ES2109516T3 - Derivados de quinoxalinodiona como antagonistas de aminoacidos excitadores. - Google Patents
Derivados de quinoxalinodiona como antagonistas de aminoacidos excitadores.Info
- Publication number
- ES2109516T3 ES2109516T3 ES93922849T ES93922849T ES2109516T3 ES 2109516 T3 ES2109516 T3 ES 2109516T3 ES 93922849 T ES93922849 T ES 93922849T ES 93922849 T ES93922849 T ES 93922849T ES 2109516 T3 ES2109516 T3 ES 2109516T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- alkyl
- chr13
- chr14
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001413 amino acids Chemical class 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 9
- 239000001257 hydrogen Substances 0.000 abstract 9
- 150000001875 compounds Chemical class 0.000 abstract 3
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical group O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- XXJGBENTLXFVFI-UHFFFAOYSA-N 1-amino-methylene Chemical compound N[CH2] XXJGBENTLXFVFI-UHFFFAOYSA-N 0.000 abstract 1
- OZDAOHVKBFBBMZ-UHFFFAOYSA-N 2-aminopentanedioic acid;hydrate Chemical compound O.OC(=O)C(N)CCC(O)=O OZDAOHVKBFBBMZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 108010011562 aspartic acid receptor Proteins 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
UN COMPUESTO QUE TIENE LA FORMULA (I) O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, EN LA QUE R ES HIDROGENO O HIDROXI; R1 ES HIDROGENO, ALQUILO, ARILALQUILO, (CH2)NOH O (CH2)NR7R8; R5 Y R6 SON CADA UNO, INDEPENDIENTEMENTE, HIDROGENO, HALOGENO, NO2, CN, CF3, SO2NR7R8, PO3R9R10, ALQUILO, ALQUENILO, ALQUINILO, (CH2)NCONR7R8, (CH2)NCO2R10, NHCOR11, EN DONDE R7 Y R8 SON CADA UNO, INDEPENDIENTEMENTE, HIDROGENO O ALQUILO O R7 Y R8 JUNTOS FORMAN UN ANILLO DE TRES A SIETE ATOMOS, R9 ES HIDROGENO O ALQUILO, R10 ES HIDROGENO O ALQUILO, R11 ES HIDROGENO O ALQUILO Y N ES UN ENTERO DE CERO A CUATRO; A ES UN ANILLO DE CINCO A SIETE ATOMOS FUSIONADO CON EL ANILLO BENZO EN LAS POSICIONES MARCADAS A Y B Y ESTA FORMADO POR LOS SIGUIENTES RADICALES BIVALENTES: A-NR12-CHR13-CHR14-B, A-CHR13CHR14-NR12-B, A-CHR13-NR12-CHR14-B, A-CHR14-CH2-NR12-CHR13-B, ACHR13-NR12-CH2-CHR14-B, A-CH2-CH2-CHR13-NR12-B, A-NR12-CHR13-CH2-CH2B, A-CH2-CH2-NR12-CH2-CH2-B, A-CH2-CH2-CH2-NR12-CH2-B, A-CH2-NR12CH2-CH2-CH2-B, A-CH2-CH2-CH2-CH2-NR12-B, A-NR12-CH2-CH2-CH2-CH2-B, EN DONDE R12 ES HIDROGENO, CH2CH2OH O ALQUILO Y R13 Y R14 SON CADA UNO, INDEPENDIENTEMENTE, HIDROGENO, CN, CONH2, CH2NH2, CH2OH, ALQUILO, ARILALQUILO, ALQUENILO O CO2R15, EN DONDE R15 ES HIDROGENO O ALQUILO. LOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS DE MAMIFEROS Y RESPONDEN AL BLOQUEO DE RECEPTORES DE ACIDO GLUTAMICO Y ASPARTICO. TAMBIEN SE PRESENTAN LOS PROCESOS PARA LA PREPARACION DE LOS COMPUESTOS Y NUEVOS INTERMEDIOS UTILES EN LOS PROCESOS.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96015792A | 1992-10-13 | 1992-10-13 | |
| US3433293A | 1993-03-22 | 1993-03-22 | |
| US12477093A | 1993-09-24 | 1993-09-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2109516T3 true ES2109516T3 (es) | 1998-01-16 |
Family
ID=27364627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93922849T Expired - Lifetime ES2109516T3 (es) | 1992-10-13 | 1993-10-08 | Derivados de quinoxalinodiona como antagonistas de aminoacidos excitadores. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6703391B2 (es) |
| EP (1) | EP0664807B1 (es) |
| JP (1) | JPH08502483A (es) |
| AT (1) | ATE157977T1 (es) |
| AU (1) | AU680632B2 (es) |
