CZ282759B6 - Derivát isatinoximu, způsob jeho přípravy a farmaceutický prostředek, který ho obsahuje - Google Patents

Derivát isatinoximu, způsob jeho přípravy a farmaceutický prostředek, který ho obsahuje Download PDF

Info

Publication number
CZ282759B6
CZ282759B6 CZ94395A CZ39594A CZ282759B6 CZ 282759 B6 CZ282759 B6 CZ 282759B6 CZ 94395 A CZ94395 A CZ 94395A CZ 39594 A CZ39594 A CZ 39594A CZ 282759 B6 CZ282759 B6 CZ 282759B6
Authority
CZ
Czechia
Prior art keywords
isatinoxime
group
formula
branched
carbon atoms
Prior art date
Application number
CZ94395A
Other languages
Czech (cs)
English (en)
Other versions
CZ39594A3 (en
Inventor
Frank Watjen
Bjarne Hugo Dahl
Jorgen Drejer
Leif Helth Jensen
Original Assignee
Neurosearch A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch A/S filed Critical Neurosearch A/S
Publication of CZ39594A3 publication Critical patent/CZ39594A3/cs
Publication of CZ282759B6 publication Critical patent/CZ282759B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CZ94395A 1991-08-28 1992-08-27 Derivát isatinoximu, způsob jeho přípravy a farmaceutický prostředek, který ho obsahuje CZ282759B6 (cs)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75116591A 1991-08-28 1991-08-28
US83185192A 1992-02-05 1992-02-05
PCT/EP1992/001999 WO1993005043A1 (en) 1991-08-28 1992-08-27 Novel isatinoxime derivatives, their preparation and use

Publications (2)

Publication Number Publication Date
CZ39594A3 CZ39594A3 (en) 1994-11-16
CZ282759B6 true CZ282759B6 (cs) 1997-09-17

Family

ID=27115380

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ94395A CZ282759B6 (cs) 1991-08-28 1992-08-27 Derivát isatinoximu, způsob jeho přípravy a farmaceutický prostředek, který ho obsahuje

Country Status (18)

Country Link
EP (1) EP0529636B1 (cg-RX-API-DMAC10.html)
JP (1) JP3170584B2 (cg-RX-API-DMAC10.html)
KR (1) KR100277481B1 (cg-RX-API-DMAC10.html)
AT (1) ATE181552T1 (cg-RX-API-DMAC10.html)
AU (1) AU655672B2 (cg-RX-API-DMAC10.html)
CA (1) CA2076948C (cg-RX-API-DMAC10.html)
CZ (1) CZ282759B6 (cg-RX-API-DMAC10.html)
DE (1) DE69229461T2 (cg-RX-API-DMAC10.html)
DK (1) DK0529636T3 (cg-RX-API-DMAC10.html)
FI (1) FI107156B (cg-RX-API-DMAC10.html)
GE (1) GEP20002329B (cg-RX-API-DMAC10.html)
HU (2) HUT70753A (cg-RX-API-DMAC10.html)
MX (1) MX9204914A (cg-RX-API-DMAC10.html)
NO (1) NO301117B1 (cg-RX-API-DMAC10.html)
PL (1) PL170920B1 (cg-RX-API-DMAC10.html)
RU (1) RU2114827C1 (cg-RX-API-DMAC10.html)
SK (1) SK280578B6 (cg-RX-API-DMAC10.html)
WO (1) WO1993005043A1 (cg-RX-API-DMAC10.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2109516T3 (es) 1992-10-13 1998-01-16 Warner Lambert Co Derivados de quinoxalinodiona como antagonistas de aminoacidos excitadores.
NZ267081A (en) * 1993-05-13 1997-11-24 Neurosearch As Hetero-fused indole and quinoxaline compounds and medicaments thereof
US5843945A (en) * 1993-05-13 1998-12-01 Neurosearch A/S AMPA antagonists and a method of treatment
DK81593D0 (da) * 1993-07-07 1993-07-07 Neurosearch As Nye isatinoximderivater, deres fremstilling og anvendelse
AU687255B2 (en) * 1994-09-14 1998-02-19 Neurosearch A/S Indole-2,3-dione-3-oxime derivatives, their preparation and use
JP3164372B2 (ja) * 1994-09-14 2001-05-08 ノイロサーチ アクティーゼルスカブ 融合インドール及びキノキサリン誘導体、その製造および使用
UA54403C2 (uk) * 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
FR2768624B1 (fr) 1997-09-25 1999-11-12 Oreal Utilisation d'un inhibiteur d'acides amines excitateurs dans une composition cosmetique ou dermatologique pour peaux sensibles et composition obtenue
WO2000071102A2 (en) * 1999-05-19 2000-11-30 Neurosearch A/S Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
EP1736468A3 (en) 2000-01-24 2007-01-03 NeuroSearch A/S Isatin derivatives with neurotrophic activity useful in the treatment of diseases mediated by the nerve growth factor (NGF) activation
US7250422B2 (en) 2002-10-29 2007-07-31 Sungkyunkwan University Pharmaceutical composition containing berberine as effective ingredient for preventing and treating addiction or tolerance to morphine
KR20080070749A (ko) 2005-11-23 2008-07-30 페인셉터 파마 코포레이션 개폐 이온 통로를 조절하기 위한 조성물 및 방법
MX2015007710A (es) * 2012-12-19 2015-09-23 Bayer Cropscience Ag Indanilcarboxamidas difluorometil-nicotinicas.
WO2015129592A1 (ja) * 2014-02-28 2015-09-03 住友化学株式会社 ２－（ハロゲノメチル）－３－メチルニトロベンゼンの製造方法
PL3429352T3 (pl) 2016-03-17 2022-08-22 Fmc Corporation Sposób konwersji enancjomeru-S do jego postaci racemicznej
CN109776451B (zh) * 2017-11-15 2020-12-11 中山光禾医疗科技有限公司 光交联水凝胶材料的制备、原料、产品及应用
CN108912127B (zh) * 2018-08-27 2019-12-10 青岛农业大学 一种基于靛红骨架的苯并[b,e]氮杂卓化合物及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE69677B1 (en) * 1989-12-11 1996-10-02 Neurosearch As Isatine derivatives their preparation and use

