (ja) 1996-04-16
AU702184B2 (en) 1999-02-18
US5824782A (en) 1998-10-20
ES2167391T3 (es) 2002-05-16
PT706799E (pt) 2002-05-31
ZA957808B (en) 1996-05-07
NO953650D0 (no) 1995-09-15
CA2158322C (en) 2009-06-16
DE69523857D1 (de) 2001-12-20
ATE208633T1 (de) 2001-11-15
CZ237595A3 (en) 1996-04-17
NO953650L (no) 1996-03-18
HUT75836A (en) 1997-05-28
DK0706799T3 (da) 2002-02-25
KR100386171B1 (ko) 2003-08-21
CN1123185A (zh) 1996-05-29
KR960010023A (ko) 1996-04-20
SK282263B6 (sk) 2001-12-03
HU221989B1 (hu) 2003-03-28
EP0706799A3 (en) 1996-12-04
NO315976B1 (no) 2003-11-24
CA2158322A1 (en) 1996-03-17
JP3865802B2 (ja) 2007-01-10
PL182636B1 (pl) 2002-02-28
RU2157701C2 (ru) 2000-10-20
EP0706799B1 (en) 2001-11-14
HU9502711D0 (en) 1995-11-28
JP2006117684A (ja) 2006-05-11
DE69523857T2 (de) 2002-06-13
SK114595A3 (en) 1997-03-05

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