| DE (1) | DE69313866T2 (es) |
| DK (1) | DK0664807T3 (es) |
| ES (1) | ES2109516T3 (es) |
| GR (1) | GR3025257T3 (es) |
| WO (1) | WO1994009000A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69407407T2 (de) * | 1993-05-13 | 1998-04-09 | Neurosearch As | Ampa antagonisten und behandlungsmethode |
| US5843945A (en) * | 1993-05-13 | 1998-12-01 | Neurosearch A/S | AMPA antagonists and a method of treatment |
| EP0705834A1 (de) * | 1994-07-27 | 1996-04-10 | Ciba-Geigy Ag | Azaaliphatisch Überbrückte Chinoxalin-2,3-dione |
| EP0705835A1 (de) * | 1994-09-01 | 1996-04-10 | Ciba-Geigy Ag | Oxa- oder thiaaliphatisch überbrückte Chinoxalin-2,3-dione |
| JP3164371B2 (ja) * | 1994-09-14 | 2001-05-08 | ノイロサーチ アクティーゼルスカブ | インドール−２，３−ジオン−３−オキシム誘導体、その製造および使用 |
| NZ293266A (en) * | 1994-09-14 | 1998-01-26 | Neurosearch As | Fused indole and quinoxaline dione and dione oxime derivatives, preparation and pharmaceutical compositions |
| WO1996028445A1 (en) * | 1995-03-14 | 1996-09-19 | Warner-Lambert Company | Novel glutamate (ampa/kainate) receptor antagonists: n-substituted fused azacycloalkylquinoxalinediones |
| AU3571997A (en) * | 1996-08-01 | 1998-02-25 | Warner-Lambert Company | Novel glutamate receptor antagonists: fused cycloalkyl quinoxalinediones |
| WO2002014277A1 (fr) * | 2000-08-10 | 2002-02-21 | Tanabe Seiyaku Co., Ltd. | Composes de biphenylcarboxamidoisoindoline, procedes de preparation de ceux-ci et produits intermediaires destines a la synthese de ceux-ci |
| AU2001277727A1 (en) * | 2000-08-10 | 2002-02-25 | Tanabe Seiyaku Co., Ltd. | Benzoylaminoisoindoline compounds, processes for the preparation of the same andintermediates for the synthesis thereof |
| DE10121215A1 (de) | 2001-04-30 | 2002-10-31 | Merck Patent Gmbh | Dihydro-imidazo[4,5-e]indol- und 7H-Pyrrolo[3,2-f]chinoxalin Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden |
| US7718641B2 (en) | 2005-11-23 | 2010-05-18 | Aros Pharma Aps | Pyrrolo [3,4-H] isoquinoline compounds and methods for modulating gated ion channels |
| CA2652307A1 (en) * | 2006-04-10 | 2007-10-18 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| CN103237794B (zh) * | 2010-07-29 | 2016-07-06 | 日本化学医药株式会社 | P2x4受体拮抗剂 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK146787A (da) * | 1987-03-23 | 1988-09-24 | Ferrosan | Heterocykliske forbindelser, deres fremstilling og anvendelse |
| DK160941C (da) | 1988-06-28 | 1991-10-21 | Novo Nordisk As | Kondenserede 2,3-dihydroxypyraziner, fremgangsmaade til deres fremstilling og farmaceutiske praeparater, hvori forbindelserne indgaar |
| DK716188D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Quinoxalinforbindelser, deres fremstilling og anvendelse |
| DK101290D0 (da) | 1990-04-24 | 1990-04-24 | Novo Nordisk As | Heterocykliske forbindelser, deres fremstilling og anvendelse |
| EP0556393B1 (en) | 1990-11-06 | 2000-07-26 | Yamanouchi Pharmaceutical Co. Ltd. | Fused pyrazine derivative |
| MX9204914A (es) | 1991-08-28 | 1993-07-01 | Frank Watjen | Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende. |
| WO1996028445A1 (en) * | 1995-03-14 | 1996-09-19 | Warner-Lambert Company | Novel glutamate (ampa/kainate) receptor antagonists: n-substituted fused azacycloalkylquinoxalinediones |
-
1993
- 1993-10-08 ES ES93922849T patent/ES2109516T3/es not_active Expired - Lifetime
- 1993-10-08 JP JP6510172A patent/JPH08502483A/ja active Pending
- 1993-10-08 EP EP93922849A patent/EP0664807B1/en not_active Expired - Lifetime