Also Published As

Publication number Publication date
HU211632A9 (en) 1995-12-28
FI940889A7 (fi) 1994-02-25
SK23894A3 (en) 1994-12-07
HUT70753A (en) 1995-10-30
CA2076948A1 (en) 1993-03-01
SK280578B6 (sk) 2000-04-10
DE69229461D1 (de) 1999-07-29
WO1993005043A1 (en) 1993-03-18
NO940676L (cg-RX-API-DMAC10.html) 1994-04-27
CZ39594A3 (en) 1994-11-16
CA2076948C (en) 2002-04-16
NO940676D0 (no) 1994-02-25
DK0529636T3 (da) 1999-12-13
PL170920B1 (pl) 1997-02-28
EP0529636A1 (en) 1993-03-03
FI107156B (fi) 2001-06-15
FI940889A0 (fi) 1994-02-25
ATE181552T1 (de) 1999-07-15
MX9204914A (es) 1993-07-01
RU2114827C1 (ru) 1998-07-10
HU9400595D0 (en) 1994-05-30
JP3170584B2 (ja) 2001-05-28
GEP20002329B (en) 2000-12-25
AU2482092A (en) 1993-04-05
NO301117B1 (no) 1997-09-15
KR100277481B1 (ko) 2001-02-01
JPH06510056A (ja) 1994-11-10
AU655672B2 (en) 1995-01-05
EP0529636B1 (en) 1999-06-23
DE69229461T2 (de) 1999-10-21

Similar Documents

Publication Publication Date Title
EP0587473B1 (fr) Dérivés condensés de la pyridine comme inhibiteurs de l'effet des radicaux libres
RU2114827C1 (ru) Производные изатина или изатиноксима, способ получения производных изатиноксима и фармацевтическая композиция
KR100192641B1 (ko) 하이드라존 유도체, 이의 제조방법 및 이를 포함하는 약제학적 조성물
EP0059391A1 (de) Imidazodiazepine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
NO154883B (no) Analogifremgangsmaate ved fremstilling av nye, terapeutisk aktive 2-acylaminomethyl-1,4-benzodiazepiner.
DK164704B (da) 3,6-disubstituerede triazolo-oe3,4-aaa-ftalazinderivater, fremgangsmaade til fremstilling deraf, udgangsforbindelse til anvendelse i fremgangsmaaden samt anvendelse af og farmaceutisk praeparat indeholdende forbindelserne
Hussenether et al. Clozapine derived 2, 3-dihydro-1H-1, 4-and 1, 5-benzodiazepines with D4 receptor selectivity: synthesis and biological testing
JP3010558B2 (ja) 新規の１，７‐融合１ｈ‐インドール‐２‐カルボン酸‐ｎ‐（１，４‐ベンゾジアゼピン‐３‐イル）‐アミド、その製法及びこれを含有するコレシストキニン拮抗作用薬剤
US5436250A (en) Isatineoxime derivatives, their preparation and use
US5242918A (en) Isatinoxime derivatives, their preparation and use
DE3587556T2 (de) 2-Substituierte Aminomethyl-1,4-benzodiazepine, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen.
CS226743B2 (en) Method of preparing new 1,4,9,10-tetrahydropyrazolo (4,3-e)pyrido (3,2-b) l,4)diazepin-10-ones
CA2443870A1 (en) Cyclohexylphenyl vasopressin agonists
US6602865B1 (en) Pyridazino(4,5-b)(1,5)oxazepinone, -thiazepinone and -diazepinone compounds
JP3781698B2 (ja) 新規ピリミジン−４−オン化合物、その調製方法、およびそれらを含む医薬組成物
JP2001512124A (ja) 新規な２，３−ベンゾジアゼピン誘導体
AU762526B2 (en) Novel type condensed pyridazinone compounds
KR0128975B1 (ko) 9-아실아미노-테트라히드로아크리딘 유도체 및 그 유도체를 활성 성분으로 포함하는 기억력 촉진제
WO1993008166A1 (en) Benzo-isoquinoline derivatives and analogs and their use in therapeutics
CN114671829B (zh) 以茚酮和二苯并氮杂卓为母核的杂二联体及其盐酸盐、其制备方法和用途
CN1950370B (zh) 对映体纯的六氢吡咯并环戊吡啶-衍生物
HUP0100751A2 (hu) Új aril-vagy heteroaril-kinolinilfoszfonsav-származékok, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyszerkészítmények
AT395155B (de) Verfahren zur herstellung von neuen imidazo(1,5-a)(1,4)diazepinverbindungen
LU84775A1 (fr) Nouveaux derives cycloaliphatiques condenses de pyrido(1,2-a)pyrimidines substituees
JPH04235987A (ja) 縮合ピリダジノン化合物

Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20030827