- 1993-10-08 DE DE69313866T patent/DE69313866T2/de not_active Expired - Lifetime
- 1993-10-08 WO PCT/US1993/009667 patent/WO1994009000A1/en active IP Right Grant
- 1993-10-08 DK DK93922849.0T patent/DK0664807T3/da active
- 1993-10-08 AT AT93922849T patent/ATE157977T1/de active
- 1993-10-08 AU AU51715/93A patent/AU680632B2/en not_active Ceased
-
1995
- 1995-05-18 US US08/443,507 patent/US6703391B2/en not_active Expired - Fee Related
-
1997
- 1997-11-05 GR GR970402894T patent/GR3025257T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0664807T3 (da) | 1998-04-27 |
| DE69313866D1 (de) | 1997-10-16 |
| EP0664807B1 (en) | 1997-09-10 |
| AU680632B2 (en) | 1997-08-07 |
| DE69313866T2 (de) | 1998-03-05 |
| AU5171593A (en) | 1994-05-09 |
| WO1994009000A1 (en) | 1994-04-28 |
| EP0664807A1 (en) | 1995-08-02 |
| US6703391B2 (en) | 2004-03-09 |
| US20030114422A1 (en) | 2003-06-19 |
| GR3025257T3 (en) | 1998-02-27 |
| JPH08502483A (ja) | 1996-03-19 |
| ATE157977T1 (de) | 1997-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2109516T3 (es) | Derivados de quinoxalinodiona como antagonistas de aminoacidos excitadores. | |
| PE46899A1 (es) | Derivados de n-fenil-sulfonamida | |
| PE20020721A1 (es) | Derivados de quinuclidina como agentes antimuscarinicos m3 | |
| AR068413A2 (es) | Derivados 8-amino, metodos de preparacion, composiciones farmaceuticas y su uso en terapia | |
| MY100740A (en) | Spiro-substituted glutaramide diuretic agents. | |
| SE8900039L (sv) | Isokinolinderivat, deras framstaellning och deras anvaendning | |
| EA199900531A1 (ru) | Хинолиновые и хиназолиновые соединения, применяемые в терапии, особенно при лечении доброкачественной гиперплазии простаты | |
| ES2129483T3 (es) | Derivados de indol-7-carboxamida como analgesicos. | |
| FI970785A0 (fi) | Fuusioituneet indoli- ja kinoksaliinijohdannaiset ja niiden valmistus ja käyttö | |
| ES515904A0 (es) | "procedimiento para preparar nuevas triazoloquinazolonas". | |
| ID16001A (id) | Turunan 3,4-dihidroisokuinolin dan penggunaan leburan dihidropiridina sebagai senyawa farmasi | |
| DK1068184T3 (da) | N-aryloxyethylaminderivater til behandling af despression | |
| ES544828A0 (es) | Procedimiento para preparar nuevos compuestos de 3-(aminoal-quilaminocarbonilmetoxi)-5-fenilpirazol | |
| ES2038532B1 (es) | Procedimiento de preparacion de nuevos derivados de 2-piperacinilbecimidazol. | |
| FI852672L (fi) | Ringfusionerade pyrazolo(3,4-d)-pyridin -3-onderivat. | |
| CO4950554A1 (es) | Derivados de 1,3-dihidro o 3,4-dihidroisoquinolin-benzamida | |
| DE69011714D1 (de) | Kalziumantagonisten. | |
| FI832922A (fi) | 1-fenetyl- -fenylpiperidin-3-propannitrilderivat, deras framstaellning och terapeutiska tillaempning | |
| AR009665A1 (es) | Compuestos derivados de pirrolidinamida sustituidos con heterociclos, utiles como antagonistas de receptores de taquiquininas, composiciones farmaceuticas que incluyen dichos compuestos, usos en la preparacion de composiciones farmaceuticas para tratamiento de enfermedades y procedimiento de preprac | |
| ES535628A0 (es) | Procedimiento para preparar nuevos compuestos heterociclicos | |
| DE3882589D1 (de) | 4-substituierte 10-cyanmethylenpyrrolo(4,3-e)-benzo-azepine. | |
| FI933119A (fi) | 4- ja 6-substituoidut 1,2,3,3a,8,8a-heksahydro-1,3a,8-trimetyylipyrrolo/2,3-b/indolijohdannaiset | |
| CO4750821A1 (es) | Compuestos indolina para el tratamiento de enfermedades |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 664807 Country of ref document: ES |